Applied Organometallic Chemistry最新文献

To advance our study on the GLUT's glucose recognition binding site and enhance the effectiveness of targeted anticancer compounds based on our encouraging findings, glycogenated metal complexes have shown promise in combating colon cancer (HCT-116) through salicylaldehyde-D-glucosamine Schiff base(H₂L), we proceed with our research utilizing various colon cell lines with different metal ions known for their potent anticancer effect. Newly synthesized complexes with the formulae Zn (HL)₂, (CH₃)₂Sn(HL)₂, and [Ru(L)(HL)H₂O].H₂O are directed against two colon cell lines (HCT-116 and Caco-2). Different characterization techniques are used to confirm structures. DFT was used to structurally optimize the synthesized compounds. The particle size distribution was performed for all chelates. All compounds revealed remarkable anticancer activities especially the ligand and Ru (III) complex recording IC₅₀ values of 21.73 μg/mL against HCT-116 and 49.53 μg/mL against Caco-2 cell lines, respectively. The results showed that GLUT's glucose recognition binding site can attract the sugar-conjugated compounds. The efficiency of the ligand and its Ru (III) complex was confirmed through the evaluation of GSH, SOD, MDA, NO, and LDH levels. The high affinity of metal glycoconjugates for DNA binding was explored using electrophoresis. Additionally, the metal chelates showed significant antimicrobial activity. The ligand and its Zn (II) complex showed bactericidal activity against the strain of Helicobacter pylori. The docking simulation was performed to explore the active amino acids participate in the biological interaction.

The Type II heterojunction, characterized by its favorable band alignment, facilitated efficient charge separation in photocatalysts. Concurrently, oxygen vacancies can enhance light absorption and activated reactants, thereby improving photocatalytic efficiency. This study presented the synthesis of Bi-TCPP/Bi₂S₃ heterojunction photocatalysts, which were rich in oxygen vacancies, using a green, one-pot method. The composite exhibited superior photoelectrochemical and photocatalytic reduction properties, achieving a rate constant of 0.03829 min⁻¹ for Cr(VI) reduction and a remarkable reduction rate of 95.73%. After five cycles, the photocatalytic activity remained above 91.30%, demonstrating excellent stability and efficiency in reducing persistent pollutants. This work introduced a novel strategy for photocatalyst design and made a significant contribution to the fields of environmental remediation and green chemistry.

In this study, we synthesized and characterized chitosan–silver oxide (Ag₂O) nanocomposites to investigate their dielectric properties and potential applications in advanced electronics. Comprehensive analysis using techniques such as TGA, EDX, XRD, SEM, and FTIR confirmed the successful formation of uniformly dispersed Ag₂O nanoparticles within the chitosan matrix. The interaction between silver oxide and the active sites of chitosan was crucial in achieving this stable composite structure. Our findings revealed that the dielectric permittivity of the nanocomposites decreases with increasing frequency, particularly in samples with higher Ag₂O content, because of Maxwell–Wagner–Sillars interfacial polarization. Furthermore, the electric modulus analysis indicated reduced electrode polarization and enhanced α-relaxation with increased Ag₂O, suggesting improved performance in frequency-dependent applications. The conductivity behavior, characterized by a power-law dependence on frequency, aligns with the correlated barrier hopping model of charge transport. Density functional theory (DFT) calculations supported the experimental results, highlighting the stability and enhanced reactivity of the Ag₂O/CS composite compared with pure chitosan. These combined experimental and theoretical insights underscore the potential of Ag₂O/CS nanocomposites for applications in electrical engineering, catalysis, sensing, and nanomaterial fabrication.

A series of rare-earth metal alkyl complexes containing chiral cyclohexyl-bridged bis(β-diketiminate) ligands have been synthesized, with a general chemical formula of {Cy[NC (Me)CHC (Me)NAr]₂}RECH₂SiMe₃ [Cy=(1R, 2R)-(-)-1,2-cyclohexyl, Ar=2,6-ⁱPr₂C₆H₃, RE=Dy(1), Er(2), Yb(3), Y(4)]. These compounds were prepared in good yields by the reaction of RE[CH₂SiMe₃]₃(THF)₂ with Cy[NHC (Me)CHC (Me)NAr]₂ (H₂L). Comprehensive characterizations of all compounds were achieved through spectroscopic methods and elemental analysis. The structures of Compounds 1–4 were determined by single-crystal x-ray diffraction analysis, and Compound 4 was further characterized by hydrogen-1 (¹H) NMR and carbon-13 (¹³C) NMR spectroscopy. The catalytic performance of these complexes was investigated, and their ability to catalyze the hydroamination/cyclization reaction of aminoalkenes to afford the corresponding cyclic amines was proven. The resulting heterocyclic compounds were predominantly Markovnikov addition products. The catalytic efficiency of different catalysts was not significantly affected by central metal, and over 90% conversion could be achieved with a catalyst loading as low as 3%. However, the catalytic hydroamination/cyclization reaction to six-membered ring products was found to be more challenging compared to the formation of five-membered rings.

In the pursuit of sustainable energy solutions, the spotlight shines on the advancement of effective energy storage systems and green hydrogen production. In this work, UU 200 (UU: Uppsala University) metal–organic framework (MOF)/bismuth oxide (Bi₄O₈), termed the UU 200/Bi₄O₈ nanocomposite, has been synthesized and utilized as an electrode material for supercapacitor applications and an electrocatalyst for hydrogen evolution reaction (HER). XRD, Raman, FT-IR, and XPS tests showed that the UU 200/Bi₄O₈ nanocomposite was successfully formed. The SEM and TEM images revealed that the UU 200/Bi₄O₈ nanocomposite exhibits a mixed rod and spherical structure. The supercapacitor performance of pure UU 200 and UU 200/Bi₄O₈ nanocomposite has been examined through cyclic voltammetry (CV), galvanostatic charge–discharge (GCD), and electrochemical impedance (EIS) measurements. Interestingly, the UU 200/Bi₄O₈ nanocomposite delivered a maximum specific capacitance value of 220 F g⁻¹ at 1 A g⁻¹. Furthermore, the UU 200/Bi₄O₈ nanocomposite potential was extended beyond its energy storage capability to the electrocatalytic HER process. The electrocatalytic HER performances were assessed through linear sweep voltammetry (LSV), CV, chronoamperometry (CA), and EIS analysis. The overpotential (ɳ) of 130 mV and the Tafel slope value of 131 mV dec⁻¹ indicate the UU 200/Bi₄O₈ nanocomposite supremacy in advanced applications. The UU 200/Bi₄O₈ nanocomposite electrode has excellent supercapacitor and water-splitting performance, allowing it to acquire green energy for future energy needs.

The catalytic efficacy of the Lewis acidic site in Cu₃(BTC)₂ MOF was compared with the Brønsted acidic site in MIL-101-SO₃H MOF. Both Lewis and Brønsted acidic MOFs demonstrate strong conversion rates in the synthesis of 2,4,5-triaryl imidazoles through a one-pot multicomponent reaction under a microwave condition. This outcome underscores the stability and reusability of both MOFs. The catalytic activity of the MOFs relies on the facile accessibility of catalytically active centers/sites to the reactants. Superior results were achieved with MIL-101-SO₃H MOF's Brønsted acidic sites compared with Cu₃(BTC)₂ MOF's Lewis acidic sites due to the latter's shortcomings in reusability and stability as a catalyst in the synthesis of 2,4,5-TSIs (2,4,5-trisubstituted imidazoles). MIL-101-SO₃H MOF can be reused multiple times without any loss in its catalytic activity, as demonstrated by hot filtration tests and various analytical techniques such as FTIR, powder XRD, SEM, and EDAX conducted on both fresh and reused MOF catalysts.

An efficient catalytic system was developed to rapidly synthesize benzimidazole and benzothiazole derivatives under green and mild conditions using MOF@MT-COF-Cu, which contains Zr-Cu bimetallic catalytic sites as heterogeneous catalysts. The catalysts were characterized by powder X-ray diffractometer (PXRD), field emission scanning electron microscope (FE-SEM), energy-dispersive X-ray analysis (EDS), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), N₂ adsorption–desorption, thermogravimetric analysis (TGA), and inductively coupled plasma optical emission spectroscopy (ICP-OES). The prepared hybrid material has been demonstrated to be an excellent catalyst because it has Zr and Cu bimetallic catalytic sites and combines the high specific surface area and robust stability of MOF and COF. In addition, the catalyst exhibits several advantages, including high catalytic activity, easy recovery, good repeatability, and excellent stability.

A novel Schiff base ligand derived from 1,2,4-triazole-3-thione was synthesized and complexed with platinum (IV) ion to enhance its bioactivity. Characterization techniques, including FTIR, NMR, UV-Vis, and mass spectrometry, confirmed the formation of Schiff base molecule and revealed that its Pt(IV) complex has an octahedral geometry. The antibacterial and antifungal activity of the synthesized compounds was evaluated against Staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans, and Aspergillus flavus, with the metal complex outperforming the ligand. The antioxidant properties were evaluated using a DPPH assay, with the Pt(IV) complex demonstrating superior radical-scavenging ability. Cytotoxicity studies via MTT assays on MCF-7 breast cancer cells showed dose-dependent reductions in cell viability, with the Pt(IV) complex inducing enhanced antiproliferative effects compared with the ligand. DFT calculations were performed to investigate the electronic properties of the compounds, and molecular docking studies were conducted against the alpha estrogen receptor (PDB ID: 3ERT) to predict their binding affinities. The results demonstrated that the Pt(IV) complex exhibited higher biological activity than the free ligand, suggesting its potential as an effective therapeutic agent.