Numerous studies show the significance of immunological deficits, abnormal cytokine and immune cell production, and autism. Through the use of the childhood autism rating scale (CARS), the social responsiveness scale (SRS), and the computerized Cambridge neuropsychological test automated battery (CANTAB), the current study aimed to investigate the potential role of the autoimmune regulator protein AIRE-p as an immune biomarker in the pathophysiology of autism in Saudi children. According to the study's findings, plasma levels of AIRE-p in 37 autistic children (n=37) were considerably (p=0.003) lower than those in 37 healthy controls (n=37) at 0.629 (0.776) pg/ml [median (IQR)]. Based on CARS ratings, there was no difference between AIRE-p levels in children with mild to moderate autism (median, 0.661 (0.666) pg/ml; interquartile range, 0.365 (1.114) pg/ml; p = 0.365) and children with severe autism (median, 0.365 (1.114) pg/ml; interquartile range, 0.365). On the basis of SRS, a comparable pattern between mild to moderate and severe autism was also seen. AIRE-p may be involved in the physiology of autism as shown by the reduced AIRE-p plasma levels in patients with ASD. However, unless more studies are carried out using bigger sample sizes to ascertain if the drop in AIRE-p plasma level is only a side effect of autism or whether it plays a pathogenic role in the condition, these results should be viewed with care. If AIRE-p levels may be employed as a biomarker for ASD, further research including larger patient and control cohorts would be required.
{"title":"Role of Autoimmune Regulator Protein (AIRE-P) in the Pathophysiology of Autism Spectrum Disorder (ASD)in Saudi Children","authors":"Hayfa Ali Al-Ghabban, Laila Yusuf Al-Ayadhi","doi":"10.51847/guzyrk8poy","DOIUrl":"https://doi.org/10.51847/guzyrk8poy","url":null,"abstract":"Numerous studies show the significance of immunological deficits, abnormal cytokine and immune cell production, and autism. Through the use of the childhood autism rating scale (CARS), the social responsiveness scale (SRS), and the computerized Cambridge neuropsychological test automated battery (CANTAB), the current study aimed to investigate the potential role of the autoimmune regulator protein AIRE-p as an immune biomarker in the pathophysiology of autism in Saudi children. According to the study's findings, plasma levels of AIRE-p in 37 autistic children (n=37) were considerably (p=0.003) lower than those in 37 healthy controls (n=37) at 0.629 (0.776) pg/ml [median (IQR)]. Based on CARS ratings, there was no difference between AIRE-p levels in children with mild to moderate autism (median, 0.661 (0.666) pg/ml; interquartile range, 0.365 (1.114) pg/ml; p = 0.365) and children with severe autism (median, 0.365 (1.114) pg/ml; interquartile range, 0.365). On the basis of SRS, a comparable pattern between mild to moderate and severe autism was also seen. AIRE-p may be involved in the physiology of autism as shown by the reduced AIRE-p plasma levels in patients with ASD. However, unless more studies are carried out using bigger sample sizes to ascertain if the drop in AIRE-p plasma level is only a side effect of autism or whether it plays a pathogenic role in the condition, these results should be viewed with care. If AIRE-p levels may be employed as a biomarker for ASD, further research including larger patient and control cohorts would be required.","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136208374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felicia Manole, Gabriel Mihai Mekeres, Lavinia Davidescu
Allergic rhinitis is one of the most common diseases of the upper respiratory system, which imposes a high cost on countries every year due to its high prevalence. This disease is a global health problem. In recent years, due to the increase in prevalence and clinical importance of allergic rhinitis in other diseases, such as asthma, the study of this disease has received much attention. In this article, single nucleotide polymorphisms involved in allergic rhinitis have been studied in particular. In this study, the possible candidate genes related to allergic rhinitis in people with this disease and the single nucleotide polymorphism variants related to the said disease were investigated. The data collected in this study was the result of studies conducted in different parts of the world. The population studied in the articles are people with allergic rhinitis. The results have shown the association of several single nucleotide polymorphisms in different genes with allergic rhinitis, some of which may be useful in understanding the pathophysiology and finding new methods for immunotherapy of allergic rhinitis.
{"title":"Genetic Findings in Allergic Rhinitis: A Review","authors":"Felicia Manole, Gabriel Mihai Mekeres, Lavinia Davidescu","doi":"10.51847/qzrdommmtg","DOIUrl":"https://doi.org/10.51847/qzrdommmtg","url":null,"abstract":"Allergic rhinitis is one of the most common diseases of the upper respiratory system, which imposes a high cost on countries every year due to its high prevalence. This disease is a global health problem. In recent years, due to the increase in prevalence and clinical importance of allergic rhinitis in other diseases, such as asthma, the study of this disease has received much attention. In this article, single nucleotide polymorphisms involved in allergic rhinitis have been studied in particular. In this study, the possible candidate genes related to allergic rhinitis in people with this disease and the single nucleotide polymorphism variants related to the said disease were investigated. The data collected in this study was the result of studies conducted in different parts of the world. The population studied in the articles are people with allergic rhinitis. The results have shown the association of several single nucleotide polymorphisms in different genes with allergic rhinitis, some of which may be useful in understanding the pathophysiology and finding new methods for immunotherapy of allergic rhinitis.","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135838680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hybrid Encryption Technique to Enhance Security of Health Data in Cloud Environment","authors":"Aritra Dutta, R. Bose, S. Roy, Shrabani Sutradhar","doi":"10.51847/raeh8fhbt6","DOIUrl":"https://doi.org/10.51847/raeh8fhbt6","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73490812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Parenteral Therapy in Domiciliary and Outpatient Setting: A Critical Review of the Literature","authors":"","doi":"10.51847/dhavvpyhav","DOIUrl":"https://doi.org/10.51847/dhavvpyhav","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84582699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longevity of Posterior Composite Restorations and Their Reasons for Failure: A Systematic Review","authors":"S. Ansari, Ghazel Alkhalil, Sara Achraf Alhaj","doi":"10.51847/azwmtdv6lu","DOIUrl":"https://doi.org/10.51847/azwmtdv6lu","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79077882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sami Al Issa, Mohammed Alwaily, Enas Mubarak Al Hadi, A. Businnah, M. A. Alkadi, Abdulaziz Ibrahim Alshehri
{"title":"Updated Evidence in Management of Cleft Lip and Palate: Simple Review Article","authors":"Sami Al Issa, Mohammed Alwaily, Enas Mubarak Al Hadi, A. Businnah, M. A. Alkadi, Abdulaziz Ibrahim Alshehri","doi":"10.51847/yeqrhkns56","DOIUrl":"https://doi.org/10.51847/yeqrhkns56","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76411503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiology of Hypertension in Albania, a Cross-Sectional Study","authors":"Daniela Haxhihyseni, M. Krasniqi, Rezarta Kalaja","doi":"10.51847/ftvdpmatkj","DOIUrl":"https://doi.org/10.51847/ftvdpmatkj","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75173070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knowledge, Attitude, and Practice of Medical Student towards Antibiotic Resistance and Antimicrobial Stewardship Programs:  A Cross-Sectional","authors":"Mashael Saleh Alfaifi","doi":"10.51847/plnxeyzwyc","DOIUrl":"https://doi.org/10.51847/plnxeyzwyc","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135159327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computer-Assisted Evaluation of Patient Information Leaflets (PILs) for Chronic Kidney Disease Compared with Marketed PILs","authors":"Ruhul Amin, Faruk Alam, B. Dey","doi":"10.51847/zet9xn9dhk","DOIUrl":"https://doi.org/10.51847/zet9xn9dhk","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75004491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Actinomycetoma of Left Foot - A Case Report of Neglected Tropical Disease and Medication Non-adherence","authors":"Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Vishwanatha Swamy, Ancy Chacko, Jibin James","doi":"10.51847/vym1yvkv4s","DOIUrl":"https://doi.org/10.51847/vym1yvkv4s","url":null,"abstract":"","PeriodicalId":8308,"journal":{"name":"Archives Of Pharmacy Practice","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90649302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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