Pub Date : 2024-06-17DOI: 10.24820/ark.5550190.p012.209
Ismail A. Abdelhamid, Hadeer M. Diab, Nesma E. Mahmoud, Ahmed H. M. Elwahy, Ibrahim Fares
Combining compounds with complementary bioactivities to create hybrid molecules is a new idea in drug research. In this work, we created novel hybrid molecules including bis-heterocycles connected by an isopropanol unit. This is accomplished by the condensation of 4,4'-((2-hydroxypropane-1,3-diyl)bis(oxy))dibenzaldehyde with the appropriate reagents using Hantzsch, Michael, and Biginelli reactions. The structures of the newly synthesized compounds are determined by elemental analysis, 1 H NMR, 13 C NMR, IR, and MS spectra.
将具有互补生物活性的化合物结合在一起以创造杂化分子是药物研究中的一个新想法。在这项工作中，我们创造了新型杂化分子，包括由异丙醇单元连接的双杂环。其方法是利用汉兹希反应、迈克尔反应和比吉内利反应，用适当的试剂缩合 4,4'-((2-羟基丙烷-1,3-二基)双(氧基))二苯甲醛。通过元素分析、1 H NMR、13 C NMR、IR 和 MS 光谱确定了新合成化合物的结构。
{"title":"Synthesis of New bis-Heterocyclic Hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions","authors":"Ismail A. Abdelhamid, Hadeer M. Diab, Nesma E. Mahmoud, Ahmed H. M. Elwahy, Ibrahim Fares","doi":"10.24820/ark.5550190.p012.209","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.209","url":null,"abstract":"Combining compounds with complementary bioactivities to create hybrid molecules is a new idea in drug research. In this work, we created novel hybrid molecules including bis-heterocycles connected by an isopropanol unit. This is accomplished by the condensation of 4,4'-((2-hydroxypropane-1,3-diyl)bis(oxy))dibenzaldehyde with the appropriate reagents using Hantzsch, Michael, and Biginelli reactions. The structures of the newly synthesized compounds are determined by elemental analysis, 1 H NMR, 13 C NMR, IR, and MS spectra.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17DOI: 10.24820/ark.5550190.p012.149
A. Sharifi, Marzieh Sharifi, M. S. Abaee, M. Mirzaei
{"title":"Green synthesis of 1,4-benzoxazinones using a choline chloride based deep eutectic solvent","authors":"A. Sharifi, Marzieh Sharifi, M. S. Abaee, M. Mirzaei","doi":"10.24820/ark.5550190.p012.149","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.149","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.24820/ark.5550190.p012.176
Sheng Liu, Ru Li
Indolo[3,2-c ]quinolines bearing various substituents have been prepared from o-aminobenzaldehydes and 2-nitrophenyl substituted ketones through a two-step sequence involving Friedlander condensation and Cadogan cyclization.
{"title":"A convenient synthetic approach to 11H-indolo[3,2-c]quinoline framework via Friedlander condensation and Cadogan cyclization","authors":"Sheng Liu, Ru Li","doi":"10.24820/ark.5550190.p012.176","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.176","url":null,"abstract":"Indolo[3,2-c ]quinolines bearing various substituents have been prepared from o-aminobenzaldehydes and 2-nitrophenyl substituted ketones through a two-step sequence involving Friedlander condensation and Cadogan cyclization.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-09DOI: 10.24820/ark.5550190.p012.203
Bubun Banerjee, Aditi Sharma, Pooja A. Chawla, K. Jha, Kinkar Biswas, Mayukh Dev, M. Kaur, A. Priya, Arvind Singh
A efficient, simple and facile protocol has been developed for the synthesis of a series of spiropyrano-indenoquinoxaline derivatives via one-pot four component reactions of ninhydrin, o -phenylenediamines, malononitrile and various C-H activated acids using a catalytic amount of trisodium citrate dihydrate as catalyst in an aqueous ethanol under refluxed conditions. The docking analysis revealed promising anti-cancer activities of these synthesized compounds.
{"title":"Trisodium citrate dihydrate catalyzed one-pot four component synthesis of spiropyrano-indenoquinoxaline derivatives and their molecular docking analysis on the anti-cancer efficacies","authors":"Bubun Banerjee, Aditi Sharma, Pooja A. Chawla, K. Jha, Kinkar Biswas, Mayukh Dev, M. Kaur, A. Priya, Arvind Singh","doi":"10.24820/ark.5550190.p012.203","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.203","url":null,"abstract":"A efficient, simple and facile protocol has been developed for the synthesis of a series of spiropyrano-indenoquinoxaline derivatives via one-pot four component reactions of ninhydrin, o -phenylenediamines, malononitrile and various C-H activated acids using a catalytic amount of trisodium citrate dihydrate as catalyst in an aqueous ethanol under refluxed conditions. The docking analysis revealed promising anti-cancer activities of these synthesized compounds.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141367422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.24820/ark.5550190.p012.187
Abdel-Rahman Ali Hassan Farghaly, Abdullah A. Alamria
{"title":"Recent Developments in Synthetic Strategies, Reactions and Biological Importance of Thieno[2,3-c]Pyrazoles","authors":"Abdel-Rahman Ali Hassan Farghaly, Abdullah A. Alamria","doi":"10.24820/ark.5550190.p012.187","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.187","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-21DOI: 10.24820/ark.5550190.p012.181
Mostafa E. Salem, Ahmed H. M. Elwahy, Ahmed R. S. Ginidi, Mohamed R. Shaaban, Akram H. Mohamed, Hatem M. Gaber, Laila I. Ibrahim, Ahmed M. Farag
A novel bis-triazole was synthesized in this context, and its potential usage as a flexible precursor for new bis-triazolothiadiazines and bis-triazolothiadiazoles with antioxidant properties was reported. The novel compounds' structures were determined using elemental analysis and spectrum data. According to the DPPH assay results, the newly synthesized compounds have noteworthy antioxidant characteristics
{"title":"Novel bis([triazolo[3,4-b]thiadiazoles and bis([triazolo[3,4-b][thiadiazines) with antioxidant activity","authors":"Mostafa E. Salem, Ahmed H. M. Elwahy, Ahmed R. S. Ginidi, Mohamed R. Shaaban, Akram H. Mohamed, Hatem M. Gaber, Laila I. Ibrahim, Ahmed M. Farag","doi":"10.24820/ark.5550190.p012.181","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.181","url":null,"abstract":"A novel bis-triazole was synthesized in this context, and its potential usage as a flexible precursor for new bis-triazolothiadiazines and bis-triazolothiadiazoles with antioxidant properties was reported. The novel compounds' structures were determined using elemental analysis and spectrum data. According to the DPPH assay results, the newly synthesized compounds have noteworthy antioxidant characteristics","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141115038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.24820/ark.5550190.p012.177
Abdel-Rahman Ali Hassan Farghaly, Sameh Elgogary, Nasser Amri, E. M. El-Telbani
{"title":"Syntheses of Tricyclic Fused Quinoxaline Ring Systems: Furoquinoxalines","authors":"Abdel-Rahman Ali Hassan Farghaly, Sameh Elgogary, Nasser Amri, E. M. El-Telbani","doi":"10.24820/ark.5550190.p012.177","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.177","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-12DOI: 10.24820/ark.5550190.p012.179
N. Maulide, Bogdan R Brutiu, Phillip S. Grant, Daniel Kaiser
{"title":"Stereospecific cyclization of a pseudo-C2-cymmetric unsaturated diol","authors":"N. Maulide, Bogdan R Brutiu, Phillip S. Grant, Daniel Kaiser","doi":"10.24820/ark.5550190.p012.179","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.179","url":null,"abstract":"","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-09DOI: 10.24820/ark.5550190.p012.173
V. Sureshbabu, Eti Chetan kumar, Srinivasulu Chinthaginjala
A One-step synthesis of N α -protected amino hydroxamic acids using triflic anhydride as an acid activator is demonstrated. The reaction can be executed under simple and mild conditions with good yields and purity. This method provides compatibility to Fmoc, Cbz and Boc protecting groups and the reaction is racemization-free which adds an advantage.
以三酸酐作为酸活化剂，一步合成了 N α-保护氨基羟肟酸。该反应可在简单温和的条件下进行，并具有良好的产率和纯度。该方法与 Fmoc、Cbz 和 Boc 保护基兼容，而且反应无外消旋化，这为该方法增添了优势。
{"title":"An application of triflic anhydride as an acid activator: Synthesis of N?-protected amino hydroxamic acids","authors":"V. Sureshbabu, Eti Chetan kumar, Srinivasulu Chinthaginjala","doi":"10.24820/ark.5550190.p012.173","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.173","url":null,"abstract":"A One-step synthesis of N α -protected amino hydroxamic acids using triflic anhydride as an acid activator is demonstrated. The reaction can be executed under simple and mild conditions with good yields and purity. This method provides compatibility to Fmoc, Cbz and Boc protecting groups and the reaction is racemization-free which adds an advantage.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：