Annals of Saudi Medicine最新文献

Background: Globally, the percentage of elderly patients has been increasing, leading to a higher demand for healthcare resources and intensive care. Bahrain has a majority Muslim population and Islam governs most policies, including end-of-life care. All patients at our institute receive full resuscitative measures regardless of the prognosis, leading to a high number of mechanically ventilated patients.

Objectives: Assess characteristics, outcomes, theoretical costs, and use of antibiotics in critically ill elderly patients requiring mechanical ventilation.

Design: Retrospective.

Setting: Intensive care unit and general ward of a tertiary medical care center.

Patients and methods: We studied all elderly patients (≥60 years old) admitted under general medicine in the period of January to June 2018 who needed intensive care and were intubated.

Main outcome measures: The duration of mechanical ventilation, theoretical costs, antibiotic usage.

Sample size: 140 patients.

Results: Of 140 patients, 136 died (97%) and half of the deaths (n=69, 50.7%) occurred within the first 24 hours of intubation. Sixty-nine (79.3%) of the patients on short-term ventilation (≤96 hours) died within 24 hours of intubation, while the four survivors were on long-term ventilation (>96 hours) (P<.001). All the nonsurviving patients (n=136) were on antimicrobial therapy, mostly for hospital-acquired infections. The median (interquartile range) APACHE II score was relatively high at 28.0 (8.0) with significantly higher scores in the early mortality group compared to the late mortality group (30 [10] vs 26 [7], P=.013) and higher scores in the short-term vs long-term ventilation group (29 [10] vs 26 [7], P=.029). The median theoretical cost per patient in the early and late mortality groups was USD 10 731 and USD 30 660, respectively (P<.001).

Conclusions: Given that less than 3% of patients had a favorable outcome, 50% of the cases died within 24 hours after intubation, hospital costs and antimicrobial use were high, the current policy of "full resuscitative measures for all" should be revised. We suggest implementing an end-of-life care policy, since the goal of resuscitation is to reverse premature death, not prolong the dying process.

Limitations: Small sample size and absence of long-term follow-up. Theoretical costs were used as no direct calculated costs were available in our hospital.

Conflict of interest: None.

Background: Tobacco smoking and its harmful health effects also increase economic burdens globally. Surprisingly, despite the detrimental health consequences of smoking, some studies have shown better survival among smokers compared with non-smokers, a phenomenon called "smoker's paradox". However, the impact of smoking status on clinical outcomes in severe calcified coronary artery disease (CAD) patients has yet to be reported.

Objectives: Investigate the impact of smoking on clinical outcomes in calcified CAD receiving rotational atherectomy (RA).

Design: Retrospective review of medical records.

Setting: Multicenter registry in South Korea.

Patients and methods: This multicenter registry included consecutive patients with calcified CAD who underwent RA at nine tertiary centers in Korea between January 2010 and October 2019.

Main outcome measures: Target-vessel failure (TVF) which included the composite of cardiac death, target-vessel myocardial infarction (TVMI), and target-vessel revascularization (TVR).

Sample size: 583 lesions in 540 patients followed for a median of 16.1 months.

Results: Lesions were divided into two groups: non-smokers (n=472, 81.0%) and smokers (n=111, 19.0%). TVF in the smoker group was significantly more frequent than in non-smoker group (log rank P=.016). The inverse probability of treatment weighting analysis also showed that smoking was significantly associated with a higher incidence of the primary outcome (HR: 1.617; 95% CI: 1.127-2.320; P=.009), cardiac death (HR 1.912; 95% CI: 1.105-3.311; P=.021), myocardial infarction (HR: 3.914; 95% CI: 1.884-8.132; P<.001), TVMI (HR: 3.234; 95% CI: 1.130-9.258; P=.029), and TVR (HR: 1.661; 95% CI: 1.043-2.643; P=.032). However, any bleeding was significantly observed less in the smokers.

Conclusion: Smoking is significantly associated with adverse clinical outcomes in CAD patients requiring RA.

Limitations: Retrospective design.

Conflicts of interest: None.

Aneurysms of the splenic artery represent a rare clinical entity, even though they account for 60-70% of all visceral artery aneurysms. Splenic artery aneurysms larger than 5 cm are extremely rare, and they are considered to be giant. Possible causes of splenic artery aneurysm development include: trauma, hormonal and local hemodynamic changes in pregnancy, portal hypertension, arterial degeneration, infection and postsplenectomy occurrence. Surgical treatment of giant splenic artery aneurysms includes procedures that frequently require pancreatectomy and splenectomy. We present a case of a 10.2 cm giant splenic artery aneurysm, firmly adhered to the pancreas, which was treated surgically, with spleen and pancreas preservation. SIMILAR CASES PUBLISHED: Although many cases on treatment of giant splenic artery aneurysm have been published, the majority have described additional visceral resections associated with aneurysmectomy, which is in contrast with our report. Furthermore, aneurysms reaching 10 cm in size were extremely rare.

Background: In 2015, multiple myeloma (MM) represented 1% of all cancers and about 5% of hematologic malignancies in Saudi cancer registry. We conducted this large study because only small pilot studies have examined MM outcomes after autologous stem-cell transplantation (ASCT). The standard therapy for eligible patients is induction chemotherapy followed by ASCT.

Objectives: Determine the demographic characteristics of MM patients and the outcomes of ASCT.

Design: Retrospective.

Setting: Tumor registry database of major tertiary cancer care center in Riyadh.

Patients and methods: We identified patients with newly diagnosed MM who underwent ASCT from October 1997 to March 2015.

Main outcome measures: The demographic characteristics of MM patients and the outcomes of ASCT in the form of response evaluation, progression-free survival (PFS) and overall survival (OS).

Sample size: 169 patients with newly diagnosed MM.

Results: The median age at diagnosis was 51 years (range 23-69) and 100 (59.2%) were male. The most common immunoglobulin (Ig) subtype was IgG-kappa (80 patients; 47.6%). Most patients presented with advanced ISS stage III (75 patients; 47.5%). The cytogenetic analysis was documented in only 87 patients (51.4%); about half (48.3%) had normal cytogenetics by fluorescence in situ hybridization. Deletion 13 was present in 18.4% of patients. In post-induction therapy, 84 patients (50%) achieved a complete response, which increased to 78.1% (132 patients) after ASCT. The median PFS and OS post-transplantation were 30 and 202 months, respectively. Only one patient (<1%) died in the first 100 days after transplantation.

Conclusions: Our transplant eligible MM patients tend to be younger with a higher OS and a low ASCT-related mortality (<1%) than is reported internationally.

Limitations: Usual limitations of a retrospective analysis using registry-level data; no data on quality of life.

Conflicts of interest: None.

Background: Successful evaluation of a patient with stridor requires a thorough history and physical examination followed by a flexible fiberoptic laryngoscopy (FFL), which provides visualization of the upper airway.

Objectives: Estimate the prevalence of causes of stridor in children who underwent FFL and compare different age groups. Find any significant associations between symptoms and laryngoscopic findings. Identify patients who needed further evaluation using direct laryngobronchoscopy (DLB).

Design: Retrospective, cross-sectional.

Setting: Tertiary care center in Riyadh.

Patients and methods: We included all pediatric patients aged 1 month to 14 years who underwent fiberoptic laryngoscopy for stridor evaluation from January 2015 to January 2018 (37 months). Patients older than the age of 14 years, and patients with a workable diagnosis with adenotonsillar hypertrophy, choanal atresia, or laryngotracheo-bronchitis (croup) were excluded.

Main outcome measures: Findings of FFL.

Sample size: 217 pediatric patients.

Results: The median (interquartile range) age of the patients was 5 (8) months. Laryngomalacia was the most common diagnosis (n=149, 69%) followed by laryngopharyngeal reflux (n=42, 19%). Subglottic stenosis was the most common finding in patients who underwent DLB for further evaluation (n=19, 49%). Laryngomalacia was more frequent in children ≤12 months of age (83% vs 43% in children >12 months, P<.001). Vocal cord paralysis was more common in children >12 months of age (27% vs 9%, P<.001). FFL was effective in finding the diagnosis in 178 (82%) patients; only 39 (18%) patients needed further assessment using DLB.

Conclusion: FFL is an effective and important tool for evaluating patients with stridor.

Limitations: Retrospective design and single-centered.

Conflicts of interest: None.

Background: Helicobacter pylori infection is widespread, affecting about 50% of the global population. Polymorphisms in host genes such as the toll-like receptor 4 (TLR4) might affect the susceptibility and severity of infection and treatment success.

Objective: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.

Design: Analytical, cross-sectional.

Setting: Endoscopy clinic at tertiary care center.

Patients and methods: Genomic DNA was extracted from formalin-fixed paraffin-embedded tissues collected from H pylori-infected patients and healthy individuals. The single nucleotide polymorphisms (SNPs) within the targeted TLR genes were genotyped to assess the genetic association of various SNPs with disease severity.

Main outcome measures: Effect of genotype distribution on H pylori infection.

Sample size: 250 peptic ulcer patients and 217 controls.

Results: The TLR10 genotype showed no significant association with H pylori infection except for rs10004195 (T>A) (P=.002). The genotype frequency of Rs5744174 in TLR5 had a significant association with the presence of H pylori infection (P=.046, OR=0.52). Except for gender (P=.022), there were no significant associations between clinical and demographic variables and SNPs relating to the severity of the H pylori infections.

Conclusions: Our findings are consistent with differences in severity of H pylori infection due to TLR SNPs in different ethnic groups. Understanding differences in genetic susceptibility could help in classifying patients and matching patients with various treatment options on a genetic basis.

Limitations: Lack of H pylori pathogenicity features assessment.

Conflicts of interest: None.

Background: Multiple studies have investigated medication errors in hospitals in Saudi Arabia; however, prevalence data on prescribing errors and associated factors remains uncertain.

Objective: Assess the prevalence, type, severity, and factors associated with prescribing errors.

Design: Retrospective database review.

Setting: Large tertiary care setting in Riyadh.

Patients and methods: We described and analyzed data related to prescribing errors in adults (>14 years of age) from the Medication Error Electronic Report Forms database for the two-year period from January 2017 to December 2018.

Main outcome measure: The prevalence of prescribing errors and associated factors among adult patients.

Sample size: 315 166 prescriptions screened.

Results: Of the total number of inpatient and outpatient prescriptions screened, 4934 prescribing errors were identified for a prevalence of 1.56%. The most prevalent types of prescribing errors were improper dose (n=1516; 30.7%) and frequency (n=987; 20.0%). Two-thirds of prescribing errors did not cause any harm to patients. Most prescribing errors were made by medical residents (n=2577; 52%) followed by specialists (n=1629; 33%). Prescribing errors were associated with a lack of documenting clinical information (adjusted odds ratio: 14.1; 95% CI 7.7-16.8, P<.001) and prescribing anti-infective medications (adjusted odds ratio 2.9; 95% CI 1.3-5.7, P<.01).

Conclusion: Inadequate documentation in electronic health records and prescribing of anti-infective medications were the most common factors for predicting prescribing errors. Future studies should focus on testing innovative measures to control these factors and their impact on minimizing prescribing errors.

Limitations: Polypharmacy was not considered; the data are from a single healthcare system.

Conflict of interest: None.

Background: Hearing loss is an underestimated comorbid condition in type 2 diabetes.

Objectives: Investigate hearing loss as a comorbidity associated with type 2 diabetes mellitus and evaluate the factors associated with hearing loss.

Design: Cross-sectional.

Setting: Tertiary care center, diabetes clinic.

Patients and methods: Patients with type 2 diabetes, aged 30 to 60 years, were randomly selected to participate. All patients underwent clinical ear examinations and were referred for full audiological evaluation. Otoacoustic emission was used to assess inner function, tympanometry to assess middle-ear function, and pure tone air/bone audiometry to assess hearing sensitivity. Risk factors for hearing loss were assessed by multivariate logistic regression.

Main outcome measure: Frequency, severity and risk factors for hearing loss.

Sample size: 157 RESULTS: Of the 157 patients, 77 had hearing loss in both ears (49.0%), 13 in the right ear only (8.3%), 14 in the left ear only (8.9%), and 53 (33.8%) had normal hearing. In the 181 ears with sensorineural hearing loss, 90 had mild loss (49.7%), 69 moderate loss (38.2%), 16 severe loss (8.8%) and 6 had profound loss (3.3%). Disabling hearing loss was observed in 46 (29%) patients. A higher frequency of hearing loss was present in patients with glycated hemoglobin levels ≥8%. In the multivariate logistic regression analysis, the most important factors associated with hearing loss were longer diabetes duration, poor glycemic control and the presence of hypertension.

Conclusions: Hearing loss is an underestimated comorbid condition in type 2 diabetes that warrants frequent hearing assessments and management. Strict glycemic and hypertension control is essential for the minimization of the effects of diabetes on hearing sensitivity.

Limitations: Small sample size, limited age window (30-60 years), which was chosen to eliminate the natural aging effect on hearing. Cross-sectional nature was not ideal for the assessment of causality.

Conflict of interest: None.

Background: Trauma is one of the leading causes of pediatric mortality so the prevention of pediatric trauma is an important goal of any healthcare system. There are only a few studies on pediatric trauma in Saudi Arabia. The availability of data is vital for healthcare leaders in planning for healthcare services.

Objective: Assess the epidemiology, patterns, and outcome of trauma in the pediatric population in the Qassim region in Saudi Arabia.

Design: Descriptive medical records review.

Setting: A single-center, academic specialized pediatric referral hospital.

Patients and methods: We reviewed all electronic and paper records for children (<14 years of age) admitted with a diagnosis of trauma to Maternity and Childrens Hospital (MCH) in Buraidah city in the two-year period between January 2017 and December 2018.

Main outcome measure: Type of injury, length of stay, and mortality.

Sample size: 133 children.

Result: In this cohort, 77 cases (58%) were admitted to the pediatric intensive care unit (PICU) and 56 (42%) to the pediatric surgery ward. The median (interquartile range) age was 5 (1.1-8) years, and 92 (69%) were boys. The most frequent trauma was road traffic accidents, accounting for 70 cases (52%), followed by fall from a height for 40 (30%) cases. Traumatic brain injury was the most frequent type of injury, accounting for 56 cases (42%), and blunt abdominal trauma was in 11 cases (8.3%). Neurosurgery was the primary subspecialty actively involved in 62 cases (47%). Of the injured children who were admitted to PICU, 36 (46%) needed mechanical ventilation support, while 7 (9%) of those admitted to PICU required the insertion of intra-costal drainage. The mortality in our study was 3.7% (5 cases); 4 of 5 deaths were secondary to road traffic accidents.

Conclusion: Pediatric trauma is a serious problem in our region with high mortality compared to international benchmarks. Road traffic accidents are the leading type of pediatric trauma, followed by falls from height. Further studies and perhaps national efforts are needed to identify ways to prevent road traffic accidents, and optimize the data registry and trauma services.

Limitation: There were many missing data and incomplete files that affect accuracy and preclude generalization.

Conflict of interest: None.

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19).

Objectives: Investigate the relationship between ACE I/D polymorphism and the clinical severity of COVID-19.

Design: Prospective cohort study.

Setting: Tertiary care hospital.

Patients and methods: The study included COVID-19 patients with asymptomatic, mild, and severe disease with clinical data and whole blood samples collected from 1 April 2020 to 1 July 2020. ACE I/D genotypes were determined by polymerase chain reaction and agarose gel electrophoresis.

Main outcome measure: ACE DD, DI and II genotypes frequencies.

Sample size: 90 cases, 30 in each disease severity group.

Results: Age and the frequency of general comorbidity increased significantly from the asymptomatic disease group to the severe disease group. Advanced age, diabetes mellitus and presence of ischemic heart disease were independent risk factors for severe COVID-19 [OR and 95 % CI: 1.052 (1.021-1.083), 5.204 (1.006-26.892) and 5.922 (1.109-31.633), respectively]. The ACE II genotype was the dominant genotype (50%) in asymptomatic patients, while the DD genotype was the dominant genotype (63.3 %) in severe disease. The ACE II geno-type was protective against severe COVID-19 [OR and 95% CI: .323 (.112-.929)]. All nine patients (8.9%) who died had severe disease.

Conclusions: The clinical severity of COVID-19 infection may be associated with the ACE I/D polymorphism.

Limitations: Small sample size and single center.

Conflict of interest: None.