Anales de pediatria最新文献

英文中文

Callosidad talar infantil 安静的儿童伐木

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504048

Lorena Jiménez Molina , María Lozano García , Ana Garach Gómez

引用次数: 0

Bioinformática y gestión de datos ómicos en diagnóstico genético 遗传诊断中的生物信息学和组学数据管理

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504013

Angela del Pozo

Next Generation Sequencing (NGS) encompasses a range of technologies that have transformed genomic research since the 2000s. By allowing the sequencing of large DNA fragments at a significantly lower cost than Sanger sequencing, NGS has become an indispensable tool in molecular laboratories, particularly in the field of molecular genetics. Its high efficiency and speed make it a first-line technique in genetic analysis.

A crucial step in achieving a diagnosis is bioinformatics analysis. Short-read sequencing technology generates raw data that must be processed to extract meaningful and interpretable information. This process enables the identification of causal links between genetic findings and phenotypic traits. Clinical bioinformatics specialists carry out this analysis using specialized tools and pipelines, which take into account the specific characteristics of the sequencing platforms, protocols and the particular diseases under study.

The quality review is an essential complement to the pipeline analysis. Its primary objective is to assess which samples are suitable for diagnosis and, in cases where results are negative, to identify the reasons, whether they are related to the incidence or other factors. Additionally, the quality review offers insight into the overall effectiveness of the experimental procedures.

Despite its many advantages, NGS still faces several challenges, including the need for more efficient technologies, enhanced regulatory frameworks and improved training of medical staff.

下一代测序（NGS）涵盖了自2000年代以来改变基因组研究的一系列技术。由于能够以比Sanger测序低得多的成本对大片段DNA进行测序，NGS已成为分子实验室，特别是分子遗传学领域不可或缺的工具。其高效、快速的特点使其成为遗传分析的一线技术。实现诊断的关键一步是生物信息学分析。短读测序技术产生的原始数据必须经过处理，以提取有意义和可解释的信息。这个过程可以确定遗传发现和表型性状之间的因果关系。临床生物信息学专家使用专门的工具和管道进行这种分析，这些工具和管道考虑到测序平台、协议和所研究的特定疾病的具体特征。质量评审是对管道分析的重要补充。其主要目标是评估哪些样本适合诊断，在结果为阴性的情况下，确定原因，是否与发病率或其他因素有关。此外，质量审查提供了洞察实验程序的整体有效性。尽管有许多优点，但新系统仍然面临一些挑战，包括需要更有效的技术、加强监管框架和改进对医务人员的培训。

{"title":"Bioinformática y gestión de datos ómicos en diagnóstico genético","authors":"Angela del Pozo","doi":"10.1016/j.anpedi.2025.504013","DOIUrl":"10.1016/j.anpedi.2025.504013","url":null,"abstract":"<div><div>Next Generation Sequencing (NGS) encompasses a range of technologies that have transformed genomic research since the 2000s. By allowing the sequencing of large DNA fragments at a significantly lower cost than Sanger sequencing, NGS has become an indispensable tool in molecular laboratories, particularly in the field of molecular genetics. Its high efficiency and speed make it a first-line technique in genetic analysis.</div><div>A crucial step in achieving a diagnosis is bioinformatics analysis. Short-read sequencing technology generates raw data that must be processed to extract meaningful and interpretable information. This process enables the identification of causal links between genetic findings and phenotypic traits. Clinical bioinformatics specialists carry out this analysis using specialized tools and <em>pipelines</em>, which take into account the specific characteristics of the sequencing platforms, protocols and the particular diseases under study.</div><div>The quality review is an essential complement to the pipeline analysis. Its primary objective is to assess which samples are suitable for diagnosis and, in cases where results are negative, to identify the reasons, whether they are related to the incidence or other factors. Additionally, the quality review offers insight into the overall effectiveness of the experimental procedures.</div><div>Despite its many advantages, NGS still faces several challenges, including the need for more efficient technologies, enhanced regulatory frameworks and improved training of medical staff.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 6","pages":"Article 504013"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valoración y manejo de la colestasis: Documento de consenso de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), la Asociación Española de Pediatría de Atención Primaria (AEPap) y la Sociedad Española de Pediatría Extrahospitalaria y de Atención Primaria (SEPEAP) 滞育的评估和管理：西班牙胃肠病学、肝病学和儿科营养学学会（SEGHNP）、西班牙初级保健儿科协会（AEPap）和西班牙院外儿科和初级保健学会（SEPEAP）的共识文件

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504034

Maria Mercadal-Hally , Inés Loverdos , Joaquín Reyes-Andrade , Samuel Héctor Campuzano Martín , Ana Moreno-Álvarez , Ana María Vegas-Álvarez , Ana Pilar Galera Peinado

Cholestasis is indicative of hepatobiliary dysfunction and is always pathological. Early detection helps improve the prognosis of some of the underlying diseases that cause it. The most common liver disease that causes cholestasis in the first months of life is biliary atresia, followed by monogenic diseases. The objective of this document is to provide consensus-based recommendations for the adequate management of cholestasis based on the review of the current evidence. A working group was created for the purpose, with participation of members of the Spanish Society of Pediatric Gastroenterology, Hepatology and Nutrition, Spanish Association of Outpatient and Primary Care Pediatrics and the of Outpatient and Primary Care Pediatrics. The group established 26 recommendations to guide management in everyday clinical practice in both primary care and hospital settings.

胆汁淤积是肝胆功能障碍的表现，通常是病理性的。早期发现有助于改善一些潜在疾病的预后。在出生头几个月引起胆汁淤积的最常见的肝脏疾病是胆道闭锁，其次是单基因疾病。本文件的目的是在回顾现有证据的基础上，为充分管理胆汁淤积症提供基于共识的建议。为此目的设立了一个工作组，成员包括西班牙儿科胃肠病学、肝病学和营养学学会、西班牙门诊和初级儿科护理协会以及门诊和初级儿科护理协会。该小组提出了26项建议，以指导初级保健和医院环境中日常临床实践中的管理。

{"title":"Valoración y manejo de la colestasis: Documento de consenso de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), la Asociación Española de Pediatría de Atención Primaria (AEPap) y la Sociedad Española de Pediatría Extrahospitalaria y de Atención Primaria (SEPEAP)","authors":"Maria Mercadal-Hally , Inés Loverdos , Joaquín Reyes-Andrade , Samuel Héctor Campuzano Martín , Ana Moreno-Álvarez , Ana María Vegas-Álvarez , Ana Pilar Galera Peinado","doi":"10.1016/j.anpedi.2025.504034","DOIUrl":"10.1016/j.anpedi.2025.504034","url":null,"abstract":"<div><div>Cholestasis is indicative of hepatobiliary dysfunction and is always pathological. Early detection helps improve the prognosis of some of the underlying diseases that cause it. The most common liver disease that causes cholestasis in the first months of life is biliary atresia, followed by monogenic diseases. The objective of this document is to provide consensus-based recommendations for the adequate management of cholestasis based on the review of the current evidence. A working group was created for the purpose, with participation of members of the Spanish Society of Pediatric Gastroenterology, Hepatology and Nutrition, Spanish Association of Outpatient and Primary Care Pediatrics and the of Outpatient and Primary Care Pediatrics. The group established 26 recommendations to guide management in everyday clinical practice in both primary care and hospital settings.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 6","pages":"Article 504034"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Función pulmonar y trastornos respiratorios del sueño de grandes prematuros en edad preescolar 肺功能和呼吸睡眠障碍的学龄前儿童

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504028

Alfredo Cano , Isabel Bullón González , Pilar Andrés Porras , Silvia Pérez Porra , Ana Martínez Flórez , Raquel Izquierdo Caballero , Nuria Díez Monge

Objective

To determine the prevalence of abnormalities in small airway function and sleep-disordered breathing in preschoolers born very preterm and with very low birth weight, and their association with bronchopulmonary dysplasia and other neonatal risk factors.

Methods

Cross-sectional study of children aged 3 to 6 years born before 32 weeks of gestation with a birth weight of less than 1500 grams. Respiratory oscillometry was performed, determining the resistance and reactance at 5 Hz (R5 and X5), the difference in resistance at 5 and 19 Hz (R5-19), area under the reactance curve (AX), and the resonant frequency (Fres). Nocturnal oximetry was also performed, determining the oxygen desaturation indices at thresholds of 3% (ODI3) and 4% (ODI4). We analyzed the association of the results with bronchopulmonary dysplasia and other neonatal risk factors with the χ² test or the Mann-Whitney U test.

Results

The sample included 22 children with a median (IQR) age of 4.9 (3.7-5.4) years, of who 54.5% had bronchopulmonary dysplasia. There was a high prevalence of abnormal results for all oscillometry parameters (R5-19, 10.0%; X5, 21.1%; R5, 25.0%; Fres, 40.0%; AX, 45.0%) and oximetry parameters (ODI3, 38.1%; ODI4, 33.3%). None of these results were associated with bronchopulmonary dysplasia or other neonatal risk factors.

Conclusion

Preschoolers born very preterm and with very low birth weight have a high prevalence of abnormal small airway function and, probably, sleep-disordered breathing, unrelated to bronchopulmonary dysplasia.

目的了解极早产和极低出生体重学龄前儿童小气道功能异常和睡眠呼吸障碍的患病率及其与支气管肺发育不良及其他新生儿危险因素的关系。方法对妊娠32周前出生、出生体重小于1500克的3 ~ 6岁儿童进行横断面研究。采用呼吸振荡法测定5 Hz （R5和X5）时的电阻和电抗、5和19 Hz （R5-19）时的电阻差、电抗曲线下面积（AX）和谐振频率（Fres）。还进行了夜间血氧测定，测定阈值为3% （ODI3）和4% （ODI4）时的氧去饱和指数。我们采用χ2检验或Mann-Whitney U检验分析结果与支气管肺发育不良及其他新生儿危险因素的相关性。结果样本包括22名儿童，中位（IQR）年龄为4.9（3.7-5.4）岁，其中54.5%患有支气管肺发育不良。所有振荡测量参数（R5-19, 10.0%; X5, 21.1%; R5, 25.0%; Fres, 40.0%； AX, 45.0%）和血氧饱和度参数（ODI3, 38.1%; ODI4, 33.3%）的异常发生率都很高。这些结果均与支气管肺发育不良或其他新生儿危险因素无关。结论极早产和极低出生体重的学龄前儿童小气道功能异常发生率高，可能与支气管肺发育不良无关，睡眠呼吸障碍发生率高。

{"title":"Función pulmonar y trastornos respiratorios del sueño de grandes prematuros en edad preescolar","authors":"Alfredo Cano , Isabel Bullón González , Pilar Andrés Porras , Silvia Pérez Porra , Ana Martínez Flórez , Raquel Izquierdo Caballero , Nuria Díez Monge","doi":"10.1016/j.anpedi.2025.504028","DOIUrl":"10.1016/j.anpedi.2025.504028","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the prevalence of abnormalities in small airway function and sleep-disordered breathing in preschoolers born very preterm and with very low birth weight, and their association with bronchopulmonary dysplasia and other neonatal risk factors.</div></div><div><h3>Methods</h3><div>Cross-sectional study of children aged 3 to 6 years born before 32 weeks of gestation with a birth weight of less than 1500 grams. Respiratory oscillometry was performed, determining the resistance and reactance at 5Hz (R5 and X5), the difference in resistance at 5 and 19Hz (R5-19), area under the reactance curve (AX), and the resonant frequency (Fres). Nocturnal oximetry was also performed, determining the oxygen desaturation indices at thresholds of 3% (ODI3) and 4% (ODI4). We analyzed the association of the results with bronchopulmonary dysplasia and other neonatal risk factors with the χ<sup>2</sup> test or the Mann-Whitney <em>U</em> test.</div></div><div><h3>Results</h3><div>The sample included 22 children with a median (IQR) age of 4.9 (3.7-5.4) years, of who 54.5% had bronchopulmonary dysplasia. There was a high prevalence of abnormal results for all oscillometry parameters (R5-19, 10.0%; X5, 21.1%; R5, 25.0%; Fres, 40.0%; AX, 45.0%) and oximetry parameters (ODI3, 38.1%; ODI4, 33.3%). None of these results were associated with bronchopulmonary dysplasia or other neonatal risk factors.</div></div><div><h3>Conclusion</h3><div>Preschoolers born very preterm and with very low birth weight have a high prevalence of abnormal small airway function and, probably, sleep-disordered breathing, unrelated to bronchopulmonary dysplasia.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 6","pages":"Article 504028"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

La importancia de los disruptores endocrinos: enfoque desde la prevención ambiental 内分泌干扰物的重要性：从环境预防的角度出发

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504027

Paula Ventura Wichner , Ana Prado Carro , en representación del Grupo de Trabajo de Disruptores Endocrinos de la Sociedad Española de Endocrinología Pediátrica (SEEP)

引用次数: 0

Análisis de las sobreingestas voluntarias de paracetamol atendidas en el período 2018-2021 en un centro de tercer nivel 2018-2021年三级中心发生的扑热息痛自愿性超额用药分析

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504049

Paula Muyo-Hernández , Roc Monfort-Ibáñez , Rocío Rodrigo-García , Sebastià González-Peris , Maria Mercadal-Hally

引用次数: 0

Adaptación transcultural y validación de la escala pediátrica para la predicción de la vía venosa difícil (DIVA Score) en España 西班牙难静脉曲张预测的跨文化适应和儿科量表验证（DIVA Score）

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504057

María de la Vieja-Soriano , Ignacio Zaragoza-García , Alberto Galindo-Muñoz , Ismael Ortuño-Soriano , Mónica Blanco-Daza , María Domínguez-Muñoz , Oscar Arrogante Maroto

Introduction

The percentage of difficult intravenous access cases is high in pediatric care, and multiple attempts may be needed to establish peripheral venous access. The DIVA score allows identification of these patients; however, a validated version of this tool is not yet available in Spain. The objective of this study was to develop the Spanish version of the DIVA score.

Material and methods

We conducted a cross-sectional descriptive study with psychometric analysis in two phases: adaptation of the DIVA score to Spanish and analysis of the psychometric properties of the Spanish version (DIVA-SP).

The first phase consisted in the forward and back translation and back-translation of the score followed by expert evaluation and pretesting to develop the DIVA-SP. In the second phase, the scale was validated in a sample of patients aged up to 16 years admitted to different departments of a tertiary care hospital who required peripheral venous access. The nurse in charge of the patient completed the scale, which was included in an ad-hoc questionnaire along with other items to collect sociodemographic data.

Results

A total of 353 catheterizations were included. All items exhibited reliability with kappa values greater than 0.61. In the analysis of robustness, all items were deemed adequate except the history of prematurity. For the three-variable model, a cut-off point of 4 in the DIVA score showed a sensitivity of 0.45, a specificity of 0.81, a positive predictive value of 0.64, a negative predictive value of 0.67, a positive likelihood ratio of 2.44 and a negative likelihood ratio of 0.67. Of all patients, 66% were classified correctly and 33% incorrectly.

Conclusions

The DIVA-SP is useful, valid and reliable for application in Spain. Furthermore, it exhibits better psychometric properties than the original version for identifying difficult intravenous access in pediatric patients.

在儿科护理中，静脉通路困难的病例比例很高，可能需要多次尝试才能建立外周静脉通路。DIVA评分可以识别这些患者；然而，该工具的验证版本尚未在西班牙可用。本研究的目的是开发西班牙语版的DIVA评分。材料和方法我们进行了一项横断面描述性研究，心理测量分析分为两个阶段：DIVA分数对西班牙语的适应和西班牙语版本（DIVA- sp）的心理测量特性分析。第一阶段是对评分进行前后翻译和后翻译，然后进行专家评估和预测，制定DIVA-SP。在第二阶段，该量表在一所三级护理医院不同科室收治的16岁以下患者样本中进行了验证，这些患者需要外周静脉通路。负责病人的护士完成了量表，并将其与其他项目一起包含在一份特别问卷中，以收集社会人口统计数据。结果共纳入导管353例。所有项目的信度kappa值均大于0.61。在稳健性分析中，除早产史外，所有项目均被认为是适当的。对于三变量模型，DIVA评分的截断点为4时，其敏感性为0.45，特异性为0.81，阳性预测值为0.64，阴性预测值为0.67，阳性似然比为2.44，阴性似然比为0.67。在所有患者中，66%被正确分类，33%被错误分类。结论DIVA-SP在西班牙的应用是有效、可靠的。此外，它表现出更好的心理测量特性比原来的版本识别困难的静脉注射进入儿科患者。

{"title":"Adaptación transcultural y validación de la escala pediátrica para la predicción de la vía venosa difícil (DIVA Score) en España","authors":"María de la Vieja-Soriano , Ignacio Zaragoza-García , Alberto Galindo-Muñoz , Ismael Ortuño-Soriano , Mónica Blanco-Daza , María Domínguez-Muñoz , Oscar Arrogante Maroto","doi":"10.1016/j.anpedi.2025.504057","DOIUrl":"10.1016/j.anpedi.2025.504057","url":null,"abstract":"<div><h3>Introduction</h3><div>The percentage of difficult intravenous access cases is high in pediatric care, and multiple attempts may be needed to establish peripheral venous access. The DIVA score allows identification of these patients; however, a validated version of this tool is not yet available in Spain. The objective of this study was to develop the Spanish version of the DIVA score.</div></div><div><h3>Material and methods</h3><div>We conducted a cross-sectional descriptive study with psychometric analysis in two phases: adaptation of the DIVA score to Spanish and analysis of the psychometric properties of the Spanish version (DIVA-SP).</div><div>The first phase consisted in the forward and back translation and back-translation of the score followed by expert evaluation and pretesting to develop the DIVA-SP. In the second phase, the scale was validated in a sample of patients aged up to 16 years admitted to different departments of a tertiary care hospital who required peripheral venous access. The nurse in charge of the patient completed the scale, which was included in an ad-hoc questionnaire along with other items to collect sociodemographic data.</div></div><div><h3>Results</h3><div>A total of 353 catheterizations were included. All items exhibited reliability with kappa values greater than 0.61. In the analysis of robustness, all items were deemed adequate except the history of prematurity. For the three-variable model, a cut-off point of 4 in the DIVA score showed a sensitivity of 0.45, a specificity of 0.81, a positive predictive value of 0.64, a negative predictive value of 0.67, a positive likelihood ratio of 2.44 and a negative likelihood ratio of 0.67. Of all patients, 66% were classified correctly and 33% incorrectly.</div></div><div><h3>Conclusions</h3><div>The DIVA-SP is useful, valid and reliable for application in Spain. Furthermore, it exhibits better psychometric properties than the original version for identifying difficult intravenous access in pediatric patients.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 6","pages":"Article 504057"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sistema de puntuación CoMiSS de síntomas asociados a la leche de vaca: ¿cuándo puede ser útil para los pediatras españoles? CoMiSS牛奶相关症状评分系统：什么时候对西班牙儿科医生有用？

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504056

Rafael Martín-Masot , Juan J. Díaz-Martín , Alicia Santamaria-Orleans , Víctor Manuel Navas-López

Introduction

The Cow's Milk-related Symptom Score (CoMiSS) is a practical tool to assess for cow's milk protein allergy (CMPA) in infants based on clinical manifestations, although the diagnosis of CMPA should be confirmed subsequently by a specialist in pediatrics and/or pediatric gastroenterology and nutrition. The aim of this study was to compare CoMiSS results in infants diagnosed with IgE-mediated and non-IgE-mediated CMPA.

Material and methods

Multicenter, cross-sectional survey study with participation of pediatricians throughout Spain. Pediatricians were directed to apply the CoMiSS to infants at the time of diagnosis of CMPA and 7 days after initiating nutritional management with an extensively hydrolyzed formula (EHF). We interpreted a CoMiSS score of 12 or greater as positive.

Results

A total of 294 pediatricians (mean age, 51 years) participated in the study. The analysis included CoMiSS results for 1176 infants with CMPA (mean [SD] age: 6.4 [4.9] months), of who 66.8% (n = 745) had non-IgE-mediated CMPA. We found a greater decrease in the mean score in the IgE-mediated group compared to the non-IgE-mediated group (mean [SD] −9.06 [5.74] vs −6.00 [4.05]; P < .0001). When it came to individual symptoms, there were significantly greater reductions in the mean scores for crying and regurgitation in the non-IgE-mediated group, and, conversely, significantly greater reductions in the scores for atopic eczema in the head and arms, urticaria and respiratory symptoms in the IgE-mediated group. There was also a greater decrease in the total CoMiSS score in infants with very severe CMPA compared to infants with severe, moderate and mild CMPA.

Conclusion

This survey showed that only one third of infants diagnosed with CMPA had a positive CoMiSS result of 12 points or greater at the time of diagnosis, which suggests an inadequate use of the CoMiSS. We recommend the implementation of strategies to increase knowledge of the utility of the CoMiSS for the assessment of CMPA.

牛奶相关症状评分（CoMiSS）是一种基于临床表现评估婴儿牛奶蛋白过敏（CMPA）的实用工具，尽管CMPA的诊断应随后由儿科和/或儿科胃肠病学和营养学专家确认。本研究的目的是比较CoMiSS在诊断为ige介导和非ige介导的CMPA的婴儿中的结果。材料和方法西班牙儿科医生参与的多中心横断面调查研究。指导儿科医生在诊断为CMPA时和开始用广泛水解配方奶粉（EHF）进行营养管理7天后对婴儿应用CoMiSS。我们认为CoMiSS得分为12或更高为正。结果共有294名儿科医生参与研究，平均年龄51岁。分析纳入了1176例CMPA患儿（平均[SD]年龄：6.4[4.9]个月）的CoMiSS结果，其中66.8% （n = 745）为非ige介导的CMPA。我们发现，与非ige介导组相比，ige介导组的平均评分下降幅度更大（mean [SD] - 9.06 [5.74] vs - 6.00 [4.05]; P < 0.0001）。当涉及到个体症状时，非ige介导组的哭泣和反流的平均得分显著降低，相反，ige介导组的头部和手臂特应性湿疹、荨麻疹和呼吸道症状的得分显著降低。与重度、中度和轻度CMPA的婴儿相比，极重度CMPA婴儿的CoMiSS总分也有更大的下降。结论在确诊为CMPA的患儿中，仅有1 / 3的患儿在诊断时CoMiSS为12分以上阳性，提示CoMiSS使用不充分。我们建议实施战略，以增加对CoMiSS评估CMPA效用的认识。

{"title":"Sistema de puntuación CoMiSS de síntomas asociados a la leche de vaca: ¿cuándo puede ser útil para los pediatras españoles?","authors":"Rafael Martín-Masot , Juan J. Díaz-Martín , Alicia Santamaria-Orleans , Víctor Manuel Navas-López","doi":"10.1016/j.anpedi.2025.504056","DOIUrl":"10.1016/j.anpedi.2025.504056","url":null,"abstract":"<div><h3>Introduction</h3><div>The Cow's Milk-related Symptom Score (CoMiSS) is a practical tool to assess for cow's milk protein allergy (CMPA) in infants based on clinical manifestations, although the diagnosis of CMPA should be confirmed subsequently by a specialist in pediatrics and/or pediatric gastroenterology and nutrition. The aim of this study was to compare CoMiSS results in infants diagnosed with IgE-mediated and non-IgE-mediated CMPA.</div></div><div><h3>Material and methods</h3><div>Multicenter, cross-sectional survey study with participation of pediatricians throughout Spain. Pediatricians were directed to apply the CoMiSS to infants at the time of diagnosis of CMPA and 7days after initiating nutritional management with an extensively hydrolyzed formula (EHF). We interpreted a CoMiSS score of 12 or greater as positive.</div></div><div><h3>Results</h3><div>A total of 294 pediatricians (mean age, 51years) participated in the study. The analysis included CoMiSS results for 1176 infants with CMPA (mean [SD] age: 6.4 [4.9] months), of who 66.8% (n=745) had non-IgE-mediated CMPA. We found a greater decrease in the mean score in the IgE-mediated group compared to the non-IgE-mediated group (mean [SD] −9.06 [5.74] vs −6.00 [4.05]; <em>P</em>   <!-->points or greater at the time of diagnosis, which suggests an inadequate use of the CoMiSS. We recommend the implementation of strategies to increase knowledge of the utility of the CoMiSS for the assessment of CMPA.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 6","pages":"Article 504056"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptación cultural y validación de la escala CSHCN Screener en población española 在西班牙人口中对CSHCN Screener量表进行文化适应和验证

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504033

Maria do Céu Barbieri-Figueiredo , Francisca María García-Padilla , Miriam Sánchez-Alcón , Javier Castro-Serrano , Almudena Garrido-Fernández

Introduction

Chronic diseases in childhood are becoming increasingly prevalent, requiring ongoing care. The CSHCN Screener scale detects the health needs of children and adolescents who require additional services derived from these conditions. The aim of this study was to culturally adapt the scale to the Spanish population and to evaluate its psychometric properties.

Material and methods

We conducted a cross-sectional study using a scale comprised of five dichotomous items addressed to mothers and fathers. If participants answered affirmatively, the corresponding subitems were included. We calculated descriptive statistics and performed confirmatory factor analysis (CFA). Reliability was assessed through internal consistency by means of the Cronbach α coefficient, corrected item-total correlations, the Cronbach α if item deleted and test-retest reliability. We also calculated the kappa coefficient and the intraclass correlation coefficient (ICC).

Results

A total of 987 parents (mothers and fathers) of children and adolescents aged 3 to 18 years enrolled in public schools in Andalusia participated in the study. The CFA fit indices were adequate (χ²(30) = 87.490, χ²/df = 2.926, CFI = 0.998, Tucker-Lewis index (TLI) = 0.992, RMSEA = 0.044, SRMR = 0.0138). The Cronbach α was 0.827 for the main items and 0.840 for the sub-items. ICC values exceeded 0.90, and Kappa values were greater than 0.60.

Conclusions

The Spanish version of the CSHCN Screener shows adequate psychometric properties. Thanks to this instrument, it is possible to detect Spanish children and adolescents with special health care needs in schools and it also facilitates the design of future interventions adapted to the characteristics of this population.

儿童慢性疾病正变得越来越普遍，需要持续护理。儿童健康和健康网络筛查量表检测因这些疾病而需要额外服务的儿童和青少年的健康需求。本研究的目的是使量表在文化上适应西班牙人口，并评估其心理测量特性。材料和方法我们进行了一项横断面研究，使用了一个由五个二分题组成的量表，分别针对母亲和父亲。如果参与者的回答是肯定的，则包括相应的子项。我们计算描述性统计并进行验证性因子分析（CFA）。信度通过内部一致性评估，采用Cronbach α系数、校正项目-总相关、Cronbach α如果项目被删除和重测信度。我们还计算了kappa系数和类内相关系数（ICC）。结果共有987名在安达卢西亚公立学校就读的3至18岁儿童和青少年的父母（父母）参与了研究。CFA拟合指标良好(χ2（30) = 87.490, χ2/df = 2.926, CFI = 0.998， Tucker-Lewis指数(TLI) = 0.992, RMSEA = 0.044, SRMR = 0.0138）。主条目的Cronbach α为0.827，子条目的Cronbach α为0.840。ICC值大于0.90，Kappa值大于0.60。结论西班牙语版CSHCN筛检具有足够的心理测量特性。借助这一工具，可以在学校中发现有特殊保健需要的西班牙儿童和青少年，还有助于设计适合这一群体特点的未来干预措施。

{"title":"Adaptación cultural y validación de la escala CSHCN Screener en población española","authors":"Maria do Céu Barbieri-Figueiredo , Francisca María García-Padilla , Miriam Sánchez-Alcón , Javier Castro-Serrano , Almudena Garrido-Fernández","doi":"10.1016/j.anpedi.2025.504033","DOIUrl":"10.1016/j.anpedi.2025.504033","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic diseases in childhood are becoming increasingly prevalent, requiring ongoing care. The CSHCN <em>Screener</em> scale detects the health needs of children and adolescents who require additional services derived from these conditions. The aim of this study was to culturally adapt the scale to the Spanish population and to evaluate its psychometric properties.</div></div><div><h3>Material and methods</h3><div>We conducted a cross-sectional study using a scale comprised of five dichotomous items addressed to mothers and fathers. If participants answered affirmatively, the corresponding subitems were included. We calculated descriptive statistics and performed confirmatory factor analysis (CFA). Reliability was assessed through internal consistency by means of the Cronbach α coefficient, corrected item-total correlations, the Cronbach α if item deleted and test-retest reliability. We also calculated the kappa coefficient and the intraclass correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>A total of 987 parents (mothers and fathers) of children and adolescents aged 3 to 18 years enrolled in public schools in Andalusia participated in the study. The CFA fit indices were adequate (χ<sup>2</sup>(30)=87.490, χ<sup>2</sup>/df=2.926, CFI=0.998, Tucker-Lewis index (TLI) =0.992, RMSEA=0.044, SRMR=0.0138). The Cronbach α was 0.827 for the main items and 0.840 for the sub-items. ICC values exceeded 0.90, and Kappa values were greater than 0.60.</div></div><div><h3>Conclusions</h3><div>The Spanish version of the CSHCN <em>Screener</em> shows adequate psychometric properties. Thanks to this instrument, it is possible to detect Spanish children and adolescents with special health care needs in schools and it also facilitates the design of future interventions adapted to the characteristics of this population.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 6","pages":"Article 504033"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malformación capilar-malformación arteriovenosa: presentación neonatal atípica 毛细血管畸形-动脉静脉畸形：非典型新生儿

IF 2.1 4区医学 Q2 PEDIATRICS

Anales de pediatria

Pub Date : 2025-12-01 DOI: 10.1016/j.anpedi.2025.504054

Ana Espinosa , Ruth del Río , Eulàlia Baselga , José Hinojosa

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Anales de pediatria

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀