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Histological clonal change - A feature for dysplasia diagnosis 组织学克隆变化——诊断发育不良的一个特征
Pub Date : 2018-08-28 DOI: 10.29328/JOURNAL.APCR.1001008
Lewei Zhang, Tarinee Lubpairee, D. Laronde, M. Guillaud, C. MacAulay, M. Rosin
Aims: Histological diagnostic criteria are used for the assessment of the degree of dysplasia and hence the risk of cancer progression for premalignant lesions. Clonal changes in the form of hyperorthokeratosis and hyperchromasia that are sharply demarcated from adjacent areas are not currently part of the criterion for dysplasia diagnosis. The objective of this study was to determine whether such clonal change should be regarded as a diagnostic feature for dysplasia. The following histological conditions were used to defi ne such change: (1) hyperorthokeratosis; (2) hyperchromatism but no other features of dysplasia; (3) sharp margin demarcation from adjacent area by both the hyperorthokeratosis and hyperchromasia (clonal change), and (4) no prominent rete ridges, marked acanthosis or heavy infl ammation. Lesions fi tting these criteria were termed orthokeratotic lesions with no dysplasia. Methods: Patients from a population-based longitudinal study with more than 10 years of follow up were analyzed. Of the 214 patients with primary oral premalignant lesions, 194 had mild or moderate dysplasia (dysplasia group) and 20 fi t the criteria for orthokeratotic lesions without dysplasia (orthokeratotic with no dysplasia group). The two groups were compared for their cancer risks using clinical (site and toluidine blue), histological (nuclear phenotype score), and molecular criteria (loss of heterozygosity) and by outcome (progression). Results and conclusions: The lesions from orthokeratotic with no dysplasia group showed a similar cancer risk (clinical, histological and molecular risk) and time to progression as the dysplastic lesions. We recommend that the clonal change should be included as a criterion for dysplasia diagnosis. Research Article Histological clonal change A feature for dysplasia diagnosis Lewei Zhang1-3*, Tarinee Lubpairee1,3, Denise M Laronde1,3,4, Martial Guillaud3,4, Calum E MacAulay3,4 and Miriam P Rosin3-5 1Department of Oral Biological and Medical Sciences, Faculty of Dentistry, the University of British Columbia (BC), Vancouver, Canada 2BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada 3BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada 4BC Cancer Research Centre, Vancouver, Canada 5School of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada *Address for Correspondence: Lewei Zhang, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, BC Oral Biopsy Service, Vancouver General Hospital, BC Oral Cancer Prevention Program, BC Cancer Agency, 2199 Wesbrook Mall, Vancouver BC, Canada, V6T 1Z3, Tel: +1-604-875-4318 / 778-387-3885; Email: leweizhang888@gmail.com Submitted: 23 September 2017 Approved: 27 August 2018 Published: 28 August 2018 Copyright: © 2018 Zhang L, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and re
目的:组织学诊断标准用于评估发育不良的程度,从而评估癌前病变癌症进展的风险。与邻近区域明显区分的高骨质增生症和高增生症形式的克隆性变化目前不是发育不良诊断标准的一部分。本研究的目的是确定这种克隆变化是否应被视为发育不良的诊断特征。以下组织学条件用于定义这种变化:(1)高骨再生病;(2) 深染,但没有其他发育不良特征;(3) 高骨质增生症和高增生症(克隆性改变)与邻近区域的边界清晰,(4)没有突出的网嵴、明显的棘皮病或严重炎症。符合这些标准的病变称为无发育不良的角膜塑形性病变。方法:对一项基于人群的纵向研究中随访超过10年的患者进行分析。在214名原发性口腔癌前病变患者中,194名患者患有轻度或中度发育不良(发育不良组),20名患者符合无发育不良的角膜塑形病变标准(无发育不良角膜塑形组)。使用临床(部位和甲苯胺蓝)、组织学(核表型评分)和分子标准(杂合性缺失)以及结果(进展)比较两组的癌症风险。结果和结论:无发育不良的角膜矫正术组病变与发育不良病变具有相似的癌症风险(临床、组织学和分子风险)和进展时间。我们建议将克隆性改变作为诊断发育不良的标准。研究文章组织学克隆变化发育不良诊断的特征Lewei Zhang1-3*,Tarinee Lubbairee1,3,Denise M Laronde1,3,4,Martial Guillaud3,4,Calum E MacAulay3,4和Miriam P Rosin3-51不列颠哥伦比亚大学牙科学院口腔生物与医学科学系,加拿大温哥华2BC口腔活检服务,温哥华总医院,温哥华,加拿大3BC口腔癌症预防计划,BC癌症机构,加拿大温哥华4BC癌症研究中心,加拿大温哥华5生物医学生理学和运动学学院,西蒙·弗雷泽大学,加拿大伯纳比*通讯地址:Lewei Zhang,不列颠哥伦比亚大学口腔生物与医学科学系,温哥华综合医院,不列颠哥伦比亚省口腔癌症预防计划,不列颠哥伦比亚癌症机构,加拿大不列颠哥伦比亚省温哥华威斯布鲁克购物中心2199号,V6T 1Z3,电话:+1-604-875-4318/778-387-3885;电子邮件:leweizhang888@gmail.com提交:2017年9月23日批准:2018年8月27日发布:2018年08月28日版权所有:©2018张L等。这是一篇根据知识共享署名许可证分发的开放获取文章,该许可证允许在任何媒体上不受限制地使用、分发和复制,前提是正确引用原作
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引用次数: 0
A great mimicker of Bone Secondaries: Brown Tumors, presenting with a Degenerative Lumber Disc like pain 骨继发性的巨大模仿者:棕色肿瘤,表现为退行性腰椎间盘样疼痛
Pub Date : 2017-07-17 DOI: 10.29328/JOURNAL.HJPCR.1001004
Z. Bayramoğlu, R. Yılmaz, A. Bayram
This report presents an adult patient suffering from sacroiliitis like low back pain, lumbosacral radiculopathy and elbow swelling. Multimodality imaging revealed multiple lytic bone lesions located in supra acetabular iliac bone, sacrum, and distal end of radius. Painful numerous lesions due to the extension to the articular surfaces are not expected for Brown tumors. Less than ten cases with multiple Brown tumor due to primary hyperparathyroidism has been reported. Although Brown tumors are mostly diagnosed incidentally, this case would awake the physicians about rheumatological symptoms in the presentation of Brown tumors. Since Brown tumors are non-touch bone lesions that are expected to regress after parathyroid adenoma removal, it is important to distinguish Brown tumors from the giant cell tumors. Case Report A great mimicker of Bone Secondaries: Brown Tumors, presenting with a Degenerative Lumber Disc like pain Zuhal Bayramoglu1*, Ravza Yılmaz1 and Aysel Bayram2 1Department of Radiology, Istanbul Medical Faculty, Istanbul University, Capa, Fatih, 34093, Istanbul, Turkey 2Department of Pathology, Istanbul Medical Faculty, Istanbul University, Capa, Fatih, 34093, Istanbul, Turkey *Address for Correspondence: Dr. Zuhal Bayramoglu, Department of Radiology, Istanbul Medical Faculty, Istanbul University, Capa, Fatih, 34093, Istanbul, Turkey, Tel: +90-212414-20-00, Fax: +90-212-631-07-28; Email: incezuhal@yahoo.com Submitted: 06 June 2017 Approved: 14 July 2017 Published: 17 July 2017 Copyright: 2017 Bayramoglu Z. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
这个报告提出了一个成人患者患有骶髂炎像腰痛,腰骶神经根病和肘部肿胀。多模态影像显示位于髋臼上髂骨、骶骨和桡骨远端多发溶解性骨病变。由于延伸到关节面,疼痛的大量病变在棕色肿瘤中是不可能出现的。据报道,原发性甲状旁腺功能亢进导致多发棕色肿瘤的病例不足10例。虽然棕色肿瘤大多是偶然诊断的,但本病例将提醒医生注意棕色肿瘤的风湿病症状。由于褐色肿瘤为非接触性骨病变,切除甲状旁腺瘤后会消退,因此将褐色肿瘤与巨细胞肿瘤区分开来是很重要的。病例报告:棕色肿瘤,表现为退行性椎间盘样疼痛Zuhal Bayramoglu1*, Ravza Yılmaz1和Aysel Bayram2 1伊斯坦布尔大学伊斯坦布尔医学院放射学系,卡帕,法提赫,34093,伊斯坦布尔,土耳其2伊斯坦布尔大学伊斯坦布尔医学院病理学系,卡帕,法提赫,34093,伊斯坦布尔,土耳其*通信地址:Zuhal Bayramoglu医生,伊斯坦布尔大学,伊斯坦布尔医学院放射科,卡帕,法提赫,34093,伊斯坦布尔,土耳其,电话:+90-212414-20-00,传真:+90-212-631-07-28;电子邮件:incezuhal@yahoo.com提交:2017年6月6日批准:2017年7月14日发布:2017年7月17日版权:2017 Bayramoglu Z.这是一篇根据知识共享署名许可发布的开放获取文章,允许在任何媒介上不受限制地使用,分发和复制,前提是原始作品被适当引用。
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引用次数: 0
MicroRNA Therapeutics in Triple Negative Breast Cancer 三阴性乳腺癌的MicroRNA治疗
Pub Date : 2017-06-27 DOI: 10.29328/JOURNAL.HJPCR.1001003
Sarmistha Mitra
Breast cancer is a complex disease and one of the main causes of cancer-related mortality in women worldwide. In case of approximately 15% of all breast cancers, three markers i.e. estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptors-2 (HER2) are not expressed, and is commonly termed as triple-negative breast cancer (TNBC). Particularly, TNBC is associated with a higher percentage of breast cancer related mortality, which is often aggressive and most frequently found with a BRCA1 mutation or increased basal marker expression. However, due to the limitations of chemotherapy and radiation based treatment; the current challenge is to establish a new strategy of diagnosis and treatment of TNBC. The deregulation of a number of microRNAs (miRNAs) in breast cancer has been widely reported. Therefore, this review is directed towards enhancing our understanding of the involvement of various miRNAs in the pathology of TNBC, their upregulations and downregulations and the effects on various factors. From recent studies a number of miRNAs are found to be related with TNBC, which have great potential to be used as a biomarker to determine the disease prognosis and predict the fate of disease. Again miRNA can be targeted to be applied as a therapeutic to provide a great benefi t to the patients of TNBC by fi nding a new, safe, and effective treatment strategy. Review Article MicroRNA Therapeutics in Triple Negative Breast Cancer Sarmistha Mitra* Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh *Address for Correspondence: Sarmistha Mitra, Department of Pharmacy, Faculty of Biological Science, University of Chittagong, Chittagong-4331, Bangladesh, Tel: +8801521484840; Email: sarmisthacu@gmail.com Submitted: 31 May 2017 Approved: 23 June 2017 Published: 27 June 2017 Copyright: 2017 Mitra S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
乳腺癌是一种复杂的疾病,也是全世界妇女癌症相关死亡的主要原因之一。在大约15%的乳腺癌中,三种标志物即雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体-2 (HER2)不表达,通常被称为三阴性乳腺癌(TNBC)。特别是,TNBC与乳腺癌相关死亡率的比例较高,这通常是侵袭性的,最常见的是BRCA1突变或基础标志物表达增加。然而,由于化疗和放疗的局限性;目前的挑战是建立一种新的诊断和治疗策略。许多microRNAs (miRNAs)在乳腺癌中的失调已经被广泛报道。因此,本综述旨在加强我们对各种mirna在TNBC病理中的参与,它们的上调和下调以及对各种因素的影响的理解。从最近的研究中发现了许多与TNBC相关的mirna,它们有很大的潜力作为确定疾病预后和预测疾病命运的生物标志物。再次,miRNA可以作为一种靶向治疗,通过寻找一种新的、安全有效的治疗策略,为TNBC患者提供巨大的益处。综述文章MicroRNA治疗三阴性乳腺癌Sarmistha Mitra*吉大港大学药学系,吉大港4331,孟加拉国*通讯地址:吉大港大学生物科学学院药学系Sarmistha Mitra,吉大港4331,孟加拉国,电话:+8801521484840;电子邮件:sarmisthacu@gmail.com提交:2017年5月31日批准:2017年6月23日发布:2017年6月27日版权:2017 Mitra S.这是一篇根据知识共享署名许可发布的开放获取文章,允许在任何媒介上不受限制地使用,分发和复制,前提是原始作品被适当引用。
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引用次数: 10
Hypernatremia and central Diabetes Insipidus following Neurosurgical procedure of Trauma 创伤神经外科手术后的高钠血症和中枢性尿崩症
Pub Date : 2017-06-12 DOI: 10.29328/journal.hjpcr.1001002
A. Magbri, Eussera El-Magbri, Seth Hershit
The greater risk of hypernatremia in patients over 65 years old are associated with impaired mental status and physical disability which may result in impaired sensation to thirst, impaired ability to express thirst, and/or decrease access to water [1,2]. Normally, anti-diuretic hormone (ADH, also known as arginine-vasopressin, AVP) is secreted in response to 1-2% increase in osmolality which stimulate thirst, as do hypovolemia and hypotension. Broadly, speaking hypernatremia is due to hypotonic luid loss or hypertonic sodium gain. Hypotonic luid loss is mainly caused by diabetes insipidus. There are many causes of central diabetes incipidus (CDI). Pituitary and hypothalamus injuries caused by trauma, neurosurgical procedures, hemorrhage, ischemia, autoimmune diseases e.g. hypophysitis, IgG4 related disease or tumors involving hypothalamic-pituitary axis (HPA) are but few causes of CDI. Central diabetes incipidus is also reported with traumatic brain injuries causing ischemia to the HPA [3] and presented with exertion of large volumes of diluted urine (polyuria). Polyuria is de ined by a urine volume in excess of 2 L/m2/24 h or approximately 40-50 ml/kg/24 h in older children or adult.
65岁以上患者发生高钠血症的风险较大,与精神状态受损和身体残疾有关,这可能导致口渴感觉受损、口渴表达能力受损和/或饮水减少[1,2]。正常情况下,抗利尿激素(ADH,也称为精氨酸-抗利尿素,AVP)在渗透压升高1-2%刺激口渴时分泌,低血容量和低血压也是如此。一般来说,高钠血症是由于低渗液体损失或高渗钠增加引起的。低渗失水主要由尿崩症引起。中枢性糖尿病(CDI)有多种病因。外伤、神经外科手术、出血、缺血、自身免疫性疾病如垂体炎、IgG4相关疾病或涉及下丘脑-垂体轴(HPA)的肿瘤引起的垂体和下丘脑损伤是CDI的少数原因。中枢性糖尿病也有外伤性脑损伤引起下丘脑缺血的报道,并表现为大量稀释尿液(多尿)。大龄儿童或成人尿量超过2 L/m2/24小时或约40-50 ml/kg/24小时为多尿症。
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引用次数: 2
Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour 癌相关成纤维细胞在口腔鳞状细胞癌失巢抵抗中的作用——时不我待
Pub Date : 2017-01-30 DOI: 10.29328/journal.hjpcr.1001001
Anjali P Ganjre
Anoikis resistance (AR) is a favorable attribute exhibited by cancer cells for metastasis. Carcinoma associated Fibroblasts (CAFs) plays a crucial role in AR in various cancers. It was proved in array of studies in different cancers that there was defi nite interrelationship between CAFs and AR. But its role in OSCC is ambiguous. It is the need of the time to reveal the correlation of CAF and oral squamous cell carcinoma (OSCC) in relation with anoikis. Molecular pathways which affects the AR via CAFs in various cancers has been highlighted in this communication. Divulging the importance of CAF in cancer will aid in designing customized novel chemoprevention therapy and thus will help in enhancing the prognosis of patient in OSCC. Short Communication
抗Anoikis(AR)是癌症细胞对转移表现出的有利特性。癌相关成纤维细胞(CAFs)在各种癌症的AR中起着至关重要的作用。一系列针对不同癌症的研究证明,CAFs和AR之间存在明确的相互关系。但其在OSCC中的作用尚不明确。揭示CAF和口腔鳞状细胞癌(OSCC)与失巢的相关性是时间的需要。在这篇通讯中,通过CAFs影响各种癌症中AR的分子途径得到了强调。揭示CAF在癌症中的重要性将有助于设计定制的新型化学预防疗法,从而有助于改善OSCC患者的预后。短通信
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引用次数: 0
Predicament of classification: Multisystem small vessel vasculitis with cresentic Glomerulonephritis 分型困境:多系统小血管炎合并月牙性肾小球肾炎
Pub Date : 2017-01-01 DOI: 10.29328/JOURNAL.APCR.1001005
A. Magbri
{"title":"Predicament of classification: Multisystem small vessel vasculitis with cresentic Glomerulonephritis","authors":"A. Magbri","doi":"10.29328/JOURNAL.APCR.1001005","DOIUrl":"https://doi.org/10.29328/JOURNAL.APCR.1001005","url":null,"abstract":"","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"2 1","pages":"001-005"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69930799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In at the deep end: Psychosocial aspects of developing autonomy in histopathology training 深入研究:组织病理学训练中自主性发展的社会心理方面
Pub Date : 2017-01-01 DOI: 10.29328/JOURNAL.APCR.1001007
Finall Ai
Medical postgraduate trainees are given increasing levels of responsibility during training in the apprenticeship-model of training [1-3]. Responsibility is said to be a key driver of deep learning and understanding [4-7]. Trainees with greater levels of responsibility for decision making have higher levels of motivation to learn compared with trainees who self-assess as having less autonomy [5]. The Royal College of Pathologists (RCPath) indicate that ‘graded responsibility’ is part of training histopathologists and provided a framework for implementation with increasingly complex specimens suitable for reporting by more senior trainees [8,9].
在学徒培训模式下,医学研究生受训者在培训过程中被赋予越来越多的责任[1-3]。责任感被认为是深度学习和理解的关键驱动力[4-7]。与自我评估为自主性较低的受训者相比,对决策负有更大责任的受训者有更高的学习动机。皇家病理学家学院(RCPath)指出,“分级责任”是培训组织病理学家的一部分,并为越来越复杂的标本提供了一个框架,适合由更高级的受训者报告[8,9]。
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引用次数: 1
Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams 氯氰菊酯对雁卡公羊睾丸和副性腺的病理影响
Pub Date : 2017-01-01 DOI: 10.29328/journal.apcr.1001006
U. Simon, O. David, R. Peter, Rwuaan Joseph, Chibuogwu Ijeoma, N. Celestine
An investigation into the pathological lesions of Cypermethrin on the testes, accessory sexual and pituitary glands of Yankasa rams was carried out. Sixteen Yankasa rams aged 18 30 months and weighing between 21.5 46.5kg were used. The 16 rams were divided equally into two groups (A and B) A served as the treatment group while B served as the control. Group (A) were given Cypermethrin (3%) at the dose rate of 3mg/kg (0.1ml/kg) body weight, topically. Group (B) rams were given distilled water at the same dose rate and route. These treatments were repeated every two weeks for a period of 12 weeks. The rams were sacrifi ced at the end of 12 weeks and the following organs (testes, pituitary, vesicular and prostate glands), were collected and weighed, gross pathological lesions were observed and photographs were taken. The samples were kept for histopathology. Results showed that there were no gross pathological lesions found on the testes, pituitary, prostate glands and the seminal vesicles of both groups. The mean weight of the pituitary gland, the prostate glands and the seminal vesicles of the treated and control groups were statistically not signifi cant (P>0.05). No histologic lesions were found on them. The mean testicular weights of the treated (143.81±7.71g) and the control (130.43±0.63g) were signifi cantly different (P<0.05). There was a reduced number of spermatozoa in the lumen of the seminiferous tubules of the treated group. It was concluded that Cypermethrin reduced spermatozoa in the lumen of the seminiferous tubules. Research Article Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams Ubah Simon1*, Ogwu David1, Rekwot Peter1, Rwuaan Joseph1, Chibuogwu Ijeoma2 and Njoku Celestine3 1Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria 2Animal Science Department, Faculty of Agriculture, University of Abuja, Abuja, Nigeria 3Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria *Address for Correspondence: Ubah Simon, Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria, Tel: +2348036097428; Email: drubah2000@yahoo.com Submitted: 06 June 2018 Approved: 19 June 2018 Published: 20 June 2018 Copyright: 2018 Simon U, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
研究了氯氰菊酯对雁卡公羊睾丸、副性腺和垂体的病理损害。选用16只18 ~ 30月龄、体重在21.5 ~ 46.5kg之间的洋卡公羊。将16只公羊平均分为A、B两组,A组为治疗组,B组为对照组。A组给予氯氰菊酯(3%),剂量率为3mg/kg (0.1ml/kg体重),局部注射。B组公羊按相同剂量率和途径给予蒸馏水。这些治疗每两周重复一次,持续12周。12周后处死公羊,取其睾丸、垂体、囊泡、前列腺等脏器称重,观察大体病理病变并拍照。标本留作组织病理学检查。结果两组大鼠睾丸、垂体、前列腺及精囊均未见明显病理病变。治疗组与对照组垂体、前列腺、精囊的平均重量比较,差异均无统计学意义(P < 0.05)。两组均未见组织学病变。实验组平均睾丸质量(143.81±7.71g)与对照组平均睾丸质量(130.43±0.63g)差异有统计学意义(P<0.05)。治疗组精管腔内精子数量减少。结论氯氰菊酯可减少精管腔内精子数量。研究文章氯氰菊酯对Yankasa Rams Ubah Simon1*、Ogwu David1、Rekwot Peter1、Rwuaan Joseph1、Chibuogwu ijeom2和Njoku celestine1睾丸和副性腺的病理影响1尼日利亚扎里亚Ahmadu Bello大学兽医学院动物发生与生产系2尼日利亚阿布贾大学农学院动物科学系3尼日利亚阿布贾大学兽医学院兽医病理学系*通讯地址:Ubah Simon,兽医学院兽医学与生产学系,尼日利亚,扎里亚,电话:+2348036097428;电子邮件:drubah2000@yahoo.com提交时间:2018年6月6日批准时间:2018年6月19日发布时间:2018年6月20日版权所有:2018 Simon U, et al。这是一篇在知识共享署名许可下发布的开放获取文章,该许可允许在任何媒体上不受限制地使用、分发和复制,只要原始作品被适当引用。
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引用次数: 3
Uncommon Causes of Stroke: Systemic lupus erythematosus 不常见的中风病因:系统性红斑狼疮
Pub Date : 2008-01-01 DOI: 10.1017/CBO9780511544897.046
N. Futrell
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引用次数: 0
Sickle cell anemia 镰状细胞性贫血
Pub Date : 2004-01-01 DOI: 10.1007/3-540-29662-X_2435
L. Moreland
{"title":"Sickle cell anemia","authors":"L. Moreland","doi":"10.1007/3-540-29662-X_2435","DOIUrl":"https://doi.org/10.1007/3-540-29662-X_2435","url":null,"abstract":"","PeriodicalId":8289,"journal":{"name":"Archives of pathology","volume":"1 1","pages":"800-800"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51529646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of pathology
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