Alexandra Florentina Stamate, M. Dună, V. Herlea, D. Predețeanu
Abstract A rare genetical autosomal recessive disorder called Wilson disease (WD) is characterized by excess copper being deposited in numerous major organs, mainly the liver and brain causing hepatic, neurological and mental symptoms. WD is caused by mutations in the gene ATP7B. Although not always present, Kayser-Fleischer (KF) ring is the pathognomonic indication of WD and is caused by the deposition of copper in the corneas of the eyes. The condition worsens with time and, if ignored, may lead to fatality, liver illness and problems with the central nervous system. Preventing serious long-term damage and perhaps fatal consequences may be possible with early diagnosis and treatment. The goal of treatment is to lower the level of accumulated copper in the body and then maintain it to normal levels. We present the case of a 26-year-old patient, known herself and also her sister with genetically confirmed hepato-lenticular degeneration, who came to our clinic for bilateral gonalgia with mixed mechanical and inflammatory character and for chronic low back pain. Other signs and symptoms of WD may include joint and bone disease, including osteoporosis and the development of osteophytes in the large joints, which is why the patient was investigated both clinico-biologically and imagistically in order to establish the optimal specialist treatment.
{"title":"A Case of a Young Girl Suffering from Genetically Confirmed Wilson Disease with Orthotopic Liver Transplantation","authors":"Alexandra Florentina Stamate, M. Dună, V. Herlea, D. Predețeanu","doi":"10.2478/inmed-2023-0241","DOIUrl":"https://doi.org/10.2478/inmed-2023-0241","url":null,"abstract":"Abstract A rare genetical autosomal recessive disorder called Wilson disease (WD) is characterized by excess copper being deposited in numerous major organs, mainly the liver and brain causing hepatic, neurological and mental symptoms. WD is caused by mutations in the gene ATP7B. Although not always present, Kayser-Fleischer (KF) ring is the pathognomonic indication of WD and is caused by the deposition of copper in the corneas of the eyes. The condition worsens with time and, if ignored, may lead to fatality, liver illness and problems with the central nervous system. Preventing serious long-term damage and perhaps fatal consequences may be possible with early diagnosis and treatment. The goal of treatment is to lower the level of accumulated copper in the body and then maintain it to normal levels. We present the case of a 26-year-old patient, known herself and also her sister with genetically confirmed hepato-lenticular degeneration, who came to our clinic for bilateral gonalgia with mixed mechanical and inflammatory character and for chronic low back pain. Other signs and symptoms of WD may include joint and bone disease, including osteoporosis and the development of osteophytes in the large joints, which is why the patient was investigated both clinico-biologically and imagistically in order to establish the optimal specialist treatment.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"97 - 104"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46351254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction. The largest challenge for patients with COPD is the correct use of inhaler devices. In COPD, inhalation therapy has a key role in symptom control, reducing the exacerbation rate, hospitalization and improving the quality of life. Choosing the active substance(s) administered by inhaler devices is an easy task because of the Gold guideline recommendations, but, when it comes to choosing the inhaler device, it is much more difficult to get recommendations. Methods. Our analysis included 200 subjects divided into two groups and its objective was the identification of some mechanisms that connect education, exacerbation and adherence to treatment, placed in the context of measuring technical skills and patients` preference for a particular inhaler device. All subjects included in the analysis were subjected to a technical skills test that included a set of 10 questions with a 30-minute solving time. The subjects in the working group were put in the position of deciding factor for the choice of an inhaler device, and implicitly for the treatment they would follow during monitoring. Results. In both groups, the lowest treatment dropout rate at T12 was recorded among those with higher levels of education, while those with poor education levels recorded very high dropout rates. In both groups we noticed that, as the level of education increased, technical skills were also increasingly better. Both in the control group and in the working group, dropout subjects at T12 had significantly lower technical skills compared to subjects who did not drop out. The level of technical skills was significantly lower in both groups in subjects with exacerbations. Statistical analysis proved the relationship between the low level of technical skills and exacerbation. The subjects with lower technical skills proved to be more prone to dropout of inhaler therapy as well. The proportion of subjects with exacerbations in the control group was significantly higher than the proportion of those with exacerbations in the work group. The proportion of subjects with exacerbations in the control group was significantly higher than the proportion of those with exacerbations in the work group. Conclusions. The authors consider that the involvement of the patient in choosing the inhaler device had a positive impact on disease control and reducing the rate of exacerbations.
{"title":"The Impact of Technical Skills and Education on Exacerbations, Adherence to Treatment and the Choice of Inhaler Device in Patients with COPD","authors":"Sorin Bivolaru, A. Constantin","doi":"10.2478/inmed-2023-0236","DOIUrl":"https://doi.org/10.2478/inmed-2023-0236","url":null,"abstract":"Abstract Introduction. The largest challenge for patients with COPD is the correct use of inhaler devices. In COPD, inhalation therapy has a key role in symptom control, reducing the exacerbation rate, hospitalization and improving the quality of life. Choosing the active substance(s) administered by inhaler devices is an easy task because of the Gold guideline recommendations, but, when it comes to choosing the inhaler device, it is much more difficult to get recommendations. Methods. Our analysis included 200 subjects divided into two groups and its objective was the identification of some mechanisms that connect education, exacerbation and adherence to treatment, placed in the context of measuring technical skills and patients` preference for a particular inhaler device. All subjects included in the analysis were subjected to a technical skills test that included a set of 10 questions with a 30-minute solving time. The subjects in the working group were put in the position of deciding factor for the choice of an inhaler device, and implicitly for the treatment they would follow during monitoring. Results. In both groups, the lowest treatment dropout rate at T12 was recorded among those with higher levels of education, while those with poor education levels recorded very high dropout rates. In both groups we noticed that, as the level of education increased, technical skills were also increasingly better. Both in the control group and in the working group, dropout subjects at T12 had significantly lower technical skills compared to subjects who did not drop out. The level of technical skills was significantly lower in both groups in subjects with exacerbations. Statistical analysis proved the relationship between the low level of technical skills and exacerbation. The subjects with lower technical skills proved to be more prone to dropout of inhaler therapy as well. The proportion of subjects with exacerbations in the control group was significantly higher than the proportion of those with exacerbations in the work group. The proportion of subjects with exacerbations in the control group was significantly higher than the proportion of those with exacerbations in the work group. Conclusions. The authors consider that the involvement of the patient in choosing the inhaler device had a positive impact on disease control and reducing the rate of exacerbations.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"27 - 41"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45387038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Tuberculosis has taken on a new face in the context of emergent drug use. The combination of conditions such as HIV infection, hepatitis B or C, arising from the use of injectable drugs create serious problems in hospitals. In this new context, the authors analyze epidemiological aspects, predisposing factors, clinical expressions and therapeutic solutions for these cases, but also the programs that must be adopted to allow the control of this new worldwide challenge.
{"title":"Pulmonary TB Faces in the New Context of Drug Users","authors":"F. Mihălțan, A. Constantin, R. Ulmeanu","doi":"10.2478/inmed-2023-0238","DOIUrl":"https://doi.org/10.2478/inmed-2023-0238","url":null,"abstract":"Abstract Tuberculosis has taken on a new face in the context of emergent drug use. The combination of conditions such as HIV infection, hepatitis B or C, arising from the use of injectable drugs create serious problems in hospitals. In this new context, the authors analyze epidemiological aspects, predisposing factors, clinical expressions and therapeutic solutions for these cases, but also the programs that must be adopted to allow the control of this new worldwide challenge.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"57 - 71"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48161553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction. The infection with hepatitis C (HCV) is a major cause of chronic liver diseases, with approximately 71,000.000 chronically infected persons worldwide. Material and methods. This study includes the results of the evaluation of the quality of life of patients with chronic hepatic diseases, on a group of 122 patients divided into two lots. The study period was January 2020 - december 2022. Our aim was to study the impact of the antiviral therapy on the patients quality of life before and after the interferon free antiviral therapy, as well as to study the quality of life of the patients with chronic viral hepatitis C who did not receive interferon free antiviral therapy because they did not meet the eligibility criteria, but accepted to participate in the study. Results. Following the analysis and the interpretation of the questionnaire used, we found that the patients who did not receive the treatment presented more frequently a psychosocial unbalance (social activities), psychoemotional and loss of interest for the sexual activity. In the case of patients treated with interferon free regimens we found an improvement of the quality of the whole duration of the therapy, this being correlated, especially, with drug interaction that were limited or easily manageable and had minimal adverse effects, increasing psychoemotional, balance, and the sexual activity was not influenced. Conclusions. The results of our study indicate that the patients who were treated with the antiviral interferon free therapy become aware the fact that the problems related to the chronic hepatic disease are solvable, which influences the quality of life in a positive way.
{"title":"Efficiency and Tolerability of Interferon Free Therapy - Positive Impact on the Quality of Life of Patients with Chronic Viral Hepatitis C","authors":"A. Stavar, S. Rugina, T. Adam","doi":"10.2478/inmed-2023-0234","DOIUrl":"https://doi.org/10.2478/inmed-2023-0234","url":null,"abstract":"Abstract Introduction. The infection with hepatitis C (HCV) is a major cause of chronic liver diseases, with approximately 71,000.000 chronically infected persons worldwide. Material and methods. This study includes the results of the evaluation of the quality of life of patients with chronic hepatic diseases, on a group of 122 patients divided into two lots. The study period was January 2020 - december 2022. Our aim was to study the impact of the antiviral therapy on the patients quality of life before and after the interferon free antiviral therapy, as well as to study the quality of life of the patients with chronic viral hepatitis C who did not receive interferon free antiviral therapy because they did not meet the eligibility criteria, but accepted to participate in the study. Results. Following the analysis and the interpretation of the questionnaire used, we found that the patients who did not receive the treatment presented more frequently a psychosocial unbalance (social activities), psychoemotional and loss of interest for the sexual activity. In the case of patients treated with interferon free regimens we found an improvement of the quality of the whole duration of the therapy, this being correlated, especially, with drug interaction that were limited or easily manageable and had minimal adverse effects, increasing psychoemotional, balance, and the sexual activity was not influenced. Conclusions. The results of our study indicate that the patients who were treated with the antiviral interferon free therapy become aware the fact that the problems related to the chronic hepatic disease are solvable, which influences the quality of life in a positive way.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"7 - 15"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49444879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena-Andreea Moales, I. Zota, L. Tribuș, C. D. Cozma, F. Mitu
Abstract Chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) are common pathologies in the elderly patient. The simultaneous occurrence of the two conditions influences the quality of life and increases the rate of exacerbations. About two-thirds of patients with atrial fibrillation have dyspnea. Severe dyspnea in the patient with COPD and AF can be difficult to manage, suggesting an exacerbation of the disease, the onset of atrial fibrillation or even a symptom of associated comorbidities, the most common of which being heart failure. The risk of developing AF in COPD increases with the severity of airflow obstruction. Factors such as smoking, aging, dyslipidemia, the presence of diabetes, hypertension or heart failure influence the prognosis of patients with COPD and AF. Furthermore, oxidative stress, hypoxia, systemic inflammation or immunological changes decrease the survival rate and may favor the recurrence of AF. In the evolution of concomitant COPD- FA cases, proinflammatory cytokines such as tumor necrosis factor α (TNF-α), monocyte chemotactic protein (MCP-1), interleukin-6 (IL-6), interleukin-8 (IL- 8) intervene. This paper aims at analyzing data related to the factors that would influence the prognosis of patients with COPD and AF.
{"title":"Prognosis Factors in Patients with Copd and Atrial Fibrillation – Mini Review","authors":"Elena-Andreea Moales, I. Zota, L. Tribuș, C. D. Cozma, F. Mitu","doi":"10.2478/inmed-2023-0239","DOIUrl":"https://doi.org/10.2478/inmed-2023-0239","url":null,"abstract":"Abstract Chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) are common pathologies in the elderly patient. The simultaneous occurrence of the two conditions influences the quality of life and increases the rate of exacerbations. About two-thirds of patients with atrial fibrillation have dyspnea. Severe dyspnea in the patient with COPD and AF can be difficult to manage, suggesting an exacerbation of the disease, the onset of atrial fibrillation or even a symptom of associated comorbidities, the most common of which being heart failure. The risk of developing AF in COPD increases with the severity of airflow obstruction. Factors such as smoking, aging, dyslipidemia, the presence of diabetes, hypertension or heart failure influence the prognosis of patients with COPD and AF. Furthermore, oxidative stress, hypoxia, systemic inflammation or immunological changes decrease the survival rate and may favor the recurrence of AF. In the evolution of concomitant COPD- FA cases, proinflammatory cytokines such as tumor necrosis factor α (TNF-α), monocyte chemotactic protein (MCP-1), interleukin-6 (IL-6), interleukin-8 (IL- 8) intervene. This paper aims at analyzing data related to the factors that would influence the prognosis of patients with COPD and AF.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"73 - 80"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43552590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oana Irina Gavril, I. Eșanu, O. Gavrilescu, R. Popa, M. Cobzeanu, Diana Tatarciuc, T. Vasilcu, Andrei Drugescu, R. Gavril, F. Mitu
Abstract Introduction. Hepatic steatosis represents a common pathological feature in patients with chronic viral C infection and can be independently associated with obesity, increased alcohol consumption, type 2 diabetes, and hyperlipidemia. These factors can contribute to the development of hepatic steatosis in patients with chronic HCV (Hepatitis C virus) infection. Materials and methods. 64 patients who underwent treatment with oral antivirals were included and evaluated through non-invasive methods for the degree of hepatic steatosis. Results. After at least 3 months of sustained viral response, all patients with advanced hepatic steatosis were categorized into lower classes in the Steatotest evaluation. Conclusion. This study highlights the importance of direct acting antiviral (DAA) treatment in the medical care of patients with chronic viral C infection and hepatic steatosis. Thirty years after the discovery of the hepatitis C virus, treatment with oral antivirals revolutionizes the medical care of patients with this chronic infection.
{"title":"Liver Steatosis and its Implications in Patients with Chronic Viral Hepatitis C","authors":"Oana Irina Gavril, I. Eșanu, O. Gavrilescu, R. Popa, M. Cobzeanu, Diana Tatarciuc, T. Vasilcu, Andrei Drugescu, R. Gavril, F. Mitu","doi":"10.2478/inmed-2023-0235","DOIUrl":"https://doi.org/10.2478/inmed-2023-0235","url":null,"abstract":"Abstract Introduction. Hepatic steatosis represents a common pathological feature in patients with chronic viral C infection and can be independently associated with obesity, increased alcohol consumption, type 2 diabetes, and hyperlipidemia. These factors can contribute to the development of hepatic steatosis in patients with chronic HCV (Hepatitis C virus) infection. Materials and methods. 64 patients who underwent treatment with oral antivirals were included and evaluated through non-invasive methods for the degree of hepatic steatosis. Results. After at least 3 months of sustained viral response, all patients with advanced hepatic steatosis were categorized into lower classes in the Steatotest evaluation. Conclusion. This study highlights the importance of direct acting antiviral (DAA) treatment in the medical care of patients with chronic viral C infection and hepatic steatosis. Thirty years after the discovery of the hepatitis C virus, treatment with oral antivirals revolutionizes the medical care of patients with this chronic infection.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"17 - 25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44387635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Dobrescu, D. Păun, Adina Ghimigean, Sorina Buculei, C. Poiană
Abstract Acromegaly is associated with cardiovascular disease, the principal cause of increased mortality. Direct cardiac effects of GH/IGF-1 are cardiomyocyte growth and cardiac contractility, cardiac remoddeling. Other important risk factors in acromegaly are hypertension, valvular diseases, arrhytmias. Older patients with long-term uncontrolled disease may develop congestive heart failure as end-stage of acromegalic cardiomyopathy. Early treatment of acromegaly is essential for evolution and prognosis of cardiovascular complications.
{"title":"Cardiovascular Risk in Acromegaly","authors":"M. Dobrescu, D. Păun, Adina Ghimigean, Sorina Buculei, C. Poiană","doi":"10.2478/inmed-2023-0237","DOIUrl":"https://doi.org/10.2478/inmed-2023-0237","url":null,"abstract":"Abstract Acromegaly is associated with cardiovascular disease, the principal cause of increased mortality. Direct cardiac effects of GH/IGF-1 are cardiomyocyte growth and cardiac contractility, cardiac remoddeling. Other important risk factors in acromegaly are hypertension, valvular diseases, arrhytmias. Older patients with long-term uncontrolled disease may develop congestive heart failure as end-stage of acromegalic cardiomyopathy. Early treatment of acromegaly is essential for evolution and prognosis of cardiovascular complications.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"43 - 55"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43250066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Cobilinschi, A. Constantinescu, Egor Șargarovschi, M. Popescu, Iuliana Barbu, A. Balanescu, D. Opriș-Belinski
{"title":"Imagistic Progression of Alveolar Hemorrhage in COVID 19-Induced ANCA-Associated Vasculitis","authors":"C. Cobilinschi, A. Constantinescu, Egor Șargarovschi, M. Popescu, Iuliana Barbu, A. Balanescu, D. Opriș-Belinski","doi":"10.2478/inmed-2023-0242","DOIUrl":"https://doi.org/10.2478/inmed-2023-0242","url":null,"abstract":"","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"20 1","pages":"105 - 106"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45524518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Gaube, A. Michire, I. A. Vacaroiu, Andra-Elena Balcangiu-Stroescu, D. Georgescu, M. Georgescu, R. Tulin, A. Călinoiu
Abstract We report the case of a 69-year-old-female with synchronous endometrial and breast cancer. The imaging and pathology results confirmed the diagnosis. The patient underwent surgery and chemotherapy for endometrial cancer, and surgery followed by external beam radiotherapy for breast cancer. The patient’s clinical condition and imaging showed a favorable evolution after 2 months of follow-up.
{"title":"Challenges in Treatment and the Importance of Radiotherapy in a Synchronous Endometrial and Breast Cancer","authors":"Alexandra Gaube, A. Michire, I. A. Vacaroiu, Andra-Elena Balcangiu-Stroescu, D. Georgescu, M. Georgescu, R. Tulin, A. Călinoiu","doi":"10.2478/inmed-2022-0232","DOIUrl":"https://doi.org/10.2478/inmed-2022-0232","url":null,"abstract":"Abstract We report the case of a 69-year-old-female with synchronous endometrial and breast cancer. The imaging and pathology results confirmed the diagnosis. The patient underwent surgery and chemotherapy for endometrial cancer, and surgery followed by external beam radiotherapy for breast cancer. The patient’s clinical condition and imaging showed a favorable evolution after 2 months of follow-up.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"19 1","pages":"89 - 97"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49531241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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