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American journal of neuroprotection and neuroregeneration最新文献

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Symptomatic Treatment in Multiple Sclerosis 多发性硬化的对症治疗
American journal of neuroprotection and neuroregeneration
Pub Date : 2015-10-01 DOI: 10.1166/AJNN.2015.1112
S. Ivanova
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引用次数: 0
Neutralizing Antibodies: Impact on Protein-Based Disease—Modifying Therapies in Multiple Sclerosis 中和抗体:对多发性硬化症中基于蛋白质的疾病改善疗法的影响
American journal of neuroprotection and neuroregeneration
Pub Date : 2015-10-01 DOI: 10.1166/AJNN.2015.1113
S. Ivanova
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引用次数: 0
Effect of One-Time Warm Paste on Patients Comfort Level During Venous Transfusion 一次性温贴对静脉输液患者舒适度的影响
American journal of neuroprotection and neuroregeneration
Pub Date : 2015-10-01 DOI: 10.1166/ajnn.2015.1099
Yang Yiting, L. Ke, Sun Yuemeng
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引用次数: 0
Repetitive Transcranial Magnetic Stimulation 重复经颅磁刺激
American journal of neuroprotection and neuroregeneration
Pub Date : 2015-10-01 DOI: 10.1166/AJNN.2015.1102
I. Milanov
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引用次数: 6
Application of Lidocaine-Sprayed Catheter and Its Effect on Patient's Pain 喷淋利多卡因导管的应用及其对患者疼痛的影响
American journal of neuroprotection and neuroregeneration
Pub Date : 2015-10-01 DOI: 10.1166/ajnn.2015.1098
Yang Yiting, L. Ke, Sun Yuemeng
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引用次数: 0
The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment 在母体大鼠长期给予无毒浓度的锌钛后，产仔大鼠表现出的行为反应的改变可以通过同时给予叶酸来逆转
American journal of neuroprotection and neuroregeneration
Pub Date : 2015-10-01 DOI: 10.1166/AJNN.2015.1101
Silvia Ratti, E. O. Alvarez
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引用次数: 2
Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster. 脑溶素加速黑腹果蝇的变态和减弱高温的加速衰老作用。
American journal of neuroprotection and neuroregeneration
Pub Date : 2014-10-01 DOI: 10.1166/ajnn.2014.1083
V Navrotskaya, G Oxenkrug, L Vorobyova, H Sharma, D Muresanu, P Summergrad

Cerebrolysin® (CBL) is a neuroprotective drug used for the treatment of neurodegenerative diseases. CBL's mechanisms of action remain unclear. Involvement of tryptophan (TRP)-kynurenine (KYN) pathway in neuroprotective effect of CBL might be suggested considering that modulation of KYN pathway of TRP metabolism by CBL, and protection against eclosion defect and prolongation of life span of Drosophila melanogaster with pharmacologically or genetically-induced down-regulation of TRP conversion into KYN. To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature. CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies. Further research of CBL effects on metamorphosis and resistance to aging-accelerating effect of high temperature might offer new insights in mechanisms of its neuroprotective action and expand its clinical applications.

脑溶素®(CBL)是一种用于治疗神经退行性疾病的神经保护药物。CBL的作用机制尚不清楚。考虑到CBL通过调节TRP代谢的KYN通路，通过药理学或基因诱导下调TRP向KYN的转化，对黑腹果蝇的羽化缺陷和延长寿命起到保护作用，提示CBL可能参与了色氨酸-犬尿氨酸通路的神经保护作用。为了探讨TRP-KYN通路可能参与CBL神经保护作用的机制，我们评估了CBL在23℃和28℃环境温度下对黑腹果蝇(Drosophila melanogaster)变态和寿命的影响。CBL加速了果蝇的蜕变，在雌性果蝇中有较强的延长寿命倾向(p = 0.04)，而在雄性果蝇中没有，并且在雌性和雄性果蝇中都减弱了高温(28℃)的加速衰老作用。进一步研究CBL在高温下的变态和抗衰老作用，可能为其神经保护作用的机制提供新的见解，并扩大其临床应用。
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引用次数: 5
Diffusion Tensor Imaging Findings in Traumatic Spinal Cord Injury: A Pilot Study 外伤性脊髓损伤的弥散张量成像结果:一项初步研究
American journal of neuroprotection and neuroregeneration
Pub Date : 2014-10-01 DOI: 10.1166/ajnn.2014.1082
F. Wang, Xijing He
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引用次数: 0
Chronic Fatigue Syndrome/Fibromyalgia: Past and Present 慢性疲劳综合征/纤维肌痛:过去和现在
American journal of neuroprotection and neuroregeneration
Pub Date : 2014-10-01 DOI: 10.1166/AJNN.2014.1077
N. Rishiraj
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引用次数: 0
The Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats are Mediated Primarily by Te 母鼠长期给予无毒浓度的锌钛后，产仔大鼠表现出的行为反应主要是由锌钛介导的
American journal of neuroprotection and neuroregeneration
Pub Date : 2014-10-01 DOI: 10.1166/AJNN.2014.1080
Silvia Ratti, E. O. Alvarez
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引用次数: 3
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