Applied Organometallic Chemistry最新文献

In the field of water decontamination, the design of luminance sensor for sensitive detection of heavy metal ion toxic and nitroaromatic compounds are important and challenging. Herein, a new luminescent Cd(II) metal–organic framework (MOF), {[Cd₂(H₂O)₃(4-CPCA)₂]·2H₂O}_n (SNUT-27) (H₂(4-CPCA) = 1-(4-carboxyphenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid) was obtained by the reaction of flexible ligand H₂(4-CPCA) and Cd(II) ions, characterized by single crystal X-ray diffraction, PXRD, FT-IR, and TGA, the samples were further analyzed. The analysis of single crystal X-ray diffraction showed that SNUT-27 possesses a distinct three-dimensional spatial arrangement and demonstrates impressive fluorescence properties. Particularly, SNUT-27 showed a highly sensitive response to the nitro-aromatic compounds nitrobenzene by fluorescence quenching, and in contrast, showed a fluorescence enhancement response to Al³⁺ and Cu²⁺. SNUT-27 can be effortlessly recycled by simply rinsing with water post-sensing experiments, showcasing its reusability. Additionally, potential detection mechanisms have been explored.

Within the current challenges in medicinal chemistry, the creation of novel and improved therapeutic agents stands out. 2-Cyano-3-(thiophen-2-yl)prop-2-enethioamide (CTPTA) ligand was complexed with palladium (II) and platinum (II) ions within the nanoscale with the molecular formula [M (CTPTA)Cl₂]. H₂O. The CTPTA ligand and its complexes were characterized by elemental analysis, UV–Vis spectra, FTIR, mass spectra, TGA, magnetic measurement, and the molar conductance technique. Analysis with a scanning electron microscope (SEM) revealed that the nanostructure dimension of both complexes is predominantly between 10 and 30 nm. The CTPTA ligand functions as a bidentate ligand, utilizing thione sulfur, and cyanide nitrogen atoms. Density functional theory was employed to analyze the geometric structure properties of the CTPTA ligand and its complexes. Natural population (NPA) and Mulliken population (MPA) methods were used to calculate the charge distribution. The cytotoxic impact results of all compounds on human liver cancer (HepG2) cell line were satisfactory. The ligand and its complexes were also tested against gram-negative and gram-positive bacteria in vitro. The findings of the molecular docking study supported the cytotoxicity and antibacterial effects. The antioxidant and anti-inflammation activities of synthesized palladium (II) and platinum (II) complexes had a great spectrum of activity. The preclinical pharmacokinetic studies on albino rats revealed that the newly studied complexes achieved excellent antitumor results. This was clear in the investigated parameters, especially the amelioration of AFP levels, liver weight, oxidative stress, and lobular hepatic architecture injury.

A novel TiO₂/CoFe₂O₄/SiO₂ magnetic nanocomposite was successfully synthesized using sol–gel and hydrothermal methods. This nanocomposite consists of highly dispersed CoFe₂O₄ and TiO₂ nanoparticles on the surface of the SiO₂ matrix. The synthesis process involved the utilization of activated carbon, which played a dual role as a support for depositing the CoFe₂O₄ and TiO₂ nanoparticles and as a rigid pattern for producing the silica matrix that enmeshed the nanoparticles. To study the unique characteristics of the samples, a range of analytical techniques, such as FT-IR, VSM, XRD, SEM, N₂ adsorption–desorption analysis, BET and EDX were employed. We carried out a complete examination of the catalytic performance of the TiO₂/CoFe₂O₄/SiO₂ nanocomposite for the reduction of different substances, including methyl orange (MO), safranin O (SO), methylene blue (MB), rhodamine B (RhB), chromium (VI) ions, and nitroaromatic compounds such as 2-nitrophenol (2-NP), 4-nitroaniline (4-NA), 2-nitroaniline (2-NA), and 4-nitrophenol (4-NP). The findings of our study demonstrate the remarkable efficacy of the TiO₂/CoFe₂O₄/SiO₂ nanocomposite in efficiently reducing dyes, Cr (VI), and nitroaromatic compounds to their desired forms in environmentally friendly aqueous solutions. Notably, the nanocomposite stands out due to its simple synthesis process, effortless recyclability, and its convenient separation by a magnet.

N-Methylbenzylamine and ethylenediamine were utilized as primary and auxiliary ligands, respectively, alongside metal salts to synthesize ternary metal complexes: [FeCl₃(Nmba)(en)], [CoCl₂(Nmba)(en)(H₂O)] and [CuCl₂(Nmba)(en)(H₂O)]. These complexes were thoroughly characterized using spectral and analytical techniques, revealing an octahedral geometry for all. Coats–Redfern calculations indicated their non-spontaneous nature yet highlighted their thermal stability. DNA binding studies unveiled a groove binding mode for the complexes, with intrinsic binding constants (K_b) and Stern–Volmer quenching constant (K_sq) supporting their strong binding capabilities. Nuclease activity against pBR322 was assessed through gel electrophoresis. Additionally, docking studies using AutoDock 4.2 software provided insights into their binding affinities. In terms of biological activities, the Cu complex demonstrated superior cytotoxicity and antibacterial and antifungal properties compared to the other ternary metal complexes. This suggests its potential for further exploration in biomedical applications.

Enhancing the efficiency of charge carrier separation is crucial for improving the performance of photocatalysts, thereby offering more effective solutions to energy and environmental pollution challenges. In this study, a carbon-deficient ultra-thin porous g-C₃N₄ (Vc-UPCN) was synthesized and subsequently was integrated with Bi₂Fe₄O₉ (BFO) using a sonochemical self-assembly technique, a Bi₂Fe₄O₉/Vc-UPCN (BC) photocatalyst featuring a Z-scheme heterojunction. The BC catalyst was subjected to corona poling treatment to obtain BCp, which possesses an intrinsic electric field. Compared with pure BFO and Vc-UPCN, the BC heterojunction exhibited higher photo-generated electron–hole separation efficiency and photodegradation ability. Upon introduction of corona polarization, the photocatalytic performance of BC was further enhanced. Specifically, BCp-15 (BFO/BC mass fraction = 15) achieved complete degradation of methylene blue (MB) within 30 min. BCp-15 demonstrated that its degradation efficiency for MB was 1.28 times higher than that of BC-15, 1.85 times higher than that of Vc-UPCN, and impressive 7.69 times higher than that of pure BFO. The coupling effect of the heterojunction and ferroelectric polarization significantly improved the separation efficiency of photo-generated carriers in BCp. This study is expected to provide a reference for the synergistic application of heterojunction and ferroelectric polarization in traditional semiconductor photocatalysis.

2-Aminophenol-based Schiff bases and their metal complexes have drawn a lot of interest because of their wide range of biological activity and their uses in several fields. These Schiff bases are synthesized through the condensation of 2-aminophenol and various carbonyl compounds, and metal complexes formed easily by coordinating Schiff bases with transition metal ions possess a wide range of intriguing properties that have rendered them promising candidates in biomedical research. These compounds have a diverse array of captivating biological properties including antibacterial, antifungal, anticancer, and antioxidant actions. Their versatile nature and potential for tailored modifications hold the promise for innovative biomedical applications. Compared to standard antibiotics and other studied compounds, C2, C8–C11, and C116 complexes, along with L16 and L17 ligands, exhibit the highest antibacterial activity, while C3 and C115 complexes demonstrate the highest antifungal activity. The metal chelate formation of the ligands enhanced the antimicrobial activity by increasing their lipophilic nature. C66, C76, and C112 complexes and L39 ligand showed higher anticancer activity than standard anticancer drugs. The metal complexes have higher anticancer activity than the ligand due to improved permeability and cellular uptake. The anticancer activity of the complexes is related to the substituents of the Schiff base ligands. In compounds containing an electron-withdrawing group (e.g., Cl or Br or NO₂), the activity is obviously better than others. Ligands L1–L3 and L5, L6, and L32 demonstrated the most potent antioxidant activity, surpassing both metal complexes and standard conventional antioxidants. The ligands showed greater antioxidant activity than the metal complexes due to their capability of donating free protons to scavenge free radicals. More study is needed to fully explore the potential of 2-aminophenol-based Schiff bases and their transition metal complexes for the development of new drugs. This review summarizes different synthetic methods, biological activities, and the structure–activity relationship. This study aims to conduct further research on 2-aminophenol-based Schiff bases and their metal complexes.

Oxidovanadium meso-tetrakis(3,4,5-trimethoxyphenyl) porphyrin [VO(T(OMe)3PP)] (Complex 1) was prepared. The oxidation product of Complex 1 has been characterized by cyclic voltammetry (CV), UV–visible spectrophotometer, electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) by the addition of SbCl₅ to Complex 1. There is a one-electron oxidation product in Complex 1 that creates π–cation radicals in CV data. This is supported by an IR spectrophotometer. Subsequent EPR spectra verified the initiation of the π–cation monoradical, which subsequently transforms into a triplet state where S = 1. DNA binding and antibacterial analysis with Complex 1 have also been analysed. In the DNA-binding analysis, the CV data confirm the interaction between Complex 1 and DNA. Furthermore, the fact that Complex 1 is more effective at killing bacteria shows that the metal ion's chelation with the porphyrin ligand makes it more lipophilic.

The micro-morphology of photocatalytic materials has a great influence on their photocatalytic performance. Quantum dots can provide the plasmon resonance effect and broaden the wavelength range of light absorption. In this study, a kind of 3D spherical flower-like structure was constructed by self-assembly of 2D nanosheets, the Bi₂S₃ particles with 5 ± 1 nm diameter were modified on the surfaces of Bi₂O₂CO₃ nanosheets to prepare the Bi₂S₃/Bi₂O₂CO₃ composite. The energy level difference (0.45 eV) between the conduction bands (CB) of Bi₂S₃ and Bi₂O₂CO₃ led to which the e⁻ was transferred to CB of Bi₂O₂CO₃. The energy level difference (0.83 eV) between the CB of Bi₂O₂CO₃ and the valence band (VB) of Bi₂S₃ was much smaller than the band gap (1.28 eV) of Bi₂S₃, and it led to which the electrons on the CB of Bi₂O₂CO₃ were recombined with the holes on the VB of Bi₂S₃. A kind of innovative type heterojunction was constructed between Bi₂S₃ and Bi₂O₂CO₃, which encouraged the photogenerated h⁺ and ·OH to be located on the VB of Bi₂O₂CO₃ with the strongest oxidation potential, the prepared material showed excellent performance for the photodegradation of RhB, and the active groups were also controlled in the photocatalysis process.

Synthesis of 5-alkynyl furopyrimidine nucleoside analogs, with free-ribose groups, was carried out, and their biological activity was evaluated. The substituents introduced at the C-5 included propargyl and homopropargyl alcohols, 4-methylphenyl (p-tolyl), and 4-pentylphenyl substituted alkynyl groups (56%–88%). Subsequently, alkyne function was coordinated to dicobalt hexacarbonyl unit, yielding the corresponding dicobalt hexacarbonyl 5-alkynyl furopyrimidine nucleosides (51%–75%). All compounds contained 4-pentylphenyl group attached at the C-6 position of the bicyclic base, in line with most active antiviral structures. The antiproliferative effect of these modified nucleosides on cancer cells of different phenotypes was determined using in vitro studies. The tested compounds show antiproliferative effects with median inhibitory concentration (IC₅₀) values of 16–23 and 9–15 μM for HeLa and K562 cells, respectively. The determination of reactive oxygen species (ROS) formation in K562 cells in the presence of modified nucleosides may suggest that the mode of action of the examined compounds may be attributed to the induction of oxidative stress.