{"title":"Antiparasitic effects of nitric oxide in an in vitro murine model of Chlamydia trachomatis infection and an in vivo murine model of Leishmania major infection.","authors":"M L Woods, J Mayer, T G Evans, J B Hibbs","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"60 ","pages":"179-95"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19240423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interaction of Histoplasma capsulatum yeasts and conidia with human and animal macrophages.","authors":"S L Newman, W E Bullock","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"60 ","pages":"517-32"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19241006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1994-01-01DOI: 10.1201/9781003067245-23
W. West, A. Rhoads, C. Akogyeram
IL2 immunotherapy alone or with LAK cells represents a novel approach to the treatment of metastatic cancers. Similarly, other BRMs and classical chemotherapeutic drugs through their molecular effects on the components of the immune system reveal new and exciting prospects for the better use of these agents. Both approaches converge in that they restore balance among numerous components of the immune surveillance system. This review raises the possibility of improved protocols through the judicious use of these agents and stresses the need for further investigation of combined use of chemotherapy and immunotherapy.
{"title":"Biological response modifiers and chemotherapeutic agents that alter interleukin 2 activities.","authors":"W. West, A. Rhoads, C. Akogyeram","doi":"10.1201/9781003067245-23","DOIUrl":"https://doi.org/10.1201/9781003067245-23","url":null,"abstract":"IL2 immunotherapy alone or with LAK cells represents a novel approach to the treatment of metastatic cancers. Similarly, other BRMs and classical chemotherapeutic drugs through their molecular effects on the components of the immune system reveal new and exciting prospects for the better use of these agents. Both approaches converge in that they restore balance among numerous components of the immune surveillance system. This review raises the possibility of improved protocols through the judicious use of these agents and stresses the need for further investigation of combined use of chemotherapy and immunotherapy.","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 1","pages":"207-26"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1994-01-01DOI: 10.1201/9781003067245-18
T. Whiteside, R. Goldfarb
To develop effective antimetastatic response, effector cells have to reach the tissue site of tumor metastasis. Different lymphocyte subsets vary in their ability to extravasate and reach sites of tissue injury or tumor growth. The ability of lymphoid cells to extravasate is a function of several different parameters, including cellular activation state and ability to release cytokines, proteolytic enzymes or to respond to chemotactic stimuli present in the tumor microenvironment. Adoptively transferred effector cells can only be therapeutically effective if they extravasate, reach the tumor or its microenvironment and interfere with tumor growth or metastasis. A large number of events that might be involved in accumulation of effector cells such as, e.g., A-NK cells in tumor metastases, are illustrated in the schema in Figure 3. The future challenge will be to gain an in-depth understanding of these events, including effector cell migration and extravasation, to assure optimal transfers of these cells to patients with metastatic disease.
{"title":"Antitumor effector cells: extravasation and control of metastasis.","authors":"T. Whiteside, R. Goldfarb","doi":"10.1201/9781003067245-18","DOIUrl":"https://doi.org/10.1201/9781003067245-18","url":null,"abstract":"To develop effective antimetastatic response, effector cells have to reach the tissue site of tumor metastasis. Different lymphocyte subsets vary in their ability to extravasate and reach sites of tissue injury or tumor growth. The ability of lymphoid cells to extravasate is a function of several different parameters, including cellular activation state and ability to release cytokines, proteolytic enzymes or to respond to chemotactic stimuli present in the tumor microenvironment. Adoptively transferred effector cells can only be therapeutically effective if they extravasate, reach the tumor or its microenvironment and interfere with tumor growth or metastasis. A large number of events that might be involved in accumulation of effector cells such as, e.g., A-NK cells in tumor metastases, are illustrated in the schema in Figure 3. The future challenge will be to gain an in-depth understanding of these events, including effector cell migration and extravasation, to assure optimal transfers of these cells to patients with metastatic disease.","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 1","pages":"159-73"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phenotypic and functional characteristics of human A-NK cells.","authors":"N L Vujanovic, T L Whiteside","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"41-54"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of monocytes by IL-2-activated killer cells.","authors":"J Y Djeu, S Wei, D K Blanchard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Up-regulation of tumor cell sensitivity to natural cell-mediated cytotoxicity by UV light irradiation.","authors":"M Begovic, R B Herberman, E Gorelik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"105-24"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19005903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interactions between Leishmania major and macrophages.","authors":"R G Titus, C M Theodos, A H Shankar, L R Hall","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"60 ","pages":"437-59"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19241000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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