Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.2260
Nicholas J Butler, Eric B Suhler
Comment. The first report of unilateral RPE dysgenesis was published in 2002. In this report, 3 young men and 1 woman aged 16 to 34 years were noted to have a round leopard-spot lesion contiguous with the optic nerve. In 2009, the typical characteristics of unilateral RPE dysgenesis were described in a set of 9 affected patients, 6 males and 3 females aged 14 to 42 years. The margin of the lesion is pathognomonic, with a scalloped reticular fringe of mild fibrosis and atrophy with inverted FAF imaging relative to fluorescein angiography, and is identical to the lesion in our patient. The differential diagnosis of this lesion includes acute zonal occult outer retinopathy. However, acute zonal occult outer retinopathy typically has a smooth curvilinear border on autofluorescence and the electroretinographic findings are abnormal. Alternative differential diagnoses include traumatic retinal pigment epitheliopathy and combined hamartoma of the retina and RPE. This case is unique in that it shows bilateral loss of the RPE in a multifocal, scattered, stellate fashion, best appreciated with FAF imaging. To our knowledge, this is the first reported case of unilateral RPE dysgenesis with abnormal findings on FAF imaging in the fellow eye. In the previously reported series of 9 patients by Cohen et al, only 3 cases were evaluated with FAF imaging and no evidence of bilateral disease was seen. However, as most patients in the case series did not have FAF imaging performed, some of these unilateral cases may have had subclinical bilateral disease. The etiology of this condition remains elusive. It may be an RPE dysgenesis or dystrophy, or it could reflect previous inflammatory, infectious, or autoimmune insult to the RPE. It is intuitive that a dysgenesis should ultimately be bilateral, and this is the first report to our knowledge illustrating this for RPE dysgenesis, which perhaps should no longer be termed unilateral.
{"title":"Levofloxacin-associated panuveitis with chorioretinal lesions.","authors":"Nicholas J Butler, Eric B Suhler","doi":"10.1001/archophthalmol.2012.2260","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2260","url":null,"abstract":"Comment. The first report of unilateral RPE dysgenesis was published in 2002. In this report, 3 young men and 1 woman aged 16 to 34 years were noted to have a round leopard-spot lesion contiguous with the optic nerve. In 2009, the typical characteristics of unilateral RPE dysgenesis were described in a set of 9 affected patients, 6 males and 3 females aged 14 to 42 years. The margin of the lesion is pathognomonic, with a scalloped reticular fringe of mild fibrosis and atrophy with inverted FAF imaging relative to fluorescein angiography, and is identical to the lesion in our patient. The differential diagnosis of this lesion includes acute zonal occult outer retinopathy. However, acute zonal occult outer retinopathy typically has a smooth curvilinear border on autofluorescence and the electroretinographic findings are abnormal. Alternative differential diagnoses include traumatic retinal pigment epitheliopathy and combined hamartoma of the retina and RPE. This case is unique in that it shows bilateral loss of the RPE in a multifocal, scattered, stellate fashion, best appreciated with FAF imaging. To our knowledge, this is the first reported case of unilateral RPE dysgenesis with abnormal findings on FAF imaging in the fellow eye. In the previously reported series of 9 patients by Cohen et al, only 3 cases were evaluated with FAF imaging and no evidence of bilateral disease was seen. However, as most patients in the case series did not have FAF imaging performed, some of these unilateral cases may have had subclinical bilateral disease. The etiology of this condition remains elusive. It may be an RPE dysgenesis or dystrophy, or it could reflect previous inflammatory, infectious, or autoimmune insult to the RPE. It is intuitive that a dysgenesis should ultimately be bilateral, and this is the first report to our knowledge illustrating this for RPE dysgenesis, which perhaps should no longer be termed unilateral.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1342-4"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30960646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archopht.130.10.1249
Saramaccan is an Atlantic English creole with substratal tonal features, including high tone spread. While high tone spread is generally leftward, an analysis of rightward spread accounts for the data in serial verb constructions where there are high tones that cannot be explained by leftward spread. However, there are other serial verb constructions with high tones that can be explained by leftward spread. There are two sets of high tone spread rules, then, but rightward spread is basically limited to constructions that are unequivocally of substrate origin, namely serial verb constructions. Significantly, while the origin of leftward spread is unknown, the primary substrate language Fongbe has rightward high tone spread, and is the apparent source of Saramaccan serial verb constructions. This uniquely substrate construction, then, may have transferred with its own rightward tone spread rules, which adapted to leftward tone spread rules resulting in rightward tone spread rules in Saramaccan that are more complex than the source.
{"title":"About this journal.","authors":"","doi":"10.1001/archopht.130.10.1249","DOIUrl":"https://doi.org/10.1001/archopht.130.10.1249","url":null,"abstract":"Saramaccan is an Atlantic English creole with substratal tonal features, including high tone spread. While high tone spread is generally leftward, an analysis of rightward spread accounts for the data in serial verb constructions where there are high tones that cannot be explained by leftward spread. However, there are other serial verb constructions with high tones that can be explained by leftward spread. There are two sets of high tone spread rules, then, but rightward spread is basically limited to constructions that are unequivocally of substrate origin, namely serial verb constructions. Significantly, while the origin of leftward spread is unknown, the primary substrate language Fongbe has rightward high tone spread, and is the apparent source of Saramaccan serial verb constructions. This uniquely substrate construction, then, may have transferred with its own rightward tone spread rules, which adapted to leftward tone spread rules resulting in rightward tone spread rules in Saramaccan that are more complex than the source.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1249"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31494592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.1506
Jessica L Chen, Elizabeth A Hodapp, Lauren S Blieden, Robert M Knape, Joseph F Panarelli, Michael R Banitt, Anna K Junk, Joyce C Schiffman, William J Feuer, Richard K Parrish
{"title":"Effect of cataract surgery and 5-Fluorouracil on trabeculectomy function.","authors":"Jessica L Chen, Elizabeth A Hodapp, Lauren S Blieden, Robert M Knape, Joseph F Panarelli, Michael R Banitt, Anna K Junk, Joyce C Schiffman, William J Feuer, Richard K Parrish","doi":"10.1001/archophthalmol.2012.1506","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1506","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1353; author reply 1353-4"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30959052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.2270
Adam M Dubis, Deborah M Costakos, C Devika Subramaniam, Pooja Godara, William J Wirostko, Joseph Carroll, Jan M Provis
Objective: To assess outer retinal layer maturation during late gestation and early postnatal life using optical coherence tomography and histologic examination.
Methods: Thirty-nine participants 30 weeks' postmenstrual age or older were imaged using a handheld optical coherence tomography system, for a total of 102 imaging sessions. Foveal images from 16 participants (21 imaging sessions) were normal and evaluated for inner retinal excavation and the presence of outer retinal reflective bands. Reflectivity profiles of central, parafoveal, and parafoveal retina were extracted and were compared with age-matched histologic sections.
Results: The foveal pit morphologic structure in infants was generally distinguishable from that in adults. Reflectivity profiles showed a single hyperreflective band at the fovea in all the infants younger than 42 weeks' postmenstrual age. Multiple bands were distinguishable in the outer retina at the peri fovea by 32 weeks' postmenstrual age and at the fovea by 3 months' postterm. By 17 months' postnatal, the characteristic appearance of 4 hyperreflective bands was evident across the foveal region. These features are consistent with previous results from histologic examinations. A "temporal divot" was present in some infants, and the foveal pit morphologic structure and the extent of inner retinal excavation were variable.
Conclusions: Handheld optical coherence tomography is a viable technique for evaluating neonatal retinas. In premature infants who do not develop retinopathy of prematurity, the foveal region seems to follow a developmental time course similar to that associated with in utero maturation.
Clinical relevance: As pediatric optical coherence tomography becomes more common, a better understanding of normal foveal and macular development is needed. Longitudinal imaging offers the opportunity to track postnatal foveal development among preterm infants in whom poor visual outcomes are anticipated or to follow up treatment outcomes in this population.
{"title":"Evaluation of normal human foveal development using optical coherence tomography and histologic examination.","authors":"Adam M Dubis, Deborah M Costakos, C Devika Subramaniam, Pooja Godara, William J Wirostko, Joseph Carroll, Jan M Provis","doi":"10.1001/archophthalmol.2012.2270","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2270","url":null,"abstract":"<p><strong>Objective: </strong>To assess outer retinal layer maturation during late gestation and early postnatal life using optical coherence tomography and histologic examination.</p><p><strong>Methods: </strong>Thirty-nine participants 30 weeks' postmenstrual age or older were imaged using a handheld optical coherence tomography system, for a total of 102 imaging sessions. Foveal images from 16 participants (21 imaging sessions) were normal and evaluated for inner retinal excavation and the presence of outer retinal reflective bands. Reflectivity profiles of central, parafoveal, and parafoveal retina were extracted and were compared with age-matched histologic sections.</p><p><strong>Results: </strong>The foveal pit morphologic structure in infants was generally distinguishable from that in adults. Reflectivity profiles showed a single hyperreflective band at the fovea in all the infants younger than 42 weeks' postmenstrual age. Multiple bands were distinguishable in the outer retina at the peri fovea by 32 weeks' postmenstrual age and at the fovea by 3 months' postterm. By 17 months' postnatal, the characteristic appearance of 4 hyperreflective bands was evident across the foveal region. These features are consistent with previous results from histologic examinations. A \"temporal divot\" was present in some infants, and the foveal pit morphologic structure and the extent of inner retinal excavation were variable.</p><p><strong>Conclusions: </strong>Handheld optical coherence tomography is a viable technique for evaluating neonatal retinas. In premature infants who do not develop retinopathy of prematurity, the foveal region seems to follow a developmental time course similar to that associated with in utero maturation.</p><p><strong>Clinical relevance: </strong>As pediatric optical coherence tomography becomes more common, a better understanding of normal foveal and macular development is needed. Longitudinal imaging offers the opportunity to track postnatal foveal development among preterm infants in whom poor visual outcomes are anticipated or to follow up treatment outcomes in this population.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1291-300"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30960631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.1914
James G Ravin
N early a century ago, Karl Germain (1878-1956), a magician who had an international reputation for conjuring, became blind from a brain tumor. It ended his career. His physicians in Cleveland, Ohio, advised him to consult the eminent neurosurgeon Harvey Cushing, MD (1869-1939), in Boston, Massachusetts. Cushing successfully removed the tumor and reported the case in his landmark article on meningiomas arising from the tuberculum sellae published in the first issue of the Archives of Ophthalmology in 1929. Germain is case number 1 in this publication. Cushing’s description of the tumor earned him the Hermann Knapp Medal of the Section on Ophthalmology from the American Medical Association, named in honor of the founder of the Archives of Ophthalmology. Cushing described Germain again in his most important medical book, Meningiomas, which was the culmination of decades of work and was not published until 1938, the next to last year of Cushing’s life.
{"title":"The magician with a meningioma.","authors":"James G Ravin","doi":"10.1001/archophthalmol.2012.1914","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1914","url":null,"abstract":"N early a century ago, Karl Germain (1878-1956), a magician who had an international reputation for conjuring, became blind from a brain tumor. It ended his career. His physicians in Cleveland, Ohio, advised him to consult the eminent neurosurgeon Harvey Cushing, MD (1869-1939), in Boston, Massachusetts. Cushing successfully removed the tumor and reported the case in his landmark article on meningiomas arising from the tuberculum sellae published in the first issue of the Archives of Ophthalmology in 1929. Germain is case number 1 in this publication. Cushing’s description of the tumor earned him the Hermann Knapp Medal of the Section on Ophthalmology from the American Medical Association, named in honor of the founder of the Archives of Ophthalmology. Cushing described Germain again in his most important medical book, Meningiomas, which was the culmination of decades of work and was not published until 1938, the next to last year of Cushing’s life.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1317-21"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1914","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30960635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.850
Suzanne Yzer, Adrian T Fung, Irene Barbazetto, Lawrence A Yannuzzi, K Bailey Freund
C entral serous chorioretinopathy (CSC) is typically seen in hyperopic or emmetropic eyes, 1 most of which have a thickened choroid. 2 We describe 6 eyes of 6 patients with CSC and significant myopia (Table and Figure). All eyes had a thickened choroid relative to their refractive error as measured by enhanced-depth imaging spectral-domain optical coherence tomography (Heidelberg Spectralis HRA ϩ OCT; Heidelberg Engineering, Inc). No patients were receiving steroids. Methods. The diagnosis of CSC in 6 patients with moderate to high myopia was confirmed by clinical examination , fluorescein angiography, indocyanine green angiography, fundus autofluorescence imaging, and spectral-domain optical coherence tomography. Choroi-dal thickness was measured subfoveally using enhanced-depth imaging spectral-domain optical coherence tomography. Results. The clinical information as well as the choroi-dal thickness measurement and expected choroidal thickness are summarized in the Table. In each of the 3 eyes in which an expected choroidal thickness calculation was appropriate, the expected choroidal thickness was less than the measured thickness. Comment. In a study of 28 eyes with CSC, the mean (SD) subfoveal choroidal thickness was 505 (124) µm. 2 This contrasts with a mean (SD) subfoveal choroidal thickness of 287 (76) µm in normal eyes. 4 Although choroi-dal thickness decreases with age in normal eyes, the same pattern may not hold for patients with CSC. 2,4 Our 6 eyes with CSC are unusual in that they were all myopic. With the exception of patient 6, the choroi-dal thickness of our cases would not normally be considered high for emmetropic eyes. However, it is high for myopic eyes. In a study of 31 patients with high myopia (mean refractive error, −11.9 diopters), the mean sub-foveal choroidal thickness was 93.2 µm. 3 A regression analysis suggested a decrease in subfoveal choroidal thickness of 7.84 µm per diopter of myopia in eyes with no history of choroidal neovascularization. 3 These cases remind us that CSC can occur in myopic eyes. In the absence of a neurosensory detachment, the diagnosis of CSC can be made based on history, fundus appearance, fundus autofluorescence imaging, and measurement of choroidal thickness. In myopic eyes without a neurosensory detachment, CSC may be missed when axial length–related choroidal thickness differences are not considered. Awareness of thin choroids in " normal " myopic patients would allow for the recognition of " thick " choroids relative to refraction in eyes with CSC. Abbreviations: BCVA, best-corrected visual acuity; D, diopters; NA, not …
{"title":"Central serous chorioretinopathy in myopic patients.","authors":"Suzanne Yzer, Adrian T Fung, Irene Barbazetto, Lawrence A Yannuzzi, K Bailey Freund","doi":"10.1001/archophthalmol.2012.850","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.850","url":null,"abstract":"C entral serous chorioretinopathy (CSC) is typically seen in hyperopic or emmetropic eyes, 1 most of which have a thickened choroid. 2 We describe 6 eyes of 6 patients with CSC and significant myopia (Table and Figure). All eyes had a thickened choroid relative to their refractive error as measured by enhanced-depth imaging spectral-domain optical coherence tomography (Heidelberg Spectralis HRA ϩ OCT; Heidelberg Engineering, Inc). No patients were receiving steroids. Methods. The diagnosis of CSC in 6 patients with moderate to high myopia was confirmed by clinical examination , fluorescein angiography, indocyanine green angiography, fundus autofluorescence imaging, and spectral-domain optical coherence tomography. Choroi-dal thickness was measured subfoveally using enhanced-depth imaging spectral-domain optical coherence tomography. Results. The clinical information as well as the choroi-dal thickness measurement and expected choroidal thickness are summarized in the Table. In each of the 3 eyes in which an expected choroidal thickness calculation was appropriate, the expected choroidal thickness was less than the measured thickness. Comment. In a study of 28 eyes with CSC, the mean (SD) subfoveal choroidal thickness was 505 (124) µm. 2 This contrasts with a mean (SD) subfoveal choroidal thickness of 287 (76) µm in normal eyes. 4 Although choroi-dal thickness decreases with age in normal eyes, the same pattern may not hold for patients with CSC. 2,4 Our 6 eyes with CSC are unusual in that they were all myopic. With the exception of patient 6, the choroi-dal thickness of our cases would not normally be considered high for emmetropic eyes. However, it is high for myopic eyes. In a study of 31 patients with high myopia (mean refractive error, −11.9 diopters), the mean sub-foveal choroidal thickness was 93.2 µm. 3 A regression analysis suggested a decrease in subfoveal choroidal thickness of 7.84 µm per diopter of myopia in eyes with no history of choroidal neovascularization. 3 These cases remind us that CSC can occur in myopic eyes. In the absence of a neurosensory detachment, the diagnosis of CSC can be made based on history, fundus appearance, fundus autofluorescence imaging, and measurement of choroidal thickness. In myopic eyes without a neurosensory detachment, CSC may be missed when axial length–related choroidal thickness differences are not considered. Awareness of thin choroids in \" normal \" myopic patients would allow for the recognition of \" thick \" choroids relative to refraction in eyes with CSC. Abbreviations: BCVA, best-corrected visual acuity; D, diopters; NA, not …","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1339-40"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30960644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.2008
Catherine A Cukras, Wai T Wong, Rafael Caruso, Denise Cunningham, Wadih Zein, Paul Sieving
{"title":"Fundus autofluorescence patterns in stargardt disease over time-reply.","authors":"Catherine A Cukras, Wai T Wong, Rafael Caruso, Denise Cunningham, Wadih Zein, Paul Sieving","doi":"10.1001/archophthalmol.2012.2008","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2008","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1354-5"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31495294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.662
Ruben Kuruvilla, Priya D Sahu, Murray A Meltzer
These data hint that arteritis may be more prevalent in the frontal branch than the parietal branch. Notably, in the majority of patients who had imaging signs of temporal arteritis, abnormalities were present in one branch but not the other, at least on one side. Although neuroimaging is not equivalent to the gold standard of histopathological analysis, this result suggests that selective involvement of a single branch of the superficial temporal artery is not rare. Bilateral temporal artery biopsy is sometimes performed to improve the chance of obtaining a positive result, especially if systemic symptoms are present. However, only a handful of patients will have a negative biopsy finding on one side and a positive biopsy finding on the other side. If a second biopsy is contemplated, it may be more fruitful to sample the other branch of the artery on the same side rather than the same branch on the other side. In the future, surgeons should record whether they have biopsied the frontal or parietal branch so that data can be gathered to determine which branch is inflamed most frequently. This information may increase the diagnostic yield of temporal artery biopsy. Author Affiliations: Department of Ophthalmology, School of Medicine, Dankook University, Cheonan, South Korea (Dr Kyung); Massachusetts Eye and Ear Infirmary, Boston (Dr Yoon); and Departments of Ophthalmology, Neurology, and Physiology, University of California, San Francisco (Drs Crawford and Horton). Correspondence: Dr Horton, Beckman Vision Center, University of California, San Francisco, 10 Koret Way, San Francisco, CA 94143 (hortonj@vision.ucsf.edu). Financial Disclosure: None reported. Funding/Support: This work was supported by grants EY10217 (Dr Horton) and EY02162 (Beckman Vision Center) from the National Eye Institute and by Research to Prevent Blindness.
{"title":"Systemic uptake of chlorpromazine after delivery via retrobulbar injection.","authors":"Ruben Kuruvilla, Priya D Sahu, Murray A Meltzer","doi":"10.1001/archophthalmol.2012.662","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.662","url":null,"abstract":"These data hint that arteritis may be more prevalent in the frontal branch than the parietal branch. Notably, in the majority of patients who had imaging signs of temporal arteritis, abnormalities were present in one branch but not the other, at least on one side. Although neuroimaging is not equivalent to the gold standard of histopathological analysis, this result suggests that selective involvement of a single branch of the superficial temporal artery is not rare. Bilateral temporal artery biopsy is sometimes performed to improve the chance of obtaining a positive result, especially if systemic symptoms are present. However, only a handful of patients will have a negative biopsy finding on one side and a positive biopsy finding on the other side. If a second biopsy is contemplated, it may be more fruitful to sample the other branch of the artery on the same side rather than the same branch on the other side. In the future, surgeons should record whether they have biopsied the frontal or parietal branch so that data can be gathered to determine which branch is inflamed most frequently. This information may increase the diagnostic yield of temporal artery biopsy. Author Affiliations: Department of Ophthalmology, School of Medicine, Dankook University, Cheonan, South Korea (Dr Kyung); Massachusetts Eye and Ear Infirmary, Boston (Dr Yoon); and Departments of Ophthalmology, Neurology, and Physiology, University of California, San Francisco (Drs Crawford and Horton). Correspondence: Dr Horton, Beckman Vision Center, University of California, San Francisco, 10 Koret Way, San Francisco, CA 94143 (hortonj@vision.ucsf.edu). Financial Disclosure: None reported. Funding/Support: This work was supported by grants EY10217 (Dr Horton) and EY02162 (Beckman Vision Center) from the National Eye Institute and by Research to Prevent Blindness.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1348-9"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.662","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30959048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1001/archophthalmol.2012.1490
Mary C Whitman, Michael Kazim
{"title":"Dent in the forehead: a rare manifestation of metastatic cancer.","authors":"Mary C Whitman, Michael Kazim","doi":"10.1001/archophthalmol.2012.1490","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1490","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":"130 10","pages":"1349-51"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30959049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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