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Annales de l'Institut Pasteur. Immunology最新文献

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Techniques immunoenzymatiques immunoenzymatiques技术
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90154-7
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引用次数: 0
Endogenous and exogenous TNF therapy (EET therapy): conceptual and experimental grounds. 内源性和外源性TNF治疗(EET治疗):概念和实验依据。
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01
D Mizuno, G I Soma
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引用次数: 0
Natural lymphocyte activation in postnatal development of germ-free and conventional mice 天然淋巴细胞活化在无菌和常规小鼠出生后发育中的作用
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90138-9
L. Forni , C. Heusser , A. Coutinho

The degree of activation of B and T cells in the developing spleen during postnatal life was studied in germ-free (GF) and specific-pathogen-free (SPF) BALB/c mice of the same breeding stock. We found that the progeny of GF mothers up to 3 weeks of age contain higher numbers of activated splenic cells than baby SPF mice, thus suggesting qualitative differences in maternally-derived antibodies. This «advantageå of GF mice is also indicated by anticipated maturation of the splenic lymphoid compartment and is reflected in higher frequencies of B and T lymphocytes in adult life.

In both kinds of mice, the frequency of activated cells is very high at birth and then declines, reaching minimal valyes by 4 weeks of age. Later, activated B cells increase sharply in SPF mice, suggesting polyclonal activation mediated by bacterial products. Results are discussed on the basis of the mutual influences between B and T cells in the establishment of a functional network.

本文研究了同一种畜的无菌(GF)和无特异性病原体(SPF) BALB/c小鼠出生后脾脏中B细胞和T细胞的活化程度。我们发现3周龄的GF母鼠的后代比SPF幼鼠含有更多的活化脾细胞，从而提示母鼠来源的抗体有质的差异。GF小鼠的这种“优势”也可以通过脾脏淋巴室的预期成熟来证明，并反映在成年后B淋巴细胞和T淋巴细胞的较高频率上。在这两种小鼠中，激活细胞的频率在出生时都非常高，然后下降，在4周龄时达到最小值。随后，活化的B细胞在SPF小鼠中急剧增加，提示细菌产物介导的多克隆活化。在建立功能网络的基础上，讨论了B细胞和T细胞之间的相互影响。
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引用次数: 18
23rd forum in immunology. Non-specific lymphoid effectors: characterization and activation mechanisms. 第23届免疫学论坛。非特异性淋巴效应器:表征和激活机制。
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01
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引用次数: 0
In vivo anti-tumour activity of recombinant human tumour necrosis factor-alpha against Meth-A sarcoma requires L3T4-positive T cells 重组人肿瘤坏死因子- α对甲基a型肉瘤的体内抗肿瘤活性需要l3t4阳性T细胞
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90144-4
M.A. Palladino, I.S. Figari
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引用次数: 5
Nuclear location of the p55 subunit of the IL-2 receptor following activation of the HT-2 T helper cell line ht - 2t辅助细胞系激活后IL-2受体p55亚基的核定位
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90137-7
S. Jothy , A. Abadie , P. Froussard , M. Duphot , J. Thèze

After mitogenic or antigenic stimulation, T cells express interleukin-2 receptors (IL-2R). The mechanism and control of signal transduction following binding of IL-2 to IL-2R are poorly understood.

Using two rat monoclonal antibodies (5A2 and 7D4) specific for two distinct epitopes of the p55 subunit of mouse IL-2R, we have studied the cellular localization of this molecule by immunocytochemistry during the IL-2-mediated activation of mouse T helper cell clone HT-2. During the activation cycle, nuclear staining for the p55 subunit of the IL-2 receptor was transiently observed. It is suggested that the transient nuclear location of the IL-2R may play a critical role in the control of T-cell activation, proliferation and/or differentiation.

在有丝分裂或抗原刺激后，T细胞表达白细胞介素-2受体(IL-2R)。IL-2与IL-2R结合后信号转导的机制和控制尚不清楚。利用小鼠IL-2R p55亚基的两个不同表位特异性的两种大鼠单克隆抗体(5A2和7D4)，我们通过免疫细胞化学研究了il -2介导的小鼠T辅助细胞克隆HT-2激活过程中该分子的细胞定位。在激活周期中，短暂观察到IL-2受体p55亚基的核染色。这表明IL-2R的瞬时核定位可能在t细胞活化、增殖和/或分化的控制中起关键作用。
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引用次数: 3
TNF as an activator of vascular endothelium TNF作为血管内皮的激活剂
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90149-3
J.S. Pober
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引用次数: 33
Sensitizing effects and mechanisms of desensitization in regulation of the in vivo response to TNF 致敏效应和脱敏机制在调节TNF体内反应中的作用
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90150-X
D. Wallach, H. Holtmann, D. Aderka, T. Hahn, H. Engelmann, Y. Nophar
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引用次数: 1
Sjögren's syndrome clinical and immunological aspects Sjögren's综合征的临床和免疫学方面
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90160-2
G. Dighiero
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引用次数: 0
The pathophysiologic role of cachectin/TNF in septic shock and cachexia 恶病质在脓毒性休克和恶病质中的病理生理作用
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-05-01 DOI: 10.1016/0769-2625(88)90148-1
K.J. Tracey, S.F. Lowry , A. Cerami
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引用次数: 19
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