{"title":"Striae.","authors":"J. Stroud, J. V. Van Dersarl","doi":"10.32388/2zaswy","DOIUrl":"https://doi.org/10.32388/2zaswy","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"103 1 1","pages":"103-4"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44337333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Markou, M. Pagoni, T. Tegos, G. Andreou, D. Rontogianni, Nicolaos Harhalakis
A 64-year-old man was admitted to the Hematology ward in July 2012 due to neutropenia and thrombocytopenia. The only symptom in the month preceding his admission was significant weight loss. Based on clinical and laboratory investigations, specifically bone marrow aspiration and biopsy (Figure), the patient was diagnosed with aggressive systemic mastocytosis (WHO 2008 ICD-0 code 9741/3). The patient initially received treatment with cladribine 8.5 mg once daily in 2-hour intravenous infusion for a 5-day period/28-day cycle. Following the completion of a 5-cycle treatment course with cladribine, thrombocytopenia improved, but there was no significant change in neutropenia, while the hematocrit remained stable. However, the patient did not show any clinical improvement. Thus, he was reevaluated with bone marrow biopsy, which showed 40% infiltration by malignant mast cells. There was underlying disease of myeloblastic/myeloproliferative neoplasm unclassifiable with 3% IMAGES IN MEDICINE
{"title":"Systemic mastocytosis.","authors":"I. Markou, M. Pagoni, T. Tegos, G. Andreou, D. Rontogianni, Nicolaos Harhalakis","doi":"10.32388/qzbfdh","DOIUrl":"https://doi.org/10.32388/qzbfdh","url":null,"abstract":"A 64-year-old man was admitted to the Hematology ward in July 2012 due to neutropenia and thrombocytopenia. The only symptom in the month preceding his admission was significant weight loss. Based on clinical and laboratory investigations, specifically bone marrow aspiration and biopsy (Figure), the patient was diagnosed with aggressive systemic mastocytosis (WHO 2008 ICD-0 code 9741/3). The patient initially received treatment with cladribine 8.5 mg once daily in 2-hour intravenous infusion for a 5-day period/28-day cycle. Following the completion of a 5-cycle treatment course with cladribine, thrombocytopenia improved, but there was no significant change in neutropenia, while the hematocrit remained stable. However, the patient did not show any clinical improvement. Thus, he was reevaluated with bone marrow biopsy, which showed 40% infiltration by malignant mast cells. There was underlying disease of myeloblastic/myeloproliferative neoplasm unclassifiable with 3% IMAGES IN MEDICINE","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"92 4 1","pages":"481-2"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48667081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-07DOI: 10.3109/9780203493397-11
A. W. Gulick
{"title":"Condyloma acuminatum.","authors":"A. W. Gulick","doi":"10.3109/9780203493397-11","DOIUrl":"https://doi.org/10.3109/9780203493397-11","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"114 5 1","pages":"798"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41378737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Keratosis.","authors":"W. Reed, P. Porter","doi":"10.32388/144uov","DOIUrl":"https://doi.org/10.32388/144uov","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"104 1 1","pages":"99-100"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46101461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-07DOI: 10.1007/3-540-29668-9_610
R. T. Jessen, S. Thompson, E. Smith
{"title":"Cobb syndrome.","authors":"R. T. Jessen, S. Thompson, E. Smith","doi":"10.1007/3-540-29668-9_610","DOIUrl":"https://doi.org/10.1007/3-540-29668-9_610","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"113 11 1","pages":"1587-90"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47185389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Angiolipoma.","authors":"W. R. Howard, E. B. Helwig","doi":"10.32388/5pj88b","DOIUrl":"https://doi.org/10.32388/5pj88b","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"82 1","pages":"924-31"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48621677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Progeria, also known as the Hutchinson-Gilford syndrome, is an extremely rare condition that was initially reported by Johnathan Hutchinson in 1886 and further described by Hastings Gilford in 1904. Transmission is most likely from a sporadic autosomal dominant mutation. Clinical manifestations are evident by the first or second year of life and include the physical characteristics usually associated with the elderly. Mentally, patients are alert and attentive with normal intelligence and emotions. Histopathologic changes occur primarily in the skin, bone, and cardiovascular tissues, while other organs appear to be unaffected. Laboratory findings are unremarkable, with the exception of an increased urinary excretion of hyaluronic acid. The diagnosis rests on the clinical presentation; at present, no treatment has been proved to be effective. Death results from cardiovascular abnormalities in the majority of cases and usually occurs between the ages of 10 and 15 years. Current research suggests an underlying defect of hyaluronic acid that may possibly account for the entire process.
{"title":"Progeria.","authors":"A. Badame","doi":"10.32388/u4h9hj","DOIUrl":"https://doi.org/10.32388/u4h9hj","url":null,"abstract":"Progeria, also known as the Hutchinson-Gilford syndrome, is an extremely rare condition that was initially reported by Johnathan Hutchinson in 1886 and further described by Hastings Gilford in 1904. Transmission is most likely from a sporadic autosomal dominant mutation. Clinical manifestations are evident by the first or second year of life and include the physical characteristics usually associated with the elderly. Mentally, patients are alert and attentive with normal intelligence and emotions. Histopathologic changes occur primarily in the skin, bone, and cardiovascular tissues, while other organs appear to be unaffected. Laboratory findings are unremarkable, with the exception of an increased urinary excretion of hyaluronic acid. The diagnosis rests on the clinical presentation; at present, no treatment has been proved to be effective. Death results from cardiovascular abnormalities in the majority of cases and usually occurs between the ages of 10 and 15 years. Current research suggests an underlying defect of hyaluronic acid that may possibly account for the entire process.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"125 4 1","pages":"540-4"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45730959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-02DOI: 10.1007/springerreference_42042
Paul K. Shitabata
{"title":"Osteoma Cutis","authors":"Paul K. Shitabata","doi":"10.1007/springerreference_42042","DOIUrl":"https://doi.org/10.1007/springerreference_42042","url":null,"abstract":"","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52972793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：