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Topical linezolid for refractory bilateral Mycobacterium chelonae post-laser-assisted in situ keratomileusis keratitis. 局部利奈唑胺治疗难治性双侧chelon分枝杆菌激光辅助原位角膜磨假性角膜炎。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1495
Rosa Dolz-Marco, Patricia Udaondo, Roberto Gallego-Pinazo, J Maria Millán, Manuel Díaz-Llopis
diagnosis; (2) successful combination of topical, oral, and intraocular therapy with drugs that can reach therapeutic levels in aqueous and vitreous and are effective in vivo for other Acanthamoeba infections; and (3) guiding treatment by effective monitoring of the response by Acanthamoeba. We think oral and topical administration of voriconazole must have achieved a sustained therapeutic dose and frequent administration of intraocular voriconazole produced high peak levels, increasing effectiveness. Topical chlorhexidine was used before the PK but the keratitis worsened, raising the question of its effectiveness in our patient. It is unknown whether topical chlorhexidine can reach aqueous therapeutic levels; however, rabbit studies have shown that frequent instillation of chlorhexidine, 0.02%, in epithelialized corneas produces concentrations 10 to 40 times lower than voriconazole but, in our experience, a similar 90% inhibitory concentration. Moreover, in the other described cases, topical antiseptics such as chlorhexidine used after PK did not prevent endophthalmitis. Therefore, we believe chlorhexidine did not play a major role in our case. The susceptibility of Acanthamoeba to trimethoprim/sulfamethoxazole, also used in our patient, is based on a few reports; we have not tested the susceptibility of the patient’s strain and cannot be sure of its real contribution.
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引用次数: 12
About this journal. 关于这本日记。
Pub Date : 2012-11-01 DOI: 10.1001/archopht.130.11.1371
Universities struggle with alternate means of instructional delivery to meet the demands of distant student needs, the competition for enrollments, and restraints from limited physical building space. For many, fully online programs of study using internet-based instruction commonly named online instruction have become viable solutions. There has been significant growth in the number of on-line degree programs since many students want to take courses that will positively impact their future careers but not hinder family and work responsibilities. Shifting from a traditional program of study to an online format is not without challenges. There are three primary areas of focus when considering an online design format for course delivery: course design, instructor role, and student role. This paper will provide one instructor’s perspective of how to improve student engagement and interaction in master’s level Educational Leadership courses over a threeyear span utilizing available data from the university Student Perception of Teacher (SPOT) assessment available.
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引用次数: 0
Scleral fistula closure at the time of glaucoma drainage device tube repositioning: a novel technique. 青光眼引流管复位时巩膜瘘管闭合:一种新技术。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.2219
Joseph F Panarelli, Michael R Banitt, Paul A Sidoti

Repositioning a glaucoma drainage device tube from the anterior chamber to the ciliary sulcus or pars plana can be a challenging procedure owing to the difficulty in obtaining tight closure of the original limbal fistula. Failure to achieve watertight and airtight closure of the fistula can result in substantial difficulty in completing other key portions of the surgery and may lead to postoperative hypotony and associated complications. A novel technique using a Tutoplast scleral plug, polyglactin sutures, and, in certain cases, fibrin tissue sealant to close a limbal fistula at the time of glaucoma drainage device tube repositioning is described. This technique can be replicated with ease and provides a tight seal so that other concurrent surgical procedures can safely be completed and postoperative hypotony is avoided.

将青光眼引流管从前房重新定位到睫状沟或睫状体平面部是一项具有挑战性的手术,因为很难将原角膜缘瘘管紧密闭合。如果不能实现瘘管的水密性和气密性关闭,则会导致完成手术其他关键部分的困难,并可能导致术后低斜视和相关并发症。本文描述了一种使用Tutoplast巩膜塞、聚乳酸缝合线以及在某些情况下使用纤维蛋白组织密封剂在青光眼引流装置管重新定位时关闭角膜缘瘘的新技术。这项技术可以很容易地复制,并提供一个紧密的密封,以便其他并发手术可以安全地完成,避免术后低斜度。
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引用次数: 7
Swedish national register for retinopathy of prematurity (SWEDROP) and the evaluation of screening in Sweden. 瑞典早产儿视网膜病变国家登记(SWEDROP)和瑞典筛查的评估。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.2357
Gerd E Holmström, Ann Hellström, Peter G Jakobsson, Pia Lundgren, Kristina Tornqvist, Agneta Wallin

Objectives: To evaluate screening for retinopathy of prematurity (ROP) in Sweden and to investigate possible modifications of the present screening guidelines.

Methods: Infants in Sweden with a gestational age (GA) of 31 weeks + 6 days or less are screened for ROP. Data from the Swedish national register for ROP (SWEDROP) during 2008 and 2009 were extracted and compared with a national perinatal quality register.

Results: In SWEDROP, there were 1791 infants born before a GA of 32 weeks from January 1, 2008, through December 31, 2009. Another 70 infants were registered in the perinatal quality register but not in SWEDROP (dropout rate, 3.8% [70 of 1861 infants]). Seven infants died before termination of screening. In the final study cohort (1784 infants), 15.6% had mild ROP and 8.5% had severe ROP. Treatment was performed in 4.4% of the infants, none of whom had a GA at birth of more than 28 weeks. Nine infants with a GA of more than 28 weeks at birth developed stage 3 ROP, which regressed spontaneously. The total number of examinations was 9286 (964 in infants with a GA of 31 weeks), and the mean (range) number of examinations of each infant was 5.2 (1-30).

Conclusions: The SWEDROP, a quality register for ROP, has a national coverage (ie, participation) of 96%. Data from 2008 to 2009 show that it seems possible to reduce the upper limit for screening in Sweden by 1 week, including only infants with a GA of 30 weeks + 6 days or less. However, such a change should be combined with a strong recommendation to neonatologists to refer also severely ill and more "mature" infants.

目的:评估瑞典早产儿视网膜病变(ROP)的筛查,并探讨现行筛查指南的可能修改。方法:在瑞典,胎龄为31周+ 6天或以下的婴儿进行ROP筛查。提取2008年和2009年瑞典国家ROP登记册(SWEDROP)的数据,并与国家围产期质量登记册进行比较。结果:在SWEDROP中,从2008年1月1日到2009年12月31日,共有1791名出生在孕周32周前的婴儿。另有70名婴儿在围产期质量登记处登记,但未在SWEDROP登记(辍学率为3.8%[70 / 1861])。7名婴儿在筛查结束前死亡。在最后的研究队列(1784名婴儿)中,15.6%患有轻度ROP, 8.5%患有重度ROP。4.4%的婴儿接受了治疗,这些婴儿出生时没有超过28周的GA。9名出生时GA超过28周的婴儿发展为3期ROP,并自发消退。总检查次数为9286次(GA为31周的婴儿964次),平均(范围)检查次数为5.2次(1-30次)。结论:SWEDROP是ROP的质量登记,全国覆盖率(即参与率)为96%。2008年至2009年的数据显示,瑞典似乎有可能将筛查的上限减少1周,仅包括总出生周为30周+ 6天或更少的婴儿。然而,这样的改变应该与强烈建议新生儿学家推荐重病和更“成熟”的婴儿相结合。
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引用次数: 70
Ten years with detached descemet membrane. 网膜脱落十年。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1684
George D Kymionis, Georgios A Kontadakis
perience with the Ahmed Glaucoma Valve implant. Am J Ophthalmol. 1999;127(1):27-33. 6. Siegner SW, Netland PA, Urban RC Jr, et al. Clinical experience with the Baerveldt glaucoma drainage implant. Ophthalmology. 1995;102 (9):1298-1307. 7. Ainsworth G, Rotchford A, Dua HS, King AJ. A novel use of amniotic membrane in the management of tube exposure following glaucoma tube shunt surgery. Br J Ophthalmol. 2006;90(4): 417-419. 8. Godfrey DG, Merritt JH, Fellman RL, Starita RJ. Interpolated conjunctival pedicle flaps for the treatment of exposed glaucoma drainage devices. Arch Ophthalmol. 2003;121(12):1772-1775. 9. Lama PJ, Fechtner RD. Tube erosion following insertion of a glaucoma drainage device with a pericardial patch graft. Arch Ophthalmol. 1999;117 (9):1243-1244. 10. Tsai JC, Grajewski AL, Parrish RK II. Surgical revision of glaucoma shunt implants. Ophthalmic Surg Lasers. 1999;30(1):41-46. 11. Sibayan SA, Latina MA. The use of processed pericardium in the repair of corneo-scleral fistulas. Ophthalmic Surg Lasers. 1997;28(4):334-335. 12. Yoo C, Kwon SW, Kim YY. Pericardium plug in the repair of the corneoscleral fistula after Ahmed Glaucoma Va lve exp lan ta t ion . Korean J Ophthalmol. 2008;22(4):268-271.
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引用次数: 0
Carl B. Camras, MD: reflections on his contributions to glaucoma research and clinical practice. Carl B. Camras,医学博士:回顾他对青光眼研究和临床实践的贡献。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1839
Nancy L Camras

My husband, Carl B. Camras, MD (chairman of the Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha), died at age 55 years in 2009. His dying wish was to be remembered for being the first to hypothesize that prostaglandins lower intraocular pressure and had potential as a medication to treat glaucoma. I reviewed the research he performed as an undergraduate at Yale University (New Haven, Connecticut), as a medical student at Columbia University (New York, New York), and on the faculty at Mount Sinai School of Medicine (New York, New York), which confirmed his hypothesis and led to the development of latanoprost. This article summarizes his contributions to glaucoma research, his role in the development of latanoprost, and the error of omission that prevented his recognition as its coinventor. Carl is best remembered as an ethical scientist, a gifted clinician, and a beloved teacher, who inspired the medical community and the next generation of ophthalmologists.

我的丈夫,Carl B. Camras,医学博士(奥马哈内布拉斯加大学医学中心眼科和视觉科学系主席),于2009年去世,享年55岁。他的遗愿是被人们记住,因为他是第一个提出前列腺素可以降低眼压的假设,并有可能成为治疗青光眼的药物。我回顾了他在耶鲁大学(纽黑文,康涅狄格州)、哥伦比亚大学(纽约,纽约州)和西奈山医学院(纽约,纽约州)担任本科生时所做的研究,这些研究证实了他的假设,并导致了拉坦前列素的发展。本文总结了他对青光眼研究的贡献,他在拉坦前列素发展中的作用,以及他被认为是共同发明者的疏忽。卡尔被人们铭记为一位有道德的科学家、一位天才的临床医生和一位受人爱戴的老师,他激励了医学界和下一代眼科医生。
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引用次数: 0
Real-time polymerase chain reaction for diagnosing acyclovir-resistant herpetic keratitis based on changes in viral DNA copy number before and after treatment. 基于治疗前后病毒DNA拷贝数变化的实时聚合酶链反应诊断无环韦耐药疱疹性角膜炎
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1176
Tomoyuki Inoue, Rumi Kawashima, Takashi Suzuki, Yuichi Ohashi
Acyclovir (ACV) is a specific anti– herpes simplex virus (HSV) and anti–varicella-zoster virus agent for herpetic infection; topical ACV ointment, 3%, has been the treatment of choice for HSV infection in Japan. Based on the widespread use of ACV, in some cases of recurrent herpetic keratitis, the disease was refractory to topical ACV treatment , which was previously reported as ACV-resistant herpetic kerat i t i s . 1 3 Convent ional ly , definitive diagnosis of an ACVresistant HSV keratitis requires a laboratory examination of viral cultures following in vitro drug sensitivity testing, which is generally difficult and complicated because of the low rates of replication of these viruses and the small number of ocular samples. A rapid, simple, and accurate method of diagnosing drug-resistant herpetic infection remains to be established. Realtime polymerase chain reaction (PCR) is a highly sensitive method for the detection and quantification of pathogens. We report 4 cases of ACV-resistant HSV keratitis using real-time PCR analysis; these cases were diagnosed based on changes in the viral DNA copy numbers before and after ACV treatment.
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引用次数: 8
Cystic epithelial ingrowth in a case of deep anterior lamellar keratoplasty. 深前板层角膜移植术1例囊性上皮向内生长。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.509
Jayangshu Sengupta, Archana Khetan
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引用次数: 1
Novel etiological agent: molecular evidence for trematode-induced anterior uveitis in children. 新的病因:儿童吸虫性前葡萄膜炎的分子证据。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.729
Sivakumar R Rathinam, Lalan Kumar Arya, Kim R Usha, Lalitha Prajna, Veena Tandon
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引用次数: 21
Improving preterm ophthalmologic care in the era of accountable care organizations. 在责任医疗机构时代改善早产儿眼科护理。
Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1890
C Jason Wang, Alison A Little, Karen Kamholz, Jaime Bruce Holliman, Marissa D Wise, Jonathan Davis, Steven Ringer, Cynthia Cole, Deborah K Vanderveen, Stephen P Christiansen, Howard Bauchner

OBJECTIVES To understand retinopathy of prematurity (ROP) follow-up care for preterm very low-birth-weight infants (VLBW; <1500 g) in the context of the chronic care model and identify opportunities for improvement under accountable care organizations. METHODS We conducted focus groups and interviews with parents (N = 47) of VLBW infants and interviews with neonatal intensive care unit and ophthalmologic providers (N = 28) at 6 sites in Massachusetts and South Carolina. Themes are reported according to consolidated criteria for reporting qualitative research guidelines. RESULTS Respondents perceived that legal liability and low reimbursement contributed to shortages of ROP providers. Some neonatal intensive care units offered subsidies to attract ophthalmologic providers or delayed transfers to institutions that could not provide ROP examinations and/or treatment. Sites used variable practices for coordinating ROP care. Even at sites with a tracking database and a dedicated ROP coordinator, significant time was required to ensure that examinations and treatment occurred as scheduled. Parents' ability to manage their children's health care was limited by parental understanding of ROP, feeling overwhelmed by the infant's care, and unmet needs for resources to address social stressors. CONCLUSIONS Under accountable care organizations, hospitals and ophthalmology practices should share responsibility for ensuring coordinated ROP care to mitigate liability concerns. To promote integrated care, reimbursement for ROP care should be bundled to include screening, diagnosis, treatment, and appropriate follow-up. Clinical information systems should be enhanced to increase efficiency and limit lapses in care. Self-management tools and connections to community resources could help promote families' attendance of follow-up appointments.

目的了解极低出生体重儿(VLBW)早产儿视网膜病变(ROP)随访护理;<1500 g)在慢性护理模式的背景下,并确定在负责任的护理组织下改进的机会。方法我们在马萨诸塞州和南卡罗来纳州的6个地点对VLBW婴儿的父母(N = 47)和新生儿重症监护病房和眼科提供者(N = 28)进行了焦点小组和访谈。根据报告定性研究指南的综合标准报告主题。结果受访者认为法律责任和低报销是导致ROP提供者短缺的原因。一些新生儿重症监护病房提供补贴,以吸引眼科医生或延迟转移到无法提供ROP检查和/或治疗的机构。站点使用不同的实践来协调ROP护理。即使在有跟踪数据库和专门ROP协调员的现场,也需要大量时间来确保检查和处理如期进行。由于父母对ROP的理解、对婴儿的照顾感到不堪重负以及对解决社会压力源的资源需求未得到满足,父母管理子女保健的能力受到限制。结论:在负责任的医疗机构下,医院和眼科实践应共同承担责任,确保协调的ROP护理,以减轻责任问题。为促进综合护理,ROP护理的报销应捆绑在一起,包括筛查、诊断、治疗和适当的随访。应加强临床信息系统,以提高效率和限制护理失误。自我管理工具和与社区资源的联系有助于促进家庭参加后续预约。
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引用次数: 11
期刊
Archives of ophthalmology
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