Pub Date : 2025-04-29DOI: 10.1080/00032719.2025.2496934
Chamindu Liyanapatirana, Frank X Weber, James M Harrington, Laura G Haines, Reshan A Fernando, Keith E Levine, Suramya Waidyanatha
Arsenic (As) and As-containing compounds have a wide array of applications in medicine, industry, and agriculture and has been associated with adverse health outcomes. In support of studies investigating the toxicity and toxicokinetic behavior of arsenic compounds, we developed and validated a high-resolution sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) method to quantitate total arsenic in Sprague-Dawley (SD) rat plasma and heart. Primary matrix standard curves prepared in male SD rat plasma were linear (r ≥ 0.999) over the range of 5 to 1250 ng As/mL plasma with accuracy determined as relative error (RE) was ≤ ±20% at the lower limit of quantitation (LLOQ) of 5 ng/mL and ≤ ±15% for all other concentrations. The method limit of detection (LOD) was 0.728 ng/mL plasma. Mean extraction recovery was 96.7%, with a relative standard deviation (RSD) of 4.0%. The method demonstrated acceptable inter- (≤ ±7.3% RE and ≤ 8.0% RSD) and intra-day (≤ ±14.9% RE and ≤ 6.8% RSD) accuracy and precision. Method selectivity was ≤ 20% of the response for the LLOQ. Method performance was also evaluated in SD rat heart by preparing QC samples in heart homogenate and quantifying using plasma calibration curve. The mean RE value was -3.8% and the RSD value was 3.4% demonstrating that the method is suitable for quantitation of arsenic in rat heart.
{"title":"Quantitation of Arsenic in biological matrices: Use of Sector Field Inductively Coupled Plasma-Mass Spectrometry for Improved Accuracy and Specificity.","authors":"Chamindu Liyanapatirana, Frank X Weber, James M Harrington, Laura G Haines, Reshan A Fernando, Keith E Levine, Suramya Waidyanatha","doi":"10.1080/00032719.2025.2496934","DOIUrl":"https://doi.org/10.1080/00032719.2025.2496934","url":null,"abstract":"<p><p>Arsenic (As) and As-containing compounds have a wide array of applications in medicine, industry, and agriculture and has been associated with adverse health outcomes. In support of studies investigating the toxicity and toxicokinetic behavior of arsenic compounds, we developed and validated a high-resolution sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) method to quantitate total arsenic in Sprague-Dawley (SD) rat plasma and heart. Primary matrix standard curves prepared in male SD rat plasma were linear (r ≥ 0.999) over the range of 5 to 1250 ng As/mL plasma with accuracy determined as relative error (RE) was ≤ ±20% at the lower limit of quantitation (LLOQ) of 5 ng/mL and ≤ ±15% for all other concentrations. The method limit of detection (LOD) was 0.728 ng/mL plasma. Mean extraction recovery was 96.7%, with a relative standard deviation (RSD) of 4.0%. The method demonstrated acceptable inter- (≤ ±7.3% RE and ≤ 8.0% RSD) and intra-day (≤ ±14.9% RE and ≤ 6.8% RSD) accuracy and precision. Method selectivity was ≤ 20% of the response for the LLOQ. Method performance was also evaluated in SD rat heart by preparing QC samples in heart homogenate and quantifying using plasma calibration curve. The mean RE value was -3.8% and the RSD value was 3.4% demonstrating that the method is suitable for quantitation of arsenic in rat heart.</p>","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12383451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-09-17DOI: 10.1080/00032719.2024.2403144
Sharmin Sultana, Megan B Guetzloff, Ramu Kakumanu, Trevor R Ostlund, Fathi T Halaweish, Brian A Logue
Chlorine interacts with the aqueous environment, including the mucosa and alveolar fluid in the lungs, causes the immediate transformation of chlorine to hypochlorous acid (HClO) and hydrochloric acid (HCl) which induces cellular damage and may produce systemic toxicity. There are multiple techniques to monitor hypochlorite (HClO/ClO-) from various matrices, however, they each have significant disadvantages, including limited sensitivity, complexity, and slow response. In this study, we developed a water-soluble fluorescein-based probe, called fluorescein thioacid (FSH), for the rapid and sensitive detection of HClO/ClO- in aqueous solutions via oxidation of FSH to produce fluorescein. FSH was synthesized via a simple, one-step procedure and exhibited excellent selectivity for ClO-, maintaining 82% signal stability for 24 h. FSH performed well over a wide pH range (4 to 10; optimum pH of 4), produced a linear range from 1 to 100 μM, and had a detection limit of 100 nM. The probe was able to accurately quantify HClO/ClO- concentrations in tap water (13.8 μM) and swimming pool water (56.9 μM) samples. Overall, FSH is simple to synthesize, highly selective, highly sensitive, has excellent water solubility, and produces a fast response for monitoring of aqueous ClO- levels.
{"title":"Development of a Rapid Fluorescence Probe for the Determination of Aqueous Hypochlorite.","authors":"Sharmin Sultana, Megan B Guetzloff, Ramu Kakumanu, Trevor R Ostlund, Fathi T Halaweish, Brian A Logue","doi":"10.1080/00032719.2024.2403144","DOIUrl":"10.1080/00032719.2024.2403144","url":null,"abstract":"<p><p>Chlorine interacts with the aqueous environment, including the mucosa and alveolar fluid in the lungs, causes the immediate transformation of chlorine to hypochlorous acid (HClO) and hydrochloric acid (HCl) which induces cellular damage and may produce systemic toxicity. There are multiple techniques to monitor hypochlorite (HClO/ClO<sup>-</sup>) from various matrices, however, they each have significant disadvantages, including limited sensitivity, complexity, and slow response. In this study, we developed a water-soluble fluorescein-based probe, called fluorescein thioacid (FSH), for the rapid and sensitive detection of HClO/ClO<sup>-</sup> in aqueous solutions via oxidation of FSH to produce fluorescein. FSH was synthesized via a simple, one-step procedure and exhibited excellent selectivity for ClO<sup>-</sup>, maintaining 82% signal stability for 24 h. FSH performed well over a wide pH range (4 to 10; optimum pH of 4), produced a linear range from 1 to 100 μM, and had a detection limit of 100 nM. The probe was able to accurately quantify HClO/ClO<sup>-</sup> concentrations in tap water (13.8 μM) and swimming pool water (56.9 μM) samples. Overall, FSH is simple to synthesize, highly selective, highly sensitive, has excellent water solubility, and produces a fast response for monitoring of aqueous ClO<sup>-</sup> levels.</p>","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"58 13","pages":"2249-2263"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-14DOI: 10.1080/00032719.2024.2403020
Cheng Lin, Xuelian Zhang, Xueyang Yan, Yan Cai, Wenjie Li
An all-optical double-pass quartz enhanced photoacoustic spectroscopy (QEPAS) sensor for the detection of acetylene (C2H2) at part-per-billion (ppb) levels was developed and experimentally validate...
{"title":"Part-per-Billion (Ppb)-Level Acetylene Sensor Employing Optical Quartz Enhanced Photoacoustic Spectroscopy (QEPAS) with an Erbium-Doped Fiber Amplifier (EDFA) and a Fiber-Optic Fabry–Perot Interferometer","authors":"Cheng Lin, Xuelian Zhang, Xueyang Yan, Yan Cai, Wenjie Li","doi":"10.1080/00032719.2024.2403020","DOIUrl":"https://doi.org/10.1080/00032719.2024.2403020","url":null,"abstract":"An all-optical double-pass quartz enhanced photoacoustic spectroscopy (QEPAS) sensor for the detection of acetylene (C2H2) at part-per-billion (ppb) levels was developed and experimentally validate...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"9 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-14DOI: 10.1080/00032719.2024.2401172
Hilal Akbiyik, Hakan Serbes, Yağmur Kilinç, Sude Oflu, Selim Gürsoy, Nizamettin Özdoğan, Gülten Çetin, Sezgin Bakirdere
Liquid phase microextraction (LPME) with a dithizone/deep eutectic solvent (DTZ-DES)-based probe was employed for the determination of trace cadmium by flame atomic absorption spectrometry (FAAS). ...
{"title":"Development of Analytical Strategy for the Determination of Cadmium by Flame Atomic Absorption Spectrometry After Dithizone/Deep Eutectic Solvent Probe Based Liquid Phase Microextraction","authors":"Hilal Akbiyik, Hakan Serbes, Yağmur Kilinç, Sude Oflu, Selim Gürsoy, Nizamettin Özdoğan, Gülten Çetin, Sezgin Bakirdere","doi":"10.1080/00032719.2024.2401172","DOIUrl":"https://doi.org/10.1080/00032719.2024.2401172","url":null,"abstract":"Liquid phase microextraction (LPME) with a dithizone/deep eutectic solvent (DTZ-DES)-based probe was employed for the determination of trace cadmium by flame atomic absorption spectrometry (FAAS). ...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"40 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1080/00032719.2024.2400708
Yiting Tang, Yu Tan, Yongming Guo
Carbon quantum dots (CQDs) have received considerable interest due to their excellent properties, including low-cost, easy fabrication, tunable emission, high quantum yields, good photostability, a...
{"title":"Carbon Quantum Dots: Synthesis and Fluorescence Determination of Hemoglobin: A Minireview","authors":"Yiting Tang, Yu Tan, Yongming Guo","doi":"10.1080/00032719.2024.2400708","DOIUrl":"https://doi.org/10.1080/00032719.2024.2400708","url":null,"abstract":"Carbon quantum dots (CQDs) have received considerable interest due to their excellent properties, including low-cost, easy fabrication, tunable emission, high quantum yields, good photostability, a...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"84 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-08DOI: 10.1080/00032719.2024.2399178
Rameez Abbas Khan, M. Anwar-ul-haq, M. Qasim, Nasar Ahmed
Laterite is a geological formation in tropical and subtropical regions with high iron and aluminum content. It is extensively used in cement production, water filtration, and the formation of geopo...
红土是热带和亚热带地区一种含铁和铝较多的地质构造。它被广泛应用于水泥生产、水过滤和地质勘探。
{"title":"Improved Elemental Analysis of Laterite by Calibration-Free Laser Induced Breakdown Spectroscopy (CF-LIBS) Using Escape Factor Based Self-Absorption Correction","authors":"Rameez Abbas Khan, M. Anwar-ul-haq, M. Qasim, Nasar Ahmed","doi":"10.1080/00032719.2024.2399178","DOIUrl":"https://doi.org/10.1080/00032719.2024.2399178","url":null,"abstract":"Laterite is a geological formation in tropical and subtropical regions with high iron and aluminum content. It is extensively used in cement production, water filtration, and the formation of geopo...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"30 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-05DOI: 10.1080/00032719.2024.2400269
Xiaomei Lin, Ke Ding, Yao Li, Yutao Huang, Jiangfei Yang, Yongkang Ren, Xin Zhen, Changjin Che, Jingjun Lin
The accuracy of quantitative analysis in soil laser-induced breakdown spectroscopy (LIBS) is frequently compromised by self-absorption. Eliminating this influence is imperative for attaining reliab...
{"title":"Self-Absorption Correction for Laser-Induced Breakdown Spectroscopy (LIBS) Using Column Density-Saha-Boltzmann (CD-SB) Theory","authors":"Xiaomei Lin, Ke Ding, Yao Li, Yutao Huang, Jiangfei Yang, Yongkang Ren, Xin Zhen, Changjin Che, Jingjun Lin","doi":"10.1080/00032719.2024.2400269","DOIUrl":"https://doi.org/10.1080/00032719.2024.2400269","url":null,"abstract":"The accuracy of quantitative analysis in soil laser-induced breakdown spectroscopy (LIBS) is frequently compromised by self-absorption. Eliminating this influence is imperative for attaining reliab...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/00032719.2024.2399182
Zhiyu Liu, Yuwei Yang, Yunfei Bai, Qinyu Ge
Considerable interest has focused on cell-free DNA (cfDNA) methylation for noninvasive prenatal diagnosis. We investigated maternal plasma DNA methylation using a simple protocol. Eighty plasma sam...
人们对用于无创产前诊断的无细胞 DNA（cfDNA）甲基化非常感兴趣。我们采用简单的方法研究了母体血浆 DNA 甲基化。80份血浆样本...
{"title":"Determination of Cell-Free DNA (cfDNA) Methylation by Methylation-Sensitive High-Resolution Melting (MS-HRM) in Human Plasma for the Diagnosis of Gestational Diabetes Mellitus (GDM)","authors":"Zhiyu Liu, Yuwei Yang, Yunfei Bai, Qinyu Ge","doi":"10.1080/00032719.2024.2399182","DOIUrl":"https://doi.org/10.1080/00032719.2024.2399182","url":null,"abstract":"Considerable interest has focused on cell-free DNA (cfDNA) methylation for noninvasive prenatal diagnosis. We investigated maternal plasma DNA methylation using a simple protocol. Eighty plasma sam...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"38 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1080/00032719.2024.2395411
Xu Chen, Lelin Qian, Juan Zhang
A new DNAzyme walker biosensor has been constructed to sensitively determine chromium (III). The DNAzyme walker consisted of enzyme strands (ES) as the walking strand and carboxyfluorescein-labeled...
我们构建了一种新的 DNA 酶步行器生物传感器来灵敏地测定铬（III）。DNA 酶步行器由作为步行链的酶链 (ES) 和羧基荧光素标记的...
{"title":"A Novel DNAzyme Walker Biosensor for the Determination of Chromium(III)","authors":"Xu Chen, Lelin Qian, Juan Zhang","doi":"10.1080/00032719.2024.2395411","DOIUrl":"https://doi.org/10.1080/00032719.2024.2395411","url":null,"abstract":"A new DNAzyme walker biosensor has been constructed to sensitively determine chromium (III). The DNAzyme walker consisted of enzyme strands (ES) as the walking strand and carboxyfluorescein-labeled...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"43 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142186920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-26DOI: 10.1080/00032719.2024.2393241
Hui-Ling Wu, Jing Chen, Fei Pan, Qi-Sheng Xia, Shi-Wei Zhang, Xue-Jian Chen, Rong-Hu Feng, Gui-Hong Zhang, Lei Liu, Xin-Tian Lai, Pan Tan
Pseudomonas cocovenenans subsp. farinofermentans is a pathogenic bacterium that causes the poisoning of fermented rice products. Its isomeric products, bongkrekic acid (BA) and isobongkrekic acid (...
{"title":"Screening for Bongkrekic Acid in Food Using a Monoclonal Antibody-Based Indirect Competitive Enzyme-Linked Immunosorbent Assay (icELISA)","authors":"Hui-Ling Wu, Jing Chen, Fei Pan, Qi-Sheng Xia, Shi-Wei Zhang, Xue-Jian Chen, Rong-Hu Feng, Gui-Hong Zhang, Lei Liu, Xin-Tian Lai, Pan Tan","doi":"10.1080/00032719.2024.2393241","DOIUrl":"https://doi.org/10.1080/00032719.2024.2393241","url":null,"abstract":"Pseudomonas cocovenenans subsp. farinofermentans is a pathogenic bacterium that causes the poisoning of fermented rice products. Its isomeric products, bongkrekic acid (BA) and isobongkrekic acid (...","PeriodicalId":7788,"journal":{"name":"Analytical Letters","volume":"11 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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