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SLC26A4-AS1 Aggravates AngII-induced Cardiac Hypertrophy by Enhancing SLC26A4 Expression. SLC26A4-AS1通过增强SLC26A4的表达加重AngII诱导的心脏肥大。
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-21 eCollection Date: 2023-01-01 DOI: 10.36660/abc.20210933
Xiaoliang Han, Chao Li, Qinjiong Ji, Ling Zhang, Xiaofei Xie, Huijuan Shang, Hong Ye

Background: It has been reported that solute carrier family 26 members 4 antisense RNA 1 (SLC26A4-AS1) is highly related to cardiac hypertrophy.

Objective: This research aims to investigate the role and specific mechanism of SLC26A4-AS1 in cardiac hypertrophy, providing a novel marker for cardiac hypertrophy treatment.

Methods: Angiotensin II (AngII) was infused into neonatal mouse ventricular cardiomyocytes (NMVCs) to induce cardiac hypertrophy. Gene expression was detected by quantitative real-time PCR (RT-qPCR). Protein levels were evaluated via western blot. Functional assays analyzed the role of SLC26A4-AS1. The mechanism of SLC26A4-AS1 was assessed by RNA-binding protein immunoprecipitation (RIP), RNA pull-down, and luciferase reporter assays. The P value <0.05 was identified as statistical significance. Student's t-test evaluated the two-group comparison. The difference between different groups was analyzed by one-way analysis of variance (ANOVA).

Results: SLC26A4-AS1 is upregulated in AngII-treated NMVCs and promotes AngII-induced cardiac hypertrophy. SLC26A4-AS1 regulates its nearby gene solute carrier family 26 members 4 (SLC26A4) via functioning as a competing endogenous RNA (ceRNA) to modulate the microRNA (miR)-301a-3p and miR-301b-3p in NMVCs. SLC26A4-AS1 promotes AngII-induced cardiac hypertrophy via upregulating SLC26A4 or sponging miR-301a-3p/miR-301b-3p.

Conclusion: SLC26A4-AS1 aggravates AngII-induced cardiac hypertrophy via sponging miR-301a-3p or miR-301b-3p to enhance SLC26A4 expression.

背景：据报道，溶质载体家族26成员4反义RNA 1（SLC26A4-AS1）与心肌肥大高度相关。目的：本研究旨在探讨SLC26A4-AS1在心肌肥大中的作用及其具体机制，为心肌肥大的治疗提供新的标志物。方法：将血管紧张素II（AngII）注入新生小鼠心室心肌细胞（NMVC），诱导心肌肥大。通过实时定量PCR（RT-qPCR）检测基因表达。蛋白质水平通过蛋白质印迹进行评估。功能测定分析了SLC26A4-AS1的作用。通过RNA结合蛋白免疫沉淀（RIP）、RNA下拉和荧光素酶报告基因测定来评估SLC26A4-AS1的机制。P值结果：SLC26A4-AS1在AngII治疗的NMVC中上调，并促进AngII诱导的心肌肥大。SLC26A4-AS1通过作为竞争性内源性RNA（ceRNA）调节NMVC中的微小RNA（miR）-301b-3p和miR-301b-3p来调节其附近的基因溶质载体家族26成员4（SLC26A4）。SLC26A4-AS1通过上调SLC26A4或吸收miR-301a-3p/miR-301b-3p来促进AngII诱导的心肌肥大。
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引用次数: 1
The Challenge of Making Cardiac Resonance a Global Reality. 使心脏共振成为全球现实的挑战。
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-21 DOI: 10.36660/abc.20230187
Hélder Jorge Andrade Gomes, Alcides Rocha de Figueredo Junior
Hélder Jorge Andrade Gomes1,2,3,4,5 e Alcides Rocha de Figueredo Junior1 Departamento de Clínica Médica – Faculdade de Medicina de Jundiaí,1 Jundiaí, SP – Brasil Tomografia e Ressonância Cardiovascular – ICON Diagnósticos por Imagem,2 Jundiaí, SP – Brasil Hospital Vera Cruz,3 Campinas, SP – Brasil Prevent Senior,4 São Paulo, SP – Brasil Hospital Samaritano de São Paulo,5 São Paulo, SP – Brasil Minieditorial referente ao artigo: Ressonância Magnética Cardíaca como Ferramenta Diagnóstica Etiológica em Pacientes Recuperados de Morte Súbita Cardíaca ou Arritmias Ventriculares Instáveis
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引用次数: 0
Left Ventricular Mechanics: Untwisting the Pathways of the Cardiovascular Response to Exercise. 左心室力学:解开心血管对运动反应的途径。
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-21 DOI: 10.36660/abc.20230181
Eduardo M Vilela, Ricardo Fontes-Carvalho
Correspondência: Eduardo M. Vilela • Serviço de Cardiologia, Centro Hospitalar de Vila Nova de Gaia/Espinho – Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia – Portugal E-mail: eduardomvilela@gmail.com Palavras-chave Doenças Cardiovasculares/prevenção e controle; Doença Arterial Coronariana; Diagnóstico por Imagem/métodos; Ecocardiografia/métodos A doença cardiovascular (DCV) é uma das principais causas de morbimortalidade, sendo a doença arterial coronariana (DAC) uma de suas apresentações mais desafiadoras.1 Ao longo dos anos, diversas estratégias permitiram melhorias marcantes em sua gestão. O exercício físico (um componente central dos programas de reabilitação cardíaca) é atualmente uma pedra angular das estratégias contemporâneas abrangentes de prevenção secundária.2 Embora os benefícios do exercício físico tenham sido extensivamente descritos na presença de DAC, as inúmeras vias mecanísticas pelas quais essa intervenção exerce seus diversos efeitos não foram totalmente elucidadas.3,4 De fato, embora seu impacto positivo na capacidade funcional tenha sido destacado, o papel relativo do treinamento físico na função sistólica mostrou alguma variabilidade em diferentes estudos.4,5 Sem deixar de ter em consideração o fato de as diferenças nos desenhos dos programas e das populações em estudo poderem, pelo menos em parte, ajudar a explicar algumas dessas divergências, o estudo dos mecanismos pelos quais o exercício pode ter impacto na função cardíaca (nomeadamente no contexto da DAC) continua a ser um tema de grande interesse.
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引用次数: 1
Multi-Arterial Grafting in Surgical Coronary Revascularization. The Renewed Quest for Enhanced Outcomes. 外科冠状动脉血运重建中的多动脉移植。提高疗效的新追求。
IF 2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20230094
Walter J Gomes
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引用次数: 0
Infective Endocarditis: New Spectra, Same Severity. 感染性心内膜炎:新的光谱，相同的严重性。
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20230117
Tiago Bignoto
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引用次数: 0
Nuclear Cardiology in the Optimization of Resynchronization Therapy: Quo Vadis? 核心脏病学在再同步治疗优化中的应用:现状?
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20230136
Gabriel Blacher Grossman
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引用次数: 0
Paraoxonase-1 Genotype and Angiogram Positive Coronary Artery Disease. 对氧磷酶-1基因型与冠状动脉造影阳性
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20220665
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
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引用次数: 0
Exercise-Based Cardiac Rehabilitation (ECBR): New Frontiers in the Post-Novel Coronavirus. 基于运动的心脏康复(ECBR):后新型冠状病毒的新领域
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20230120
Rosane Maria Nery, Antonio Cardoso Dos Santos, Eduardo Lima Garcia
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引用次数: 0
Good Practices In Cardiology - A Lesson From Performance Indicators. 心脏病学的良好实践-从绩效指标中吸取的教训。
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20230033
Otávio Azevedo Bertoletti
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引用次数: 0
Does the BUN/Cr Ratio Confer a Worse Prognosis in All Ejection Fraction Spectra? 在所有射血分数谱中，BUN/Cr比值是否预示较差的预后?
IF 2.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Arquivos Brasileiros de Cardiologia
Pub Date : 2023-04-07 DOI: 10.36660/abc.20230107
Giovanni Possamai Dutra, Bruno Ferraz de Oliveira Gomes
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引用次数: 0
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