IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-07 DOI: 10.1016/j.alcohol.2025.05.001

Mariann R. Piano , Shane A. Phillips , Chueh-Lung Hwang , Keng-Yu Chang , Kevin M. Najarro , Rachel H. McMahan , Elizabeth J. Kovacs

Background

This exploratory study examined plasma levels of pro-inflammatory cytokines, chemokines and growth factors as well as intestinal fatty acid-binding protein (iFABP) and zonulin levels between young adult male and female low-risk and at-risk drinkers.

Methods

A total of 33 low-risk (phosphatidylethanol levels <20 ng/ml; 19 female) and 44 at-risk drinkers (phosphatidylethanol levels ≥20 ng/ml; 30 female) were included in this study. Fasting blood samples were obtained in all participants. A multiplex assay was used to measure 48 chemokines and growth factors. An enzyme-linked immunoassay was used to measure plasma levels of human iFABP and zonulin.

Results

We found that in young female, at-risk drinkers had a lower level of granulocyte-macrophage colony-stimulating factor (p = 0.04) and platelet-derived growth factor BB (P = 0.04) than low-risk drinkers, while in males, an elevated level of interferon-gamma was found in at-risk drinkers compared to low-risk drinkers (P = 0.04). Intestinal fatty acid-binding protein levels were significantly higher and zonulin levels were significantly lower in at-risk-risk drinkers compared to low-risk drinkers (P = 0.001 and P = 0.02, respectively).

Conclusions

These findings suggest that at-risk drinking in young adults is associated with alterations in specific cytokines and proteins involved in intestinal barrier function.

背景：本探索性研究检测了血浆中促炎细胞因子、趋化因子和生长因子水平以及肠道脂肪酸结合蛋白（iFABP）和zonulin水平在年轻成年男性和女性低危和高危饮酒者之间。结果：我们发现在年轻女性中，高危饮酒者的粒细胞-巨噬细胞集落刺激因子（p=0.04）和血小板衍生生长因子BB （p=0.04）水平低于低危饮酒者，而在男性中，与低危饮酒者相比，高危饮酒者的干扰素γ水平升高（p=0.04）。与低风险饮酒者相比，高危饮酒者肠道脂肪酸结合蛋白水平显著升高，zonulin水平显著降低（P分别=0.001和P=0.02）。结论：这些研究结果表明，年轻人的高危饮酒与肠道屏障功能相关的特定细胞因子和蛋白质的改变有关。

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引用次数: 0

Resilience building discourse in online spaces: A comparative analysis of user statements following the disclosure of a break in alcohol abstinence 网络空间中的弹性建构话语：对戒酒中断披露后用户陈述的比较分析。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-04-29 DOI: 10.1016/j.alcohol.2025.04.003

Lynda K. Maxfield, Tara M. Emmers-Sommer

This study investigates statements made by individuals who either disclose having experienced a break in alcohol abstinence or provide a first-level response to such disclosures. An average month of public Reddit data were examined, resulting in 193 posts and 1238 responses. Post statements were binarily considered according to eight a priori categories, primarily guided by the communication resilience process scale (CRPS; Wilson et al., 2021). Coded response posts were collapsed into sets corresponding to initial posts, facilitating the saturation comparison of resilience building statements between initial and response posts. Results indicate that responses were more resilience-heavy than initial posts, suggesting users looking to disclose an abstinence break have a good chance of experiencing resilience building responses. Notably, the top three resilience building categories identified in this study were identical for initial and response posts. Discussion, implications, and future research directions regarding communicating resilience and resilience building discourse follow.

这项研究调查了一些人的陈述，这些人要么透露自己经历了戒酒的中断，要么对这种披露提供了一级反应。研究人员检查了Reddit平均一个月的公开数据，共有193条帖子和1238条回复。后陈述根据八个先验类别进行二元考虑，主要以沟通弹性过程量表(CRPS；Wilson et al., 2021)。编码响应岗位被压缩成与初始岗位相对应的集合，便于初始岗位和响应岗位弹性建设陈述的饱和比较。结果表明，回应比最初的帖子更有弹性，这表明希望透露禁欲休息的用户很有可能经历弹性建设的回应。值得注意的是，本研究确定的前三个弹性建设类别对于初始和响应职位是相同的。最后，讨论了沟通弹性和弹性建设的相关问题，并提出了未来的研究方向。

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引用次数: 0

Corrigendum to “Time-course concentration of ethanol, acetaldehyde and acetate in rat brain dialysate following alcohol self-administration” [Alcohol 123 (2025) 69–76] “自我给药后大鼠脑透析液中乙醇、乙醛和醋酸盐的时间过程浓度”的勘误表[酒精123 (2025)69-76]

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-04-23 DOI: 10.1016/j.alcohol.2025.03.004

Tse-Ang Lee , Hongjoo J. Lee , Regina A. Mangieri , Rueben Gonzales , Heba Ajmal , Tanya Hutter

引用次数: 0

New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting 饮酒对免疫、炎症和器官功能影响的新进展：2024年酒精和免疫学研究兴趣小组（AIRIG）会议总结

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-04-21 DOI: 10.1016/j.alcohol.2025.04.002

Madison M. Tschann , Vidula Vachharajani , Eileen M. Redmond , Andrew Hoisington , Sarah E. Cohen , Moses New-Aaron , Cristina Llorente , Janos Paloczi , Claudia R. Keating , Wiramon Rungratanawanich , Ellen L. Burnham , John J. Callaci , Preeti Raju , Weizhe Zhong , Abhishek Mandal , Justine R. Zimmerly , Adriana S.P. Nuncio , Pranoti Mandrekar , Rebecca L. McCullough , Rachel H. McMahan , Mashkoor A. Choudhry

The 29th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held on November 22nd, 2024, at Loyola University Chicago, Health Science Campus, Maywood, Illinois. The meeting was divided into three plenary sessions and a poster session. The overall focus of this year’s meeting was on alcohol and host immunity, alcohol and organ dysfunction, and alcohol, inflammation, and tissue injury. The presentations in each session shared the latest developments on the impact of alcohol in a wide variety of fields including trauma, emergency care and hospitalization, cardiovascular health, neurodegenerative disease, gut microbiome, and hepatology.

第29届年度酒精和免疫学研究兴趣小组（AIRIG）会议于2024年11月22日在伊利诺伊州梅伍德的芝加哥洛约拉大学健康科学校区举行。会议分为三次全体会议和一次海报会议。今年会议的总体重点是酒精与宿主免疫、酒精与器官功能障碍以及酒精、炎症和组织损伤。每次会议的报告都分享了酒精在各种领域的影响的最新进展，包括创伤、急诊护理和住院、心血管健康、神经退行性疾病、肠道微生物群和肝病学。

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引用次数: 0

Analysis of the synergy between prenatal ethanol and postnatal adolescent ethanol exposure 产前乙醇和产后青少年乙醇暴露的协同作用分析

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-04-09 DOI: 10.1016/j.alcohol.2025.04.001

Leonardo Marengo , Rodrigo García Virgolini , Victoria Mujica , María Carolina Fabio , Ricardo Marcos Pautassi

Prenatal ethanol exposure (PEE) is associated with long-lasting neurodevelopmental alterations that increase susceptibility to adverse behavioral outcomes, including greater likelihood of binge drinking during adolescence. However, the interactive effects of these two developmental risk factors remain underexplored. The present study investigated the synergistic impact of PEE and adolescent binge-like ethanol exposure on behavioral and ethanol consumption patterns in Wistar rats. Pregnant dams received ethanol (2.0 g/kg/day) or vehicle from gestational days 17–20. Offspring were subjected to intermittent ethanol exposure (4.0 g/kg/day, two days on–two days off) or vehicle from postnatal days 23–36. Behavioral assessments included tests for anxiety-like behaviors (light–dark box test), anhedonia (sucrose preference test), exploratory behavior (multivariate concentric square field test), and voluntary ethanol consumption in early adulthood. PEE was associated with increased overall fluid consumption (p = 0.001, η²p = 0.17) and a sex-dependent increase in ethanol intake (p = 0.001, η²p = 0.05). PEE rats displayed reduced sucrose preference (p = 0.02, η²p = 0.07), suggesting an anhedonic-like phenotype independent of adolescent ethanol exposure. The latter exposure induced an anxious phenotype, characterized by reduced time in the illuminated compartment of the light–dark box test, which was attenuated in PEE-exposed rats (p = 0.03, η²p = 0.06). These findings suggest that PEE (a) facilitates ethanol consumption in offspring, potentially through tolerance mechanisms or altered chemosensory processing; and (b) modulates anxiety-like behaviors induced by adolescent ethanol exposure. Understanding these interactions is critical for elucidating the mechanisms underlying alcohol use disorders and designing targeted interventions for at-risk populations.

产前乙醇暴露（PEE）与长期的神经发育改变有关，增加了不良行为结果的易感性，包括青春期酗酒的可能性更大。然而，这两种发育风险因素的相互作用仍未得到充分探讨。本研究探讨了PEE和青少年酒精暴露对Wistar大鼠行为和酒精消费模式的协同影响。从妊娠第17-20天开始，孕鼠接受乙醇（2.0 g/kg/天）或载药。子代从出生后23-36天开始接受间歇乙醇暴露（4.0 g/kg/天，开两天，休息两天）或车辆。行为评估包括焦虑样行为（光-暗盒测试）、快感缺乏（蔗糖偏好测试）、探索性行为（多变量同心方场测试）和成年早期的自愿乙醇消费测试。PEE与总液体消耗量增加（p = 0.001, η2p = 0.17）和乙醇摄入量增加（p = 0.001, η2p = 0.05）相关。PEE大鼠表现出较低的蔗糖偏好（p = 0.02, η2p = 0.07），提示一种与青春期乙醇暴露无关的快感缺乏样表型。后一种暴露诱发了焦虑表型，其特征是在明暗箱试验的光照室中停留的时间减少，在pee暴露的大鼠中这种情况有所减弱（p = 0.03, η2p = 0.06）。这些发现表明，PEE (a)可能通过耐受性机制或改变化学感觉加工促进后代对乙醇的消耗；(b)调节青少年酒精暴露诱导的焦虑样行为。了解这些相互作用对于阐明酒精使用障碍的机制和为高危人群设计有针对性的干预措施至关重要。

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引用次数: 0

Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species 酒精降低人干细胞来源的脑微血管内皮细胞屏障完整性：活性氧的作用

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-04-03 DOI: 10.1016/j.alcohol.2025.03.005

Kameron T. Bell , Jason M. Hughes , Wesley A. Borman , Ryan D. Stoffel , Scott G. Canfield

The World Health Organization has linked alcohol consumption to over 200 diseases including neurodegenerative diseases. A dysfunctional blood–brain barrier (BBB) has been found to be influential in a number of brain disorders. The BBB is critical in maintaining homeostasis between the brain vasculature and parenchyma and a loss in barrier integrity would enable otherwise impermeable immune cells, molecules, and inflammatory mediators to reach the brain parenchyma. A subset of studies demonstrated that alcohol could diminish BBB integrity, but it is unclear if this effect translates clinically. In this study, we utilize a human stem cell-derived BBB model with near in vivo properties to investigate the effects of alcohol on critical barrier properties. Barrier forming brain-like microvascular endothelial cells (BMECs) were derived from human induced pluripotent stem cells (iPSCs) and exposed to several alcohol concentrations. Alcohol decreased barrier integrity observed by a loss in trans-endothelial electrical resistance and an increase in sodium fluorescein permeability. Alcohol decreased expression and junctional localization of tight junction proteins, a critical component to barrier integrity. Additionally, alcohol did not affect efflux transporter activity or cell viability in BMECs. The detrimental effects of alcohol on BBB properties were due to in part elevated reactive oxygen species (ROS); as scavenging ROS improved barrier properties, including the restoration of tight junction expression and localization. These data suggest that excessive alcohol consumption could diminish the BBB and contribute to the development or exacerbation of brain disorders.

Clinical trial number and registry URL

Not applicable.

世界卫生组织将饮酒与200多种疾病联系起来，其中包括神经退行性疾病。血脑屏障功能障碍（BBB）已被发现对许多脑部疾病有影响。血脑屏障在维持脑血管和脑实质之间的稳态中起着至关重要的作用，屏障完整性的丧失将使原本不可渗透的免疫细胞、分子和炎症介质能够到达脑实质。一部分研究表明，酒精可以降低血脑屏障的完整性，但尚不清楚这种影响是否在临床上转化。在这项研究中，我们利用具有接近体内特性的人类干细胞衍生血脑屏障模型来研究酒精对关键屏障特性的影响。形成屏障的脑样微血管内皮细胞（BMECs）来源于人诱导多能干细胞（iPSCs），并暴露于几种浓度的酒精中。酒精降低屏障完整性，观察到跨内皮电阻的损失和荧光素钠通透性的增加。酒精降低了紧密连接蛋白的表达和连接定位，紧密连接蛋白是屏障完整性的关键组成部分。此外，酒精不影响bmec的外排转运蛋白活性或细胞活力。酒精对血脑屏障性能的有害影响部分是由于活性氧（ROS）的升高；清除活性氧可以改善屏障特性，包括恢复紧密连接的表达和定位。这些数据表明，过量饮酒可能会减少血脑屏障，导致大脑疾病的发展或恶化。临床试验编号和注册地址：不适用。

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引用次数: 0

Epidemiological and demographic drivers of alcohol-attributable pancreatitis from 1990 to 2021: Findings from the 2021 Global Burden of Disease study 1990年至2021年酒精所致胰腺炎的流行病学和人口统计学驱动因素：来自2021年全球疾病负担研究的结果发表于：酒精。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-03-21 DOI: 10.1016/j.alcohol.2025.03.001

Tang Yujin , Dai Dandan , Zhong Qian , Pan Wenhao , Di Xingwei

Background

Alcohol significantly contributes to pancreatitis, causing high global mortality and health burden. This study examines trends in alcohol-attributable pancreatitis (AAP) from 1990 to 2021 using Global Burden of Disease (GBD) 2021 data, focusing on demographic, temporal, and regional variations to inform policymaking.

Methods

AAP-related deaths and disability-adjusted life years (DALYs) were analyzed across 204 countries from 1990 to 2021, stratified by Sociodemographic Index (SDI), gender, and age groups. An age-period-cohort model assessed age-standardized DALY rates (ASDR), and decomposition analysis quantified impacts of population growth, aging, and epidemiological changes.

Results

AAP-related DALYs rose from 401,700 in 1990 to 699,300 in 2021, though ASDR and ASMR showed declines globally. Burden increased notably in low and lower-middle SDI regions, especially among those under 40, while high SDI regions achieved better control. Males faced a disproportionately high burden due to alcohol consumption patterns, although some regions saw rising female burdens. Low-SDI areas suffered from limited healthcare, increasing alcohol use, and weak policies, with younger populations contributing significantly to rising burdens. Projections estimate 1.146 million DALYs annually by 2050, with males comprising over 90%. A GBD-AAP visualization platform was developed to present burden data and trends.

Conclusions

AAP exhibits significant regional and gender disparities. Targeted measures, including alcohol regulation, resource allocation, and public health education, are critical in low-SDI regions and among young males to mitigate AAP burden. The GBD-AAP platform offers valuable tool for targeted interventions.

背景：酒精对胰腺炎有显著影响，导致全球高死亡率和健康负担。本研究利用2021年全球疾病负担（GBD）数据，研究了1990年至2021年酒精所致胰腺炎（AAP）的趋势，重点关注人口统计学、时间和区域变化，为政策制定提供信息。方法：根据社会人口指数（SDI）、性别和年龄组，分析1990年至2021年204个国家的aap相关死亡和残疾调整生命年（DALYs）。年龄-时期-队列模型评估了年龄标准化死亡率（ASDR），分解分析量化了人口增长、老龄化和流行病学变化的影响。结果：与aap相关的DALYs从1990年的40.17万增加到2021年的69.93万，尽管ASDR和ASMR在全球范围内呈下降趋势。低SDI和中低SDI地区，特别是40岁以下人群的负担明显增加，而高SDI地区的控制效果较好。由于酒精消费模式，男性面临着不成比例的高负担，尽管一些区域的女性负担有所增加。低sdi地区的医疗保健有限，酒精使用增加，政策薄弱，年轻人口是负担增加的主要原因。据预测，到2050年，每年残疾调整生命年为114.6万，其中男性占90%以上。开发了一个GBD-AAP可视化平台来显示负担数据和趋势。结论：AAP存在显著的地区差异和性别差异。在低sdi地区和年轻男性中，有针对性的措施，包括酒精管制、资源分配和公共卫生教育，对于减轻AAP负担至关重要。GBD-AAP平台为有针对性的干预提供了有价值的工具。

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引用次数: 0

Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure 受惩罚的酒精自我管理的个体差异不受酒精蒸气暴露的影响。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-03-17 DOI: 10.1016/j.alcohol.2025.03.003

Maya N. Bluitt , Ana C. Muñoz , Joyce Besheer

Continued alcohol use despite negative consequences is a defining feature of alcohol use disorder (AUD). It remains poorly understood whether individual variability in drinking despite negative consequences is due to inherent differences or emerges after prolonged alcohol use. The goal of the present study was to use a rat model of drinking despite negative consequences to assess individual differences in foot shock-punished alcohol self-administration prior to and following alcohol vapor exposure in male Wistar rats. After baseline operant self-administration was established, rats underwent additional self-administration sessions in which random, response-contingent foot shock punishment was introduced. Average percent change from baseline was calculated for each rat during punished sessions and rats were classified into shock-sensitive (SS) and shock-resistant (SR) subgroups using the top and bottom thirds. Rats then underwent 3 cycles of air or alcohol vapor exposure every other week, with unpunished self-administration sessions occurring during the intervening weeks. Following the last vapor cycle, rats were re-assessed for resistance to foot shock during punished self-administration sessions. Alcohol vapor exposure had no effect on punished self-administration overall, nor by subgroup. Examination of individual differences showed that rats classified as SR showed increased unpunished self-administration relative to baseline regardless of air vs. vapor condition. These data suggest that alcohol history has a minimal effect on individual differences in foot shock-punished self-administration.

不顾不良后果继续饮酒是酒精使用障碍（AUD）的一个显著特征。人们对不顾负面后果饮酒的个体差异是由于固有差异还是在长期饮酒后出现的这一问题仍然知之甚少。本研究的目的是利用雄性 Wistar 大鼠不顾负面后果饮酒的模型来评估酒精蒸汽暴露前后脚部休克惩罚性酒精自我给药的个体差异。在建立了基线操作性自我给药后，大鼠接受了额外的自我给药训练，其中引入了随机的、与反应相关的脚震惩罚。计算每只大鼠在惩罚过程中与基线相比的平均变化百分比，并使用上下三分之二将大鼠分为电击敏感（SS）和电击耐受（SR）亚组。然后，每隔一周对大鼠进行 3 个周期的空气或酒精蒸汽暴露，并在中间的几周内进行不受惩罚的自我给药。在最后一个水蒸气周期之后，重新评估大鼠在受惩罚的自我给药过程中对脚部冲击的抵抗力。总体而言，酒精蒸汽暴露对惩罚性自我管理没有影响，对不同亚组也没有影响。对个体差异的研究表明，无论在空气还是蒸汽条件下，被归类为 SR 的大鼠在未受惩罚的自我管理方面都比基线时有所提高。这些数据表明，酒精史对脚电击惩罚性自我管理的个体差异影响很小。

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引用次数: 0

The use of baclofen to reduce alcohol-attributable hospitalizations and emergency department admissions 使用巴氯芬减少酒精引起的住院和急诊住院。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-03-15 DOI: 10.1016/j.alcohol.2025.03.002

Ming-Chyi Huang , Kevin Tsai , Yu-Hsuan Joni Shao

Aims

The potential benefit of baclofen in reducing hospitalizations and emergency department (ED) admissions attributed to alcohol-related diagnoses has not been conclusively established. This study aimed to examine the relationship between baclofen use and the incidence of alcohol-attributable hospitalizations and ED admissions in the general population.

Methods

We conducted a self-controlled case series study (SCCS) using data from the Taiwan National Health Insurance Research Database. 2904 patients who had at least one alcohol-attributable hospitalization or emergency department admission and were prescribed 28 or more days of baclofen unrelated to alcohol were included. Conditional Poisson regression was used to estimate the incidence rate ratio (IRR) and 95% confidence interval (CI) for the risk of alcohol-attributable hospitalizations and ED admissions during exposure to baclofen, as well as the pre- and post-exposure periods, relative to the baseline period. The contribution of concomitant psychotropic medication use was also assessed.

Results

Baclofen was associated with a reduced incidence of alcohol-attributable hospitalizations (IRR = 0.64; 95% CI: 0.53∼0.77) and ED admissions (IRR = 0.56; 95% CI: 0.49∼0.65) in multivariate models. No statistically significant reduction was observed in any admission method in either the pre- or post-exposure period. A dose-dependent response in ED admissions was observed with baclofen, i.e. >60 mg/day associated with a greater decrease in the IRR (0.25, 95% CI: 0.10∼0.62) relative to doses of <30 (0.63, 95% CI: 0.53∼0.75) and 30–60 mg/day (IRR = 0.50, 95% CI: 0.40∼0.63).

Conclusions

These findings suggest a possible beneficial effect of baclofen in reducing the incidence of alcohol-attributable hospitalizations and ED admissions.

目的：巴氯芬在减少因酒精相关诊断导致的住院和急诊（ED）入院方面的潜在益处尚未最终确定。本研究旨在探讨巴氯芬的使用与普通人群中因酒精引起的住院和急诊科入院发生率之间的关系。使用条件泊松回归来估计巴氯芬暴露期间酒精导致的住院和急诊风险的发生率比（IRR）和95%置信区间（CI），以及暴露前后相对于基线期的风险。同时还评估了伴随精神药物使用的贡献。结果：巴氯芬与酒精引起的住院发生率降低相关(IRR=0.64；95% CI: 0.53 ~ 0.77)和ED入院(IRR=0.56；在多变量模型中95% CI: 0.49 ~ 0.65)。无论是暴露前还是暴露后，任何入院方法均未观察到统计学上显著的减少。在ED入院患者中观察到巴氯芬的剂量依赖性反应，即与< 30 （0.63,95% CI: 0.53 ~ 0.75）和30 ~ 60 mg/天（IRR=0.50, 95% CI: 0.40 ~ 0.63）的剂量相比，bbb60 mg/天与IRR （0.25, 95% CI: 0.10 ~ 0.62）的降低相关（0.25,95% CI: 0.10 ~ 0.62）。结论：这些发现表明巴氯芬在减少酒精引起的住院和急诊科入院发生率方面可能具有有益作用。

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引用次数: 0

Pain predicts past-month co-use of alcohol and cannabis among emerging adults: Results from the Population Assessment of Tobacco and Health (PATH) Study 疼痛预测过去一个月初成人酒精和大麻的共同使用：烟草和健康人口评估（PATH）研究的结果。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-02-25 DOI: 10.1016/j.alcohol.2025.02.003

Callon M. Williams , Nadine R. Mastroleo , Mark F. Lenzenweger , Emily L. Zale

Alcohol use, cannabis use, and pain are public health concerns among emerging adults (18–24 years old). Co-use of alcohol and cannabis is of particular concern since individuals who co-use alcohol and cannabis use more of each substance and experience greater substance-related harm. Pain and substance use frequently co-occur, and a growing body of literature indicates pain is unique risk factor for substance use. The goal of the current study was to examine moderate/severe pain (vs. no/low pain) as a prospective predictor of engaging in co-use of alcohol and cannabis among emerging adults, and to test sex as a moderator of this hypothesized relationship. Data were drawn from Waves 1–5 of the Population Assessment of Tobacco and Health Study (n = 3544). Unadjusted logistic regression revealed that those with moderate/severe pain at baseline were 1.4 times more likely to engage in past-month co-use of alcohol and cannabis over the next four years (p = .046). The effects of pain on co-use were no longer significant after inclusion of covariates and a pain∗sex interaction term, which was also nonsignificant (ps > .05). These findings provide initial support for pain as a risk factor for engaging in co-use of alcohol and cannabis during emerging adulthood. Future research should continue investigating how pain may motivate co-use of alcohol and cannabis, exploring how pain is associated with other measures of co-use, and determining how providers can incorporate pain-substance use psychoeducation for emerging adults in clinical settings.

酒精使用、大麻使用和疼痛是新兴成人（18-24岁）的公共卫生问题。同时使用酒精和大麻是一个特别令人关切的问题，因为同时使用酒精和大麻的个人使用的每种物质更多，受到的与物质有关的伤害也更大。疼痛和药物使用经常同时发生，越来越多的文献表明疼痛是药物使用的独特风险因素。当前研究的目的是检查中度/重度疼痛（与无/轻度疼痛相比）作为新兴成年人共同使用酒精和大麻的前瞻性预测因素，并测试性别作为这种假设关系的调节因素。数据来自烟草与健康研究人口评估的第1-5波（n = 3,544）。未经调整的逻辑回归显示，那些在基线时有中度/重度疼痛的人在过去一个月里同时使用酒精和大麻的可能性是未来四年的1.4倍（p = 0.046）。在纳入协变量和疼痛*性别相互作用项后，疼痛对共同使用的影响不再显著，也不显著（ps >.05）。这些发现初步支持了疼痛是初成年期酒精和大麻共同使用的风险因素。未来的研究应该继续调查疼痛如何激励酒精和大麻的共同使用，探索疼痛如何与其他共同使用的措施相关联，并确定提供者如何在临床环境中为新成年患者提供疼痛物质使用心理教育。

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引用次数: 0

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