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Impact of chronic pelvic pain on quality of life in diverse young adults. 慢性盆腔疼痛对不同年轻人生活质量的影响。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-23 DOI: 10.1007/s00404-024-07783-w
Catherine Graeve, Grace Gao, Vera Stephenson, Rachel Helland, Alvin D Jeffery

Purpose: To examine the relationship between quality of life (QoL) and chronic pelvic pain (CPP), including an evaluation of whether differences exist between reported races and coping mechanisms used.

Methods: We used a cross-sectional survey design and analyzed data using descriptive and inferential statistics. We administered two surveys: the World Health Organization Quality of Life-BREF (26 items) and the Impact of Female Chronic Pelvic Pain Questionnaire (8 items). We recruited young adults aged 18-25 who menstruate from college campuses in a large metropolitan area in the Midwest region of the United States, utilizing flyers, online social media platforms, and snowball sampling techniques.

Results: Out of the 585 respondents, 153 (26%) reported "yes," and 95 (16%) were "unsure" they had CPP. Those with CPP and unsure reported using various coping mechanisms for pain. They had lower scores in all four domains (physical health, psychological, social relationship, and environment) and statistically significant lower scores in three domains (physical health, social relationship, and environment) on the World Health Organization Quality of Life-BREF when compared to those who said "no." Respondents identifying as Black, Indigenous, or People of Color had statistically significantly lower QoL in the physical health and environment domains compared to white respondents.

Conclusion: Young adults with CPP experience a significantly lower QoL than those without CPP, and racial differences further widen this gap. Future research should explore coping mechanisms that could benefit young adults' daily lives.

目的:研究生活质量(QoL)与慢性盆腔疼痛(CPP)之间的关系,包括评估所报告的种族和所使用的应对机制之间是否存在差异:我们采用横断面调查设计,并使用描述性和推论性统计方法分析数据。我们进行了两项调查:世界卫生组织生活质量-BREF(26 个项目)和女性慢性盆腔疼痛影响问卷(8 个项目)。我们利用传单、在线社交媒体平台和滚雪球抽样技术,在美国中西部一个大都市地区的大学校园中招募了 18-25 岁的月经期青年:在 585 名受访者中,153 人(26%)表示 "有",95 人(16%)表示 "不确定 "自己有 CPP。患有 CPP 和不确定患有 CPP 的受访者表示使用了各种疼痛应对机制。与表示 "没有 "的受访者相比,他们在所有四个领域(身体健康、心理、社会关系和环境)的得分都较低,而在世界卫生组织生活质量REF 中,他们在三个领域(身体健康、社会关系和环境)的得分明显较低。与白人受访者相比,黑人、土著或有色人种受访者在身体健康和环境领域的生活质量明显较低:结论:患有 CPP 的年轻人的 QoL 明显低于未患有 CPP 的年轻人,种族差异进一步拉大了这一差距。未来的研究应探索有利于年轻人日常生活的应对机制。
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引用次数: 0
Retraction Note: To do or not to do emergency cervical cerclage (a rescue stitch) at 24-28 weeks gestation in addition to progesterone for patients coming early in labor? A prospective randomized trial for efficacy and safety. 撤回声明:妊娠24-28周时,对早产患者除使用黄体酮外,还要不要进行紧急宫颈环扎术(抢救性缝合)?疗效和安全性的前瞻性随机试验。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-22 DOI: 10.1007/s00404-024-07798-3
Ahmed Ragab, Yasser Mesbah
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引用次数: 0
Emergent cesarean section during active labor-does cervical dilatation matter? 活跃产程中的紧急剖宫产--宫颈扩张重要吗?
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-22 DOI: 10.1007/s00404-024-07787-6
Gil Shechter Maor, Ziv Shapira, Chen Manor Bar, Shiran Sara Moore, Yael Yagur, Tal Biron-Shental, Omer Weitzner

Purpose: To compare the immediate and late complications associated with emergent cesarean sections (CS) performed during the first and second stages of active labor.

Methods: We conducted a retrospective analysis of electronic medical records from a single academic center, including data from 577 patients who underwent emergent cesarean sections at 4 cm or more of cervical dilatation. Patients were divided into two groups: those who had CS during the first stage of labor (4-9 cm dilatation) and those who had CS at complete dilatation (10 cm). Maternal and neonatal outcomes were compared, including rates of complications such as uterine atony, post-partum hemorrhage, infection, and neonatal intensive care unit (NICU) admission.

Results: Of the 577 patients, 352 underwent CS during active labor and 255 at complete dilatation. The complete dilatation group exhibited significantly higher rates of uterine atony (19.6% vs. 11.6%, p = 0.009) and uterine incision extension (34.2% vs. 16.5%, p = 0.0001). In addition, they had longer hospital stays (4.8 vs. 4.25 days, p = 0.003) and higher outpatient clinic visit rates (21.3% vs. 9.9%, p = 0.0001). Infection-related complications on readmission were more common in the complete dilatation group (20% vs. 9.7%, p = 0.001). Neonatal outcomes, including APGAR scores and NICU admissions, did not differ significantly between the groups.

Conclusion: Emergent cesarean sections performed at complete cervical dilatation are associated with increased intra-operative and post-operative complications compared to those performed during active labor. These findings highlight the importance of considering the stage of labor when planning cesarean delivery to minimize risks and optimize outcomes for both mother and neonate.

目的:比较在活跃产程第一和第二阶段实施紧急剖宫产术(CS)的近期和后期并发症:我们对一家学术中心的电子病历进行了回顾性分析,其中包括 577 名在宫颈扩张 4 厘米或以上时接受紧急剖宫产术的患者的数据。患者被分为两组:在第一产程(宫颈扩张 4-9 厘米)时进行剖宫产的患者和在宫颈完全扩张(10 厘米)时进行剖宫产的患者。对产妇和新生儿的结局进行了比较,包括并发症的发生率,如子宫失弛缓、产后出血、感染和新生儿重症监护室(NICU)入院率:在577名患者中,352人在活跃产程中进行了CS,255人在宫口完全扩张时进行了CS。完全宫口扩张组的子宫失弛缓率(19.6% 对 11.6%,P = 0.009)和子宫切口扩展率(34.2% 对 16.5%,P = 0.0001)明显高于完全宫口扩张组。此外,他们的住院时间更长(4.8 天 vs. 4.25 天,p = 0.003),门诊就诊率更高(21.3% vs. 9.9%,p = 0.0001)。完全扩张组再次入院时感染相关并发症更常见(20% 对 9.7%,P = 0.001)。新生儿预后,包括APGAR评分和新生儿重症监护室入院率,在两组之间没有显著差异:结论:与在活跃产程中进行的剖宫产手术相比,在宫颈完全扩张时进行的紧急剖宫产手术会增加术中和术后并发症。这些发现强调了在计划剖宫产时考虑产程的重要性,以最大限度地降低风险,优化母亲和新生儿的预后。
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引用次数: 0
Perinatal outcomes of selective termination in dichorionic twin pregnancies: a retrospective study from a single center. 二绒毛膜双胎选择性终止妊娠的围产期结局:来自一个中心的回顾性研究。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-21 DOI: 10.1007/s00404-024-07784-9
Chunyan Deng, Qing Hu, Hua Liao, Guiqiong Huang, Xiaodong Wang, Haiyan Yu

Objective: Selective termination (ST) is an appropriate procedure for managing discordant fetal anomalies in dichorionic diamniotic (DCDA) twin pregnancies. The aim of this study was to investigate the perinatal outcomes of ST at different gestational ages in DCDA twin pregnancies.

Methods: This retrospective study was conducted on DCDA twin pregnancies with STs at West China Second University Hospital between January 2012 and December 2022. According to the gestational age at which ST was performed, the patients were assigned to four groups: Group 1 (13 to 17 + 6 weeks), Group 2 (18 to 23 + 6 weeks), Group 3 (24 to 27 + 6 weeks), and Group 4 (≥ 28 weeks).

Results: We identified 230 patients for this study. The overall rates of miscarriage, preterm delivery at < 32 weeks, and term delivery were 1.3%, 10.5%, and 50%, respectively, while the rates of live birth and neonatal survival were 98.7% and 98.2%, respectively. The rate of term birth was highest (70.6%) and the birth weight was heaviest (2931 ± 535 g) in Group 1 (p = 0.000). In the presence of a fetus subjected to feticide, the mean delivery age was earlier than that in the non-presenting group (p = 0.017); accordingly, the mean birth weight in the feticide group was lower (2366 ± 628 g) than that in the non-presenting group (2590 ± 634 g) (p = 0.011). When we examined the relative relationship between reduction weeks and delivery weeks of twins by correlation analysis, we observed that with regard to maternal prognosis, two pregnancies involved preterm premature rupture of membranes (PPROM) at 7 days and 3 days after the procedure. Intrauterine infection occurred in two patients in Group 4, but there were no maternal deaths or maternal coagulatory abnormalities.

Conclusions: Optimal perinatal outcomes were obtained by ST of DCDA pregnancies before 18 weeks, regardless of whether or not the reduced fetus was the presenting twin. However, if legally possible, late (i.e., after 28 weeks) procedures can be a safe alternative for patients diagnosed after the 18th week of gestation. Overall, we herein noted a negative correlation between the procedure week and the delivery week in this study. Moreover, ST of the non-presenting twin was associated with a heavier birth weight and later gestational age at delivery.

目的:选择性终止妊娠(ST)是处理二绒毛膜双胎(DCDA)胎儿畸形的适当方法。本研究旨在调查二绒毛膜双胎妊娠在不同孕龄进行选择性终止妊娠的围产期结局:这项回顾性研究的对象是2012年1月至2022年12月期间在华西第二大学医院妊娠合并ST的DCDA双胎妊娠。根据实施ST的胎龄,将患者分为四组:第1组(13至17+6周)、第2组(18至23+6周)、第3组(24至27+6周)和第4组(≥28周):我们为这项研究确定了 230 名患者。流产、早产的总发生率在得出结论时为 0.5%:无论畸形胎儿是否为双胎,在 18 周前对 DCDA 孕妇进行 ST 均可获得最佳围产期结局。然而,如果法律允许,晚期(即 28 周后)手术对于妊娠 18 周后确诊的患者来说是一个安全的替代方案。总体而言,在本研究中,我们注意到手术周数与分娩周数呈负相关。此外,无症状双胎的 ST 与较重的出生体重和较晚的分娩胎龄有关。
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引用次数: 0
Prenatal diagnosis, ultrasound findings, and pregnancy outcome of 17q12 deletion and duplication syndromes: a retrospective case series. 17q12缺失和重复综合征的产前诊断、超声检查结果和妊娠结局:回顾性病例系列。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-21 DOI: 10.1007/s00404-024-07789-4
Xiaojin Luo, Xiaohang Chen, Xiaoyi Cong, Hongyan Niu, Fei Zhou, Jinshuang Song, Liang Hu, Yuanyuan Pei, Yanyun Guo
<p><strong>Objective: </strong>Analyze the ultrasound findings, single-nucleotide polymorphism array (SNP-array) results, and pregnancy outcomes of fetuses with 17q12 deletions and duplications in the second and third trimesters. Explore the prenatal ultrasound characteristics and pregnancy outcomes of these fetuses.</p><p><strong>Methods: </strong>Retrospective data were collected for 16 fetuses diagnosed with 17q12 deletion and seven fetuses with 17q12 duplication through SNP-array during prenatal diagnosis at a single Chinese tertiary medical center from January 2017 to December 2023. Maternal demographics, ultrasound findings of the fetuses, SNP-array results, pregnancy outcomes, and follow-up information were reviewed and analyzed. Peripheral blood from the parents was extracted to determine whether the CNVs in the fetuses were inherited or de novo.</p><p><strong>Results: </strong>The copy-number variation (CNV) sizes ranged from 1.39 to 1.94 Mb in cases of 17q12 deletion and from 1.42 to 1.91 Mb in cases of 17q12 duplication. These CNVs included 15 OMIM genes, such as HNF1B, LHX1, and ACACA. In fetuses with a 17q12 deletion, the primary manifestation was renal abnormalities (93.8%, 15/16). Of these, 13 cases (81.3%, 13/16) exhibited bilateral or unilateral hyperechogenic kidneys, and 12 cases (75%, 12/16) had multicystic hyperechogenic kidneys. Two cases (12.5%, 2/16) showed multiple organ structural abnormalities. In fetuses with a 17q12 duplication, four cases (57.1%, 4/7) revealed cardiovascular system abnormalities, including tetralogy of fallot, pulmonary artery stenosis, ventricular septal defect, and tricuspid regurgitation. Two cases (28.6%, 2/7) presented with upper gastrointestinal obstruction. Additionally, one case was particularly unique, characterized by multiple structural malformations, such as ventricular septal defect, microcephaly, cleft lip, and palate. Nine cases opted for pregnancy termination, and 14 chose to continue the pregnancy. Two cases underwent surgical treatment after birth for upper gastrointestinal obstruction, and the prognosis was good. Among the 10 cases of 17q12 deletion, six cases showed consistent prenatal ultrasound findings and postnatal clinical features. Four cases were found to have discrepancies with prenatal ultrasound findings; while the renal ultrasound phenotype appeared normal during the last follow-up, two of these cases were subsequently diagnosed with neuropsychiatric phenotypes.</p><p><strong>Conclusion: </strong>Our study expanded the clinical phenotype spectrum of fetuses with 17q12 deletion and duplication, and conducted a preliminary evaluation of prenatal ultrasound findings and postnatal clinical phenotypes in follow-up cases. We further demonstrated a high correlation between fetuses with 17q12 deletion and hyperechogenic, multicystic kidneys. The primary manifestations in fetuses with 17q12 duplication are likely cardiovascular system malformations, which also exhibit a broad sp
目的分析17q12缺失和重复胎儿在第二和第三个孕期的超声检查结果、单核苷酸多态性阵列(SNP-array)结果和妊娠结局。探讨这些胎儿的产前超声特征和妊娠结局:2017年1月至2023年12月,在一家中国三级医疗中心的产前诊断过程中,通过SNP-array收集了16个被诊断为17q12缺失的胎儿和7个17q12重复的胎儿的回顾性数据。研究人员回顾并分析了产妇的人口统计学特征、胎儿的超声检查结果、SNP-阵列结果、妊娠结局以及随访信息。提取了父母的外周血,以确定胎儿的 CNV 是遗传的还是新生的:结果:17q12缺失病例的拷贝数变异(CNV)大小从1.39到1.94 Mb不等,17q12重复病例的拷贝数变异大小从1.42到1.91 Mb不等。这些 CNV 包括 15 个 OMIM 基因,如 HNF1B、LHX1 和 ACACA。在 17q12 缺失的胎儿中,主要表现为肾脏异常(93.8%,15/16 例)。其中,13 例(81.3%,13/16)表现为双侧或单侧低回声肾,12 例(75%,12/16)表现为多囊性低回声肾。两个病例(12.5%,2/16)显示多器官结构异常。在 17q12 重复的胎儿中,4 例(57.1%,4/7)显示心血管系统异常,包括法洛氏四联症、肺动脉狭窄、室间隔缺损和三尖瓣反流。两个病例(28.6%,2/7)出现上消化道梗阻。此外,有一个病例特别特殊,具有多种结构畸形,如室间隔缺损、小头畸形、唇腭裂。9 例选择终止妊娠,14 例选择继续妊娠。2 例在出生后因上消化道梗阻接受了手术治疗,预后良好。在 10 例 17q12 缺失病例中,有 6 例的产前超声检查结果与产后临床特征一致。结论:我们的研究扩大了17q12缺失儿的临床表型范围:我们的研究扩展了 17q12 缺失和重复胎儿的临床表型谱系,并对随访病例的产前超声结果和产后临床表型进行了初步评估。我们进一步证实了 17q12 缺失胎儿与高回声多囊肾之间的高度相关性。17q12 缺失胎儿的主要表现可能是心血管系统畸形,其表型特征也很广泛。
{"title":"Prenatal diagnosis, ultrasound findings, and pregnancy outcome of 17q12 deletion and duplication syndromes: a retrospective case series.","authors":"Xiaojin Luo, Xiaohang Chen, Xiaoyi Cong, Hongyan Niu, Fei Zhou, Jinshuang Song, Liang Hu, Yuanyuan Pei, Yanyun Guo","doi":"10.1007/s00404-024-07789-4","DOIUrl":"https://doi.org/10.1007/s00404-024-07789-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Analyze the ultrasound findings, single-nucleotide polymorphism array (SNP-array) results, and pregnancy outcomes of fetuses with 17q12 deletions and duplications in the second and third trimesters. Explore the prenatal ultrasound characteristics and pregnancy outcomes of these fetuses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Retrospective data were collected for 16 fetuses diagnosed with 17q12 deletion and seven fetuses with 17q12 duplication through SNP-array during prenatal diagnosis at a single Chinese tertiary medical center from January 2017 to December 2023. Maternal demographics, ultrasound findings of the fetuses, SNP-array results, pregnancy outcomes, and follow-up information were reviewed and analyzed. Peripheral blood from the parents was extracted to determine whether the CNVs in the fetuses were inherited or de novo.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The copy-number variation (CNV) sizes ranged from 1.39 to 1.94 Mb in cases of 17q12 deletion and from 1.42 to 1.91 Mb in cases of 17q12 duplication. These CNVs included 15 OMIM genes, such as HNF1B, LHX1, and ACACA. In fetuses with a 17q12 deletion, the primary manifestation was renal abnormalities (93.8%, 15/16). Of these, 13 cases (81.3%, 13/16) exhibited bilateral or unilateral hyperechogenic kidneys, and 12 cases (75%, 12/16) had multicystic hyperechogenic kidneys. Two cases (12.5%, 2/16) showed multiple organ structural abnormalities. In fetuses with a 17q12 duplication, four cases (57.1%, 4/7) revealed cardiovascular system abnormalities, including tetralogy of fallot, pulmonary artery stenosis, ventricular septal defect, and tricuspid regurgitation. Two cases (28.6%, 2/7) presented with upper gastrointestinal obstruction. Additionally, one case was particularly unique, characterized by multiple structural malformations, such as ventricular septal defect, microcephaly, cleft lip, and palate. Nine cases opted for pregnancy termination, and 14 chose to continue the pregnancy. Two cases underwent surgical treatment after birth for upper gastrointestinal obstruction, and the prognosis was good. Among the 10 cases of 17q12 deletion, six cases showed consistent prenatal ultrasound findings and postnatal clinical features. Four cases were found to have discrepancies with prenatal ultrasound findings; while the renal ultrasound phenotype appeared normal during the last follow-up, two of these cases were subsequently diagnosed with neuropsychiatric phenotypes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study expanded the clinical phenotype spectrum of fetuses with 17q12 deletion and duplication, and conducted a preliminary evaluation of prenatal ultrasound findings and postnatal clinical phenotypes in follow-up cases. We further demonstrated a high correlation between fetuses with 17q12 deletion and hyperechogenic, multicystic kidneys. The primary manifestations in fetuses with 17q12 duplication are likely cardiovascular system malformations, which also exhibit a broad sp","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspergillus-superinfected pulmonary metastases following treatment of recurrent endometrial cancer with immune checkpoint inhibitor. 用免疫检查点抑制剂治疗复发性子宫内膜癌后出现的曲霉菌超级感染肺转移灶。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-18 DOI: 10.1007/s00404-024-07771-0
Hillary Chappus-McCendie, Shannon Salvador, Gabriel Levin
{"title":"Aspergillus-superinfected pulmonary metastases following treatment of recurrent endometrial cancer with immune checkpoint inhibitor.","authors":"Hillary Chappus-McCendie, Shannon Salvador, Gabriel Levin","doi":"10.1007/s00404-024-07771-0","DOIUrl":"https://doi.org/10.1007/s00404-024-07771-0","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does maximal effort cytoreductive surgery after 6-cycles of chemotherapy play a role in the management of advanced ovarian cancer? 6 个周期化疗后的最大努力细胞剥脱手术在晚期卵巢癌的治疗中是否发挥作用?
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-17 DOI: 10.1007/s00404-024-07778-7
Viktor Cassar, Stuart Rundle, Velangali Bhavya Swetha Rongali, Porfyrios Korompelis, Christine Ang
<p><strong>Background: </strong>The current gold standard in the surgical management of advanced ovarian cancer recommended by ESGO and ASCO is complete resection of all visible disease. If this is not deemed possible in the upfront setting, then interval cytoreductive surgery should be undertaken after 3-4-cycles of neo-adjuvant chemotherapy. Occasionally, surgery in the interval setting may not be possible either due to factors associated with patient fitness, or due to persistence of disease in sites deemed unresectable on interval scanning. Limited published data assessing outcomes from surgery delayed to after 6-cycles of NACT (delayed cytoreductive surgery) suggests a potential benefit over no surgery and suggests that if interval cytoreductive surgery is not possible, then the clinician might consider delayed surgery on a case by case basis. We sought to review the outcomes of patients with Advanced Ovarian Cancer presenting to the Northern Gynaecological Oncology Centre who underwent delayed surgery.</p><p><strong>Methodology: </strong>This study is a retrospective analysis looking at patients with epithelial ovarian cancer of FIGO stage IIIC and above, who were not deemed suitable to undergo either primary or interval cytoreductive surgery, referred to the Northern Gynaecological Oncology Centre Gateshead, UK, between January 2014 and December 2020. We compared survival outcomes in women receiving non-standard treatment for advanced ovarian cancer, comparing two groups of patients; those completing at least six cycles of platinum-based chemotherapy as part of their first-line treatment and not having surgery with those who received delayed cytoreductive surgery after completing of 6-cycles of primary chemotherapy.</p><p><strong>Results: </strong>A total of 89 cases were included in the analysis and 78/89 patients had completed at least 6-cycles of primary chemotherapy in the first-line treatment setting without any attempt at surgical cytoreduction. 11/89 patients underwent DDS after completion of 6-cycles of primary chemotherapy. The majority of included cases 87/89 (98%) were high-grade serous ovarian cancer (HGSOC). Surgery and no-surgery groups were well matched in terms of stage comparison at presentation with an overall stage distribution of 62% FIGO stage IIIC, 10% stage IVA and 28% stage IVB. The surgery group were significantly younger than the no-surgery group with median age of 68 (interquartile range (IQR) 59-71 years) and 77 years (IQR 70-82 years) (p < 0.01), respectively. The overall survival (OS) of the surgery and no-surgery groups was 25 months and 23 months, respectively (p = 0.38) with a median follow-up of 20 months (IQR 11-29 months). The 1 year disease-specific mortality for both groups was 18%.</p><p><strong>Conclusion: </strong>Maximal effort cytoreductive surgery after 6-cycles is not associated with a survival benefit (even with complete cytoreduction) but may be considered in the context of symptomatic disease
背景:目前,ESGO 和 ASCO 推荐的晚期卵巢癌手术治疗金标准是完全切除所有可见病灶。如果在前期治疗中无法做到这一点,则应在接受 3-4 个周期的新辅助化疗后进行间歇性囊肿切除手术。有时,由于与患者体质有关的因素,或由于间隔期扫描认为无法切除的部位仍存在疾病,可能无法在间隔期进行手术。有限的已发表数据评估了延迟至 6 个 NACT 周期后进行手术(延迟细胞剥脱手术)的疗效,这些数据表明延迟手术可能比不手术更有疗效,同时也表明如果无法进行间期细胞剥脱手术,临床医生可以根据具体情况考虑延迟手术。我们试图回顾在北方妇科肿瘤中心接受延迟手术的晚期卵巢癌患者的治疗效果:本研究是一项回顾性分析,研究对象为2014年1月至2020年12月期间转诊至英国盖茨黑德北方妇科肿瘤中心的FIGO IIIC期及以上上皮性卵巢癌患者,这些患者被认为不适合接受初次或间歇性细胞减灭术。我们比较了接受非标准治疗的晚期卵巢癌妇女的生存结果,并对两组患者进行了比较:完成至少六个周期的铂类化疗作为一线治疗的一部分但未进行手术的患者,以及在完成六个周期的基础化疗后接受延迟细胞切除手术的患者:共有89例患者被纳入分析,其中78/89例患者在一线治疗中至少完成了6个周期的基础化疗,但未尝试过手术细胞减灭术。11/89的患者在完成6个周期的基础化疗后接受了DDS。87/89(98%)例患者为高级别浆液性卵巢癌(HGSOC)。手术组和不手术组在发病时的分期比较方面非常匹配,总体分期分布为 62% FIGO IIIC 期、10% IVA 期和 28% IVB 期。手术组明显比不手术组年轻,中位年龄分别为 68 岁(四分位间距 59-71 岁)和 77 岁(四分位间距 70-82 岁)(p 结论:手术组比不手术组更年轻:6 个周期后的最大努力细胞还原手术与生存获益无关(即使是完全细胞还原),但在无症状疾病或可通过手术缓解症状的情况下可以考虑。
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引用次数: 0
Postoperative outcomes in minimally invasive total versus supracervical hysterectomy for endometriosis: a NSQIP study. 子宫内膜异位症微创全子宫切除术与宫颈上位术的术后效果:NSQIP 研究。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-16 DOI: 10.1007/s00404-024-07749-y
Raanan Meyer, Jill McDonnell, Kacey M Hamilton, Rebecca J Schneyer, Gabriel Levin, Kelly N Wright, Matthew T Siedhoff

Purpose: To study the rate and odds of 30 day postoperative complications among patients undergoing minimally invasive total (TLH) compared to supracervical (LSCH) hysterectomy for endometriosis.

Study design: A cohort study of patients with a diagnosis of endometriosis undergoing hysterectomy. We used prospectively collected data from the American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2020. We compared short-term (30 day) complications, following minimally invasive TLH and LSCH for endometriosis. The primary outcome was the risk of any postoperative complications according to the surgical approach.

Results: A total of 5,278 patients were included, 4,952 (93.8%) underwent TLH and 326 (6.2%) underwent LSCH. The incidence of any complication was significantly lower in the LSCH group compared to the TLH group (3.7% vs. 8.5%, p = .001). Both major complications (1.5% vs. 3.7%, p = 0.043) and minor complications (2.8% vs. 5.4%, p = .039) were less frequent in the LSCH group compared to the TLH group. In multivariable regression analysis, patients undergoing LSCH had significantly lower odds of any complication [aOR 95%CI 0.40 (0.22-0.72)], and of minor complications [aOR 95%CI 0.47 (0.24-0.92)] compared to TLH.

Conclusions: LSCH is associated with a lower odd of short-term postoperative complications compared to TLH for patients with endometriosis.

目的:研究因子宫内膜异位症而接受微创全子宫切除术(TLH)与宫颈上子宫切除术(LSCH)的患者术后30天并发症的发生率和几率:研究设计:对确诊患有子宫内膜异位症并接受子宫切除术的患者进行队列研究。我们使用了从美国外科学院国家手术质量改进计划数据库中收集的 2012 年至 2020 年的前瞻性数据。我们比较了微创 TLH 和 LSCH 治疗子宫内膜异位症后的短期(30 天)并发症。主要结果是根据手术方法的不同,术后并发症的风险也不同:共纳入了 5278 名患者,其中 4952 人(93.8%)接受了 TLH,326 人(6.2%)接受了 LSCH。与TLH组相比,LSCH组任何并发症的发生率都明显较低(3.7% vs. 8.5%,P = .001)。与TLH组相比,LSCH组的主要并发症(1.5% vs. 3.7%,p = 0.043)和轻微并发症(2.8% vs. 5.4%,p = .039)发生率都较低。在多变量回归分析中,与TLH相比,接受LSCH的患者发生任何并发症[aOR 95%CI 0.40 (0.22-0.72)] 和轻微并发症[aOR 95%CI 0.47 (0.24-0.92)] 的几率明显较低:结论:对于子宫内膜异位症患者而言,与TLH相比,LSCH术后短期并发症的发生率较低。
{"title":"Postoperative outcomes in minimally invasive total versus supracervical hysterectomy for endometriosis: a NSQIP study.","authors":"Raanan Meyer, Jill McDonnell, Kacey M Hamilton, Rebecca J Schneyer, Gabriel Levin, Kelly N Wright, Matthew T Siedhoff","doi":"10.1007/s00404-024-07749-y","DOIUrl":"https://doi.org/10.1007/s00404-024-07749-y","url":null,"abstract":"<p><strong>Purpose: </strong>To study the rate and odds of 30 day postoperative complications among patients undergoing minimally invasive total (TLH) compared to supracervical (LSCH) hysterectomy for endometriosis.</p><p><strong>Study design: </strong>A cohort study of patients with a diagnosis of endometriosis undergoing hysterectomy. We used prospectively collected data from the American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2020. We compared short-term (30 day) complications, following minimally invasive TLH and LSCH for endometriosis. The primary outcome was the risk of any postoperative complications according to the surgical approach.</p><p><strong>Results: </strong>A total of 5,278 patients were included, 4,952 (93.8%) underwent TLH and 326 (6.2%) underwent LSCH. The incidence of any complication was significantly lower in the LSCH group compared to the TLH group (3.7% vs. 8.5%, p = .001). Both major complications (1.5% vs. 3.7%, p = 0.043) and minor complications (2.8% vs. 5.4%, p = .039) were less frequent in the LSCH group compared to the TLH group. In multivariable regression analysis, patients undergoing LSCH had significantly lower odds of any complication [aOR 95%CI 0.40 (0.22-0.72)], and of minor complications [aOR 95%CI 0.47 (0.24-0.92)] compared to TLH.</p><p><strong>Conclusions: </strong>LSCH is associated with a lower odd of short-term postoperative complications compared to TLH for patients with endometriosis.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between ovarian tumors and exposure to assisted reproductive technologies and ovarian stimulation: a systematic review and meta-analysis. 卵巢肿瘤与接触辅助生殖技术和卵巢刺激之间的关系:系统回顾和荟萃分析。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-16 DOI: 10.1007/s00404-024-07763-0
Artur de Oliveira Macena Lôbo, Victória Morbach, Francinny Alves Kelly, Francisco Cezar Aquino de Moraes

Introduction:  The question of whether assisted reproductive technologies (ART) and ovulation induction are related to a higher incidence of ovarian tumors (OTs) is still controversial in the literature.

Methods: We performed a comprehensive search of PubMed, Embase, and Web of Science databases for case-control and cohort studies that investigated ART and ovulation induction exposure as risk factors for OT in infertile women. Odds ratios (OR) with 95% confidence intervals (CI) were employed for all endpoints.

Results: A total of nine case-control and twelve cohort studies were included, encompassing 439,477 women. ART was not associated with a higher risk of OTs (OR 1.05; 95% CI 0.86-1.29; p = 0.64; I2 = 36%), nor when considering only borderline OTs (OR 1.13; 95% CI 0.84-1.51; p = 0.42; I2 = 31%). In a subgroup analysis by study type, the risk difference of OTs remained non-significant for case-control (OR 1.12; 95% CI 0.70-1.78; p = 0.65; I2 = 60%) and cohort studies (OR 1.05; 95% CI 0.87-1.27; p = 0.60; I2 = 1%). For borderline OTs, the difference between groups was also non-significant for case-control studies (OR 1.44; 95% CI 0.73-2.87; p = 0.30; I2 = 40%) and cohort studies (OR 1.00; 95% CI 0.75-1.34; p = 0.99; I2 = 24%).

Conclusion: In this systematic review and meta-analysis, ART exposure in infertile women was not associated with a higher risk of OTs in general or borderline tumors, even when accounting for study type differences.

简介:辅助生殖技术(ART)和促排卵是否与卵巢肿瘤(OTs)发病率升高有关? 辅助生殖技术(ART)和促排卵是否与卵巢肿瘤(OTs)的高发病率有关,这一问题在文献中仍存在争议:方法:我们在PubMed、Embase和Web of Science数据库中进行了全面检索,寻找将ART和促排卵暴露作为不孕妇女卵巢肿瘤风险因素的病例对照和队列研究。所有终点均采用带 95% 置信区间 (CI) 的比值比 (OR):结果:共纳入了 9 项病例对照研究和 12 项队列研究,涉及 439 477 名妇女。抗逆转录病毒疗法与更高的 OT 风险无关(OR 1.05;95% CI 0.86-1.29;P = 0.64;I2 = 36%),仅考虑边缘 OT 时也是如此(OR 1.13;95% CI 0.84-1.51;P = 0.42;I2 = 31%)。在按研究类型进行的亚组分析中,病例对照研究(OR 1.12;95% CI 0.70-1.78;P = 0.65;I2 = 60%)和队列研究(OR 1.05;95% CI 0.87-1.27;P = 0.60;I2 = 1%)的OT风险差异仍然不显著。对于边缘性 OT,病例对照研究(OR 1.44;95% CI 0.73-2.87;P = 0.30;I2 = 40%)和队列研究(OR 1.00;95% CI 0.75-1.34;P = 0.99;I2 = 24%)的组间差异也不显著:在这项系统综述和荟萃分析中,即使考虑到研究类型的差异,不孕妇女的抗逆转录病毒疗法暴露与一般肿瘤或边缘性肿瘤的较高风险无关。
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引用次数: 0
Innovations in ultrasound training in obstetrics. 产科超声波培训的创新。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-15 DOI: 10.1007/s00404-024-07777-8
Agnes Wittek, Brigitte Strizek, Florian Recker

Introduction: Ultrasound technology is critical in obstetrics, enabling detailed examination of the fetus and maternal anatomy. However, increasing complexity demands specialised training to maximise its potential. This study explores innovative approaches to ultrasound training in obstetrics, focussing on enhancing diagnostic skills and patient safety.

Methods: This review examines recent innovations in ultrasound training, including competency-based medical education (CBME), simulation technologies, technology-based resources, artificial intelligence (AI), and online-learning platforms. Traditional training methods such as theoretical learning, practical experience, and peer learning are also discussed to provide a comprehensive view of current practises.

Results: Innovations in ultrasound training include the use of high-fidelity simulators, virtual reality (VR), augmented reality (AR), and hybrid-learning platforms. Simulation technologies offer reproducibility, risk-free learning, diverse scenarios, and immediate feedback. AI and machine learning facilitate personalised-learning paths, real-time feedback, and automated-image analysis. Online-learning platforms and e-learning methods provide flexible, accessible, and cost-effective education. Gamification enhances learning motivation and engagement through educational games and virtual competitions.

Discussion: The integration of innovative technologies in ultrasound training significantly improves diagnostic skills, learner confidence, and patient safety. However, challenges such as high costs, the need for comprehensive instructor training, and integration into existing programs must be addressed. Standardisation and certification ensure high-quality and consistent training. Future developments in AI, VR, and 3D printing promise further advancements in ultrasound education.

Conclusion: Innovations in ultrasound training in obstetrics offer significant improvements in medical education and patient care. The successful implementation and continuous development of these technologies are crucial to meet the growing demands of modern obstetrics.

简介超声技术在产科中至关重要,可对胎儿和产妇的解剖结构进行详细检查。然而,由于其复杂性不断增加,需要进行专门培训才能最大限度地发挥其潜力。本研究探讨了产科超声培训的创新方法,重点是提高诊断技能和患者安全:本综述探讨了超声培训领域的最新创新,包括基于能力的医学教育(CBME)、模拟技术、基于技术的资源、人工智能(AI)和在线学习平台。此外,还讨论了理论学习、实践经验和同伴学习等传统培训方法,以全面了解当前的做法:超声波培训的创新包括使用高保真模拟器、虚拟现实(VR)、增强现实(AR)和混合学习平台。模拟技术具有可重复性、无风险学习、场景多样化和即时反馈等特点。人工智能和机器学习为个性化学习路径、实时反馈和自动图像分析提供了便利。在线学习平台和电子学习方法提供了灵活、便捷、经济的教育方式。游戏化通过教育游戏和虚拟竞赛提高了学习动力和参与度:将创新技术融入超声波培训可显著提高诊断技能、增强学习者的信心和患者安全。然而,必须解决高成本、需要对讲师进行全面培训以及与现有课程整合等挑战。标准化和认证可确保培训的高质量和一致性。人工智能、VR 和 3D 打印技术的未来发展有望进一步推动超声教育的进步:产科超声培训的创新极大地改善了医学教育和患者护理。这些技术的成功实施和持续发展对于满足现代产科日益增长的需求至关重要。
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引用次数: 0
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Archives of Gynecology and Obstetrics
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