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May Antarctic plants grow on Martian and Lunar soil simulants under terrestrial conditions? 南极植物可以在火星和月球模拟土壤上生长吗?
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240571
Cesar R L Amaral, Dafne Anjos, Fábio L V Bones, Antonio Carlos DE Freitas, Maithê G P Magalhães, Lucas M Moreira, Rodrigo Goldenberg-Barbosa, Anna Donato

Extremophile organisms have been largely studied in Astrobiology. Among them, two antarctic plants emerge as good candidates to become colonizers of other celestial bodies, such as Mars and the Moon. The present research aimed to evaluate survival and growing capacity of Sanionia uncinata and Colobanthus quitensis on Martian (MGS-1) and Lunar (LMS-1) regolith simulants, under terrestrial conditions. The survival responses of both species on the simulators and the original sampling site of Antarctic soil were observed during 15 days, in laboratory conditions at 'Comandante Ferraz' Station. Based on physiological parameters changes under the three soil conditions tested, our results suggest that Martian soil can be too harsh for plant growth, showing expressive decay, especially for C. quitensis. While lunar soil might provide more favorable conditions, with less observed changes, similarly to how they would in Antarctic soil from their natural habitat. This preliminary study provides resources and fosters knowledge about the possibility of these Antarctic species to survive in extraterrestrial environments, starting with soil parameters; and discusses the importance and use of Antarctic plants in astrobiology.

在天体生物学中对极端微生物进行了大量的研究。其中,两种南极植物成为其他天体(如火星和月球)殖民的良好候选者。本研究旨在评估火星(MGS-1)和月球(LMS-1)模拟风化层条件下,山仙子(Sanionia uncinata)和秋花石(Colobanthus quitensis)在陆地条件下的生存和生长能力。在“费拉兹指挥官”站的实验室条件下,观察了这两个物种在模拟器和南极土壤原始采样点上的生存反应,为期15天。根据三种土壤条件下的生理参数变化,我们的研究结果表明,火星土壤对植物生长来说可能过于苛刻,表现出明显的腐烂,尤其是对C. quitensis。虽然月球土壤可能提供更有利的条件,但观察到的变化较少,类似于它们在南极土壤中的自然栖息地。这项初步研究提供了资源,并促进了这些南极物种在地外环境中生存的可能性的知识,从土壤参数开始;并讨论了南极植物在天体生物学中的重要性和用途。
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引用次数: 0
Salt-affected soils in the Lopez de Bertodano Formation, polar semi-desert of Seymour Island, Antarctica: topographic or lithological controls? 南极洲西摩岛极地半沙漠洛佩斯-德-贝尔托达诺地层盐蚀土壤:地形或岩性控制?
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240584
Daniel N Krum, Carlos Ernesto G R Schaefer, Fábio S Oliveira, Roberto F M Michel, Heitor P Palma, Marcos Paulo E Tomaz, Ana Carolina P Amaral, Márcio R Francelino, Gustavo V Veloso

Salinization is one of the main pedogenetic processes occurring on the semiarid zone of the Weddel sea, like in Seymour Island, where salt-affected soils are widespread. This study aimed to investigate whether topography controls the distribution of salt-affected soils on Seymour Island, particularly with reference to the Lopez de Bertodano Formation. Chemical and physical results from 45 soil profiles were used, where morphometric variables were extracted. Descriptive statistical analysis, extraction of morphometric variables, cluster analysis and principal component analysis were carried out in this database. The separation of soils associated with the López de Bertodano Formation into two groups is explained by topographic atributes, and not by soil properties. Hence, the salts in soils have a geogenic origin, and despite differences in geological units, the uniform mineralogical composition of all Lopez de Bertodano Formation results in the widespread accumulation of salts in soils, influenced by the saline parent material and the semi-desert climate. Despite the lack of topographic control in the distribution of saline soils as a whole, geomorphology play a distinct role in the formation of secondary saline features, such as crusts, efflorescences, and columnar structures, or in salt composition of salts present in the soils.

盐碱化是发生在威德尔海半干旱区的主要成土过程之一,比如在西摩岛,受盐影响的土壤分布广泛。本研究旨在调查地形是否控制了西摩岛盐蚀土壤的分布,特别是洛佩兹德贝托达诺地层。使用了45个土壤剖面的化学和物理结果,其中提取了形态计量变量。对该数据库进行描述性统计分析、形态计量变量提取、聚类分析和主成分分析。与López de Bertodano地层相关的土壤分成两组是由地形属性而不是土壤属性来解释的。因此,土壤中的盐具有地质成因,尽管地质单位不同,但所有Lopez de Bertodano组的均匀矿物学组成导致土壤中盐的广泛积累,受含盐母质和半沙漠气候的影响。尽管在盐渍土的整体分布中缺乏地形控制,但地貌在次生盐渍特征的形成中起着明显的作用,如结壳、风化和柱状结构,或者在土壤中存在的盐的盐组成中起着重要作用。
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引用次数: 0
Vertical distribution of the zooplankton in the Antarctic Peninsula during the austral summer of 2017. 2017年南方夏季南极半岛浮游动物的垂直分布。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240144
Camila M Leonor, Erik Muxagata

Zooplankton plays a crucial role as the primary consumers in the Southern Ocean and its ecological processes, particularly in the Antarctic Peninsula, influenced by regional glaciological and oceanographic changes. To assess the overall composition of these communities, vertical samples were collected at various depths using a Multinet at oceanographic stations in the Antarctic Peninsula during the XXXV OPERANTAR expedition in summer 2017. Abiotic data (temperature, salinity and chlorophyll-a) were collected using a CTD and a fluoremeter. Organisms were identified to a higher level, with Chaetognatha and Euphausiacea identified to species whenever possible. Copepoda were the most abundant (73.4%), with Calanoida present in all samples and more abundant at 300m. Salpidae ranked as the second most abundant taxon (16.6%) up to 100m. Three species of Chaetognatha were identified, with Eukrohnia hamata being the most abundant, particularly at 300m. Two species of Euphausiacea were found, Euphausia superba and Thysanoesa macrura, with low abundances. Abiotic parameters showed significant relationships with the taxa. The region exhibits complex oceanography associated with zooplankton communities. The recorded data align with the zooplankton characterization of this region, uncovering a prevalence of Copepoda and surface abundant Salpidae, along with Chaetognatha (particulary E. hamata) and Euphausiacea.

浮游动物在受区域冰川学和海洋学变化影响的南大洋及其生态过程中,特别是在南极半岛,作为主要消费者发挥着至关重要的作用。为了评估这些群落的整体组成,在2017年夏季第XXXV OPERANTAR考察期间,利用南极半岛海洋站的多网在不同深度收集了垂直样本。使用CTD和荧光计收集非生物数据(温度、盐度和叶绿素-a)。对生物进行了更高层次的鉴定,尽可能将Chaetognatha和Euphausiacea鉴定为种。桡足类最多(73.4%),Calanoida在所有样品中均有存在,在300m处更为丰富。Salpidae(16.6%)为第二大分类单元。发现了3种毛齿动物,其中hamata Eukrohnia最为丰富,特别是在300米处。发现了2种低丰度的金蝇科植物(Euphausia superba和Thysanoesa macrura)。非生物参数与分类群有显著关系。该地区展示了与浮游动物群落相关的复杂海洋学。记录的数据与该地区的浮游动物特征一致,揭示了桡足类的普遍存在和丰富的水面Salpidae,以及毛纲(特别是E. hamata)和Euphausiacea。
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引用次数: 0
First report of Penicillium brevicompactum causing disease in Pleurotus ostreatus. 短孔青霉菌引起平菇疾病的首次报道。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420210103
Ricardo Scheffer DE Andrade Silva, Tiago Miguel Jarek, Gabriel Lucas DE Jesus, Gabriel Dias DE Oliveira, Francine Lorena Cuquel

Oyster mushroom (Pleurotus ostreatus) is the second most produced mushroom globally, but increased production is linked to new diseases. This study reports the first occurrence of Penicillium brevicompactum on P. ostreatus mushrooms. Symptoms, identified in the primordia, include atrophy, malformation, drying, and sporulation, causing up to 100% losses. The pathogen was confirmed with 99% identity via ITS region analysis and phylogenetic comparison. The research highlights P. brevicompactum's infection of mushroom primordia, emphasizing the need for pathogen identification and preventive measures to mitigate production losses.

平菇(Pleurotus ostreatus)是全球产量第二大的蘑菇,但产量的增加与新的疾病有关。本研究报道了短压缩青霉在青霉上的首次发现。在原基中发现的症状包括萎缩、畸形、干燥和产孢,导致高达100%的损失。经ITS区域分析和系统发育比较,病原菌的鉴定率为99%。本研究重点介绍了短苞假单胞菌对蘑菇原基的侵染,强调了病原鉴定和预防措施的必要性,以减轻生产损失。
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引用次数: 0
Gas Chromatography-mass Spectrometry analysis, Biotoxicity and Antibiofilm Activities of Syzygium aromaticum against Corynebacterium diphtheriae. 香合子对白喉棒状杆菌的气相色谱-质谱分析、生物毒性及抗菌活性。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420230368
Marcia B Alves, Katyane S Nascimento, Jéssica Mayara M Araújo, Wellyson C A Firmo, Victor Elias Mouchrek Filho, Dionney A DE Sousa, Ana Luíza M Guaraldi, Lídio G Lima Neto, Priscila S Sabbadini

The objective of this study was to investigate the chemical composition of Syzygium aromaticum essential oil (SAEO), both as its toxicity and biological activities on Corynebacterium diphtheriae. The essential oil (EO) was obtained by hydrodistillation and verified by GC-MS. The main chemical components were eugenol (48.79%), caryophyllene (44.29%) and α-humulene (4.87%). In vitro tests with human red blood cells, blood compatibility. SAEO showed high toxicity for Artemia salina and the bioassay on Tenebrio molitor larvae revealed an average survival rate of 80.00%. The antioxidant activity of SAEO was moderate (40.60%) using the phosphomolybdenum method. SAEO inhibited the growth of all C. diphtheriae strains tested at minimum inhibitory concentrations of 62.5-1000 µg mL-1 (strong to moderate). The minimum bactericidal concentration of SAEO was observed in two strains. Microorganisms cultivated in the presence of subinhibitory concentrations (subMIC) do not show morphological changes. The subMIC of SAEO inhibited in some strains, but in most cases, increased biofilm formation. In conclusion, the results of this study found that SAEO has an inhibitory effect against C. diphtheriae, representing an alternative antimicrobial therapy, although more in vivo biological studies, alone or in combination with occasional antimicrobials, should be carried out to better evaluate its effects.

本研究的目的是研究香薷精油(SAEO)的化学成分,以及其对白喉棒状杆菌的毒性和生物活性。采用加氢蒸馏法得到精油,并采用气相色谱-质谱法进行鉴定。主要化学成分为丁香酚(48.79%)、石竹烯(44.29%)和α-葎草烯(4.87%)。用人类红细胞进行体外测试血液相容性SAEO对盐渍蒿具有高毒性,对黄粉虫幼虫的平均存活率为80.00%。经磷钼法测定,SAEO的抗氧化活性中等(40.60%)。SAEO在最低抑制浓度为62.5 ~ 1000µg mL-1(强至中等)时,对所有白喉支原体均有抑制作用。在两株菌株中观察到SAEO的最低杀菌浓度。在亚抑制浓度(mic)下培养的微生物没有表现出形态变化。SAEO的亚mic抑制部分菌株,但在大多数情况下,增加生物膜的形成。综上所述,本研究结果发现SAEO对白喉支原体具有抑制作用,是一种替代的抗菌治疗方法,但还需要进行更多的体内生物学研究,单独使用或与偶尔使用的抗菌药物联合使用,以更好地评估其效果。
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引用次数: 0
Biochemical and histological effects of the subchronic treatment with a beer containing Baccharis dracunculifolia in an experimental model of diabetes. 含龙骨酒啤酒亚慢性治疗糖尿病实验模型的生化和组织学影响。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420231369
Ricardo A Pereira, Albimara Hey, Aline B DE Jesus, Aline T Marin, Fernanda Fiorini, Renata Corassa, Ana Karolina S Goes, Mayara Grolli, Anayana Z Dangui, Jéssica Wouk, Anaclara Prasniewski, Tatiane Luiza C Oldoni, Giuseppina Paola Parpinello, Urszula Tylewicz, Emerson Carraro, Carlos Ricardo M Malfatti

This article reports the development of a beer made with Baccharis dracunculifolia and its application in an experimental model of diabetes. Initially, the production of the beverage was standardized in order to incorporate the plant extract properly. Next, the beer was analyzed by the UHPLC-MS to identify the substances present. Among others, caffeic acid (5.85 mg / L), m-coumaric acid (5.16 mg / L), pinocembrin (2.99 mg / L), chrysin (10.86 mg / L), myricetin (1.73 mg / L) and spathulenol (9.30 mg / L) were found. Animal tests indicate improvement in biochemical and histological parameters of STZ-induced Wistar rats that ingested the beer made with the plant. The antidiabetic potential of this beverage was observed in the different tests that evaluated insulin resistance and the decrease of the clinical manifestations of diabetes in animals. The use of the drink as an adjunct in clinical treatments for DM2 may be useful, especially in suppressing the oxidative damage caused by the disease.

本文报道了一种以龙骨酒为原料的啤酒的研制及其在糖尿病实验模型中的应用。最初,饮料的生产是标准化的,以便适当地加入植物提取物。接下来,用UHPLC-MS对啤酒进行分析,以确定存在的物质。其中,咖啡酸(5.85 mg / L)、间香豆酸(5.16 mg / L)、松皮素(2.99 mg / L)、菊花素(10.86 mg / L)、杨梅素(1.73 mg / L)和鸡血酚(9.30 mg / L)含量最高。动物实验表明,饮用由该植物制成的啤酒后,stz诱导的Wistar大鼠的生化和组织学参数有所改善。在不同的试验中观察到该饮料的抗糖尿病潜力,以评估动物的胰岛素抵抗和减少糖尿病的临床表现。在临床治疗DM2的辅助治疗中使用这种饮料可能是有用的,特别是在抑制由该疾病引起的氧化损伤方面。
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引用次数: 0
Lectin-carbohydrate analysis by molecular dynamics: Parkia lectins case study. 分子动力学分析凝集素-碳水化合物:Parkia凝集素案例研究。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420230677
Kyria S Nascimento, Vinicius J S Osterne, Messias V Oliveira, Jorge L C Domingos, Wandemberg P Ferreira, Els J M VAN Damme, Benildo S Cavada, Vanir R Pinto-Junior

Understanding lectin-carbohydrate interactions at the structural and molecular levels is crucial to the field of lectins, as the diverse roles and biological activities exhibited by these proteins are fundamentally linked to their specific binding to target glycoconjugates. This study aimed to apply molecular dynamics to analyze the structure and binding properties of Parkia lectins. 3D structures of Parkia platycephala and P. biglobosa lectins, both unliganded and in complex with D-mannose, were used as inputs for simulations. The trajectories data enabled the study of stability, carbohydrate-binding interactions, and intermonomeric contacts for both proteins. The results revealed stable binding of D-mannose within the lectin domains and their binding mode at each of the three domains, displaying consistent binding motifs across the sites, with slight variations between the lectins and other Jacalin-related lectins. Despite these variations, the binding energies of the lectins with the ligand, as estimated using MM/GBSA, demonstrated favorable interactions in all cases. The dimeric interfaces of both lectins could be identified, and the main contacts have been mapped. These findings enhance our understanding of lectin-carbohydrate interactions and provide insights into the structural properties of Parkia lectins for potential biological and therapeutic applications.

在结构和分子水平上了解凝集素-碳水化合物的相互作用对凝集素领域至关重要,因为这些蛋白质所表现出的多种作用和生物活性从根本上与它们与靶糖缀合物的特异性结合有关。本研究旨在应用分子动力学方法分析Parkia凝集素的结构和结合特性。以未配体的和与d -甘露糖复合物的白头Parkia platycephala和P. biglobosa凝集素的三维结构作为模拟输入。这些轨迹数据使研究这两种蛋白质的稳定性、碳水化合物结合相互作用和单体间接触成为可能。结果显示d -甘露糖在凝集素结构域内的稳定结合及其在三个结构域上的结合模式,在这些位点上显示出一致的结合基序,而凝集素与其他jacalin相关凝集素之间存在轻微差异。尽管存在这些差异,根据MM/GBSA估计,凝集素与配体的结合能在所有情况下都表现出良好的相互作用。两种凝集素的二聚体界面均可识别,并绘制了主要的接触图谱。这些发现增强了我们对凝集素-碳水化合物相互作用的理解,并为潜在的生物学和治疗应用提供了Parkia凝集素结构特性的见解。
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引用次数: 0
Changes and collapse in lacustrine system in Antarctic Peninsula ice-free area: Boeckella and Buenos Aires lakes. 南极半岛无冰区湖泊系统的变化和崩塌:Boeckella和Buenos Aires湖泊。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240578
Rosemary Vieira, Priscila Cardoso, Kátia K DA Rosa, Carina Petsch, Juan Manuel Lirio

Some Antarctic ice-free areas have been affected by changes in lacustrine zones and permafrost thawing due to rising air temperatures over the last 60 years Temperature time-series were analyzed to understand the processes leading to the changes of Boeckella and Buenos Aires lakes, north Antarctic Peninsula. Statistical calculations were applied to average, maximum, and minimum temperatures, as well as to indexes such as Positive Degrees Day, Freezing/Thaw Day, and days with temperatures ≥ 0 °C and ≥ 10 °C. Changes in the region over recent decades were observed in mean and maximum temperatures and an increase in minimum temperature since the mid-1990s. In addition, the Normalized Difference Water Index was extracted from Landsat images from 2003, 2016, 2020, and 2021. These images were used to calculate changes in the areas of Boeckella and Buenos Aires lakes. These data revealed an 87% decrease in the area (m²) of Boeckella Lake and a 60% increase in Buenos Aires Lake´s area (m²). Concern has been raised about the modifying lake areas in the Antarctic Peninsula, where the collapse of Boeckella Lake could be the first case recorded in ice-free areas of Antarctica continent.

近60年来,由于气温升高,一些南极无冰地区受到了湖泊带变化和永久冻土融化的影响。为了了解导致南极半岛北部Boeckella湖和Buenos Aires湖变化的温度时间序列。统计计算平均、最高和最低温度,以及正度日、冻结/解冻日、温度≥0°C和≥10°C的天数等指标。观测到近几十年来该地区的平均和最高温度的变化以及自20世纪90年代中期以来最低温度的增加。此外,从2003年、2016年、2020年和2021年的Landsat图像中提取归一化差水指数。这些图像被用来计算Boeckella和布宜诺斯艾利斯湖泊地区的变化。这些数据显示,Boeckella湖的面积(m²)减少了87%,而布宜诺斯艾利斯湖的面积(m²)增加了60%。人们对南极半岛湖泊地区的变化感到担忧,在那里,博凯拉湖的崩塌可能是南极大陆无冰地区记录的第一例。
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引用次数: 0
Retreat of Greenwich, Livingston, Robert and Snow Islands glaciers, Antarctica, between 1956 and 2023. 1956年至2023年间,南极洲的格林尼治、利文斯顿、罗伯特和雪岛冰川的撤退。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240555
Danielle D Soffiatti, Kátia K Rosa, Júlia L Lorenz, Filipe Lindau, Carina Petsch, Francisco E Aquino, Jefferson C Simões

Glaciers are sensitive to environmental climatic conditions and show their variability over time. This study investigates the environmental characteristics and variation in glacial cover of the Greenwich, Livingston, Robert and Snow islands, Antarctica, between 1956 and 2023. The glacier extension mapping was based on visual interpretation of the Landsat 4, 7 and 8 optical images and normalised difference indexes combination. The REMA 8 digital elevation model was applied to the islands' geomorphometric analysis. Results were compared to climatic series and environmental characteristics. The glacial coverage decreased by 16.9% from 1956 to 2023, equivalent to 209.95 ± 0.113 km². Snow Island, with shallow bathymetry near glacial margins and land-terminating ice-fronts, exhibited the smallest retreat rate values. The glacial coverage of Livingston Island decreased significantly (18%, equivalent to 153.2 ± 0.113 km²) from 1956-2021, representing the highest values in the study. The changes in glacial coverage of the Robert and Greenwich islands were more substantial in the 1989-2023 period than in 1956-1989. Sectors with marine-terminating glaciers, associated with high bathymetric amplitudes, exhibited more significant variations compared to other sectors, contributing to the evolution of fjord-type bays. Glacial coverage has been lost in recent decades due to regional atmospheric and oceanic warming.

冰川对环境气候条件很敏感,并随时间变化。本研究调查了1956年至2023年间南极洲格林尼治岛、利文斯顿岛、罗伯特岛和斯诺岛冰川覆盖的环境特征和变化。冰川扩展制图基于Landsat 4、7和8光学图像的目视解译和归一化差指数组合。采用REMA 8数字高程模型对岛屿进行地貌分析。结果与气候序列和环境特征进行了比较。从1956年到2023年,冰川覆盖减少了16.9%,相当于209.95±0.113 km²。雪岛的水深较浅,靠近冰缘和止陆冰锋,退缩速率最小。1956-2021年,利文斯顿岛的冰川覆盖面积显著减少(18%,相当于153.2±0.113 km²),是研究中最高的。罗伯特岛和格林尼治岛冰川覆盖的变化在1989-2023年期间比1956-1989年期间更为显著。与其他扇区相比,具有海洋终点冰川的扇区与高水深幅值相关,表现出更显著的变化,有助于峡湾型海湾的演变。近几十年来,由于区域性大气和海洋变暖,冰川覆盖面积已经减少。
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引用次数: 0
Short-term high-fat diet alters behavior, peripheral metabolism, and brain mitochondrial function in Swiss mice. 短期高脂肪饮食改变瑞士小鼠的行为、外周代谢和脑线粒体功能。
IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240880
Adriano Emanuel Machado, Peterson Rezer, Gianni Mancini, Alexandra Latini, Eduardo Luiz G Moreira

Understanding the temporal dynamics of high-fat diets (HFD) effects on behavior and metabolism is crucial for comprehending their negative impact on organisms. This study investigated the short-term effects (15, 25, and 35 days) of HFD in Swiss mice. Our findings revealed distinct behavioral and metabolic changes throughout the treatment. After 15 days of HFD, mice exhibited impaired exploratory habituation and significant increases in visceral adipose mass, fasting glucose levels, and glucose intolerance. Extending the diet to 25 days intensified the metabolic effects, resulting in compromised acquisition of recognition memory, increased body mass gain, and elevated plasma total cholesterol and triglyceride levels. After 35 days of HFD, these effects were further intensified and accompanied by anxiogenic-like responses in the open field test. Additionally, we observed a positive correlation between metabolic changes and behavioral impairments alongside prefrontal cortex mitochondrial dysfunction. In conclusion, our study reveals the temporal dynamics of behavioral and metabolic changes induced by short-term HFD in Swiss mice, highlighting the relationship between metabolic dysfunction and behavioral impairments. These findings pave the way for future research to unravel the underlying mechanisms and develop strategies to counteract the detrimental effects of HFD on behavior and metabolism.

了解高脂肪饮食(HFD)对行为和代谢影响的时间动态对于理解它们对生物体的负面影响至关重要。本研究调查了HFD对瑞士小鼠的短期影响(15、25和35天)。我们的研究结果揭示了在整个治疗过程中明显的行为和代谢变化。食用HFD 15天后,小鼠表现出探索性习惯化受损,内脏脂肪量、空腹血糖水平和葡萄糖耐受不良显著增加。将饮食延长至25天,代谢效应加剧,导致识别记忆的获得受损,体重增加,血浆总胆固醇和甘油三酯水平升高。在HFD治疗35天后,这些作用进一步增强,并在野外试验中伴有焦虑样反应。此外,我们观察到代谢变化和行为障碍以及前额皮质线粒体功能障碍之间的正相关。总之,我们的研究揭示了短期HFD引起的瑞士小鼠行为和代谢变化的时间动态,突出了代谢功能障碍与行为障碍之间的关系。这些发现为未来的研究铺平了道路,揭示了潜在的机制,并制定了抵消HFD对行为和代谢的有害影响的策略。
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引用次数: 0
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