Pub Date : 2024-09-25Epub Date: 2024-08-06DOI: 10.3400/avd.ra.24-00065
Atsushi Guntani
In recent years, endovascular therapy (EVT) has come to play an important role in the revascularization of the femoropopliteal artery region; however, the number of cases that cannot be treated with EVT is increasing, and the importance of bypass surgery has been reaffirmed. We will provide an overview of the revascularization of the femoropopliteal artery region in accordance with the JCS/JSVS 2022 Guideline on the Management of Peripheral Arterial Disease. (This is a translation of Jpn J Vasc Surg 2024; 33: 57-59).
{"title":"Revascularization of the Femoropopliteal Artery Region.","authors":"Atsushi Guntani","doi":"10.3400/avd.ra.24-00065","DOIUrl":"10.3400/avd.ra.24-00065","url":null,"abstract":"<p><p>In recent years, endovascular therapy (EVT) has come to play an important role in the revascularization of the femoropopliteal artery region; however, the number of cases that cannot be treated with EVT is increasing, and the importance of bypass surgery has been reaffirmed. We will provide an overview of the revascularization of the femoropopliteal artery region in accordance with the JCS/JSVS 2022 Guideline on the Management of Peripheral Arterial Disease. (This is a translation of Jpn J Vasc Surg 2024; 33: 57-59).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 3","pages":"219-221"},"PeriodicalIF":0.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In patients with abdominal aortic aneurysm (AAA), early detection and optimal elective treatment before rupture are desirable. In the absence of an established public screening system, opportunistic screening during ultrasound examination for another purpose might be efficacious. The aim of this study was to evaluate the efficacy of opportunistic screening for AAA. Methods: This prospective multicenter observational study enrolled patients who were scheduled to undergo ultrasound for reasons other than AAA. After the ultrasound for the original purpose, evaluation of the abdominal aorta was added. If the abdominal aorta was clear enough for measurement, its diameter and shape were recorded. Furthermore, information on comorbidities was collected for each patient. Results: A total of 10325 patients (echocardiography: 6150; abdominal ultrasound: 4162) from 16 institutions were enrolled. The abdominal aorta was well visualized in 92.9% of patients who underwent echocardiography. Among 9791 patients, AAA was diagnosed in 122 (1.3%) (107 fusiform and 15 saccular), with a diameter range of 30-63 mm. The diagnostic rate increased with age. On multivariate analysis, older age, male sex, coronary artery disease, peripheral arterial disease, and smoking habituation were the risk factors for AAA. Conclusion: Opportunistic screening for AAA was efficacious.
{"title":"Opportunistic Ultrasound Screening for Abdominal Aortic Aneurysm.","authors":"Yasuharu Funamizu, Hitoshi Goto, Ayaka Oda, Takashi Miki, Yoshifumi Saijo","doi":"10.3400/avd.oa.23-00110","DOIUrl":"10.3400/avd.oa.23-00110","url":null,"abstract":"<p><p><b>Objective</b>: In patients with abdominal aortic aneurysm (AAA), early detection and optimal elective treatment before rupture are desirable. In the absence of an established public screening system, opportunistic screening during ultrasound examination for another purpose might be efficacious. The aim of this study was to evaluate the efficacy of opportunistic screening for AAA. <b>Methods</b>: This prospective multicenter observational study enrolled patients who were scheduled to undergo ultrasound for reasons other than AAA. After the ultrasound for the original purpose, evaluation of the abdominal aorta was added. If the abdominal aorta was clear enough for measurement, its diameter and shape were recorded. Furthermore, information on comorbidities was collected for each patient. <b>Results</b>: A total of 10325 patients (echocardiography: 6150; abdominal ultrasound: 4162) from 16 institutions were enrolled. The abdominal aorta was well visualized in 92.9% of patients who underwent echocardiography. Among 9791 patients, AAA was diagnosed in 122 (1.3%) (107 fusiform and 15 saccular), with a diameter range of 30-63 mm. The diagnostic rate increased with age. On multivariate analysis, older age, male sex, coronary artery disease, peripheral arterial disease, and smoking habituation were the risk factors for AAA. <b>Conclusion</b>: Opportunistic screening for AAA was efficacious.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"157-163"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Owing to the unique anatomical features, the endovascular repair for Kommerell diverticulum poses a surgical challenge. An 80-year-old, asymptomatic female with Kommerell diverticulum and associated right-sided aortic arch underwent an endovascular repair, consisting of an aortic arch endografting with a proximal extension, axillo-axillary crossover bypass, and right subclavian parallel endografting. An additional stent was promptly placed retrogradely at the right carotid artery origin as the completion aortography revealed an ostial occlusion. During the 6th month follow-up, she remained well without any neurological deficits. This report elucidated the disease-specific and procedure-related causes leading to right carotid artery ostium occlusion.
{"title":"Right Carotid Artery Origin Compression Caused by Endovascular Repair for Kommerell Diverticulum Associated with a Right-Sided Aortic Arch.","authors":"Hiroomi Nishio, Atsushi Iwakura, Naoki Takahashi, Kenji Aida, Kyozo Inoue, Fumie Takai, Masanosuke Ishigami, Hiroshi Yukawa, Hisashi Sakaguchi, Takashi Fukushima, Fujio Hayashi","doi":"10.3400/avd.cr.24-00002","DOIUrl":"10.3400/avd.cr.24-00002","url":null,"abstract":"<p><p>Owing to the unique anatomical features, the endovascular repair for Kommerell diverticulum poses a surgical challenge. An 80-year-old, asymptomatic female with Kommerell diverticulum and associated right-sided aortic arch underwent an endovascular repair, consisting of an aortic arch endografting with a proximal extension, axillo-axillary crossover bypass, and right subclavian parallel endografting. An additional stent was promptly placed retrogradely at the right carotid artery origin as the completion aortography revealed an ostial occlusion. During the 6th month follow-up, she remained well without any neurological deficits. This report elucidated the disease-specific and procedure-related causes leading to right carotid artery ostium occlusion.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"201-204"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25Epub Date: 2024-03-13DOI: 10.3400/avd.ra.24-00010
Hiroyoshi Komai
The most important vascular lesion associated with diabetes is arteriosclerosis obliterans (ASO). Differential diagnosis from diabetic foot lesions that produce neurogenic ulcers is important, and the presence of ischemia must be diagnosed as soon as possible. It has been reported that diabetes makes ASO more severe and often leads to lower extremity amputation. In addition to the need for appropriate early control of diabetes, vascular surgeons are required to perform immediate revascularization in cases of ulcer and necrosis, and to aggressively use surgical treatment with good long-term prognosis. (This is a translation of Jpn J Vasc Surg 2023; 32: 105-109.).
{"title":"Vascular Disease and Diabetes.","authors":"Hiroyoshi Komai","doi":"10.3400/avd.ra.24-00010","DOIUrl":"10.3400/avd.ra.24-00010","url":null,"abstract":"<p><p>The most important vascular lesion associated with diabetes is arteriosclerosis obliterans (ASO). Differential diagnosis from diabetic foot lesions that produce neurogenic ulcers is important, and the presence of ischemia must be diagnosed as soon as possible. It has been reported that diabetes makes ASO more severe and often leads to lower extremity amputation. In addition to the need for appropriate early control of diabetes, vascular surgeons are required to perform immediate revascularization in cases of ulcer and necrosis, and to aggressively use surgical treatment with good long-term prognosis. (This is a translation of Jpn J Vasc Surg 2023; 32: 105-109.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"109-113"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A popliteal venous aneurysm (PVA) is a rare vascular disorder. We report a case of PVA discovered through further evaluation of sudden cardiac arrest (CA) caused by a pulmonary embolism (PE). It is well-known that PVA causes PE; however, there are few reports of PVA causing CA. A tangential aneurysmectomy and lateral venorrhaphy were performed. The patient's postoperative course was uneventful. When contrast-enhanced computed tomography is performed to search for the cause of CA, PVA should be considered and thus, screening below the knee is recommended. At 1-year follow-up, there were no complications.
腘静脉动脉瘤(PVA)是一种罕见的血管疾病。我们报告了一例通过进一步评估肺栓塞(PE)导致的心脏骤停(CA)而发现的 PVA 病例。众所周知,PVA 会导致 PE,但很少有 PVA 导致 CA 的报道。医生为患者实施了切向动脉瘤切除术和侧支静脉切开术。患者术后恢复顺利。在进行造影剂增强计算机断层扫描以寻找 CA 的病因时,应考虑到 PVA,因此建议对膝关节以下部位进行筛查。随访1年,未发现并发症。
{"title":"A Case of Popliteal Venous Aneurysm Diagnosed after Sudden Cardiac Arrest.","authors":"Daigo Shinoda, Koichi Yuri, Atsushi Miyagawa, Nobu Yokoyama","doi":"10.3400/avd.cr.23-00097","DOIUrl":"10.3400/avd.cr.23-00097","url":null,"abstract":"<p><p>A popliteal venous aneurysm (PVA) is a rare vascular disorder. We report a case of PVA discovered through further evaluation of sudden cardiac arrest (CA) caused by a pulmonary embolism (PE). It is well-known that PVA causes PE; however, there are few reports of PVA causing CA. A tangential aneurysmectomy and lateral venorrhaphy were performed. The patient's postoperative course was uneventful. When contrast-enhanced computed tomography is performed to search for the cause of CA, PVA should be considered and thus, screening below the knee is recommended. At 1-year follow-up, there were no complications.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"188-191"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25Epub Date: 2024-03-13DOI: 10.3400/avd.cr.23-00076
Yumi Sasaki, Jun Yamanouchi, Katsuto Takenaka
Inherited Protein S (PS) deficiency is an autosomal dominant thrombotic disorder. We encountered a case of inherited type I PS deficiency following a close examination for recurrent pregnancy loss and identified the mutation responsible; a novel splice donor site mutation in intron 13 of the PROS1 gene appeared to have caused a frameshift with premature termination at amino acid +551. These results will contribute to the creation of an accurate database and define the molecular basis for PS deficiency.
{"title":"A Novel Splice Donor Site Mutation Leading to Inherited Type I Protein S Deficiency.","authors":"Yumi Sasaki, Jun Yamanouchi, Katsuto Takenaka","doi":"10.3400/avd.cr.23-00076","DOIUrl":"10.3400/avd.cr.23-00076","url":null,"abstract":"<p><p>Inherited Protein S (PS) deficiency is an autosomal dominant thrombotic disorder. We encountered a case of inherited type I PS deficiency following a close examination for recurrent pregnancy loss and identified the mutation responsible; a novel splice donor site mutation in intron 13 of the <i>PROS1</i> gene appeared to have caused a frameshift with premature termination at amino acid +551. These results will contribute to the creation of an accurate database and define the molecular basis for PS deficiency.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"179-182"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25Epub Date: 2024-03-15DOI: 10.3400/avd.ra.24-00013
Hiroko Morisaki
Hereditary aortic aneurysms and dissections, such as Marfan syndrome, differ in that they occur in younger patients without generally recognized risk factors, have a predilection for the thoracic rather than the abdominal aorta, and are at risk for dissection even at smaller aortic diameters. Early diagnosis, careful follow-up, and early intervention, such as medication to reduce aortic root growth and prophylactic aortic replacement to prevent fatal aortic dissection, are essential for a better prognosis. Molecular genetic testing is extremely useful for early diagnosis. However, in actual clinical practice, the question often arises as to when and to which patient genetic testing should be offered since the outcome of the tests can have important implications for the patient and the relatives. Pre- and post-test genetic counseling is essential for early intervention to be effective. (This article is a secondary translation of Jpn J Vasc Surg 2023; 32: 261-267.).
{"title":"Hereditary Aortic Aneurysms and Dissections: Clinical Diagnosis and Genetic Testing.","authors":"Hiroko Morisaki","doi":"10.3400/avd.ra.24-00013","DOIUrl":"10.3400/avd.ra.24-00013","url":null,"abstract":"<p><p>Hereditary aortic aneurysms and dissections, such as Marfan syndrome, differ in that they occur in younger patients without generally recognized risk factors, have a predilection for the thoracic rather than the abdominal aorta, and are at risk for dissection even at smaller aortic diameters. Early diagnosis, careful follow-up, and early intervention, such as medication to reduce aortic root growth and prophylactic aortic replacement to prevent fatal aortic dissection, are essential for a better prognosis. Molecular genetic testing is extremely useful for early diagnosis. However, in actual clinical practice, the question often arises as to when and to which patient genetic testing should be offered since the outcome of the tests can have important implications for the patient and the relatives. Pre- and post-test genetic counseling is essential for early intervention to be effective. (This article is a secondary translation of Jpn J Vasc Surg 2023; 32: 261-267.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"128-134"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25Epub Date: 2024-03-13DOI: 10.3400/avd.cr.23-00122
Yusuke Nakata, Kazuyuki Miyamoto
Ruptured abdominal aortic aneurysms and common iliac artery aneurysms (CIAAs) are rarely associated with an arteriovenous fistula (AVF). In such cases, surgery is frequently extremely difficult and the prognosis is usually poor. We report a case of a ruptured CIAA with a common iliac AVF in a 58-year-old male patient who presented with symptoms of severe edema in his left lower extremity. We used an aneurysm wall patch to repair the fistula and successfully reconstruct the common iliac vein, and a bifurcated prosthetic graft for abdominal aortic and iliac artery replacement.
{"title":"Successful Repair of a Ruptured Common Iliac Aneurysm with Associated Arteriovenous Fistula Using Aneurysm Wall.","authors":"Yusuke Nakata, Kazuyuki Miyamoto","doi":"10.3400/avd.cr.23-00122","DOIUrl":"10.3400/avd.cr.23-00122","url":null,"abstract":"<p><p>Ruptured abdominal aortic aneurysms and common iliac artery aneurysms (CIAAs) are rarely associated with an arteriovenous fistula (AVF). In such cases, surgery is frequently extremely difficult and the prognosis is usually poor. We report a case of a ruptured CIAA with a common iliac AVF in a 58-year-old male patient who presented with symptoms of severe edema in his left lower extremity. We used an aneurysm wall patch to repair the fistula and successfully reconstruct the common iliac vein, and a bifurcated prosthetic graft for abdominal aortic and iliac artery replacement.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"175-178"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25Epub Date: 2024-04-23DOI: 10.3400/avd.cr.24-00019
Sameer Peer, Lovleen
In this series of three cases, we describe the vascular steal phenomenon in an otherwise normal lower limb secondary to hyperemia in the contralateral lower limb. In each of the cases, post-inflammatory hyperemia in the involved lower limb was associated with a significant reduction in blood flow in the contralateral normal lower limb. We attempt to explain the imaging findings in these three cases using the equation of continuity in fluid dynamics. To the best of our knowledge, a description of such kind is unavailable in the published literature.
{"title":"Vascular Steal Phenomenon in Lower Limb due to Reactive Hyperemia in Contralateral Limb: A Case Series and an Explanation of a Rare Phenomenon Using Continuity Equation.","authors":"Sameer Peer, Lovleen","doi":"10.3400/avd.cr.24-00019","DOIUrl":"10.3400/avd.cr.24-00019","url":null,"abstract":"<p><p>In this series of three cases, we describe the vascular steal phenomenon in an otherwise normal lower limb secondary to hyperemia in the contralateral lower limb. In each of the cases, post-inflammatory hyperemia in the involved lower limb was associated with a significant reduction in blood flow in the contralateral normal lower limb. We attempt to explain the imaging findings in these three cases using the equation of continuity in fluid dynamics. To the best of our knowledge, a description of such kind is unavailable in the published literature.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"205-210"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 79-year-old man underwent 1-debranched thoracic endovascular aortic repair (TEVAR) for a saccular aneurysm of the distal arch of the aorta. Computed tomography performed 3 years after surgery revealed a significant displacement of the distal side of the stent graft and severe deformity due to displacement of the aorta. There were no obvious findings after aortic dissection. Endovascular treatment was selected, and surgery was performed semiemergency. Additional TEVAR was performed to restore the aortic shape and displacement to its normal position.
{"title":"A Case of Aortic Strain due to Spring Back Force by Stent Graft 3 Years after Thoracic Endovascular Aortic Repair.","authors":"Kuntae Ahn, Nobuyuki Yoshitani, Hironobu Sugiyama, Takuya Misato, Taro Hayashi, Masato Yamaguchi","doi":"10.3400/avd.cr.23-00081","DOIUrl":"10.3400/avd.cr.23-00081","url":null,"abstract":"<p><p>A 79-year-old man underwent 1-debranched thoracic endovascular aortic repair (TEVAR) for a saccular aneurysm of the distal arch of the aorta. Computed tomography performed 3 years after surgery revealed a significant displacement of the distal side of the stent graft and severe deformity due to displacement of the aorta. There were no obvious findings after aortic dissection. Endovascular treatment was selected, and surgery was performed semiemergency. Additional TEVAR was performed to restore the aortic shape and displacement to its normal position.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"17 2","pages":"171-174"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}