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Idiotypes, tailors and networks 独特类型，裁缝和网络
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90049-9
A. Coutinho, A. Grandien, J. Faro-Rivas, T.A. Mota-Santos
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引用次数: 8
Idiotypic analyses of anti-DNA antibodies in systemic lupus and monoclonal gammopathy 系统性狼疮和单克隆γ病抗dna抗体的独特型分析
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90053-0
A. Davidson, A. Livneh, A. Manheimer-Lory, R. Shefner, J.B. Katz, K.L. Sewell, B. Diamond
{"title":"Idiotypic analyses of anti-DNA antibodies in systemic lupus and monoclonal gammopathy","authors":"A. Davidson, A. Livneh, A. Manheimer-Lory, R. Shefner, J.B. Katz, K.L. Sewell, B. Diamond","doi":"10.1016/0769-2625(88)90053-0","DOIUrl":"10.1016/0769-2625(88)90053-0","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90053-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14392798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Genetics of the induction of antigen-specific immunity in anti-idiotype-treated mice and derivation of monoclonal Ab3 antibodies 抗独特型处理小鼠抗原特异性免疫诱导的遗传学及单克隆Ab3抗体的衍生
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90057-8
S.L. Epstein , S.O. Sharrow , D.H. Sachs

Antiidiotypic antibodies can be used as a means other than antigen of clone-specific intervention in the immune system. In a number of cases, antiidiotypic antibodies induce potent, antigen-specific responses without exposure of the recipient animals to antigen, and a better understanding of such responses will aid in the application of idiotype manipulation to both immunological and practical problems. The Ia.7 system expresses a major, cross-reactive idiotype on antibodies to an epitope of the mouse I-E antigen. Here, we examine genetic control of the I-E-specific response to anti-idiotype in this model system. Results demonstrate that both heavy chain allotype-linked and non-allotype-linked loci contribute to the control of this response. In addition, monoclonal antibodies representing the non-antigen-specific portion of the Ab3 response were derived. Two idiotype-positive clones were demonstrated to be of IgM isotype, contrasting with previous data showing that the serum Ab3 response is predominantly IgG1.

抗独特型抗体可以作为抗原以外的克隆特异性干预免疫系统的手段。在许多情况下，抗独特型抗体诱导有效的抗原特异性反应，而不使受体动物暴露于抗原，更好地了解这种反应将有助于将独特型操作应用于免疫学和实际问题。Ia.7系统在针对小鼠I-E抗原表位的抗体上表达一种主要的、交叉反应的独特型。在此，我们研究了该模型系统中i- e对抗独特型特异性反应的遗传控制。结果表明，重链同种异体连锁和非同种异体连锁基因座都有助于控制这种反应。此外，还获得了代表Ab3应答的非抗原特异性部分的单克隆抗体。两个独特型阳性克隆被证明是IgM同型，与先前显示血清Ab3反应主要是IgG1的数据形成对比。
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引用次数: 2
Effect of in vivo treatment with anti-idiotype on the immune response to anti-human chorionic gonadotropin 体内抗独特型治疗对抗人绒毛膜促性腺激素免疫应答的影响
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90058-X
A. Quadri , S.K. Gupta , P.-A. Cazenave , G.P. Talwar
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引用次数: 0
A structural basis for human cross-reacting idiotypes 人类交叉反应独特型的结构基础
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90054-2
R. Makar, I. Sanz , J.W. Thomas , J.D. Capra
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引用次数: 10
Table des auteurs 作者表
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90059-1
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引用次数: 0
Self-immunity and the autoimmune network: A molecular perspective to ontogeny and regulation of the immune system 自身免疫和自身免疫网络:免疫系统个体发生和调节的分子视角
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90051-7
M. Zanetti
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引用次数: 7
Index des livres reçus 收到书籍索引
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90062-1
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引用次数: 0
Molecular and immunologic analyses of a functional i internal image formed by an anti-receptor antibody 抗受体抗体形成的功能性i内像的分子和免疫学分析
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90055-4
W.V. Williams , H.R. Guy , J.A. Cohen , D.B. Weiner , M.I. Greene
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引用次数: 4
The start of an autoimmune disease: idiotypic network during early progression of myasthenia gravis 自身免疫性疾病的开始:重症肌无力早期进展中的独特型网络
Annales de l'Institut Pasteur. Immunology
Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90052-9
A.K. Lefvert

Anti-acetylcholine-receptor antibodies of IgG and IgM classes and antiidiotypic a antibodies were determined in patients with myasthenia gravis at various times after the start of the disease. Patients with a disease duration of less than one year had a higher prevalence of antiidiotypic antibodies (31/32) than patients who had had the disease for more than 5 years (49/79), and the concentration of antiidiotypic antibodies was also higher in patients with early disease (p < 0.005). The concentrations of antiidiotypic antibodies decreased during progression of the disease concomittant with an increase in IgG anti-receptor antibodies. A change from IgM to IgG anti-receptor antibody production was also found. In two patients, who developed myasthenia after bone-marrow grafting and who were followed before start of disease, antiidiotypic antibodies appeared before anti-receptor antibodies and before symptoms of myasthenia were present.

The high prevalence and concentration of antiidiotypic antibodies in early disease indicate that development and expression of antiidiotypic antibodies are important in early myasthenia gravis.

测定重症肌无力患者发病后不同时间的抗乙酰胆碱受体IgG、IgM类抗体和抗独特型a抗体。病程小于1年的患者抗独特型抗体的患病率(31/32)高于病程大于5年的患者(49/79)，且早期发病患者抗独特型抗体的浓度也较高(p <0.005)。在疾病进展过程中，抗独特型抗体的浓度下降，同时IgG抗受体抗体增加。抗受体抗体的产生也从IgM转变为IgG。在骨髓移植后出现肌无力的两例患者中，在疾病开始前随访，在抗受体抗体和肌无力症状出现之前出现抗独特型抗体。早期疾病中抗独特型抗体的高发病率和高浓度表明，抗独特型抗体的发育和表达在早期重症肌无力中起重要作用。
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引用次数: 13
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