Therapy for alopecia areata (AA) in pediatric patients is challenging and unstandardized. Common treatments for alopecia include topical agents, triamcinolone injections, and systemic agents. Treatment using systemic agents in children is controversial due to possible negative side effects and the need for long term therapy because of potential relapse after cessation. The purpose of this study was to evaluate the efficacy and safety of methotrexate therapy for the treatment of AA in pediatric patients.
{"title":"Retrospective Analysis of Pediatric Alopecia Areata Treated with Methotrexate","authors":"E. Correia","doi":"10.36959/661/318","DOIUrl":"https://doi.org/10.36959/661/318","url":null,"abstract":"Therapy for alopecia areata (AA) in pediatric patients is challenging and unstandardized. Common treatments for alopecia include topical agents, triamcinolone injections, and systemic agents. Treatment using systemic agents in children is controversial due to possible negative side effects and the need for long term therapy because of potential relapse after cessation. The purpose of this study was to evaluate the efficacy and safety of methotrexate therapy for the treatment of AA in pediatric patients.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88123084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kondo Rogério Nabor, Cestari Ariane Itimura, Soares Bruno Mendes, Scalone Fabiana De Mari, Yabar Silvia Irla Alfaro
Introduction: Basal cell carcinoma (BCC) is the most common skin cancer. When located in the nasal region and the resulting defect is greater than 3 centimeters becomes challenging for the dermatological surgeon. The pinwheel technique (PWT) is a rotating flap to correct defects, mainly on the scalp, but we use it to close two nasal defects after CBC excision. Objectives and methods: We report two cases of BCCs located in the nasal region and reconstructed with a pinwheel flap. Results and conclusions: In both cases, the results were satisfactory, both for cosmetics and functionality.
{"title":"Pinwheel Flap as an Option to Reconstruct a Nasal Defect: A Series of Two Cases","authors":"Kondo Rogério Nabor, Cestari Ariane Itimura, Soares Bruno Mendes, Scalone Fabiana De Mari, Yabar Silvia Irla Alfaro","doi":"10.36959/661/317","DOIUrl":"https://doi.org/10.36959/661/317","url":null,"abstract":"Introduction: Basal cell carcinoma (BCC) is the most common skin cancer. When located in the nasal region and the resulting defect is greater than 3 centimeters becomes challenging for the dermatological surgeon. The pinwheel technique (PWT) is a rotating flap to correct defects, mainly on the scalp, but we use it to close two nasal defects after CBC excision. Objectives and methods: We report two cases of BCCs located in the nasal region and reconstructed with a pinwheel flap. Results and conclusions: In both cases, the results were satisfactory, both for cosmetics and functionality.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87614112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Calcium channel blockers are frequently used for treatment of hypertension. Studies have reported hyperpigmentation secondary to calcium channel blockers, although cases are limited and mostly related to diltiazem and nifedipine. To our knowledge, there are only two cases describing hyperpigmentation secondary to amlodipine.
{"title":"Amlodipine-Induced Hyperpigmentation","authors":"Hal Harper","doi":"10.36959/661/316","DOIUrl":"https://doi.org/10.36959/661/316","url":null,"abstract":"Calcium channel blockers are frequently used for treatment of hypertension. Studies have reported hyperpigmentation secondary to calcium channel blockers, although cases are limited and mostly related to diltiazem and nifedipine. To our knowledge, there are only two cases describing hyperpigmentation secondary to amlodipine.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80044808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carpio-Orantes Luis Del, Sánchez Salvador, Moguel Karla Gabriela-Peniche, Aparicio-Sánchez Elisa Estefania, Segura-Rodríguez Orlando Israel, Aguilar-Silva Andrés, G. Omar, E. Alejandro, Velasco-Caicero Andrés Realino, Segovia Olga González, Pacheco-Perez Ernesto Javier
This syndrome is characterized by necrohemorrhage of the adrenal glands in the course of a serious infectious disease, which is characterized by septic shock with multiple organ failure (prevailing neurological, renal and hematological failure even with criteria for disseminated intravascular coagulation), disseminated purpura and data on acute adrenal insufficiency. Initially described by an English physician in 1911, Dr. Rupert Waterhouse and later studied further by a Danish pediatrician, Dr. Carl Friderichsen in 1917 [1-3].
{"title":"Waterhouse Friderichsen Syndrome Report of Two Cases","authors":"Carpio-Orantes Luis Del, Sánchez Salvador, Moguel Karla Gabriela-Peniche, Aparicio-Sánchez Elisa Estefania, Segura-Rodríguez Orlando Israel, Aguilar-Silva Andrés, G. Omar, E. Alejandro, Velasco-Caicero Andrés Realino, Segovia Olga González, Pacheco-Perez Ernesto Javier","doi":"10.36959/661/312","DOIUrl":"https://doi.org/10.36959/661/312","url":null,"abstract":"This syndrome is characterized by necrohemorrhage of the adrenal glands in the course of a serious infectious disease, which is characterized by septic shock with multiple organ failure (prevailing neurological, renal and hematological failure even with criteria for disseminated intravascular coagulation), disseminated purpura and data on acute adrenal insufficiency. Initially described by an English physician in 1911, Dr. Rupert Waterhouse and later studied further by a Danish pediatrician, Dr. Carl Friderichsen in 1917 [1-3].","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78647253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carpio-Orantes Luis Del, G. Sergio, Sánchez Salvador, Peniche-Moguel Karla Gabriela, Aparicio-Sánchez Elisa Estefania, Segura-Rodríguez Orlando Israel, Aguilar-Silva Andrés, G. Omar, E. Alejandro, Ahumada-Zamudio Azael, Velasco-Caicero Andrés Realino, González-Segovia Olga, Pacheco-Perez Ernesto Javier
A large number of viral infections are characterized by the presence of cutaneous manifestations. Multiple dermatological manifestations have been observed in patients with COVID-19, however, among the main challenges that dermatology faces is the difficult relationship between the appearance of dermatological lesions with the infection itself, as well as the poor description of the lesions that are normally determined only as “rash” [1-4].
{"title":"Dermatological Manifestations in Patients with COVID-19 Pneumonia in Veracruz, Mexico","authors":"Carpio-Orantes Luis Del, G. Sergio, Sánchez Salvador, Peniche-Moguel Karla Gabriela, Aparicio-Sánchez Elisa Estefania, Segura-Rodríguez Orlando Israel, Aguilar-Silva Andrés, G. Omar, E. Alejandro, Ahumada-Zamudio Azael, Velasco-Caicero Andrés Realino, González-Segovia Olga, Pacheco-Perez Ernesto Javier","doi":"10.36959/661/314","DOIUrl":"https://doi.org/10.36959/661/314","url":null,"abstract":"A large number of viral infections are characterized by the presence of cutaneous manifestations. Multiple dermatological manifestations have been observed in patients with COVID-19, however, among the main challenges that dermatology faces is the difficult relationship between the appearance of dermatological lesions with the infection itself, as well as the poor description of the lesions that are normally determined only as “rash” [1-4].","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74838564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Therapy for alopecia areata (AA) in a pediatric patient population is challenging and controversial. Common treatments include a variety of topical or injected agents. Systemic steroid treatment in children is controversial due to concern of negative side effects. The purpose of this study was to evaluate the efficacy and safety of systemic corticosteroid therapy for the treatment of AA in pediatric patients. Methods: This retrospective chart review included patients treated with standard courses of oral corticosteroids (3-week taper starting at 1 mg/kg) for AA who were managed by the Dermatology Section at the Children’s Hospital of Philadelphia between 2015 and 2018. The following data was extracted from patients’ charts: Severity of disease measured by Severity of Alopecia Tool (SALT) scores for AA, treatment regimen, duration of treatment and number of steroid courses, side effects, age, gender, and weight percentiles. SALT scores and weight percentiles were recorded at pretreatment as well as at 3 months and 6 months after initiation of treatment. SALT scores, when available, were additionally recorded at 9, 12, and 15 months after initiation of treatment. Results: 82 pediatric subjects were included in the study. Subjects were grouped according to severity at pretreatment with systemic corticosteroids with < 50% SALT as mild and > 50% SALT as Severe. Subjects in the > 50% SALT score group followed at 5 intervals (pre-treatment, 3 months, 6 months, 9 months, 12 months, 15 months) showed statistically-significant improvement/lowering of SALT scores, while subjects in the < 50% SALT group did not over the same time period. No serious adverse side effects were documented in any subjects treated. However, 67 patients of a total of 82 studied relapsed during the time intervals observed. The average time to relapse was 21.9 weeks after initiation of treatment (standard deviation: 16.76 weeks; range: 4.71 to 73.43 Additionally, weight percentiles a statistically significant baseline. Conclusion: Patients with baseline SALT scores ≥ 50 improved significantly after a course of systemic steroids but relapsed on average 4-5 months later with concomitant weight gain.
{"title":"Retrospective Analysis of Systemic Corticosteroids for Alopecia Areata in Pediatric Patients","authors":"Tamazian Shant, Rogers Rachel, C. Leslie","doi":"10.36959/661/313","DOIUrl":"https://doi.org/10.36959/661/313","url":null,"abstract":"Background: Therapy for alopecia areata (AA) in a pediatric patient population is challenging and controversial. Common treatments include a variety of topical or injected agents. Systemic steroid treatment in children is controversial due to concern of negative side effects. The purpose of this study was to evaluate the efficacy and safety of systemic corticosteroid therapy for the treatment of AA in pediatric patients. Methods: This retrospective chart review included patients treated with standard courses of oral corticosteroids (3-week taper starting at 1 mg/kg) for AA who were managed by the Dermatology Section at the Children’s Hospital of Philadelphia between 2015 and 2018. The following data was extracted from patients’ charts: Severity of disease measured by Severity of Alopecia Tool (SALT) scores for AA, treatment regimen, duration of treatment and number of steroid courses, side effects, age, gender, and weight percentiles. SALT scores and weight percentiles were recorded at pretreatment as well as at 3 months and 6 months after initiation of treatment. SALT scores, when available, were additionally recorded at 9, 12, and 15 months after initiation of treatment. Results: 82 pediatric subjects were included in the study. Subjects were grouped according to severity at pretreatment with systemic corticosteroids with < 50% SALT as mild and > 50% SALT as Severe. Subjects in the > 50% SALT score group followed at 5 intervals (pre-treatment, 3 months, 6 months, 9 months, 12 months, 15 months) showed statistically-significant improvement/lowering of SALT scores, while subjects in the < 50% SALT group did not over the same time period. No serious adverse side effects were documented in any subjects treated. However, 67 patients of a total of 82 studied relapsed during the time intervals observed. The average time to relapse was 21.9 weeks after initiation of treatment (standard deviation: 16.76 weeks; range: 4.71 to 73.43 Additionally, weight percentiles a statistically significant baseline. Conclusion: Patients with baseline SALT scores ≥ 50 improved significantly after a course of systemic steroids but relapsed on average 4-5 months later with concomitant weight gain.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"13 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91257447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Stessy, Potop Diana, Chalhoub Khalil, Verdier Emmanuelle, Auger Marie, Levard Guillaume, Mcheik Jiad N
Background: Cystic lymphangioma (CL) is a rare and benign tumor derived from the lymphatic system that can have different localisations. This tumor consists of several numbers of cysts that have cavity-like appearance. During childhood, cystic lymphangiomas are as common in boys as in girls (sex ratio 1:1). This lesion can have a sudden onset, a rapid growth or stability and can even regress spontaneously. It has a variable clinical presentation and sometimes can be asymptomatic. For this rare malformation the final diagnosis is a histological confirmation. Case presentation: We present the case of a 7-year-old girl that was diagnosed before birth with a retroperitoneal CL by ultrasound and Magnetic Resonance Imaging (MRI) with a left lumbar subcutaneous extension associated with a cutaneous lymphangioma. This retroperitoneal lesion remained asymptomatic, non visible clinically and it had a spontaneous resolution without any treatment; however, the cutaneous lesion kept evol-ving. Conclusion: The diagnosis of CL can be made by imaging during the prenatal period and sometimes during adulthood. The usual treatment for asymptomatic CL is regular clinical and radiological monitoring. However for symptomatic lesions the first line treatment is surgery. In our case, surgical treatment was performed only for the skin lesions.
{"title":"Retroperitoneal Cystic Lymphangioma: A Case Report of Spontaneous Regression and Review of Literature","authors":"K. Stessy, Potop Diana, Chalhoub Khalil, Verdier Emmanuelle, Auger Marie, Levard Guillaume, Mcheik Jiad N","doi":"10.36959/661/309","DOIUrl":"https://doi.org/10.36959/661/309","url":null,"abstract":"Background: Cystic lymphangioma (CL) is a rare and benign tumor derived from the lymphatic system that can have different localisations. This tumor consists of several numbers of cysts that have cavity-like appearance. During childhood, cystic lymphangiomas are as common in boys as in girls (sex ratio 1:1). This lesion can have a sudden onset, a rapid growth or stability and can even regress spontaneously. It has a variable clinical presentation and sometimes can be asymptomatic. For this rare malformation the final diagnosis is a histological confirmation. Case presentation: We present the case of a 7-year-old girl that was diagnosed before birth with a retroperitoneal CL by ultrasound and Magnetic Resonance Imaging (MRI) with a left lumbar subcutaneous extension associated with a cutaneous lymphangioma. This retroperitoneal lesion remained asymptomatic, non visible clinically and it had a spontaneous resolution without any treatment; however, the cutaneous lesion kept evol-ving. Conclusion: The diagnosis of CL can be made by imaging during the prenatal period and sometimes during adulthood. The usual treatment for asymptomatic CL is regular clinical and radiological monitoring. However for symptomatic lesions the first line treatment is surgery. In our case, surgical treatment was performed only for the skin lesions.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88547923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GRANULOMA ANNULARE.","authors":"A. Falk, S. Bielinski, J. Bettenhausen","doi":"10.32388/57lol5","DOIUrl":"https://doi.org/10.32388/57lol5","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"89 1","pages":"624"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48819899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Telangiectasia.","authors":"S. Friedman, W. P. Su, J. A. Doyle","doi":"10.32388/drp1pu","DOIUrl":"https://doi.org/10.32388/drp1pu","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"121 12 1","pages":"1484"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47469948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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