{"title":"[Linoside A and B, two new flavone-C-glycosides from Linum maritimum L].","authors":"H Wagner, W Budweg, M A Iyengar, O Volk, M Sinn","doi":"10.1515/znb-1972-0716","DOIUrl":"https://doi.org/10.1515/znb-1972-0716","url":null,"abstract":"","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"809-12"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znb-1972-0716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Authors have studied the biosynthesis of some furocoumarins contained in Ruta graveolens. Labeled 5,7- and 7,8-dihydroxycoumarins have been administered to the herb, however practically no incorporation of radioactivity was observed in the isolated furocoumarins. Moreover, with the aim to study in a more detailed way the role of rutaretin and marmesin, trapping experiments have been performed administering to the herb labeled umbelliferone together with unlabeled rutaretin and marmesin respectively. A very effective incorporation was observed into marmesin, in lesser extent into rutaretin. In trapping experiments carried out using labeled rutaretin together with unlabeled marmesin and “vice versa”, the results obtained clearly show that while marmesin was converted into rutaretin in a very effective way, rutaretin was transformed into marmesin only in a smaller extent. The Authors suggest the biogenetic origin of rutaretin and moreover formulate a new and more detailed aspect of the scheme for the biosynthetic pathway of furocoumarins in Ruta graveolens.
{"title":"Biosynthesis of furocoumarins: further studies on Ruta graveolens.","authors":"F Dall'Acqua, A Capozzi, S Marciani, G Caporale","doi":"10.1515/znb-1972-0717","DOIUrl":"https://doi.org/10.1515/znb-1972-0717","url":null,"abstract":"The Authors have studied the biosynthesis of some furocoumarins contained in Ruta graveolens. Labeled 5,7- and 7,8-dihydroxycoumarins have been administered to the herb, however practically no incorporation of radioactivity was observed in the isolated furocoumarins. Moreover, with the aim to study in a more detailed way the role of rutaretin and marmesin, trapping experiments have been performed administering to the herb labeled umbelliferone together with unlabeled rutaretin and marmesin respectively. A very effective incorporation was observed into marmesin, in lesser extent into rutaretin. In trapping experiments carried out using labeled rutaretin together with unlabeled marmesin and “vice versa”, the results obtained clearly show that while marmesin was converted into rutaretin in a very effective way, rutaretin was transformed into marmesin only in a smaller extent. The Authors suggest the biogenetic origin of rutaretin and moreover formulate a new and more detailed aspect of the scheme for the biosynthetic pathway of furocoumarins in Ruta graveolens.","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"813-7"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znb-1972-0717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Experiments on intramolecular energy transfer in BU-DNA of the PBSH phage from Bacillus subtilis after long-wave UV irradiation].","authors":"F Mönkehaus, W Köhnlein","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"833-9"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cellular activity of ouabain-sensitive sodium-potassium-activated adenosine triphosphatase (Na+-K+-ATPase) and ouabain-insensitive Mg++-ATPase was analysed in sublines of Ehrlich ascites tumor cells serially cultivated either in isotonic media or in media with progressively increased NaCl concentration (up to 0.40 ᴍ). Progressive elevation in the NaCl content of the medium resulted in a progressive increase of cellular ATPase activity, Na+-K+-ATPase thereby being more affected than Mg++-ATPase. These alterations in ATPase activities are interpreted as “adaptive” changes in response to the elevated ionic environment, since “readaptation” of these “high-salt”-tolerant cells to growth in isotonic media resulted in a reversion of the enzyme activities to the level characteristic of the original parent cells.
{"title":"Increase in adenosine triphosphatase activity of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content.","authors":"D O Schachtschabel","doi":"10.1515/znb-1972-0722","DOIUrl":"https://doi.org/10.1515/znb-1972-0722","url":null,"abstract":"The cellular activity of ouabain-sensitive sodium-potassium-activated adenosine triphosphatase (Na+-K+-ATPase) and ouabain-insensitive Mg++-ATPase was analysed in sublines of Ehrlich ascites tumor cells serially cultivated either in isotonic media or in media with progressively increased NaCl concentration (up to 0.40 ᴍ). Progressive elevation in the NaCl content of the medium resulted in a progressive increase of cellular ATPase activity, Na+-K+-ATPase thereby being more affected than Mg++-ATPase. These alterations in ATPase activities are interpreted as “adaptive” changes in response to the elevated ionic environment, since “readaptation” of these “high-salt”-tolerant cells to growth in isotonic media resulted in a reversion of the enzyme activities to the level characteristic of the original parent cells.","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"840-2"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znb-1972-0722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Relations between changes of plasma copper content and growth of Morris hepatoma 3924].","authors":"K Wayss, M Volm, H Wesch, J Zimmerer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"846-9"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Localization of monogalactosyldiglycerides in thylakoid membranes using serological methods].","authors":"A Radunz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"822-6"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15226657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The antibacterial activity of 2-thiouracil, 2-methylthiouracil, 2-hydrazinouracil, 2,4-dithiouracil, 2-thio-4-hydrazinouracil, 2-thio-6-azathymine, 2-hydrazino-6-azathymine, 2,4-dithio-6-azathymine, 2-thio-4-hydrazino-6-azathymine, 2,4-dimethylthio-6-azathymine, 2-methylthio-4-hydrazino-6-azathymine, 4-thio-6-azauracil and 4-hydrazino-6-azauracil has been studied on the growth of: Staphylococcus aureus 209, Streptococcus faecalis 775, Escherichiia coli 387, Pseudomonas aeruginosa, Bacillus subtilis, Candida tropicalis and Neurospora crassa 9863. The highest inhibitory effect was observed with 4-hydrazino-derivatives of 2-thiouracil, 6-azauracil and 2-thio-6-azathymine.
{"title":"Effect of thio- and hydrazino-derivatives of uracil, 6-azauracil and 6-azathymine on the growth of some microorganisms in vitro.","authors":"A Spassov, E Golovinsky, N Spassovska, L Maneva","doi":"10.1515/znb-1972-0718","DOIUrl":"https://doi.org/10.1515/znb-1972-0718","url":null,"abstract":"The antibacterial activity of 2-thiouracil, 2-methylthiouracil, 2-hydrazinouracil, 2,4-dithiouracil, 2-thio-4-hydrazinouracil, 2-thio-6-azathymine, 2-hydrazino-6-azathymine, 2,4-dithio-6-azathymine, 2-thio-4-hydrazino-6-azathymine, 2,4-dimethylthio-6-azathymine, 2-methylthio-4-hydrazino-6-azathymine, 4-thio-6-azauracil and 4-hydrazino-6-azauracil has been studied on the growth of: Staphylococcus aureus 209, Streptococcus faecalis 775, Escherichiia coli 387, Pseudomonas aeruginosa, Bacillus subtilis, Candida tropicalis and Neurospora crassa 9863. The highest inhibitory effect was observed with 4-hydrazino-derivatives of 2-thiouracil, 6-azauracil and 2-thio-6-azathymine.","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"818-21"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znb-1972-0718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diaphorase and transhydrogenase activities (system NADPH; dichlorophenolindophenol and NADPH;NAD, respectively) of ferredoxin-NADP reductase are increased by ferredoxin. Reduced thionicotinamide-NADP (TN-NADPH) only slightly inhibits these activities with no ferredoxin present in the assay, but the activity increments in the presence of ferredoxin are strongly decreased. Photosynthetic pyridine nucleotide reduction is also inhibited by the reduced analog, the extent of inhibition being approx. in the same order with all three activities. The ferredoxin stimulated activities therefore appear to be due to the same interaction between reductase and ferredoxin in all three cases. The inhibition by TN-NADPH resembles that with Na-pyrophosphate (or NaCl), although in contrast to salt inhibition it is a.) not alleviated by higher ferredoxin concentrations, and b.) it still allows reductase/ferredoxin binding. The binding of the reduced pyridine nucleotide analog to the reductase seems to interfere rather specifically with the stimulation which ferredoxin can exert on the enzymic activities of the reductase.
{"title":"Thionicotinamide-NADP, a nucleotide analog interfering with ferredoxin-NADP reductase-ferredoxin interaction.","authors":"P Böger","doi":"10.1515/znb-1972-0720","DOIUrl":"https://doi.org/10.1515/znb-1972-0720","url":null,"abstract":"Diaphorase and transhydrogenase activities (system NADPH; dichlorophenolindophenol and NADPH;NAD, respectively) of ferredoxin-NADP reductase are increased by ferredoxin. Reduced thionicotinamide-NADP (TN-NADPH) only slightly inhibits these activities with no ferredoxin present in the assay, but the activity increments in the presence of ferredoxin are strongly decreased. Photosynthetic pyridine nucleotide reduction is also inhibited by the reduced analog, the extent of inhibition being approx. in the same order with all three activities. The ferredoxin stimulated activities therefore appear to be due to the same interaction between reductase and ferredoxin in all three cases. The inhibition by TN-NADPH resembles that with Na-pyrophosphate (or NaCl), although in contrast to salt inhibition it is a.) not alleviated by higher ferredoxin concentrations, and b.) it still allows reductase/ferredoxin binding. The binding of the reduced pyridine nucleotide analog to the reductase seems to interfere rather specifically with the stimulation which ferredoxin can exert on the enzymic activities of the reductase.","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"826-33"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ehrlich ascites tumor cells adapted to serial cultivation in vitro in media with increased NaCl content (“high-salt”-tolerant cells) exhibit — in comparison with cells cultivated either in isotonic media or intraperitoneally in mice (in vivo) — an increased rate of cellular oxygen consumption. It is suggested that this increased respiratory rate of “high-salt”-tolerant cells reflects enhanced energy requirements associated with processes of active ion transport; and that the elevated environmental NaCl concentration may have “induced” a “step up” of the respiratory metabolism of these tumor cells.
{"title":"Increased oxygen consumption of Ehrlich ascites tumor cells following serial cultivation in media with increased (Hypertonic) NaCl content.","authors":"E Kürschner, D O Schachtschabel","doi":"10.1515/znb-1972-0723","DOIUrl":"https://doi.org/10.1515/znb-1972-0723","url":null,"abstract":"Ehrlich ascites tumor cells adapted to serial cultivation in vitro in media with increased NaCl content (“high-salt”-tolerant cells) exhibit — in comparison with cells cultivated either in isotonic media or intraperitoneally in mice (in vivo) — an increased rate of cellular oxygen consumption. It is suggested that this increased respiratory rate of “high-salt”-tolerant cells reflects enhanced energy requirements associated with processes of active ion transport; and that the elevated environmental NaCl concentration may have “induced” a “step up” of the respiratory metabolism of these tumor cells.","PeriodicalId":78857,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie","volume":"27 7","pages":"843-6"},"PeriodicalIF":0.0,"publicationDate":"1972-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znb-1972-0723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15509154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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