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Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M最新文献

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Standardization: dreams, myths and reality. 标准化:梦想、神话和现实。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
R E Esch, W White
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引用次数: 0
Cloning allergen-specific antibody fragments (Fabs); tools for allergen standardization and therapy of type I allergy. 克隆过敏原特异性抗体片段(fab);过敏原标准化和I型过敏治疗的工具。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
R Valenta, P Steinberger, S Laffer, C Dolecek, P Wiedemann, S Flicker, D Kraft

Recombinant allergens have made it possible to dissect the mechanisms of allergen-antibody interactions at a molecular level. It becomes clear that monoclonal human IgG antibodies as well as animal derived antibodies can block the interaction of specific IgE antibodies as well as the allergen induced allergic effector reaction. Using PCR technology and combinatorial plasmid vectors, recombinant antibody fragments can be produced and it has even become possible to isolate allergen-specific IgE Fabs out of combinatorial IgE libraries constructed from allergic patients lymphocytes. Recombinant Fabs will represent useful tools to study the IgE-allergen interaction as well as for the standardization of allergen extracts and quantitative allergen measurements. Moreover, allergen-specific recombinant Fabs which block the allergen-IgE interaction have to be considered as tools for local therapy in effector organs of allergic patients.

重组过敏原使得在分子水平上剖析过敏原-抗体相互作用的机制成为可能。可见，单克隆人IgG抗体和动物源性抗体可以阻断特异性IgE抗体的相互作用，也可以阻断过敏原诱导的过敏效应反应。利用PCR技术和组合质粒载体，可以产生重组抗体片段，甚至可以从过敏患者淋巴细胞构建的组合IgE文库中分离出过敏原特异性IgE fab。重组fab将成为研究ige -过敏原相互作用以及过敏原提取标准化和定量过敏原测量的有用工具。此外，可阻断过敏原- ige相互作用的过敏原特异性重组fab可作为过敏患者效应器官局部治疗的工具。
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引用次数: 0
Responses to T cell tolerogenic peptides. 对T细胞耐受肽的反应。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
P S Norman
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引用次数: 0
Oral routes for immunotherapy: clinical efficacy and kinetics of the allergen. 口服免疫治疗途径:临床疗效和过敏原动力学。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
G W Canonica, G Passalacqua, G Mariani, C Motta, M Bartolomei, G Mistrello, P Falagiani, M Bagnasco
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引用次数: 0
A DNA vaccine for allergen immunotherapy using the latex allergen Hev b 5. 一种使用乳胶过敏原heb5进行过敏原免疫治疗的DNA疫苗。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
J E Slater, A Colberg-Poley
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引用次数: 0
Allergy to heated and processed foods. 对加热食品和加工食品过敏。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
S Vieths, A Jankiewicz, H Aulepp, D Haustein
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引用次数: 0
Recombinant allergens; basic and practical considerations. 重组过敏原;基本的和实际的考虑。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
H Breiteneder, K Hoffmann-Sommergruber, M Vanek-Krebitz, D Kraft, O Scheiner
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引用次数: 0
Biological reference preparations for allergens. 过敏原的生物参考制剂。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
J W Dorpema
{"title":"Biological reference preparations for allergens.","authors":"J W Dorpema","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 91","pages":"111-9"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20312880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles and practice in the monograph on allergenic extracts of the European Pharmacopoeia. 欧洲药典中致敏提取物专著的原则和实践。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
E Stevens
{"title":"Principles and practice in the monograph on allergenic extracts of the European Pharmacopoeia.","authors":"E Stevens","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 91","pages":"120-2"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20312881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epitope variability on isoforms of major allergens. 主要过敏原同种异构体的表位变异。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M
Pub Date : 1997-01-01
C Schou
{"title":"Epitope variability on isoforms of major allergens.","authors":"C Schou","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 91","pages":"177-82"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20312104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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