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Raloxifene is associated with less side effects than tamoxifen in women with early breast cancer: a questionnaire study from one physician's practice. 雷洛昔芬对早期乳腺癌患者的副作用小于他莫昔芬:一项来自一位医生实践的问卷调查研究。
Pub Date : 2002-04-01 DOI: 10.1089/152460902753668484
N. Rohatgi, R. Blau, E. Lower
OBJECTIVESelective estrogen receptor modulators (SERMs) are being used increasingly for the prevention and treatment of breast cancer. The currently available SERMs, tamoxifen and raloxifene, are both associated with antiestrogenic side effects that can be bothersome. However, no data exist on how they compare in this regard. We conducted a retrospective, questionnaire-based study to answer this question.METHODSWomen with early breast cancer in one physician's practice who had received either or both of these drugs were surveyed using a self-administered questionnaire. Respondents graded the frequency and severity of side effects related to estrogen deprivation, such as vaginal dryness, mood changes, hot flashes, weight gain, and changes in libido, as well as other side effects, such as vaginal discharge. They were separated into three groups for analysis (group 1, tamoxifen only; group 2, raloxifene only; group 3, both drugs). Side effects graded 4 or 5 (or weight gain >10 pounds) were considered severe.RESULTSTwo hundred sixty-four questionnaires were available for analysis. Women on raloxifene had a shorter average duration of therapy. In comparing the tamoxifen and raloxifene groups, vaginal discharge, severe hot flashes, and weight gain of >10 pounds were significantly more frequent with tamoxifen. However, weight gain was also related to the duration of therapy with either drug.CONCLUSIONSIn this observational study, antiestrogenic side effects were common with either tamoxifen or raloxifene. Raloxifene is associated with significantly less vaginal discharge and severe hot flashes than tamoxifen in women with early breast cancer. Although weight gain of >10 pounds may also occur less frequently on this drug, this may be confounded by the shorter average duration of raloxifene therapy.
目的选择性雌激素受体调节剂(SERMs)越来越多地用于乳腺癌的预防和治疗。目前可用的serm,他莫昔芬和雷洛昔芬,都与抗雌激素副作用有关,这可能是令人烦恼的。然而,没有数据表明它们在这方面如何比较。我们进行了一项基于问卷的回顾性研究来回答这个问题。方法采用自我管理的问卷调查方法,对接受过上述两种药物中的一种或两种的一位医生的早期乳腺癌患者进行调查。受访者对与雌激素剥夺相关的副作用的频率和严重程度进行了分级,如阴道干燥、情绪变化、潮热、体重增加、性欲变化,以及其他副作用,如阴道分泌物。将患者分为三组进行分析(第一组仅使用他莫昔芬;第2组仅使用雷洛昔芬;第三组,两种药物)。4级或5级副作用(或体重增加>10磅)被认为是严重的。结果共回收问卷264份,可供分析。服用雷洛昔芬的女性平均治疗时间较短。在比较他莫昔芬组和雷洛昔芬组时,他莫昔芬组阴道分泌物、严重潮热和体重增加>10磅明显更频繁。然而,体重增加也与两种药物治疗的持续时间有关。结论在这项观察性研究中,他莫昔芬和雷洛昔芬的抗雌激素副作用都很常见。在早期乳腺癌患者中,雷洛昔芬与他莫昔芬相比能显著减少阴道分泌物和严重的潮热。虽然使用雷洛昔芬后体重增加大于10磅的情况也较少发生,但这可能与雷洛昔芬治疗的平均持续时间较短相混淆。
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引用次数: 12
Replacement surgery and silicone gel breast implant rupture: self-report by women after mammoplasty. 乳房置换手术和硅胶假体破裂:乳房成形术后女性的自我报告。
Pub Date : 2002-04-01 DOI: 10.1089/152460902753668457
S. Lori Brown, G. Pennello
BACKGROUNDThis study examined the prevalence of revision surgery in which silicone gel breast implants were either removed (explanted) or replaced in a cohort of women from Birmingham, Alabama. The main reason leading up to the surgery and the prevalence of ruptured implants reported after explantation are described.METHODSData were collected from telephone interviews with 907 women previously identified in a larger cohort study of women with breast implants. Women who reported breast surgeries subsequent to their index mammoplasty were asked to consent to retrieval of the surgical records describing the surgery.RESULTSSurgery in which a silicone gel breast implant was removed or replaced was reported by 33% of the 907 women in this cohort. The most common reason for surgery was problems with the implant that affected the breast (103 of 303 surgeries). Of the 303 women reporting surgery, 145 (48%) reported knowing after a surgery that an implant was ruptured when it was removed, and 171 (56%) reported knowing that an implant was ruptured or leaking. Overall, 16% of the 907 women reported knowing that either of their implants was ruptured after any surgery. At least one surgical record was retrieved for 165 (54%) of the 303 women reporting surgery. Among these women, the rupture rate was 69 of 165 (42%) according to the surgical record and 85 of 165 (51.5%) according to self-reports, a statistically significant difference (p = 0.008 from McNemar's test). The mean time from implantation to surgery was 11.5 years among women reporting surgery and estimated at 21.4 years for all women.CONCLUSIONSA third of the women in this cohort underwent additional surgery after the initial mammoplasty, and nearly half who underwent surgery reported that their implants were found to be ruptured when removed. Women considering silicone gel breast implants should be informed of the risk of additional surgeries and of the potential risk of breast implant rupture.
背景:本研究调查了在阿拉巴马州伯明翰的一组女性中,硅胶乳房植入物被移除或替换的翻修手术的流行程度。主要原因导致的手术和流行的假体破裂后外植体报道的描述。方法通过电话采访907名女性收集数据,这些女性此前在一项更大规模的隆胸女性队列研究中被确认。报告在指数乳房成形术后进行乳房手术的妇女被要求同意检索描述手术的手术记录。结果907名女性中有33%的人进行了硅胶乳房植入物移除或更换手术。最常见的手术原因是植入物的问题影响了乳房(303例手术中有103例)。在报告手术的303名妇女中,145名(48%)报告在手术后知道植入物在取出时破裂,171名(56%)报告知道植入物破裂或泄漏。总的来说,907名女性中有16%的人报告说她们知道任何手术后植入物破裂。在303例报告手术的妇女中,有165例(54%)至少检索到一次手术记录。在这些女性中,165例手术记录的破裂率为69例(42%),165例自我报告的破裂率为85例(51.5%),差异有统计学意义(McNemar试验p = 0.008)。报告手术的女性从植入到手术的平均时间为11.5年,而所有女性的平均时间估计为21.4年。结论:该队列中三分之一的妇女在最初的乳房成形术后接受了额外的手术,近一半接受手术的妇女报告说,她们的植入物在取出时被发现破裂。考虑硅胶隆胸的女性应该被告知额外手术的风险和隆胸破裂的潜在风险。
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引用次数: 17
CDC contributions to women's health: focusing on prevention in midlife. 疾病预防控制中心对妇女健康的贡献:注重中年预防。
Pub Date : 2002-04-01 DOI: 10.1089/152460902753668402
Y. Green
201 MANY NOTABLE PUBLIC HEALTH achievements occurred during the 1900s. Two of the great public health achievements for the 20th century specifically focused on women—healthier mothers and babies and family planning. During the 20th century, the health and life expectancy of people residing in the United States improved dramatically.1 Prevention played a significant role then, and it continues to plays a significant role today. Although the health and safety of women have improved, much remains to be done. For women in their midlife, 45–64 years of age, the leading causes of death include cancer, heart disease, and cerebrovascular disease. The challenges lie in reducing some of the risk factors responsible for many chronic diseases, such as obesity, smoking, and lack of physical activity. Chronic diseases account for 70% of all deaths in the United States. The medical care costs of people with chronic diseases account for more than 60% of the nation’s medical care costs, and chronic diseases account for one third of the years of potential life lost before age 65. Women comprise more than half the people who die each year of cardiovascular disease.2 The Centers for Disease Control and Prevention (CDC) protects people’s health and safety by preventing and controlling diseases and injuries, enhances health decisions by providing credible information on critical health issues, and promotes healthy living through strong partnerships with local, national, and international organizations. With a diverse array of programs and activities that focus on women at every stage of life, CDC makes contributions to better understand and use prevention to reduce illness, disability, and death and to improve the quality of life. Much of this is possible because of the vital partnerships with public and private entities, such as state and local public health agencies, practicing health professionals, schools and universities, community organizations, industry and labor, foundations, and international organizations. Partnerships between CDC and women’s health advocacy groups, minority organizations, professional associations, and others have helped increase the number and type of prevention programs available to women. They have increased the understanding of the challenges, gaps, and opportunities and helped to develop innovative solutions to address some of these issues. Such partnerships have also enhanced policy development and fueled agencies, organizations, and individuals to take action. For CDC, the focus of the research and programs is prevention. Although some of the research and programs are well established, others are small, and still others are new. The expectation is that each has or will contribute to the science, understanding, policy, program design, quality of service, decision making, or action taken to improve the health and safety of women.
201 . 20世纪出现了许多显著的公共卫生成就。20世纪公共卫生领域的两大成就特别关注于妇女——更健康的母亲和婴儿以及计划生育。在20世纪,居住在美国的人的健康和预期寿命有了显著的改善预防在当时起了重要作用,今天继续发挥着重要作用。尽管妇女的健康和安全有所改善,但仍有许多工作要做。对于45-64岁的中年妇女来说,死亡的主要原因包括癌症、心脏病和脑血管疾病。挑战在于减少导致许多慢性疾病的一些风险因素,如肥胖、吸烟和缺乏体育活动。在美国,70%的死亡是由慢性病造成的。慢性病患者的医疗费用占全国医疗费用的60%以上,慢性病占65岁之前潜在寿命损失年数的三分之一。在每年死于心血管疾病的人中,妇女占一半以上疾病控制和预防中心(CDC)通过预防和控制疾病和伤害来保护人们的健康和安全,通过提供关于关键健康问题的可靠信息来加强健康决策,并通过与地方、国家和国际组织的牢固伙伴关系来促进健康生活。美国疾病控制与预防中心开展了一系列不同的项目和活动,重点关注妇女生命的各个阶段,为更好地理解和利用预防来减少疾病、残疾和死亡,提高生活质量做出了贡献。这在很大程度上是可能的,因为与公共和私营实体建立了重要的伙伴关系,如州和地方公共卫生机构、执业卫生专业人员、学校和大学、社区组织、工业和劳工、基金会以及国际组织。疾病预防控制中心与妇女健康倡导团体、少数民族组织、专业协会和其他组织之间的伙伴关系有助于增加妇女可获得的预防项目的数量和类型。他们增进了对挑战、差距和机遇的理解,并帮助制定了解决其中一些问题的创新解决方案。这种伙伴关系还促进了政策制定,并促使各机构、组织和个人采取行动。对于疾病预防控制中心来说,研究和项目的重点是预防。虽然有些研究和项目已经很成熟,但有些规模很小,还有一些是新的。期望每个人都对科学、理解、政策、方案设计、服务质量、决策或为改善妇女健康和安全所采取的行动作出贡献。
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引用次数: 1
Correlates of physical activity among women from diverse racial/ethnic groups. 不同种族/民族妇女体育活动的相关性。
Pub Date : 2002-04-01 DOI: 10.1089/152460902753668448
A. Eyler, S. Wilcox, D. Matson-Koffman, K. Evenson, B. Sanderson, J. Thompson, J. Wilbur, D. Rohm-Young
OBJECTIVEWomen have lower rates of participation in leisure time physical activity than men and have been studied to a lesser extent than men. Because physical activity plays a vital role in overall health, it is important to identify factors than can help increase physical activity rates for women.METHODSDefining and understanding correlates of physical activity is critical for at-risk populations and for planning effective interventions. This paper reviews research conducted in the past two decades on correlates of physical activity in women. An ecological model with an added physical environment component was used to organize the correlates. Studies conducted among adult white, black, American Indian, Asian, and Hispanic women are included. A total of 91 studies were reviewed. Many studies included white women, fewer studies included black and Hispanic women, and even fewer included American Indian women, and only 3 studies included Asian women.RESULTSThe correlates most studied are sociodemographic variables, with nonwhite race, lower educational levels, and older age most consistently associated with lower levels of physical activity. Few studies focused on environmental and policy correlates. Social support was an overwhelmingly positive determinant of physical activity for all groups of women.CONCLUSIONSBased on these findings, we recommend that future research include more diverse groups of women and evaluate modifiable factors, such as psychological, interpersonal, and environmental correlates. Future research also should include more intervention and longitudinal studies.
目的:女性在闲暇时间参加体育活动的比例低于男性,研究的程度也低于男性。因为体育活动在整体健康中起着至关重要的作用,所以确定有助于增加女性体育活动率的因素是很重要的。方法定义和理解身体活动的相关因素对于高危人群和规划有效的干预措施至关重要。本文回顾了过去二十年来对女性体育活动相关因素的研究。使用一个添加了物理环境成分的生态模型来组织相关因素。研究对象包括成年白人、黑人、美洲印第安人、亚裔和西班牙裔妇女。共回顾了91项研究。许多研究包括白人妇女,少数研究包括黑人和西班牙裔妇女,更少的研究包括美国印第安妇女,只有3项研究包括亚洲妇女。结果研究最多的相关因素是社会人口变量,非白人种族、教育水平较低和年龄较大最一致地与较低的体育活动水平相关。很少有研究关注环境和政策的相关性。社会支持对所有妇女群体的体育活动都是一个绝对积极的决定因素。基于这些发现,我们建议未来的研究包括更多不同的女性群体,并评估可改变的因素,如心理、人际关系和环境相关因素。未来的研究还应该包括更多的干预和纵向研究。
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引用次数: 299
Gender differences in tobacco smoking: higher relative exposure to smoke than nicotine in women. 吸烟的性别差异:女性吸烟的相对暴露程度高于尼古丁。
Pub Date : 2002-03-01 DOI: 10.1089/152460902753645281
Marilyn V. Zeman, L. Hiraki, E. Sellers
INTRODUCTIONMen and women are thought to regulate their smoking differently and to differ in their susceptibility to nicotine addiction.METHODS AND MATERIALSVarious measures of smoke exposure were compared between 400 current regular tobacco-dependent (DSM-IV) male and female light (1-15 cigarettes per day) and heavy (>15 cigarettes per day) smokers. Between 2 and 8 PM, blood was collected for nicotine and cotinine analysis, and breath carbon monoxide (CO) was measured. Individuals with genetic variants of the CYP2A6 gene were removed from analysis (n = 25).RESULTSNo significant difference was found in the number of cigarettes per day or CO levels between the sexes. However, females had significantly lower nicotine levels than males (16.9 +/- 0.6 vs. 21.1 +/- 0.07, p < 0.01). This is only partly explained by the fact that females smoked lower nicotine-containing cigarettes. Female heavy smokers demonstrated higher -log nicotine/CO values (a representation of cost of smoking) compared with male heavy smokers (0.1 +/- 0.02 vs. 0.02 +/- 0.01 mg/L ppm, p < 0.05).CONCLUSIONSThus, gender differences appear to exist in smoking behaviors, nicotine sensitivity, and nicotine requirements. These differences are expected to contribute to gender differences in health risks and cancers associated with smoking.
人们认为男性和女性对吸烟的控制方式不同,对尼古丁成瘾的易感性也不同。方法和材料比较了400名常规烟草依赖(DSM-IV)男性和女性轻度(每天1-15支)和重度(每天100 -15支)吸烟者的各种烟雾暴露措施。在下午2点到8点之间,采集血液进行尼古丁和可替宁分析,并测量呼吸中的一氧化碳(CO)。具有CYP2A6基因变异的个体从分析中剔除(n = 25)。结果两性在每天吸烟数量和CO水平上无显著差异。然而,女性的尼古丁水平明显低于男性(16.9 +/- 0.6比21.1 +/- 0.07,p < 0.01)。女性抽的香烟尼古丁含量较低,这只能部分解释这一现象。与男性重度吸烟者相比,女性重度吸烟者表现出更高的尼古丁/CO值(代表吸烟成本)(0.1 +/- 0.02 vs. 0.02 +/- 0.01 mg/L ppm, p < 0.05)。结论吸烟行为、尼古丁敏感性和尼古丁需求存在性别差异。预计这些差异将导致与吸烟有关的健康风险和癌症方面的性别差异。
{"title":"Gender differences in tobacco smoking: higher relative exposure to smoke than nicotine in women.","authors":"Marilyn V. Zeman, L. Hiraki, E. Sellers","doi":"10.1089/152460902753645281","DOIUrl":"https://doi.org/10.1089/152460902753645281","url":null,"abstract":"INTRODUCTION\u0000Men and women are thought to regulate their smoking differently and to differ in their susceptibility to nicotine addiction.\u0000\u0000\u0000METHODS AND MATERIALS\u0000Various measures of smoke exposure were compared between 400 current regular tobacco-dependent (DSM-IV) male and female light (1-15 cigarettes per day) and heavy (>15 cigarettes per day) smokers. Between 2 and 8 PM, blood was collected for nicotine and cotinine analysis, and breath carbon monoxide (CO) was measured. Individuals with genetic variants of the CYP2A6 gene were removed from analysis (n = 25).\u0000\u0000\u0000RESULTS\u0000No significant difference was found in the number of cigarettes per day or CO levels between the sexes. However, females had significantly lower nicotine levels than males (16.9 +/- 0.6 vs. 21.1 +/- 0.07, p < 0.01). This is only partly explained by the fact that females smoked lower nicotine-containing cigarettes. Female heavy smokers demonstrated higher -log nicotine/CO values (a representation of cost of smoking) compared with male heavy smokers (0.1 +/- 0.02 vs. 0.02 +/- 0.01 mg/L ppm, p < 0.05).\u0000\u0000\u0000CONCLUSIONS\u0000Thus, gender differences appear to exist in smoking behaviors, nicotine sensitivity, and nicotine requirements. These differences are expected to contribute to gender differences in health risks and cancers associated with smoking.","PeriodicalId":80044,"journal":{"name":"Journal of women's health & gender-based medicine","volume":"1 1","pages":"147-53"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78557691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 94
Hysterectomy status and life satisfaction in older women. 高龄妇女子宫切除状况与生活满意度。
Pub Date : 2002-03-01 DOI: 10.1089/152460902753645326
D. Kritz-Silverstein, D. Wingard, E. Barrett-Connor
OBJECTIVESThis cross-sectional, population-based study examines the long-term effect of hysterectomy on life satisfaction in 1177 women aged 55-94 years.METHODSA 1992 mailed survey obtained information on menopausal history, including hysterectomy and oophorectomy status, and estrogen use. Two standardized measures ascertained general life satisfaction: the Life Satisfaction Index-Z (LSI-Z) and the Satisfaction with Life Scale (SWLS). A separate question asked participants to rate life satisfaction (better, the same, or worse) after menopause or hysterectomy compared with before.RESULTSTwenty-three percent of the women reported hysterectomy with bilateral oophorectomy an average of 24 years earlier, and 26% reported hysterectomy with ovarian conservation an average of 28 years earlier. Women who were 20 or more years posthysterectomy or postmenopause were significantly more likely to rate their life satisfaction as better than were women 5 or fewer years posthysterectomy or postmenopause (p < 0.01). Among women with a hysterectomy, 53% with oophorectomy and 60% with ovarian conservation rated life satisfaction better after hysterectomy. Only 42.2% of women without a hysterectomy rated life satisfaction as better after menopause (p < 0.001). Differences persisted after adjustment for age and other covariates: p < 0.01 for hysterectomy with ovarian conservation and p < 0.001 for hysterectomy with bilateral oophorectomy vs. no hysterectomy. Even among women who had never used estrogen, a significantly greater proportion of those who had a hysterectomy with ovarian conservation rated their life satisfaction as better compared with women who did not have a hysterectomy (p < 0.05). There were no differences in standard life satisfaction scores (LSI-Z or SWLS) by hysterectomy status.CONCLUSIONSThere are no long-term adverse effects of hysterectomy on life satisfaction. When queried specifically, women report increased life satisfaction following hysterectomy. Relief from symptoms necessitating hysterectomy may be responsible for this increase. This difference may be specific to hysterectomy because there were no differences in general life satisfaction as assessed with standardized measures.
目的:本以人群为基础的横断面研究探讨了子宫切除术对1177名55-94岁女性生活满意度的长期影响。方法通过1992年的邮寄调查,了解妇女的绝经史,包括子宫、卵巢切除情况、雌激素使用情况。两种标准化的措施确定一般生活满意度:生活满意度指数- z (LSI-Z)和生活满意度量表(SWLS)。另一个单独的问题要求参与者对绝经或子宫切除术后的生活满意度(更好、相同或更差)进行评分。结果23%的女性报告子宫切除术并双侧卵巢切除术平均提前24年,26%的女性报告子宫切除术并卵巢保留平均提前28年。绝经后20年及以上的女性对生活满意度的评价明显高于绝经后5年及以下的女性(p < 0.01)。在子宫切除术的女性中,53%的卵巢切除术患者和60%的卵巢保留患者认为子宫切除术后的生活满意度更好。只有42.2%未做子宫切除术的女性认为绝经后生活满意度更好(p < 0.001)。在调整年龄和其他协变量后,差异仍然存在:保留卵巢的子宫切除术p < 0.01,双侧卵巢切除的子宫切除术p < 0.001与不切除子宫的子宫切除术p < 0.001。即使在从未使用过雌激素的女性中,与未做过子宫切除术的女性相比,做过子宫切除术并保留卵巢的女性对生活满意度的评价明显更高(p < 0.05)。标准生活满意度评分(LSI-Z或SWLS)与子宫切除状态无差异。结论子宫切除术对生活满意度无远期不良影响。当被问及具体问题时,女性报告子宫切除术后生活满意度提高。需要切除子宫的症状缓解可能是导致这种增加的原因。这种差异可能是子宫切除术所特有的,因为用标准化方法评估的总体生活满意度没有差异。
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引用次数: 16
Evaluation of a unique oral contraceptive in the treatment of premenstrual dysphoric disorder. 评价一种独特的口服避孕药在治疗经前烦躁不安障碍。
Pub Date : 2002-03-01 DOI: 10.1089/152460902753645218
Deborah Megivern
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引用次数: 3
Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. 急性脱氢表雄酮(DHEA)对绝经后妇女性唤起的影响。
Pub Date : 2002-03-01 DOI: 10.1089/152460902753645290
L. Hackbert, J. Heiman
BACKGROUNDThe age-related decline of dehydroepiandrosterone (DHEA) has prompted research on its experimental replacement in women. Although no relationship to sexual functioning in healthy women has been shown to date, DHEA replacement has potential for affecting sexual response.METHODSTo investigate DHEA effects, 16 sexually functional postmenopausal women participated in a randomized, double-blind, crossover protocol in which oral administration of DHEA (300 mg) or placebo occurred 60 minutes before the presentation of an erotic video segment. Blood DHEA sulfate (DHEAS) changes, subjective and physiological sexual responses, as well as affective responses were measured in response to videotaped neutral and erotic video segments.RESULTSThe concentration of DHEAS increased 2-5-fold following DHEA administration in all 16 women. Subjective ratings across DHEA and placebo conditions showed significantly greater mental (p < 0.016) and physical (p < 0.036) sexual arousal to the erotic video with DHEA vs. placebo. Positive affect also increased during the erotic video across drug conditions. Vaginal pulse amplitude (VPA) and vaginal blood volume (VBV) demonstrated a significant increase (p < 0.001) between neutral and erotic film segments within both conditions (DHEA and placebo) but did not differentiate drug conditions.CONCLUSIONIn sum, increases in mental and physical sexual arousal ratings significantly increased in response to an acute dose of DHEA in postmenopausal women.
背景脱氢表雄酮(DHEA)与年龄相关的下降促使了对其在女性中的实验性替代研究。虽然到目前为止还没有发现与健康女性性功能的关系,但脱氢表雄酮替代有可能影响性反应。方法:为了研究脱氢表雄酮的作用,16名性功能正常的绝经后妇女参加了一项随机、双盲、交叉试验,在观看色情视频片段前60分钟口服脱氢表雄酮(300毫克)或安慰剂。通过对中性和情色录像片段的反应,测量受试者血液中硫酸脱氢表雄酮(DHEAS)的变化、主观和生理的性反应以及情感反应。结果16名妇女在给予脱氢表雄酮后,脱氢表雄酮浓度增加2-5倍。在DHEA和安慰剂条件下的主观评分显示,与安慰剂相比,DHEA对色情视频的精神(p < 0.016)和身体(p < 0.036)性唤起明显更高。在不同的药物条件下,色情视频中的积极情绪也有所增加。阴道脉冲振幅(VPA)和阴道血容量(VBV)在两种情况下(DHEA和安慰剂)均在中性和色情电影片段之间显着增加(p < 0.001),但在药物条件下没有差异。综上所述,急性剂量的脱氢表雄酮可显著增加绝经后妇女的精神和生理性唤起评分。
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引用次数: 83
News from the Society for Women's Health Research. Survey findings indicate a need for further education on sex-specific medical facts. 来自妇女健康研究协会的新闻。调查结果表明,需要进一步开展针对不同性别的医学事实的教育。
Pub Date : 2002-03-01 DOI: 10.1089/152460902753645236
P. Greenberger
{"title":"News from the Society for Women's Health Research. Survey findings indicate a need for further education on sex-specific medical facts.","authors":"P. Greenberger","doi":"10.1089/152460902753645236","DOIUrl":"https://doi.org/10.1089/152460902753645236","url":null,"abstract":"","PeriodicalId":80044,"journal":{"name":"Journal of women's health & gender-based medicine","volume":"93 1","pages":"101-2"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90423449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type A behavior and daily living activity among older minority women. 少数民族老年妇女的A型行为与日常生活活动。
Pub Date : 2002-03-01 DOI: 10.1089/152460902753645272
K. Eason, L. Mâsse, S. Tortolero, S. Kelder
INTRODUCTIONThe association between type A behavior pattern (TABP) and physical activity is unclear, with studies reporting both positive and negative results and some reporting no association. Because previous studies have looked primarily at the relationship between TABP and exercise, the purpose of this study was to assess the association between TABP and (1) total activity, (2) activity at work, (3) exercise, (4) household chores, (5) leisure activity, and (6) inactivity.METHODSTwo hundred twenty-seven women (111 African American, 116 Hispanic) from a larger study (Women on the Move) were used in the analysis for this study. The mean age was 49.3 years (SD 7 years), mean weight 77 kg (SD 17.6 kg), and mean body mass index (BMI) 30 (SD 6.5). As part of the Women on the Move Study, participants completed a 7-day diary and a 10-item Activity Temperament Scale. Multiple regression analysis was conducted to test the relationship between TABP and daily activity. Significant findings were observed for total activity and leisure activity with the Activity Temperament Scale summary score. Both had positive associations, indicating that those who had a higher score on the Activity Temperament Scale also had higher total activity kilocalories (kcal) and leisure activity kilocalories. Significant positive findings were also observed for total activity, leisure activity, and exercise with individual items on the Activity Temperament Scale. Household chores, work, and inactivity had significant negative associations with one or more of the individual items on the Activity Temperament Scale.CONCLUSIONSAlthough previous studies have reported on TABP and physical activity (primarily exercise), these findings provide new information specific to daily living activity by dimension in an older minority population. Results suggest a positive association between TABP and daily living activity with a general pattern of higher scores associated with higher activity and lower scores associated with higher inactivity. However, even though some significant findings were observed, the overall models did not reveal meaningful associations.
A型行为模式(TABP)与身体活动之间的关系尚不清楚,研究报告了积极和消极的结果,有些报告没有关联。由于先前的研究主要关注TABP与运动之间的关系,本研究的目的是评估TABP与(1)总活动、(2)工作活动、(3)运动、(4)家务、(5)休闲活动和(6)不活动之间的关系。方法从一项更大的研究(移动中的女性)中选取227名女性(111名非裔美国人,116名西班牙裔)用于本研究的分析。平均年龄49.3岁(SD 7年),平均体重77 kg (SD 17.6 kg),平均体重指数(BMI) 30 (SD 6.5)。作为“运动女性”研究的一部分,参与者完成了一份为期7天的日记和一份包含10个项目的活动气质量表。采用多元回归分析检验TABP与日常活动量的关系。在活动气质量表的总活动量和休闲活动量上观察到显著的结果。两者都有正相关,表明那些在活动气质量表上得分较高的人也有较高的总活动千卡(kcal)和休闲活动千卡。总体活动、休闲活动和运动在活动气质量表上的单项也有显著的积极结果。家务、工作和不活动与活动气质量表上的一个或多个单项有显著的负相关。尽管之前的研究已经报道了TABP与身体活动(主要是运动)的关系,但这些研究结果为老年少数民族人群的日常生活活动提供了新的信息。结果表明,TABP与日常生活活动之间存在正相关关系,总体模式是得分越高,活动越多,得分越低,不活动越多。然而,即使观察到一些重要的发现,整体模型并没有揭示有意义的关联。
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引用次数: 6
期刊
Journal of women's health & gender-based medicine
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