Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.00129.X
Y. Chan, S. M. Ip, W. Poon, N. Wickham
Objective: Selective uptake and retention of haematoporphyrin derivative (HpD) in tumour tissue, especially at brain adjacent to the tumour (BAT) region, is an important factor in determining the efficacy of photodynamic therapy (PDT). The uptake and distribution of HpD was studied in 10 patients with malignant glioma. Method: Five cases were injected with HpD intravenously at a dose of 5 mg/kg bodyweight. Another five cases were injected with 10 mg (2 mL) HpD by ultrasound guidance into the tumour centre. After 24 h, the patients underwent craniotomy for tumour debulking. Biopsies of the tumour tissue and BAT region were sent for analysis. Results: In the intravenous administration group, the mean HpD level in the tumour centre was 2.0 ± 0.7 μg/g, which was lower than the level of HpD in the BAT region (3.6 ± 2.3 μg/g; P > 0.05). However, in the intratumoral injection group, the level of HpD was much higher in the tumour centre than in the BAT (4.7 ± 3.2 μg/g vs 1.4 ± 0.4 μg/g; P < 0.05). Fluorescence microscopy observations showed that HpD was distributed unevenly at the periphery of the blood vessels and stroma in the intravenous group. Bright and patchy distribution of HpD was also seen in the tumour centre after direct intratumoral injection. Intracellular uptake of HpD could be observed in the BAT region of both groups. Further study with a confocal laser scanning microscope (CLSM) provided evidence that HpD was localized intracellularly. Conclusion: The study showed that conventional intravenous administration of HpD can achieve a higher level in the BAT region, but the distribution of HpD varied and was unpredictable. Intratumoral injection can achieve a much higher HpD in the tumour centre; however, the distribution in the BAT region is unsatisfactory because of the irregular shape of the tumour mass. Taking into account this variable result, the HpD level may need to be tailored to meet each individual patient's requirement. Chinese Abstract Figure Chinese Abstract.
{"title":"Photodynamic therapy in malignant brain tumour: Is intratumoral injection of photosensitizer superior to conventional intravenous administration?","authors":"Y. Chan, S. M. Ip, W. Poon, N. Wickham","doi":"10.1046/J.1442-2034.2002.00129.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.00129.X","url":null,"abstract":"Objective: Selective uptake and retention of haematoporphyrin derivative (HpD) in tumour tissue, especially at brain adjacent to the tumour (BAT) region, is an important factor in determining the efficacy of photodynamic therapy (PDT). The uptake and distribution of HpD was studied in 10 patients with malignant glioma. \u0000 \u0000 \u0000 \u0000Method: Five cases were injected with HpD intravenously at a dose of 5 mg/kg bodyweight. Another five cases were injected with 10 mg (2 mL) HpD by ultrasound guidance into the tumour centre. After 24 h, the patients underwent craniotomy for tumour debulking. Biopsies of the tumour tissue and BAT region were sent for analysis. \u0000 \u0000 \u0000 \u0000Results: In the intravenous administration group, the mean HpD level in the tumour centre was 2.0 ± 0.7 μg/g, which was lower than the level of HpD in the BAT region (3.6 ± 2.3 μg/g; P > 0.05). However, in the intratumoral injection group, the level of HpD was much higher in the tumour centre than in the BAT (4.7 ± 3.2 μg/g vs 1.4 ± 0.4 μg/g; P < 0.05). Fluorescence microscopy observations showed that HpD was distributed unevenly at the periphery of the blood vessels and stroma in the intravenous group. Bright and patchy distribution of HpD was also seen in the tumour centre after direct intratumoral injection. Intracellular uptake of HpD could be observed in the BAT region of both groups. Further study with a confocal laser scanning microscope (CLSM) provided evidence that HpD was localized intracellularly. \u0000 \u0000 \u0000 \u0000Conclusion: The study showed that conventional intravenous administration of HpD can achieve a higher level in the BAT region, but the distribution of HpD varied and was unpredictable. Intratumoral injection can achieve a much higher HpD in the tumour centre; however, the distribution in the BAT region is unsatisfactory because of the irregular shape of the tumour mass. Taking into account this variable result, the HpD level may need to be tailored to meet each individual patient's requirement. \u0000 \u0000 \u0000 \u0000Chinese Abstract \u0000 \u0000 \u0000 \u0000 \u0000Figure Chinese Abstract.","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"26 1","pages":"42-47"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77937890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-10-00134.X
I.L.O. Lo, C. H. Lau, T. Chung, J.S.T. Hwang
{"title":"SEGMENTECTOMY IS SUFFICIENT FOR HEPATOCELLULAR CARCINOMA MEASURING SMALLER THAN 5 cm","authors":"I.L.O. Lo, C. H. Lau, T. Chung, J.S.T. Hwang","doi":"10.1046/J.1442-2034.2002.T01-10-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-10-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81781390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-19-00134.X
Chi‐Yee Choi, T. Y. Lam, S. Lam, S. Kwok
{"title":"USE OF AGE AND QUESTIONNAIRE FOR THE TRIAGE OF PER‐RECTAL BLEEDING CASES IN A SPECIALIST OUTPATIENT CLINIC","authors":"Chi‐Yee Choi, T. Y. Lam, S. Lam, S. Kwok","doi":"10.1046/J.1442-2034.2002.T01-19-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-19-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89129499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-14-00134.X
K. Tse, S. W. Lee, S. Lam, S. Kwok
{"title":"HEPATECTOMY WITH INTRAHEPATIC POSTERIOR APPROACH IN HEPATIC INFLOW CONTROL","authors":"K. Tse, S. W. Lee, S. Lam, S. Kwok","doi":"10.1046/J.1442-2034.2002.T01-14-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-14-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"19 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75293678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.00130.X
Janet F.Y. Lee, S. Ng, R. Y. Yiu, K. Leung, J. Lau
Objective: To review the yield and indications of colonoscopy in a surgical unit at the Prince of Wales Hospital, the result of which may help to select future patients for colonoscopy. Method: The records of 869 patients undergoing elective colonoscopy at the Prince of Wales Hospital within an 18-month period were reviewed retrospectively. Exclusion criteria included the following: a personal history of colorectal malignancy or polyps, tumours or polyps detectable on rectal examination or rigid sigmoidoscopy, a positive physical examination suggestive of gastrointestinal malignancies, anaemia or positive faecal occult blood. Results: Per rectal bleeding was the most common indication for colonoscopy. Complete colonoscopy rate was 93.7% and abnormalities were reported in 338 patients. Forty-three patients were found to have cancer whereby age, duration of symptoms, blood mixed with stool and abdominal pain were identified as independent predictive factors. Neoplastic polyps were confirmed in 200 patients. Old age and being male were the only factors predictive of neoplastic polyps. Conclusion: Although the majority of patients present with typical haemorrhoidal bleeding, colonoscopy should be considered seriously for elderly patients, especially those who are male. Chinese Abstract Figure Chinese Abstract.
{"title":"Colonoscopy in adult patients: A review of its indications and its yield in detecting colorectal neoplasia","authors":"Janet F.Y. Lee, S. Ng, R. Y. Yiu, K. Leung, J. Lau","doi":"10.1046/J.1442-2034.2002.00130.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.00130.X","url":null,"abstract":"Objective: To review the yield and indications of colonoscopy in a surgical unit at the Prince of Wales Hospital, the result of which may help to select future patients for colonoscopy. \u0000 \u0000 \u0000 \u0000Method: The records of 869 patients undergoing elective colonoscopy at the Prince of Wales Hospital within an 18-month period were reviewed retrospectively. Exclusion criteria included the following: a personal history of colorectal malignancy or polyps, tumours or polyps detectable on rectal examination or rigid sigmoidoscopy, a positive physical examination suggestive of gastrointestinal malignancies, anaemia or positive faecal occult blood. \u0000 \u0000 \u0000 \u0000Results: Per rectal bleeding was the most common indication for colonoscopy. Complete colonoscopy rate was 93.7% and abnormalities were reported in 338 patients. Forty-three patients were found to have cancer whereby age, duration of symptoms, blood mixed with stool and abdominal pain were identified as independent predictive factors. Neoplastic polyps were confirmed in 200 patients. Old age and being male were the only factors predictive of neoplastic polyps. \u0000 \u0000 \u0000 \u0000Conclusion: Although the majority of patients present with typical haemorrhoidal bleeding, colonoscopy should be considered seriously for elderly patients, especially those who are male. \u0000 \u0000 \u0000 \u0000Chinese Abstract \u0000 \u0000 \u0000 \u0000 \u0000Figure Chinese Abstract.","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"3 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90350641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-20-00134.X
Druzhinina Ip, S. Lam, S. Kwok
{"title":"PREOPERATIVE DIAGNOSIS OF MUCOCELE OF THE APPENDIX","authors":"Druzhinina Ip, S. Lam, S. Kwok","doi":"10.1046/J.1442-2034.2002.T01-20-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-20-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83657839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-1-00134.X
B. Lang, H. Lau, F. Lee
{"title":"A COMPARATIVE STUDY OF UNILATERAL AND BILATERAL ENDOSCOPIC EXTRAPERITONEAL (EEP) INGUINAL HERNIOPLASTIES","authors":"B. Lang, H. Lau, F. Lee","doi":"10.1046/J.1442-2034.2002.T01-1-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-1-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83361897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-17-00134.X
G. Chen, J. Merchant, P. Lai, X. Hu, M. Okadu, A. Chui, D. J. Law, W. Lau
{"title":"CO-LOCALIZATION OF p53 And ZBP-89 IN RECURRENT HEPATOCELLULAR CARCINOMA","authors":"G. Chen, J. Merchant, P. Lai, X. Hu, M. Okadu, A. Chui, D. J. Law, W. Lau","doi":"10.1046/J.1442-2034.2002.T01-17-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-17-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"20 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80411879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-12-00134.X
C. Poon, K. Chan, K. Chan, C. Ko, H. Cheung, K. Lee
{"title":"2‐PORT VERSUS 4‐PORT LAPAROSCOPIC CHOLECYSTECTOMY: A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL","authors":"C. Poon, K. Chan, K. Chan, C. Ko, H. Cheung, K. Lee","doi":"10.1046/J.1442-2034.2002.T01-12-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-12-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87636841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1046/J.1442-2034.2002.T01-3-00134.X
T. Chow, C. Lam, Eric Wong, S. Kwok
{"title":"EARLY SENSATION RECOVERY IMPROVED BY GREAT AURICULAR NERVE PRESERVATION IN PAROTIDECTOMY: A PROSPECTIVE DOUBLE‐BLIND STUDY","authors":"T. Chow, C. Lam, Eric Wong, S. Kwok","doi":"10.1046/J.1442-2034.2002.T01-3-00134.X","DOIUrl":"https://doi.org/10.1046/J.1442-2034.2002.T01-3-00134.X","url":null,"abstract":"","PeriodicalId":7943,"journal":{"name":"Annals of The College of Surgeons Hong Kong","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86770241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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