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Immunology series最新文献

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Antiparasitic effects of nitric oxide in an in vitro murine model of Chlamydia trachomatis infection and an in vivo murine model of Leishmania major infection. 一氧化氮对沙眼衣原体感染小鼠体外模型和利什曼原虫感染小鼠体内模型的抗寄生虫作用。
Immunology series
Pub Date : 1994-01-01
M L Woods, J Mayer, T G Evans, J B Hibbs
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引用次数: 0
Interaction of Histoplasma capsulatum yeasts and conidia with human and animal macrophages. 荚膜组织浆酵母和分生孢子与人和动物巨噬细胞的相互作用。
Immunology series
Pub Date : 1994-01-01
S L Newman, W E Bullock
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引用次数: 0
Biological response modifiers and chemotherapeutic agents that alter interleukin 2 activities. 改变白细胞介素2活性的生物反应调节剂和化疗药物。
Immunology series
Pub Date : 1994-01-01 DOI: 10.1201/9781003067245-23
W. West, A. Rhoads, C. Akogyeram
IL2 immunotherapy alone or with LAK cells represents a novel approach to the treatment of metastatic cancers. Similarly, other BRMs and classical chemotherapeutic drugs through their molecular effects on the components of the immune system reveal new and exciting prospects for the better use of these agents. Both approaches converge in that they restore balance among numerous components of the immune surveillance system. This review raises the possibility of improved protocols through the judicious use of these agents and stresses the need for further investigation of combined use of chemotherapy and immunotherapy.
IL2免疫治疗单独或与LAK细胞代表了一种新的方法来治疗转移性癌症。同样，其他brm和经典化疗药物通过其对免疫系统成分的分子作用，为更好地利用这些药物揭示了新的和令人兴奋的前景。这两种方法的共同点在于它们恢复了免疫监视系统众多组成部分之间的平衡。这篇综述提出了通过明智地使用这些药物来改进方案的可能性，并强调需要进一步研究化疗和免疫治疗的联合使用。
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引用次数: 0
Antitumor effector cells: extravasation and control of metastasis. 抗肿瘤效应细胞:外渗及转移的控制。
Immunology series
Pub Date : 1994-01-01 DOI: 10.1201/9781003067245-18
T. Whiteside, R. Goldfarb
To develop effective antimetastatic response, effector cells have to reach the tissue site of tumor metastasis. Different lymphocyte subsets vary in their ability to extravasate and reach sites of tissue injury or tumor growth. The ability of lymphoid cells to extravasate is a function of several different parameters, including cellular activation state and ability to release cytokines, proteolytic enzymes or to respond to chemotactic stimuli present in the tumor microenvironment. Adoptively transferred effector cells can only be therapeutically effective if they extravasate, reach the tumor or its microenvironment and interfere with tumor growth or metastasis. A large number of events that might be involved in accumulation of effector cells such as, e.g., A-NK cells in tumor metastases, are illustrated in the schema in Figure 3. The future challenge will be to gain an in-depth understanding of these events, including effector cell migration and extravasation, to assure optimal transfers of these cells to patients with metastatic disease.
为了产生有效的抗转移反应，效应细胞必须到达肿瘤转移的组织部位。不同淋巴细胞亚群的外渗和到达组织损伤或肿瘤生长部位的能力各不相同。淋巴样细胞的外渗能力是几个不同参数的功能，包括细胞激活状态和释放细胞因子、蛋白水解酶或对肿瘤微环境中存在的趋化刺激作出反应的能力。过继性转移效应细胞只有在外渗、到达肿瘤或其微环境并干扰肿瘤生长或转移时才具有治疗效果。图3的模式显示了可能涉及效应细胞积累的大量事件，例如肿瘤转移中的A- nk细胞。未来的挑战将是深入了解这些事件，包括效应细胞迁移和外渗，以确保这些细胞最佳转移到转移性疾病患者。
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引用次数: 3
Up-regulation of tumor cell sensitivity to natural cell-mediated cytotoxicity by UV light irradiation. 紫外光照射下肿瘤细胞对自然细胞介导的细胞毒性敏感性的上调。
Immunology series
Pub Date : 1994-01-01
M Begovic, R B Herberman, E Gorelik
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引用次数: 0
Toxoplasma-macrophage interactions. Toxoplasma-macrophage交互。
Immunology series
Pub Date : 1994-01-01
M H Beaman, C S Subauste, S Y Wong, J S Remington
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引用次数: 0
Macrophage interactions with Candida. 巨噬细胞与念珠菌的相互作用。
Immunology series
Pub Date : 1994-01-01
R Calderone, J Sturtevant

The monocyte/macrophage, in comparison to the neutrophil, would appear to have a limited role in protection against C. albicans. This statement is based on the observations of several investigators who report that these cells have very little killing capacity unless they are activated by cytokines such as IFN-gamma and GM-CSF. The mechanisms of killing by these cells appear to include both oxidative and nonoxidative mechanisms, the latter perhaps being more important. The mechanisms of killing may be different for monocytes and macrophages. Granulocyte-macrophage colony-stimulating factor and its effect on monocytes has been studied using Candida as a target organism. Two explanations for the enhancement of monocyte killing by this cytokine have been proposed: GM-CSF augments both superoxide anion and the level of mannose receptors on treated monocytes. Both of these changes could be significant in the increased killing capacity of these cells.

单核细胞/巨噬细胞，与中性粒细胞相比，似乎对白色念珠菌的保护作用有限。这种说法是基于几位研究人员的观察，他们报告说，这些细胞只有很少的杀伤能力，除非它们被ifn - γ和GM-CSF等细胞因子激活。这些细胞的杀伤机制似乎包括氧化和非氧化机制，后者可能更重要。单核细胞和巨噬细胞的杀伤机制可能不同。以念珠菌为靶菌，研究了粒细胞-巨噬细胞集落刺激因子及其对单核细胞的影响。对于这种细胞因子对单核细胞杀伤的增强有两种解释:GM-CSF增加了处理过的单核细胞上的超氧阴离子和甘露糖受体的水平。这两种变化在增加这些细胞的杀伤能力方面可能是显著的。
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引用次数: 0
Phenotypic and functional characteristics of human A-NK cells. 人A-NK细胞的表型和功能特征。
Immunology series
Pub Date : 1994-01-01
N L Vujanovic, T L Whiteside
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引用次数: 0
Regulation of monocytes by IL-2-activated killer cells. il -2激活杀伤细胞对单核细胞的调控。
Immunology series
Pub Date : 1994-01-01
J Y Djeu, S Wei, D K Blanchard
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引用次数: 0
Tumor microenvironment and immune effector cells. Introduction. 肿瘤微环境与免疫效应细胞。介绍。
Immunology series
Pub Date : 1994-01-01
T L Whiteside
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引用次数: 0
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