An accurate prediction of disease progression after periodontal therapy would enable the clinician to intervene where and whenever necessary and to individualize supportive care. Unfortunately, predicting continued clinical attachment loss on the basis of clinical parameters on a site and tooth level seems relatively unreliable. Consequently, the clinician could play safe by possibly performing overtreatment. Reality shows, however, that persistent pathology prevails in some cases. A recent study has indicated that deep residual pockets of at least 6 mm following active periodontal therapy represent a risk for further disease progression and tooth loss. Significant associations have been shown on a site, tooth and patient level. This finding promotes a pocket elimination approach for the treatment of periodontitis. The strategy, which includes a strict extraction policy for hopeless teeth and thorough pocket disinfection usually by means of surgery, reduces the work load during supportive care. Indeed, additional tooth loss will be limited and a low prevalence of deep residual pockets limits the need for re-treatment. Besides active periodontal therapy supportive care is of pivotal importance to limit disease progression. The appropriate interval is selected on the basis of the patient's risk profile by the periodontist. Since specialists are usually understaffed to provide this for all patients, a 'co-management' concept seems the best alternative. This concept includes regular visits to the specialist and general practitioner. On the other hand, auxiliary personnel can be helpful to assist careproviders in organizing supportive therapy. This concept has proven to be effective over the world except for Belgium where oral hygienists are nonexisting and not allowed by law. Maybe it is time to reorganise health care policy in the benefit of clinicians and patients.
{"title":"[Decision making in treatment and co-management of periodontal infection: elimination or progression?].","authors":"J Cosyn, H De Bruyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An accurate prediction of disease progression after periodontal therapy would enable the clinician to intervene where and whenever necessary and to individualize supportive care. Unfortunately, predicting continued clinical attachment loss on the basis of clinical parameters on a site and tooth level seems relatively unreliable. Consequently, the clinician could play safe by possibly performing overtreatment. Reality shows, however, that persistent pathology prevails in some cases. A recent study has indicated that deep residual pockets of at least 6 mm following active periodontal therapy represent a risk for further disease progression and tooth loss. Significant associations have been shown on a site, tooth and patient level. This finding promotes a pocket elimination approach for the treatment of periodontitis. The strategy, which includes a strict extraction policy for hopeless teeth and thorough pocket disinfection usually by means of surgery, reduces the work load during supportive care. Indeed, additional tooth loss will be limited and a low prevalence of deep residual pockets limits the need for re-treatment. Besides active periodontal therapy supportive care is of pivotal importance to limit disease progression. The appropriate interval is selected on the basis of the patient's risk profile by the periodontist. Since specialists are usually understaffed to provide this for all patients, a 'co-management' concept seems the best alternative. This concept includes regular visits to the specialist and general practitioner. On the other hand, auxiliary personnel can be helpful to assist careproviders in organizing supportive therapy. This concept has proven to be effective over the world except for Belgium where oral hygienists are nonexisting and not allowed by law. Maybe it is time to reorganise health care policy in the benefit of clinicians and patients.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 4","pages":"171-6"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27994303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mechanical debridement, with of without flap elevation, is a difficult and technique-sensitive procedure resulting in suboptimal treatment outcome from time to time. Therefore, it is not surprising that antibiotics and antiseptics, used alone or in combination with scaling and root planing, have always been fairly successful in clinical practice. For a number of reasons discussed in this paper, routine use of these agents cannot be justified. Especially in general practice these agents should not be prescribed; at least not for treating periodontitis.
{"title":"[Guidelines for the use of antimicrobial agents in the treatment of chronic periodontitis in Belgium].","authors":"S Reza Miremadi, Jan Cosyn, Hugo De Bruyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mechanical debridement, with of without flap elevation, is a difficult and technique-sensitive procedure resulting in suboptimal treatment outcome from time to time. Therefore, it is not surprising that antibiotics and antiseptics, used alone or in combination with scaling and root planing, have always been fairly successful in clinical practice. For a number of reasons discussed in this paper, routine use of these agents cannot be justified. Especially in general practice these agents should not be prescribed; at least not for treating periodontitis.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 3","pages":"91-6"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27839462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Judgment and actions based on scientific evidence are modified by the unique caregiver-patient relationship. Caregivers relying exclusively upon "rational" decisions in line with evidence-based clinical recommendations avoid their relational responsibility. The "noble" purpose illustrates that decisions to treat can be at the same time pointless and valuable. Dia (through) - logue (knowledge) makes it possible to go beyond informed consent, which holds caregivers responsible for providing information and patients for the decision to treat. Finally, where healing is no longer achievable and autonomy dies away, compassion rather than therapeutic tenacity might be the answer. These examples are explained corresponding to the philosophical ideas of respectively Emmanuel Levinas en Roger Burgraeve (noble purpose), Martin Buber (dialogical thinking) and Daniel C. Dennett (autonomy loss).
{"title":"[In the beginning was a relationship].","authors":"Guido Vanbelle","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Judgment and actions based on scientific evidence are modified by the unique caregiver-patient relationship. Caregivers relying exclusively upon \"rational\" decisions in line with evidence-based clinical recommendations avoid their relational responsibility. The \"noble\" purpose illustrates that decisions to treat can be at the same time pointless and valuable. Dia (through) - logue (knowledge) makes it possible to go beyond informed consent, which holds caregivers responsible for providing information and patients for the decision to treat. Finally, where healing is no longer achievable and autonomy dies away, compassion rather than therapeutic tenacity might be the answer. These examples are explained corresponding to the philosophical ideas of respectively Emmanuel Levinas en Roger Burgraeve (noble purpose), Martin Buber (dialogical thinking) and Daniel C. Dennett (autonomy loss).</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 2","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27608945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul De Munter, Willy Peetermans, Dominique Declerck
Guidelines for the prophylaxis of infective endocarditis have historically evolved and have been based on limited medical evidence. New data suggest that infectious endocarditis is much more likely to result from frequent exposure to random bacteremias associated with daily activities than from bacteremia caused by a dental, gastrointestinal (GI) or genitourinary (GU) tract procedure, that prophylaxis may prevent an exceedingly small number of cases of endocarditis in patients who undergo a dental, GI tract or GU tract procedure and that the risk of antibiotic-associated adverse events may exceed the benefit from prophylactic antibiotic therapy. Based on these data the 2007 guidelines of the American Heart Association radically limit the indications for endocarditis prophylaxis. In its new consensus guidelines, the UZ Leuven restricts candidates for endocarditis prophylaxis to patients with cardiac conditions with an increased risk for infectious endocarditis and the highest risk of an adverse outcome. Prophylaxis is indicated in these patients in case of dental procedures that involve manipulation of gingival tissue, periapical region or in case of perforation of the mucosa. Daily oral hygiene and regular evaluation and treatment by a dentist are essential in the prevention of infectious endocarditis. The publication of these guidelines intends to stimulate discussion in order to develop uniform Belgian guidelines.
{"title":"[Prevention of endocarditis: changes in the recommendations].","authors":"Paul De Munter, Willy Peetermans, Dominique Declerck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Guidelines for the prophylaxis of infective endocarditis have historically evolved and have been based on limited medical evidence. New data suggest that infectious endocarditis is much more likely to result from frequent exposure to random bacteremias associated with daily activities than from bacteremia caused by a dental, gastrointestinal (GI) or genitourinary (GU) tract procedure, that prophylaxis may prevent an exceedingly small number of cases of endocarditis in patients who undergo a dental, GI tract or GU tract procedure and that the risk of antibiotic-associated adverse events may exceed the benefit from prophylactic antibiotic therapy. Based on these data the 2007 guidelines of the American Heart Association radically limit the indications for endocarditis prophylaxis. In its new consensus guidelines, the UZ Leuven restricts candidates for endocarditis prophylaxis to patients with cardiac conditions with an increased risk for infectious endocarditis and the highest risk of an adverse outcome. Prophylaxis is indicated in these patients in case of dental procedures that involve manipulation of gingival tissue, periapical region or in case of perforation of the mucosa. Daily oral hygiene and regular evaluation and treatment by a dentist are essential in the prevention of infectious endocarditis. The publication of these guidelines intends to stimulate discussion in order to develop uniform Belgian guidelines.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27643015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Violation of the biologic width could induce different periodontal consequences depending on many factors such as the type of the restorative material used. In this study, the histological performance and the marginal adaptation of three filling materials (amalgam, composite resin and compomer) are evaluated after a period of three months. Class V cavities with apical margin located at the alveolar bone crest were prepared on Pointer dogs teeth and restored with these three materials. Histological analysis showed that lesions in epithelial attachment were mainly noticed with amalgam fillings and the scale of inflammatory cells was the highest when amalgam was used. Compomer showed the best marginal adaptation.
{"title":"[Amalgam, composites and compomers: a comparative histologic study of periodontal tissues (Part 2)].","authors":"Carina Mehanna Zogheib, Nadim Mokbel, Nada Bou Abboud Naaman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Violation of the biologic width could induce different periodontal consequences depending on many factors such as the type of the restorative material used. In this study, the histological performance and the marginal adaptation of three filling materials (amalgam, composite resin and compomer) are evaluated after a period of three months. Class V cavities with apical margin located at the alveolar bone crest were prepared on Pointer dogs teeth and restored with these three materials. Histological analysis showed that lesions in epithelial attachment were mainly noticed with amalgam fillings and the scale of inflammatory cells was the highest when amalgam was used. Compomer showed the best marginal adaptation.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 1","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27643016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Millions of partially or fully edentulous patients worldwide have been treated by means of dental implants ever since the description of the osseointegration process by PI Brånemark. Despite high success rates, different biological and mechanical complications do occur. Peri-implantitis is a chronical infection around dental implants with irreversible crestal bone loss. Like periodontitis, peri-implantitis is a multifactorial disease caused by pathogenic species in a sensitive host. Today treatment of peri-implantitis is highly unpredictable, hence regular follow-up and prevention seems warranted. As the number of patients rehabilitated with dental implants is growing, the incidence will certainly increase. Guidelines about diagnostics, prevention and treatment of peri-implantitis are mentioned in this article based on current scientific evidence.
{"title":"[Peri-implantitis].","authors":"Stijn Vervaeke, Hugo De Bruyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Millions of partially or fully edentulous patients worldwide have been treated by means of dental implants ever since the description of the osseointegration process by PI Brånemark. Despite high success rates, different biological and mechanical complications do occur. Peri-implantitis is a chronical infection around dental implants with irreversible crestal bone loss. Like periodontitis, peri-implantitis is a multifactorial disease caused by pathogenic species in a sensitive host. Today treatment of peri-implantitis is highly unpredictable, hence regular follow-up and prevention seems warranted. As the number of patients rehabilitated with dental implants is growing, the incidence will certainly increase. Guidelines about diagnostics, prevention and treatment of peri-implantitis are mentioned in this article based on current scientific evidence.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 4","pages":"161-70"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27994302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Bouziane, Z Ismaili, A Regragui, L Guamra, O Ennibi
Vascular epulide or Lobular capillary hemangioma is a form of epulide which is marked by an inflammatory infiltrate rich of blood vessels. Angiogenic factors seem to be responsible of the important vascular proliferation. Therapeutic implications include cautions toward hemorrhagic risk. Complete ablation is also required to avoid the risk of high recurrence.
{"title":"[Vascular epulis or lobular capillary hemangioma].","authors":"A Bouziane, Z Ismaili, A Regragui, L Guamra, O Ennibi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vascular epulide or Lobular capillary hemangioma is a form of epulide which is marked by an inflammatory infiltrate rich of blood vessels. Angiogenic factors seem to be responsible of the important vascular proliferation. Therapeutic implications include cautions toward hemorrhagic risk. Complete ablation is also required to avoid the risk of high recurrence.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 1","pages":"4-14"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27643012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pulpotomy is the most performed and controversial therapeutic in pediatric dentistry. Since formocresol is known to have a toxic effect on living tissues, plus a mutagenic and carcinogenic potential with a systemic uptake of formocresol via pulpotomized teeth, other alternative products have been investigated. Twenty-five decayed primary canines and twenty-five healthy primary canines necessitating disking for orthodontic purposes were pulpotomized using non modified Zinc Oxide Eugenol. The effects of this material were evaluated both clinically and radiographically. Post operative control examinations were performed at 1, 6, 12, and 24 months trying to detect spontaneous or stimulated pain, pathological tooth mobility, abscesses or fistulas, internal or external pathological tooth resorption, periapical bone destruction, or canal obliteration. Pain was absent at 24 months post operatively. Half of the treated canines presented with a mobility, while internal and external resorptions were more frequent in decayed teeth and their number increased with time. On the other hand, abscesses and fistulas were equally found in both treated groups. The observations were compared to others related to formocresol ferric sulfate, MTA, and laser pulpotomies, using the binominal law, or the comparative test of an observed proportion to a reference proportion. In this study, and based on the excessive negative results in both groups, we demonstrated that non fixative pulpotomies on temporary canines were not a promising technique.
{"title":"[A 24 month evaluation of zinc oxide pulpotomy on primary canines].","authors":"J-C Abou Chédid, C Pilipili","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pulpotomy is the most performed and controversial therapeutic in pediatric dentistry. Since formocresol is known to have a toxic effect on living tissues, plus a mutagenic and carcinogenic potential with a systemic uptake of formocresol via pulpotomized teeth, other alternative products have been investigated. Twenty-five decayed primary canines and twenty-five healthy primary canines necessitating disking for orthodontic purposes were pulpotomized using non modified Zinc Oxide Eugenol. The effects of this material were evaluated both clinically and radiographically. Post operative control examinations were performed at 1, 6, 12, and 24 months trying to detect spontaneous or stimulated pain, pathological tooth mobility, abscesses or fistulas, internal or external pathological tooth resorption, periapical bone destruction, or canal obliteration. Pain was absent at 24 months post operatively. Half of the treated canines presented with a mobility, while internal and external resorptions were more frequent in decayed teeth and their number increased with time. On the other hand, abscesses and fistulas were equally found in both treated groups. The observations were compared to others related to formocresol ferric sulfate, MTA, and laser pulpotomies, using the binominal law, or the comparative test of an observed proportion to a reference proportion. In this study, and based on the excessive negative results in both groups, we demonstrated that non fixative pulpotomies on temporary canines were not a promising technique.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 2","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27608944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Periodontal surgery is the most effective procedure to reduce pocket depth and to gain clinical attachment at deep sites. This is not surprising as surgery provides the best access and enables the clinician to extensively alter hard and soft tissues if necessary. Still, nonsurgical debridement is usually adopted as an initial measure of treatment for all sites. This reflects the conventional scheme of periodontal therapy; that is, overall non-surgical debridement followed by re-evaluation and surgery if and wherever necessary. The underlying reasons for organizing periodontal care as such are discussed in this manuscript. The importance of patient's compliance in terms of oral hygiene in the planning of surgical treatment is also highlighted and explained.
{"title":"[Guidelines for surgical treatment of chronic periodontitis in Belgium].","authors":"Jan Cosyn, Hugo De Bruyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Periodontal surgery is the most effective procedure to reduce pocket depth and to gain clinical attachment at deep sites. This is not surprising as surgery provides the best access and enables the clinician to extensively alter hard and soft tissues if necessary. Still, nonsurgical debridement is usually adopted as an initial measure of treatment for all sites. This reflects the conventional scheme of periodontal therapy; that is, overall non-surgical debridement followed by re-evaluation and surgery if and wherever necessary. The underlying reasons for organizing periodontal care as such are discussed in this manuscript. The importance of patient's compliance in terms of oral hygiene in the planning of surgical treatment is also highlighted and explained.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 3","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27839932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preservation of natural teeth is the ultimate goal of dentistry today. Regular screening for periodontal disease, followed by infection control whenever necessary, positively affects tooth preservation, the more when the patients complies with therapy and regular maintenance. The dentist is, however, often confronted with treatment dilemmas and has to decide whether to extract or preserve teeth, to extirpate or extract, to keep or to implant, to make removable or fixed prostheses. Decision making is depending on the prognosis of teeth and becomes more difficult when teeth are supporting prosthetic restorations because the question arises: "How long will the teeth and the restoration survive?". Systematic reviews have revealed that teeth and implants have a similar prognosis. They are prone to biological and technical complications, the latter determining long term prognosis. Implant survival rates are around 93% after 10 years but the survival of the construction ranges between 80% and 90% depending on the type and extension. Complications are reported in the order of 35%. Prosthetic restoration on natural teeth have a 10-year survival of 80-90% with 34% of complications. The present paper gives a brief overview of the prognosis of dental treatments and discusses arguments that may be of help to make treatment decision choices.
{"title":"[Therapeutic choices and prognosis related to teeth or implants].","authors":"Hugo De Bruyn, Roeland De Moor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Preservation of natural teeth is the ultimate goal of dentistry today. Regular screening for periodontal disease, followed by infection control whenever necessary, positively affects tooth preservation, the more when the patients complies with therapy and regular maintenance. The dentist is, however, often confronted with treatment dilemmas and has to decide whether to extract or preserve teeth, to extirpate or extract, to keep or to implant, to make removable or fixed prostheses. Decision making is depending on the prognosis of teeth and becomes more difficult when teeth are supporting prosthetic restorations because the question arises: \"How long will the teeth and the restoration survive?\". Systematic reviews have revealed that teeth and implants have a similar prognosis. They are prone to biological and technical complications, the latter determining long term prognosis. Implant survival rates are around 93% after 10 years but the survival of the construction ranges between 80% and 90% depending on the type and extension. Complications are reported in the order of 35%. Prosthetic restoration on natural teeth have a 10-year survival of 80-90% with 34% of complications. The present paper gives a brief overview of the prognosis of dental treatments and discusses arguments that may be of help to make treatment decision choices.</p>","PeriodicalId":77359,"journal":{"name":"Revue belge de medecine dentaire","volume":"63 4","pages":"154-60"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27994301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}