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Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective. 慢性丙型肝炎：从巴西视角看流行病学和管理证据概述。
IF 1.8
Pediatric news
Pub Date : 2015-01-01 Epub Date: 2015-11-29 DOI: 10.1155/2015/852968
Rodolfo Castro, Hugo Perazzo, Beatriz Grinsztejn, Valdilea G Veloso, Chris Hyde

Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.

慢性丙型肝炎仍然是全球慢性肝病的主要病因之一，其自然病史各不相同，从轻微变化到晚期纤维化、肝硬化及其并发症，如肝细胞癌的发展。据估计，巴西约有 145 万人感染了丙型肝炎病毒，这是一个重大的公共卫生问题。本文旨在从巴西的角度回顾慢性丙型肝炎的流行病学和管理。慢性丙型肝炎的管理面临的挑战包括：使用非侵入性方法对肝纤维化进行分期，以替代肝活检；不含干扰素的新型抗病毒治疗费用高昂。此外，会议还讨论了对丙型肝炎进行成本效益分析的必要性以及近期治疗方案的变化。
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引用次数: 0
Physician groups angle for action on SGR in 2013 医生团体在2013年对SGR采取行动
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70001-8
M. Schneider
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引用次数: 0
Marijuana is most popular drug of abuse among teens 大麻是青少年最常滥用的毒品
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70004-3
A. Ault
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引用次数: 0
Antipsychotics may increase iron depletion in autism 抗精神病药物可能会增加自闭症患者的铁流失
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70014-6
S. Boschert
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引用次数: 0
Do we have the courage to demand change 我们有勇气要求改变吗
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70015-8
S. J. Yoffe
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引用次数: 1
PCV13 vaccine benefits extend to nonimmune kids PCV13疫苗的益处扩展到未免疫的儿童
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70003-1
S. London
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引用次数: 0
CF, mental retardation often comorbid with epilepsy CF，智力迟钝常与癫痫共病
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70006-7
D. Brunk
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引用次数: 0
The sword of Damocles 达摩克利斯之剑
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70019-5
Kevin T. Powell
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引用次数: 0
Help parents to address children's fears about frightening news 帮助父母解决孩子对可怕消息的恐惧
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70002-X
Susan D. Swick, M. Jellinek
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引用次数: 0
Antibiotic stewardship crucial in NICU, CF patients 抗生素管理对新生儿重症监护室、CF患者至关重要
Pediatric news
Pub Date : 2013-01-01 DOI: 10.1016/S0031-398X(13)70007-9
D. Brunk
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引用次数: 0
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