Yu Ri Woo, Arum Choi, Seo Won Song, Suyeun Kim, Sang Wook Son, Sang Hyun Cho, Sukil Kim, Jung Eun Kim
Cyclosporine (CS) is a first-line immunosuppressive agent used to manage moderate to severe atopic dermatitis (AD). To date, the risk of developing hypertension associated with the long-term use of low-dose CS in AD patients is understudied.
{"title":"Risk of Developing Hypertension in Atopic Dermatitis Patients Receiving Long-term and Low-dose Cyclosporine: A Nationwide Population-based Cohort Study.","authors":"Yu Ri Woo, Arum Choi, Seo Won Song, Suyeun Kim, Sang Wook Son, Sang Hyun Cho, Sukil Kim, Jung Eun Kim","doi":"10.5021/ad.23.099","DOIUrl":"https://doi.org/10.5021/ad.23.099","url":null,"abstract":"Cyclosporine (CS) is a first-line immunosuppressive agent used to manage moderate to severe atopic dermatitis (AD). To date, the risk of developing hypertension associated with the long-term use of low-dose CS in AD patients is understudied.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"58 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Ho Bae, Jun Ho Kwak, Chan Ho Na, Min Sung Kim, Bong Seok Shin, Hoon Choi
Acne is a common skin inflammatory condition that can significantly affect the patient's quality of life. Therefore, accurate assessment scales are very important for treatment and management of acne vulgaris. This review article issues a comprehensive review of various acne severity assessment scales. In this text, the authors review the acne grading scales, such as the Pillsbury scale, Cook's acne grading scale, Leeds acne grading system, Global Acne Grading System, and investigator's global assessment, etc. And we delve into the characteristics, advantages, limitations, and applicability of these scales. The acne grading scale to be developed in the future should be objective, accurate, comprehensive, easy to use, and applicable in a variety of clinics and research settings. Current technologies, such as artificial intelligence, could potentially contribute to the development of ideal acne grading scales that meet unmet needs.
{"title":"A Comprehensive Review of the Acne Grading Scale in 2023.","authors":"In Ho Bae, Jun Ho Kwak, Chan Ho Na, Min Sung Kim, Bong Seok Shin, Hoon Choi","doi":"10.5021/ad.23.094","DOIUrl":"https://doi.org/10.5021/ad.23.094","url":null,"abstract":"Acne is a common skin inflammatory condition that can significantly affect the patient's quality of life. Therefore, accurate assessment scales are very important for treatment and management of acne vulgaris. This review article issues a comprehensive review of various acne severity assessment scales. In this text, the authors review the acne grading scales, such as the Pillsbury scale, Cook's acne grading scale, Leeds acne grading system, Global Acne Grading System, and investigator's global assessment, etc. And we delve into the characteristics, advantages, limitations, and applicability of these scales. The acne grading scale to be developed in the future should be objective, accurate, comprehensive, easy to use, and applicable in a variety of clinics and research settings. Current technologies, such as artificial intelligence, could potentially contribute to the development of ideal acne grading scales that meet unmet needs.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myoung Eun Choi, Woo Jin Lee, Joo Yeon Ko, Kwang Joong Kim, Jung Eun Kim, Hei Sung Kim, Kui Young Park, Mi Youn Park, Dae Hun Suh, Kihyuk Shin, Min Kyung Shin, Hyo Hyun Ahn, Weon Ju Lee, Jee Bum Lee, Hee Jung Lee, Min Soo Jang, Seung Hyun Cheong, Soyun Cho, Yu Sung Choi, You Won Choi, Hoon Choi, Mi Woo Lee
Daily usage of facial masks during coronavirus disease 2019 pandemic influenced on facial dermatoses.
2019 年冠状病毒疾病大流行期间口罩的日常使用对面部皮肤病的影响。
{"title":"Facial Dermatoses Associated With Mask-Wearing in the COVID-19 Era: A Nationwide, Cross-Sectional, Multicenter, Questionnaire-based Study.","authors":"Myoung Eun Choi, Woo Jin Lee, Joo Yeon Ko, Kwang Joong Kim, Jung Eun Kim, Hei Sung Kim, Kui Young Park, Mi Youn Park, Dae Hun Suh, Kihyuk Shin, Min Kyung Shin, Hyo Hyun Ahn, Weon Ju Lee, Jee Bum Lee, Hee Jung Lee, Min Soo Jang, Seung Hyun Cheong, Soyun Cho, Yu Sung Choi, You Won Choi, Hoon Choi, Mi Woo Lee","doi":"10.5021/ad.23.061","DOIUrl":"https://doi.org/10.5021/ad.23.061","url":null,"abstract":"Daily usage of facial masks during coronavirus disease 2019 pandemic influenced on facial dermatoses.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"47 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jee Woo Kim, Min Jae Kim, Kyungho Paik, Bo Ri Kim, Chong Won Choi, Jung-Im Na
Allergic diseases include atopic dermatitis (AD) and allergic rhinitis (AR), which are chronic, relapsing inflammatory disorders of the skin or mucosa that usually accompany immunoglobulin E-mediated immune responses. They are complex, multifactorial diseases with an etiology involving interactions between genetic and environmental factors.
过敏性疾病包括特应性皮炎（AD）和过敏性鼻炎（AR），它们是皮肤或粘膜的慢性、复发性炎症性疾病，通常伴有免疫球蛋白 E 介导的免疫反应。它们是复杂的多因素疾病，病因涉及遗传和环境因素之间的相互作用。
{"title":"Genome-wide Association Study of Susceptibility Loci for Self-Reported Atopic Dermatitis and Allergic Rhinitis in the Korean Population.","authors":"Jee Woo Kim, Min Jae Kim, Kyungho Paik, Bo Ri Kim, Chong Won Choi, Jung-Im Na","doi":"10.5021/ad.22.160","DOIUrl":"https://doi.org/10.5021/ad.22.160","url":null,"abstract":"Allergic diseases include atopic dermatitis (AD) and allergic rhinitis (AR), which are chronic, relapsing inflammatory disorders of the skin or mucosa that usually accompany immunoglobulin E-mediated immune responses. They are complex, multifactorial diseases with an etiology involving interactions between genetic and environmental factors.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"243 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eun Ji Hong, Hee Jung Yoon, Min Jung Kwon, Jae Yun Kim, Jung Eun Kim, Young Lip Park, SangHoon Lee, Youin Bae, Sul Hee Lee
Biologics have demonstrated high efficacy in achieving 'almost complete' skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving 'complete' skin clearance remains a treatment goal for some highly biologics-resistant patients, as residual lesions impact their quality of life.
{"title":"Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics: A Retrospective Chart Review.","authors":"Eun Ji Hong, Hee Jung Yoon, Min Jung Kwon, Jae Yun Kim, Jung Eun Kim, Young Lip Park, SangHoon Lee, Youin Bae, Sul Hee Lee","doi":"10.5021/ad.23.074","DOIUrl":"https://doi.org/10.5021/ad.23.074","url":null,"abstract":"Biologics have demonstrated high efficacy in achieving 'almost complete' skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving 'complete' skin clearance remains a treatment goal for some highly biologics-resistant patients, as residual lesions impact their quality of life.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"14 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Huygen, Pauline Marie Thys, Andreas Wollenberg, Jan Gutermuth, Inge Kortekaas Krohn
Skin barrier function assessment is commonly done by measuring transepidermal water loss (TEWL). An important limitation of this method is the influence of intrinsic and extrinsic factors. Electrical impedance spectroscopy (EIS) is a lesser-established method for skin barrier function assessment. Some influential factors have been described, but no guidelines exist regarding the standardization of these measurements.
{"title":"Skin Barrier Function Assessment: Electrical Impedance Spectroscopy Is Less Influenced by Daily Routine Activities Than Transepidermal Water Loss.","authors":"Lisa Huygen, Pauline Marie Thys, Andreas Wollenberg, Jan Gutermuth, Inge Kortekaas Krohn","doi":"10.5021/ad.23.052","DOIUrl":"https://doi.org/10.5021/ad.23.052","url":null,"abstract":"Skin barrier function assessment is commonly done by measuring transepidermal water loss (TEWL). An important limitation of this method is the influence of intrinsic and extrinsic factors. Electrical impedance spectroscopy (EIS) is a lesser-established method for skin barrier function assessment. Some influential factors have been described, but no guidelines exist regarding the standardization of these measurements.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"103 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lichen amyloidosis is a chronic pruritic skin disorder associated with atopic dermatitis, however, the pathogenetic link between these two conditions remains to be elucidated. Only limited research has been performed on patients diagnosed with both pruritic dermatological conditions.
{"title":"Clinical Characteristics of Lichen Amyloidosis Associated with Atopic Dermatitis: A Single Center, Retrospective Study.","authors":"Seung-Min Oh, Hye-Jin Ahn, Min Kyung Shin","doi":"10.5021/ad.23.006","DOIUrl":"https://doi.org/10.5021/ad.23.006","url":null,"abstract":"Lichen amyloidosis is a chronic pruritic skin disorder associated with atopic dermatitis, however, the pathogenetic link between these two conditions remains to be elucidated. Only limited research has been performed on patients diagnosed with both pruritic dermatological conditions.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"293 2 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Byeong Geun Park, Tae Woong Seul, Jung Jin Shin, Sang Wook Son
Atopic dermatitis (AD) is a common skin disease which, depending on its severity, can have a significant impact on the quality of life of affected individuals. In cases of severe AD, systemic immunomodulatory agents can be considered for treatment. However, the available treatment options for moderate AD are limited. According to previous reports, however, 308-nm excimer light is a potential treatment for localized, moderate AD.
特应性皮炎（AD）是一种常见的皮肤病，根据其严重程度，可对患者的生活质量产生重大影响。对于重度特应性皮炎，可考虑使用全身性免疫调节剂进行治疗。然而，针对中度 AD 的现有治疗方案十分有限。不过，根据之前的报道，308 纳米准分子光是治疗局部中度 AD 的一种潜在方法。
{"title":"Preliminary Clinical Study of the Effects and Safety of 308-nm Excimer Light Treatment in Patients with Atopic Dermatitis.","authors":"Byeong Geun Park, Tae Woong Seul, Jung Jin Shin, Sang Wook Son","doi":"10.5021/ad.22.223","DOIUrl":"https://doi.org/10.5021/ad.22.223","url":null,"abstract":"Atopic dermatitis (AD) is a common skin disease which, depending on its severity, can have a significant impact on the quality of life of affected individuals. In cases of severe AD, systemic immunomodulatory agents can be considered for treatment. However, the available treatment options for moderate AD are limited. According to previous reports, however, 308-nm excimer light is a potential treatment for localized, moderate AD.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Actinic keratosis (AK) is a common precancerous skin lesion that can develop into cutaneous squamous cell carcinoma (CSCC). AK is characterized by atypical keratinocytes in the skin's outer layer and is commonly found in sun-exposed areas. Like many precancerous lesions, the development of AK is closely associated with genetic mutations. The molecular biology and transcriptional mechanisms underlying AK development are not well understood. Ultraviolet (UV) light exposure, especially UVA and UVB radiation, is a significant risk factor for AK, causing DNA damage and mutagenic effects. Besides UV exposure, comorbidities like diabetes, rheumatoid arthritis, and psoriasis may also influence AK development. AK patients have shown associations with various internal malignancies, indicating potential vulnerability in cancer-associated genes. Treatment for AK includes cryosurgery, electrodesiccation and curettage, chemotherapeutic creams, photodynamic therapy, or topical immune-modulators. Genomic studies have identified genetic aberrations in AK, with common mutations found in genes like TP53, NOTCH1, and NOTCH2. The progression from AK to CSCC involves chromosomal aberrations and alterations in oncogenes and tumor-suppressor genes. The functional relationships among these genes are not fully understood, but network analysis provides insights into their potential mechanisms. Further research is needed to enhance our understanding of AK's pathogenesis and develop novel therapeutic approaches.
日光性角化病（AK）是一种常见的癌前皮肤病变，可发展为皮肤鳞状细胞癌（CSCC）。AK的特征是皮肤外层的非典型角质细胞，常见于暴露在阳光下的部位。与许多癌前病变一样，AK 的发生与基因突变密切相关。AK发生的分子生物学和转录机制尚不十分清楚。紫外线（UV）照射，尤其是 UVA 和 UVB 辐射，是导致 AK 的重要风险因素，会造成 DNA 损伤和诱变效应。除紫外线照射外，糖尿病、类风湿性关节炎和银屑病等合并症也可能影响 AK 的发生。AK 患者与各种体内恶性肿瘤有关联，这表明与癌症相关的基因有潜在的脆弱性。AK 的治疗方法包括冷冻手术、电灼和刮除、化疗药膏、光动力疗法或局部免疫调节剂。基因组研究发现了 AK 的基因畸变，常见的基因突变包括 TP53、NOTCH1 和 NOTCH2。从 AK 发展为 CSCC 的过程涉及染色体畸变以及致癌基因和抑癌基因的改变。这些基因之间的功能关系尚未完全明了，但网络分析提供了对其潜在机制的见解。我们需要进一步开展研究，以加深对 AK 发病机制的了解，并开发新的治疗方法。
{"title":"Genetic Studies of Actinic Keratosis Development: Where Are We Now?","authors":"Young Bok Lee, Jong-Il Kim","doi":"10.5021/ad.23.072","DOIUrl":"https://doi.org/10.5021/ad.23.072","url":null,"abstract":"Actinic keratosis (AK) is a common precancerous skin lesion that can develop into cutaneous squamous cell carcinoma (CSCC). AK is characterized by atypical keratinocytes in the skin's outer layer and is commonly found in sun-exposed areas. Like many precancerous lesions, the development of AK is closely associated with genetic mutations. The molecular biology and transcriptional mechanisms underlying AK development are not well understood. Ultraviolet (UV) light exposure, especially UVA and UVB radiation, is a significant risk factor for AK, causing DNA damage and mutagenic effects. Besides UV exposure, comorbidities like diabetes, rheumatoid arthritis, and psoriasis may also influence AK development. AK patients have shown associations with various internal malignancies, indicating potential vulnerability in cancer-associated genes. Treatment for AK includes cryosurgery, electrodesiccation and curettage, chemotherapeutic creams, photodynamic therapy, or topical immune-modulators. Genomic studies have identified genetic aberrations in AK, with common mutations found in genes like <i>TP53</i>, <i>NOTCH1</i>, and <i>NOTCH2</i>. The progression from AK to CSCC involves chromosomal aberrations and alterations in oncogenes and tumor-suppressor genes. The functional relationships among these genes are not fully understood, but network analysis provides insights into their potential mechanisms. Further research is needed to enhance our understanding of AK's pathogenesis and develop novel therapeutic approaches.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoon Jin Lee, Yu Sung Choi, Sooyoung Kim, Jae Young Heo, Dong Sung Kim, Ki Dam Kim, Seung Min Nam, Hae Seon Nam, Sang Han Lee, Dongsic Choi, Moon Kyun Cho
Melanoma is one of the most aggressive and metastatic skin cancers. Although overexpression of Dock180 and Elmo1 has been identified in various cancers, including glioma, ovarian cancer, and breast cancer, their expression and functions in melanoma remain unknown.
{"title":"Overexpression of Dock180 and Elmo1 in Melanoma is Associated with Cell Survival and Migration.","authors":"Yoon Jin Lee, Yu Sung Choi, Sooyoung Kim, Jae Young Heo, Dong Sung Kim, Ki Dam Kim, Seung Min Nam, Hae Seon Nam, Sang Han Lee, Dongsic Choi, Moon Kyun Cho","doi":"10.5021/ad.23.023","DOIUrl":"https://doi.org/10.5021/ad.23.023","url":null,"abstract":"Melanoma is one of the most aggressive and metastatic skin cancers. Although overexpression of Dock180 and Elmo1 has been identified in various cancers, including glioma, ovarian cancer, and breast cancer, their expression and functions in melanoma remain unknown.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"85 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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