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Outcomes of the linking exercise for advancing daily stress (LEADS) management and resilience randomized pilot trial in African American adolescents and families. 在非裔美国青少年和家庭中,促进日常压力(LEADS)管理和恢复力的联系练习的随机试点试验的结果。
IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaaf034
Dawn K Wilson, Mary Quattlebaum, Allison M Sweeney, Timothy Simmons, Colby Kipp, Taylor White, Vashti Wood, M Lee Van Horn, Pamela Martin

Background: Previous research has examined the deleterious impact of racial stress on African Americans' mental and physical health; however, few interventions have focused on utilizing culturally salient protective factors to buffer the effect of racial stress on physical health outcomes.

Purpose: This pilot feasibility trial assessed the preliminary impact of Linking Exercise for Advancing Daily Stress (LEADS) Management and Resilience, a cultural and family-based resilience intervention aiming to increase physical activity and improve coping in overweight African American adolescents (N = 23 adolescent-caregiver dyads; adolescent Mage 14.0 ± 2.2; MBMI percentile 97.8; 61.9% female; Parents Mage 46.4 ± 8.8; MBMI 41.2 ± 7.6; 100.00% female).

Methods: The 10-week feasibility trial tested an online family-based group resilience and health promotion program compared to an online health education only program.

Results: Process evaluation demonstrated high feasibility and acceptability of both group programs. As hypothesized, among adolescents, the treatment means reflect an average increase of 4.31 min/day of moderate-to-vigorous physical activity in the intervention group compared to an average decrease of 7.84 min/day of moderate-to-vigorous physical activity in the health education group. For light physical activity, treatment means reflect an average increase of 11.08 min/day in the intervention group and an average decrease of 2.56 min/day in the health education group. Also, the intervention adolescents and parents had greater engagement in adaptive coping skills (active coping, religion to cope, cognitive reframing) from baseline to post-treatment than the health education group, and greater reductions in maladaptive, and passive coping skills (self-distraction) than the health education group.

Conclusions: This pilot feasibility trial demonstrates the acceptabity and feasibiity of integrating culturally sensitive strength-based interventions for African American families to promote health promotion behaviors and coping.

背景:之前的研究已经研究了种族压力对非裔美国人身心健康的有害影响;然而,很少有干预措施侧重于利用文化上显著的保护因素来缓冲种族压力对身体健康结果的影响。目的:本试点可行性试验评估了将运动促进日常压力管理和心理弹性联系起来的初步影响,这是一种基于文化和家庭的心理弹性干预,旨在增加体重超重的非裔美国青少年的身体活动和改善应对能力(N = 23对青少年-照顾者;青少年期14.0±2.2;MBMI百分位数97.8;61.9%的女性;家长Mage 46.4±8.8;Mbmi 41.2±7.6;100.00%的女性)。方法:为期10周的可行性试验测试了在线基于家庭的群体弹性和健康促进计划,并与在线健康教育计划进行了比较。结果:过程评价表明两组方案均具有较高的可行性和可接受性。正如假设的那样,在青少年中,治疗手段反映了干预组平均增加4.31分钟/天的中等到剧烈的身体活动,而健康教育组平均减少7.84分钟/天的中等到剧烈的身体活动。对于轻体力活动,治疗手段反映干预组平均增加11.08分钟/天,健康教育组平均减少2.56分钟/天。此外,与健康教育组相比,干预组的青少年和家长从基线到治疗后,在适应性应对技能(积极应对,宗教应对,认知重构)方面的参与度更高,在适应不良和被动应对技能(自我分心)方面的参与度也更高。结论:本试点可行性试验表明,整合基于文化敏感性力量的干预措施对非裔美国家庭促进健康促进行为和应对的可接受性和可行性。
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引用次数: 0
Insights into effective fatigue reducing interventions in kidney transplant candidates: a scoping review. 对肾移植候选人有效减少疲劳干预的见解:范围综述。
IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaaf017
Avril J Haanstra, Heleen Maring, Yvonne van der Veen, Evelien E Quint, Maya J Schroevers, Adelita V Ranchor, Stefan P Berger, Evelyn J Finnema, Coby Annema

Background: Fatigue is a prevalent and debilitating symptom among kidney transplant candidates (KTCs), significantly affecting their quality of life and overall well-being. Its complexity necessitates a comprehensive approach to manage fatigue in this population.

Purpose: To explore the effectiveness of nonpharmacological interventions in reducing fatigue in KTCs.

Methods: Nonpharmacological interventions targeting fatigue in participants aged ≥18 years, who were either on the kidney transplantation waitlist or eligible candidates, were considered. A database search was conducted in PubMed, Embase, PsycINFO, CINAHL, and Web of Science. Results were reported in accordance with the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols extension for Scoping Reviews Checklist.

Results: In total, 67 studies were included. Interventions were divided into manipulative and body-based practices, exercise, mind-body therapies, energy healing, and combined interventions. Thirty-eight studies (76%) demonstrated a significant effect on fatigue, with effect sizes ranging from 0.43 to 4.85. Reflexology, massage therapy, progressive muscle relaxation, and acupressure combined with massage therapy showed the strongest significant intervention effects on fatigue and had the strongest study quality. However, the overall study quality was weak, particularly concerning confounding control, blinding procedures, and withdrawals and dropouts.

Conclusions: Manipulative and body-based interventions showed the strongest significant effects on fatigue with the highest study quality. These interventions underscore the multifactorial nature of fatigue by targeting both its physical and psychological dimensions. Future high-quality research is needed to determine the optimal strategy for managing fatigue in KTCs.

背景:疲劳是肾移植候选者(ktc)普遍存在的衰弱症状,显著影响他们的生活质量和整体幸福感。它的复杂性需要一个全面的方法来管理这个人群的疲劳。目的:探讨非药物干预对缓解ktc患者疲劳的效果。方法:考虑针对年龄≥18岁、在肾移植等待名单上或符合条件的参与者的疲劳的非药物干预措施。在PubMed、Embase、PsycINFO、CINAHL和Web of Science进行数据库检索。结果按照系统评价首选报告项目和荟萃分析方案扩展范围评价清单提供的指南进行报告。结果:共纳入67项研究。干预措施分为操纵和基于身体的实践、锻炼、身心疗法、能量治疗和综合干预。38项研究(76%)证明了对疲劳的显著影响,效应量从0.43到4.85不等。反射疗法、按摩疗法、渐进式肌肉放松疗法和指压联合按摩疗法对疲劳的显著干预效果最强,研究质量最强。然而,整体研究质量较差,特别是在混淆控制、盲法程序、退出和退出方面。结论:手法干预和以身体为基础的干预对疲劳的影响最显著,研究质量最高。这些干预措施强调了疲劳的多因素性质,针对其生理和心理层面。未来需要高质量的研究来确定管理ktc疲劳的最佳策略。
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引用次数: 0
Couple-based lifestyle intervention for minority prostate cancer survivors: a randomized feasibility trial. 以夫妻为基础的生活方式干预少数前列腺癌幸存者:一项随机可行性试验。
IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaaf010
Dalnim Cho, Yisheng Li, Karen Basen-Engquist, Chiara Acquati, Nga T T Nguyen, Hilary Ma, Curtis A Pettaway, Lorna H McNeill

Background: Black and Hispanic prostate cancer (PCa) survivors, who face a high burden of comorbid conditions and often engage in low levels of physical activity and healthy eating, remain significantly underrepresented in lifestyle intervention studies.

Purpose: Given the significance of spousal influence, we developed a culturally tailored lifestyle intervention for these survivors and their spouses and assessed its feasibility, acceptability, and impact on behavioral change.

Methods: Survivor-spouse couples were randomly assigned to an intervention group (n = 22), which received 12 health-coaching calls over 6 months, or a usual-care control group (n = 9). Assessments were conducted at baseline (T1), mid-intervention (T2, month 3), and post-intervention (T3, month 6).

Results: The mean attendance was 10.58 sessions, and the intervention received high acceptability scores. Assessment completion rates were 84% at T2 and 81% at T3 for survivors, and 77% at T2 and 81% at T3 for spouses. Intervention group survivors showed meaningful improvements in diet quality from T1 to T2 (+ 6.56) and a clinically important increase in moderate-to-vigorous physical activity (MVPA) from T1 to T3 (+ 17.5 min/day on average). Intervention group spouses also showed meaningful improvements in diet quality from T1 to T2 (+ 8.19) and from T1 to T3 (+ 6.34) and MVPA from T1 to T3 (+ 17.3 min/day on average). Control group participants showed improvements in MVPA.

Conclusions: This couple-based lifestyle intervention is feasible, highly accepted, and promising for improving healthy lifestyle behaviors among Black and Hispanic PCa survivors and their spouses. The results should be carefully interpreted and replicated in an adequately powered trial.

背景:黑人和西班牙裔前列腺癌(PCa)幸存者面临着高负担的合并症,经常从事低水平的身体活动和健康饮食,在生活方式干预研究中的代表性仍然明显不足。目的:考虑到配偶影响的重要性,我们为这些幸存者及其配偶开发了一种适合文化的生活方式干预,并评估了其可行性、可接受性和对行为改变的影响。方法:将幸存者配偶随机分为干预组(n = 22)和常规护理对照组(n = 9),干预组在6个月内接受12次健康指导电话。评估分别在基线(T1)、干预中期(T2,第3个月)和干预后(T3,第6个月)进行。结果:平均出勤率为10.58次,干预获得较高的可接受性得分。幸存者T2和T3的评估完成率分别为84%和81%,配偶T2和T3的评估完成率分别为77%和81%。干预组幸存者从T1到T2的饮食质量有显著改善(+ 6.56),从T1到T3的中高强度体力活动(MVPA)有临床重要的增加(平均+ 17.5分钟/天)。干预组配偶的饮食质量从T1到T2(+ 8.19)和从T1到T3(+ 6.34)以及MVPA从T1到T3(平均+ 17.3分钟/天)均有显著改善。对照组参与者的MVPA有所改善。结论:这种以夫妻为基础的生活方式干预是可行的,被高度接受,并且有望改善黑人和西班牙裔前列腺癌幸存者及其配偶的健康生活方式行为。结果应仔细解释,并在充分支持的试验中重复。
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引用次数: 0
Effects of Government Mistrust and Group-Based Medical Mistrust on COVID-19 Vaccine Hesitancy Among a Sample of African Americans. 政府不信任和基于群体的医疗不信任对非裔美国人样本中COVID-19疫苗犹豫的影响
IF 3.6 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae067
Mark Manning, Rhonda Dailey, Phil Levy, Elizabeth Towner, Sheena Cresswell, Hayley S Thompson

Background: Despite the demonstrated efficacy of coronavirus disease (COVID-19) vaccines, higher rates of vaccine hesitancy among African Americans remain concerning. As determinants of vaccine hesitancy, the simultaneous roles of government mistrust and group-based medical mistrust have not been examined via from a cognitive information perspective among African Americans.

Purpose: We examined the direct and indirect effects of government mistrust and group-based medical mistrust on COVID-19 vaccine hesitancy in a sample of African Americans.

Methods: We obtained data from 382 African Americans in South-East Michigan via an online survey. We assessed demographic variables, government mistrust, group-based medical mistrust, COVID risk and COVID worry, and positive and negative beliefs regarding the COVID-19 vaccine (i.e., vaccine pros and cons), and vaccine hesitancy. We examined our hypotheses with path analyses.

Results: Results indicated significant direct effects of government mistrust on vaccine hesitancy; however, despite a significant correlation, there was no direct effect of group-based medical mistrust on vaccine hesitancy. The effect of group-based medical mistrust was fully mediated by both vaccine pros and cons, whereas the effect of government mistrust was partially mediated by vaccine pros. COVID risk and COVID worry did not mediate the effects of mistrust to vaccine hesitancy.

Conclusion: Negative effects of group-based medical mistrust on COVID-19 vaccine hesitancy among African Americans may be amenable to interventions that focus on beliefs about the vaccine rather than beliefs about vulnerability to the virus. However, given its direct effect, it may be necessary to focus directly on government mistrust to diminish its effects on COVID-19 vaccine hesitancy.

背景:尽管冠状病毒病(COVID-19)疫苗已证明有效,但非洲裔美国人的疫苗犹豫率较高仍然令人担忧。作为疫苗犹豫的决定因素,政府不信任和基于群体的医疗不信任的同时作用尚未通过非裔美国人的认知信息角度进行检查。目的:我们研究了政府不信任和基于群体的医疗不信任对非裔美国人COVID-19疫苗犹豫的直接和间接影响。方法:我们通过在线调查获得密歇根州东南部382名非裔美国人的数据。我们评估了人口统计学变量、政府不信任、基于群体的医疗不信任、COVID风险和COVID担忧、对COVID-19疫苗的积极和消极信念(即疫苗赞成和反对)以及疫苗犹豫。我们用路径分析检验了我们的假设。结果:结果表明,政府不信任对疫苗犹豫有显著的直接影响;然而,尽管存在显著的相关性,但基于群体的医疗不信任对疫苗犹豫没有直接影响。群体医疗不信任的影响被疫苗的赞成和反对完全中介,而政府不信任的影响被疫苗的赞成部分中介。COVID风险和COVID担忧并未介导不信任对疫苗犹豫的影响。结论:基于群体的医疗不信任对非洲裔美国人COVID-19疫苗犹豫的负面影响可能适用于专注于对疫苗的信念而不是对病毒脆弱性的信念的干预措施。但是,考虑到其直接影响,可能有必要直接关注政府不信任,以减少其对COVID-19疫苗犹豫的影响。
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引用次数: 0
Twenty years of intervention optimization. 二十年的干预优化。
IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae076
Linda M Collins

In the classical paradigm for intervention research, the components that are to make up an intervention are identified, pilot tested, and then immediately assembled into a treatment package and subjected to an evaluation randomized controlled trial (RCT) to assess the performance of the entire package. Intervention optimization, which adapts ideas from technological fields to intervention science in order to hasten scientific progress, is an alternative to the classical paradigm. The first article introducing intervention optimization via the multiphase optimization strategy (MOST) was published in Annals of Behavioral Medicine in 2005. In this commentary, I reflect on the evolution of intervention optimization from that first publication to today, and on what the future could hold if the intervention science field continues to adopt the optimization paradigm. I propose that if intervention optimization became standard operating procedure, the field would accumulate a coherent base of knowledge about what specific intervention strategies work, for whom, under which circumstances, and why; every intervention produced would contain only components that contribute enough to justify their resource requirements; interventions would be readily implementable; and as the knowledge base grew, interventions would be improved continually.

在干预研究的经典范式中,组成干预措施的组成部分被确定,进行试点测试,然后立即组装成一个治疗方案,并进行评估随机对照试验(RCT),以评估整个方案的性能。干预优化是对经典范式的一种替代,它将技术领域的思想引入干预科学,以促进科学进步。第一篇介绍多阶段优化策略(MOST)干预优化的文章发表在2005年的《行为医学年鉴》上。在这篇评论中,我反思了干预优化从第一次发表到今天的演变,以及如果干预科学领域继续采用优化范式,未来可能会发生什么。我建议,如果干预优化成为标准操作程序,该领域将积累一个连贯的知识基础,了解哪些具体的干预策略有效,对谁有效,在什么情况下有效,以及为什么有效;所产生的每项干预措施只包含足以证明其资源需求合理的组成部分;干预措施将容易实施;随着知识库的增长,干预措施将不断得到改进。
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引用次数: 0
Correction to: Implementation of a Telehealth Smoking Cessation Program in Primarily Socioeconomically Disadvantaged Black Patients: Courage to Quit Rolling-Virtual (CTQ-RV). 更正:在主要处于社会经济不利地位的黑人患者中实施远程医疗戒烟计划:戒烟的勇气-虚拟(CTQ-RV)。
IF 3.6 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae095
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引用次数: 0
Provided and received positive and negative social control, relationship satisfaction, and sedentary behavior in parent-child dyads. 提供和接受积极和消极的社会控制、关系满意度和亲子二人组的久坐行为。
IF 3.6 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae092
Maria Siwa, Anna Banik, Zofia Szczuka, Ewa Kulis, Monika Boberska, Dominika Wietrzykowska, Nina Knoll, Anita DeLongis, Bärbel Knäuper, Aleksandra Luszczynska

Background: The close relationship processes and health model and the dyadic health influence model posit that relationship beliefs (eg, relationship satisfaction) and influence strategies (eg, provision and receipt of positive and negative social control) mediate health behavior change. However, evidence for such mediation in parent-child dyads is limited.

Purpose: Two complementary mediation hypotheses were tested: (1) social control forms indirect relationships with sedentary behavior (SB), via relationship satisfaction acting as a mediator; and (2) relationship satisfaction forms indirect relationships with SB, with social control operating as a mediator.

Methods: Data from 247 parent-child dyads (9- to 15-year-old children) were analyzed using manifest mediation models. SB was measured with GT3X-BT accelerometers at Time 1 (T1; baseline) and Time 3 (T3; 8-month follow-up). Relationship satisfaction and social control were assessed at T1 and Time 2 (T2; 2-month follow-up). Path analysis models, controlling for baseline SB, were fit.

Results: Received positive control (children, T1) was associated with higher relationship satisfaction in both children and parents (T2), which in turn were related to lower and higher parental SB at T3, respectively. Provided positive control (parents; T1) was related to higher SB (T3) in children. Relationship satisfaction among children (T1) predicted higher levels of received positive and negative control (children, T2).

Conclusions: Provided and received positive social control may form direct and indirect associations with SB in parent-child dyads. Future research may need to consider further subtypes of positive control, which may explain the divergent effects of this form of control on SB.

背景:亲密关系过程与健康模型和二元健康影响模型假设关系信念(如关系满意度)和影响策略(如提供和接受积极和消极的社会控制)介导健康行为改变。然而,这种调解在亲子二联体的证据是有限的。目的:检验两个互补的中介假设:(1)社会控制通过关系满意度作为中介与久坐行为形成间接关系;(2)关系满意度与创业创业形成间接关系,社会控制在其中起中介作用。方法:采用表项中介模型对247对9 ~ 15岁儿童的数据进行分析。用GT3X-BT加速度计在时间1 (T1;基线)和时间3 (T3;本次追踪)。在T1和时间2 (T2;两个月的随访)。拟合了控制基线SB的通径分析模型。结果:接受的积极控制(儿童,T1)与儿童和父母(T2)的关系满意度均较高相关,而关系满意度又分别与父母在T3时较低和较高的SB相关。提供积极的控制(父母;T1)与儿童较高的SB (T3)有关。儿童的关系满意度(T1)预测较高水平的接受的积极和消极控制(儿童,T2)。结论:提供和接受的积极社会控制可能与亲子双性恋的SB形成直接和间接的关联。未来的研究可能需要考虑更多的阳性控制亚型,这可能解释这种形式的控制对SB的不同影响。
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引用次数: 0
Optimizing the Use of Personal Values to Promote Medication Adherence: A Randomized Controlled Trial Comparing Affective and Behavioral Responses to Theory-Driven Domain Congruent Versus Incongruent Values Approaches. 优化个人价值观的使用以促进坚持用药:一项随机对照试验:比较对理论驱动的领域一致与不一致价值观方法的情感和行为反应。
IF 3.6 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae064
Lauren B Finkelstein, Emma E Bright, Heng Chao J Gu, Joanna J Arch

Background: Self-affirmation theory (SAT) and acceptance and commitment therapy (ACT) embody competing approaches to leveraging personal values to motivate behavior change but are rarely compared in the domain of health behavior. This study compares these theory-driven values-based interventions for promoting medication adherence.

Purpose: To compare affective and behavioral responses to competing values-based medication adherence interventions.

Methods: In this three-armed randomized trial, participants with cancer (n = 95) or diabetes (n = 97) recruited online using Prolific and prescribed daily oral medication for that disease completed a one-session online writing intervention leveraging (1) a domain incongruent (DI) value, where the value was not connected to medication adherence; (2) a domain congruent (DC) value, where the value was connected to adherence; or (3) a control condition, focused on medication adherence procedures.

Results: There were no main effects of conditions on reported medication adherence at the 1-month follow-up. During the intervention, positive affect was higher in the values conditions than control (p < .001), and trended higher in DI versus DC (p = .054). Negative affect did not vary between the values and control groups (p = .093) but was lower in DI versus DC (p = .006). Improvements in positive affect over the course of the intervention were associated with increased adherence behavior for individuals who started with low levels of positive affect (p = .003). Disease type did not moderate findings.

Conclusions: Consistent with SAT, focusing on DI values led to more positive and less negative affect than connecting values directly to behavior in a threatening domain such as chronic illness. For some participants, increases in positive affect predicted greater adherence.

背景:自我肯定理论(SAT)和接受与承诺疗法(ACT)体现了利用个人价值观激励行为改变的竞争方法,但在健康行为领域却很少进行比较。本研究比较了这两种理论驱动的基于价值观的干预方法,以促进服药依从性。目的:比较两种相互竞争的基于价值观的服药依从性干预方法的情感和行为反应:在这项三臂随机试验中,使用 Prolific 在线招募的癌症患者(n = 95)或糖尿病患者(n = 97)完成了为期一次的在线写作干预,这些干预利用了(1)领域不一致(DI)价值观,即价值观与坚持用药无关;(2)领域一致(DC)价值观,即价值观与坚持用药有关;或(3)对照条件,侧重于坚持用药程序:结果:在 1 个月的随访中,各种条件对报告的服药依从性没有主要影响。在干预过程中,价值观条件下的积极情绪高于对照条件下(p < .001),而且 DI 与 DC 相比呈上升趋势(p = .054)。消极情绪在价值观组和对照组之间没有差异(p = .093),但在直接干预组和直觉干预组之间的差异较小(p = .006)。在干预过程中,积极情绪的改善与开始时积极情绪水平较低的人坚持治疗的行为增加有关(p = .003)。疾病类型并不影响研究结果:结论:与 SAT 一致的是,在慢性病等威胁性领域,关注 DI 价值观比直接将价值观与行为联系起来能带来更多的积极情绪和更少的消极情绪。对于一些参与者来说,积极情绪的增加预示着更大的依从性。
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引用次数: 0
Changing mindsets about methotrexate in the rheumatology clinic to reduce side effects and improve adherence: a randomized controlled trial. 改变风湿病临床对甲氨蝶呤的看法以减少副作用并提高依从性:一项随机对照试验。
IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae089
Rachael Yielder, Kari Leibowitz, Alia J Crum, Paul Manley, Nicola Dalbeth, Keith J Petrie

Background: Patients' negative expectations about medication can exacerbate side effect burden leading to low adherence and persistence. A novel intervention involves targeting mindsets about non-severe symptoms; reframing them as encouraging signs of medication working.

Purpose: This study aimed to assess whether a brief symptom-mindset intervention can improve symptom experience and adherence in patients starting methotrexate to treat an inflammatory rheumatic disease.

Methods: A randomized controlled trial was conducted with patients starting methotrexate. Participants were randomly assigned (1:1) to a mindset intervention or standard information control condition. Symptom mindset was assessed after 4 weeks to check intervention efficacy. The primary outcome was symptom experience after 4 weeks. Secondary outcomes were adherence and motivation to take methotrexate (4 weeks), as well as continuation and C-reactive protein (12 weeks).

Results: Forty-seven participants were randomly assigned to the intervention (n = 24) or control group (n = 23). All participants completed the study. After 4 weeks, compared to the control group, intervention participants endorsed more positive symptom mindsets, experienced less symptom burden (mean difference -2.70 [95% CI, -4.50, -0.90] P = .005), fewer general symptoms (3.53 [-6.99, .79] P = .045) and a similar number of methotrexate-specific symptoms (-0.79 [-2.29, 0.71] P = .295). The intervention group had better motivation and adherence to methotrexate at 4 weeks and better continuation, and C-reactive protein at 12 weeks than the control group. There was no difference in side effect attribution.

Conclusions: In patients starting methotrexate, a mindset intervention reframing the role of non-severe side effects is a promising approach for improving symptom experience and early stage medication persistence.

背景:患者对药物的负面预期会加重副作用负担,导致依从性和持久性较低。一种新的干预措施涉及针对非严重症状的心态;将它们重新定义为药物起作用的令人鼓舞的迹象。目的:本研究旨在评估短暂的症状心态干预是否可以改善开始使用甲氨蝶呤治疗炎症性风湿病患者的症状体验和依从性。方法:随机对照试验,患者开始使用甲氨蝶呤。参与者被随机分配(1:1)到心态干预组或标准信息控制组。4周后评估症状心态,观察干预效果。主要观察指标为4周后的症状体验。次要结果是依从性和服用甲氨蝶呤的动机(4周),以及延续和c反应蛋白(12周)。结果:47名参与者被随机分为干预组(n = 24)和对照组(n = 23)。所有参与者都完成了研究。4周后,与对照组相比,干预参与者表现出更积极的症状心态,症状负担更少(平均差异-2.70 [95% CI, -4.50, -0.90] P = 0.005),一般症状更少(3.53 [-6.99,.79]P = 0.045),甲氨蝶呤特异性症状数量相似(-0.79 [-2.29,0.71]P = 0.295)。干预组在4周时甲氨蝶呤的动力和依从性优于对照组,在12周时的持续性和c反应蛋白均优于对照组。在副作用归因上没有差异。结论:在开始使用甲氨蝶呤的患者中,重新定义非严重副作用作用的心态干预是改善症状体验和早期服药持久性的一种有希望的方法。
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引用次数: 0
Changes in daily stress reactivity and changes in physical health across 18 years of adulthood. 成年后18年日常压力反应的变化和身体健康的变化。
IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Pub Date : 2025-01-04 DOI: 10.1093/abm/kaae086
Jonathan Rush, Susan T Charles, Emily C Willroth, Eric S Cerino, Jennifer R Piazza, David M Almeida

Background: Stress plays a pivotal role in physical health. Although many studies have linked stress reactivity (daily within-person associations between stress exposure and negative affect) to physical health outcomes, we know surprisingly little about how changes in stress reactivity are related to changes in physical health.

Purpose: The current study examines how change in stress reactivity over 18 years is related to changes in functional health and chronic health conditions.

Methods: Three measurement bursts from the National Study of Daily Experiences (N = 2880; 55% female) each included daily measures of stressor exposure and negative affect across 8 consecutive days, yielding 33 944 days of data across 18 years of adulthood. At each wave, participants reported their functional health limitations (ie, basic activities of daily living [ADL] and instrumental activities of daily living [IADL]) and chronic health conditions. Multilevel structural equation models simultaneously modeled stress reactivity at Level 1, longitudinal changes in stress reactivity at Level 2, and the association between changes in stress reactivity and changes in functional limitations and chronic conditions at Level 3.

Results: Higher levels of stress reactivity at baseline were associated with more functional health limitations 18 years later (ADLs: Est. = 0.90, P = .001; IADLs: Est. = 1.78, P < .001). Furthermore, individuals who increased more in their stress reactivity across the 18-year period also showed greater increases in their functional health limitations (ADLs: Est. = 4.02, P = .017; IADLs: Est. = 5.74, P < .001) and chronic conditions (Est. = 11.17, P = .008).

Conclusions: These findings highlight the strong connection between health and stress in daily life, and how they travel together across adulthood.

背景:压力在身体健康中起着关键作用。尽管许多研究已经将压力反应(压力暴露和负面影响之间的日常内在联系)与身体健康结果联系起来,但令人惊讶的是,我们对压力反应的变化与身体健康的变化之间的关系知之甚少。目的:本研究探讨了18年来应激反应的变化与功能健康和慢性健康状况的变化之间的关系。方法:全国日常体验研究(N = 2880;(55%为女性),包括连续8天的压力源暴露和负面影响的每日测量,在18年的成年期中产生33944天的数据。在每个波中,参与者报告了他们的功能健康限制(即日常生活的基本活动[ADL]和日常生活的工具活动[IADL])和慢性健康状况。多层结构方程模型同时模拟了1级应力反应性,2级应力反应性的纵向变化,以及3级应力反应性变化与功能限制和慢性疾病变化之间的关系。结果:基线时较高的应激反应水平与18年后更多的功能性健康限制相关(ADLs: Est = 0.90, P = 0.001;结论:这些发现强调了日常生活中健康与压力之间的密切联系,以及它们如何在成年期相互影响。
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Annals of Behavioral Medicine
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