The MATRIX study consisted of a large population of older adults. In addition to those over the age of 65, this study included 131 patients > or =85 years old. Even though these adults were community-based, many of them had similar medical histories, comorbidities, use of multiple medications and urinary incontinence histories as those residing in long-term care settings. This study found OXY-TDS to be effective in improving quality of life in these older adults. In addition, there was a low incidence of adverse events, particularly anticholinergic events. Overall, this study supports the use of OXY-TDS in older adults-those residing in community and nursing facility settings. The next article in this series will present other results of the MATRIX study, including the changes in nocturia and pad use, as well as the effect of OXY-TDS in participants with prostate problems.
An effective safe handing program can be realized by adhering to an organized clinical approach. This consists of carefully assessing resident safe handling on a regular basis and implementing interventions based on the handling needs of each resident identified.
In summary, the MATRIX study evaluated the use of OXY-TDS in older adults residing in community settings. Although it was a community-based study, a large segment of those studied had traits similar to those residing in long-term care settings--699 patients were aged 75 years or older; many had comorbid diseases; and many had a long history of OAB. MATRIX found that the transdermal form of oxybutynin was a safe and effective method to manage OAB in this older population. Adverse events reported were minor and local, with the most common event being local skin irritation. The transdermal formulation improved the symptoms associated with OAB and improved QOL. Although nursing home residents were not studied in MATRIX, it appears that the transdermal formulation of oxybutynin would be an agent of choice in older adults.
While organizing a safe resident handling program and selecting appropriate handling equipment requires a commitment of time, money and resources by administration, the return on investment in terms of reducing staff injuries is significant.
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