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Contemporary issues in clinical biochemistry最新文献

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The possibility of clinical biochemistry nearer the patient in German hospitals. 临床生化在德国医院接近病人的可能性。
Contemporary issues in clinical biochemistry
Pub Date : 1985-01-01
L Thomas
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引用次数: 0
General practitioners' office. 全科医生办公室。
Contemporary issues in clinical biochemistry
Pub Date : 1985-01-01
P Grob
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引用次数: 0
Solid-phase analytical elements for clinical analysis. 用于临床分析的固相分析元件。
Contemporary issues in clinical biochemistry
Pub Date : 1985-01-01
B Walter, R Boguslaski

The technology of dry reagent chemistries is sufficiently advanced so that analytical elements can be developed for almost any clinical analyte. Each element contains all the reagents and separation steps necessary to conduct an analysis. This provides the user with several advantages. The ability to obtain several analyses from small sample volumes has always been recognised as desirable with neonatal and geriatric patients. With dry reagent chemistries, usually 10 microliters of serum or 30 microliters of whole blood are sufficient per analysis. Hence, a profile of 15 tests can be conducted with 150 microliters of serum. The waste of reconstituted but unused reagents is eliminated. This provides more efficient and cost-effective use of reagents. The reagents are stable and require little storage space. In addition, they are extremely convenient to use and require only a small amount of technical skill. This allows for expansion of clinical analyses into such decentralised settings as the hospital ward, physician's office and even the home.

干试剂化学技术是足够先进的，因此分析元素可以开发几乎任何临床分析物。每个元素包含进行分析所需的所有试剂和分离步骤。这为用户提供了几个优势。从小样本量中获得几种分析的能力一直被认为是新生儿和老年患者所需要的。使用干试剂化学，通常每次分析10微升血清或30微升全血就足够了。因此，可以用150微升血清进行15次测试。消除了重组但未使用的试剂的浪费。这提供了更有效和更具成本效益的试剂使用。试剂稳定，需要的储存空间小。此外，它们使用起来非常方便，只需要少量的技术技能。这允许将临床分析扩展到诸如医院病房、医生办公室甚至家庭等分散的环境中。
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引用次数: 0
Antibiotics. 抗生素。
Contemporary issues in clinical biochemistry
Pub Date : 1985-01-01
H Mattie
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引用次数: 0
Antitumour agents. 抗肿瘤剂。
Contemporary issues in clinical biochemistry
Pub Date : 1985-01-01
G W Aherne

Pharmacokinetic studies are invaluable in understanding the effects of cytotoxic drugs on the body and in defining the distribution of drug to various tumours at different sites in the body. In individual patients pharmacokinetic studies may be a more sensitive indicator for dose adjustment or for a change of therapy than liver function tests or increased creatinine levels. However, many more studies are required to define relevant indicators of impending toxicity or, with more difficulty, response. Pharmacokinetic studies have become an important aspect of chemotherapy and will play an increasing role. Efforts to increase the amount of drug available for tumour uptake by, for example, delayed release preparations, the administration of prodrugs, liposome entrapped drugs and antibody targetted drugs will rely heavily on pharmacokinetic studies. Now that sensitive specific methods of analysis such as HPLC and RIA are available, pharmacokinetic studies are likely to become increasingly used in both clinical and research studies. Because of the complex interactions of the tumour and the host, it will be necessary for such studies to be interpreted alongside studies of the biochemistry and cell kinetics of tumour cells.

药代动力学研究对于了解细胞毒性药物对人体的影响以及确定药物在体内不同部位的各种肿瘤的分布是非常宝贵的。在个别患者中，药代动力学研究可能是剂量调整或治疗改变的更敏感的指标，而不是肝功能检查或肌酐水平升高。然而，需要更多的研究来确定即将发生的毒性的相关指标，或者更困难的是确定反应。药代动力学研究已成为化疗的一个重要方面，并将发挥越来越重要的作用。通过延迟释放制剂、前药、脂质体包裹药物和抗体靶向药物等方法来增加可用于肿瘤摄取的药物量的努力将在很大程度上依赖于药代动力学研究。随着高效液相色谱(HPLC)和RIA等敏感的特异性分析方法的出现，药代动力学研究可能越来越多地用于临床和研究。由于肿瘤与宿主的复杂相互作用，有必要将这些研究与肿瘤细胞的生物化学和细胞动力学研究结合起来进行解释。
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引用次数: 0
Drug assays in the assessment of the clinical value and safety of new compounds. 药物分析在评价新化合物的临床价值和安全性方面的应用。
Contemporary issues in clinical biochemistry
Pub Date : 1985-01-01
D B Campbell
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引用次数: 0
Gastrointestinal complications of alcoholism. 酒精中毒的胃肠道并发症。
Contemporary issues in clinical biochemistry
Pub Date : 1984-01-01
G Lake-Bakaar
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引用次数: 0
Pancreatic disorders in alcoholism. 酒精中毒引起的胰腺紊乱。
Contemporary issues in clinical biochemistry
Pub Date : 1984-01-01
O Guy, H Sarles
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引用次数: 0
Alcoholism--an overview. 酗酒,概述。
Contemporary issues in clinical biochemistry
Pub Date : 1984-01-01
S B Rosalki

This chapter has reviewed the social and medical consequences of chronic alcohol excess, and lists some of the clinical features and complications of alcoholism. The prevention of alcohol dependence and the success of therapy is more likely if the diagnosis of excess drinking and the complications of alcoholism can be made at an early stage. Biochemical procedures which may facilitate this will be described in subsequent chapters.

本章回顾了慢性酒精过量的社会和医学后果，并列出了一些酒精中毒的临床特征和并发症。如果能在早期阶段诊断出过量饮酒和酒精中毒并发症，预防酒精依赖和治疗成功的可能性更大。以后的章节将描述可能促进这一过程的生化程序。
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引用次数: 0
Liver disorders in alcoholism. 酒精中毒导致肝脏紊乱。
Contemporary issues in clinical biochemistry
Pub Date : 1984-01-01
W Jenkins
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引用次数: 0
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