Pub Date : 2024-03-06DOI: 10.24820/ark.5550190.p012.129
Thomas J. J. Müller, Narges Irani, Simon P. Höwedes, Franziska K. Merkt-Tasch
4-(3-((4-M ethoxyphenyl) e thynyl) q uinoxalin-2-yl)- N , N - d i m ethyl a niline ( MEQDMA ) shows intense solid-state luminescence. As related derivatives MEQDMA is highly emission solvatochromic with considerable redshifted emission in polar solvents and a large change of dipole moment according to Lippert-Mataga analysis. A UV/Vis screening with several mono-, di-and trivalent metal triflates reveals complexation with scandium and aluminium triflate. The former is characterized by Job plots, forming a 1:1 M:L complex with a complex formation constant K ML = 2700 L 2 ⋅ mol -1 . In addition, MEQDMA also emits upon induced aggregation in binary acetonitrile/water or isopropanol/ water solutions at higher water content.
4-(3-((4-M ethoxyphenyl) e thynyl) q uinoxalin-2-yl)- N , N - d i m ethyl a niline ( MEQDMA ) 显示出强烈的固态发光。作为相关衍生物，MEQDMA 具有高度的发射溶色性，在极性溶剂中具有相当大的红移发射，而且根据 Lippert-Mataga 分析，其偶极矩变化很大。通过与几种一价、二价和三价金属三氟化物进行紫外/可见光筛选，发现了与钪和三氟化铝的络合。前者以乔布斯图为特征，形成 1:1 M:L 的络合物，络合物形成常数 K ML = 2700 L 2 ⋅ mol -1 。此外，MEQDMA 在二元乙腈/水溶液或异丙醇/水溶液中诱导聚集时也会释放出较高的水含量。
{"title":"Photophysical Properties, Complexometry, and Aggregation-induced Emission of a 2-Donor-substituted 3-Ethynylquinoxaline","authors":"Thomas J. J. Müller, Narges Irani, Simon P. Höwedes, Franziska K. Merkt-Tasch","doi":"10.24820/ark.5550190.p012.129","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.129","url":null,"abstract":"4-(3-((4-M ethoxyphenyl) e thynyl) q uinoxalin-2-yl)- N , N - d i m ethyl a niline ( MEQDMA ) shows intense solid-state luminescence. As related derivatives MEQDMA is highly emission solvatochromic with considerable redshifted emission in polar solvents and a large change of dipole moment according to Lippert-Mataga analysis. A UV/Vis screening with several mono-, di-and trivalent metal triflates reveals complexation with scandium and aluminium triflate. The former is characterized by Job plots, forming a 1:1 M:L complex with a complex formation constant K ML = 2700 L 2 ⋅ mol -1 . In addition, MEQDMA also emits upon induced aggregation in binary acetonitrile/water or isopropanol/ water solutions at higher water content.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.24820/ark.5550190.p012.153
Herbert Waldmann, Xiufen Cheng, Michael Grigalunas
Natural products have been a rich source of bioactive molecules. However, the natural evolution of natural products is a long process, which largely limits their further exploration of biologically-relevant chemical space. The pseudo-natural-products approach provides an efficient strategy to rapidly explore biologically-relevant chemical space, leading to the discovery of novel bioactive compounds. In general, pseudo-natural products are generated through the de novo recombination of natural-product fragments with different arrangements and connectivity patterns to afford new natural-product-like compounds that are unprecedented in nature. Herein, we describe the pseudo-natural-product concept and its design principles, highlight recent examples of pseudo-natural-product collections
{"title":"Progress and Opportunities of Pseudo-Natural Product Design in Molecular Discovery","authors":"Herbert Waldmann, Xiufen Cheng, Michael Grigalunas","doi":"10.24820/ark.5550190.p012.153","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.153","url":null,"abstract":"Natural products have been a rich source of bioactive molecules. However, the natural evolution of natural products is a long process, which largely limits their further exploration of biologically-relevant chemical space. The pseudo-natural-products approach provides an efficient strategy to rapidly explore biologically-relevant chemical space, leading to the discovery of novel bioactive compounds. In general, pseudo-natural products are generated through the de novo recombination of natural-product fragments with different arrangements and connectivity patterns to afford new natural-product-like compounds that are unprecedented in nature. Herein, we describe the pseudo-natural-product concept and its design principles, highlight recent examples of pseudo-natural-product collections","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.24820/ark.5550190.p011.981
Mei‐Yu Yeh, Yao-Chun Yeh, Lien-Chen Fu, Hsin-Chieh Lin
Our research revealed that the introduction of a methyl group had a profound effect on the molecular geometry, resulting in a more twisted structure. As a consequence of this non-planar structure, the material exhibited aggregation-induced emission properties, making it a promising candidate for various practical applications. To support our findings, we used a range of analytical techniques, including UV-vis absorption spectra, fluorescence spectra, and theoretical calculations. This work provides valuable insights into the relationship between molecular structure and optical properties, which could inform the development of novel materials for a range of applications.
{"title":"The effect of N-methylation on photophysical properties of imidazole-based fluorescent molecules","authors":"Mei‐Yu Yeh, Yao-Chun Yeh, Lien-Chen Fu, Hsin-Chieh Lin","doi":"10.24820/ark.5550190.p011.981","DOIUrl":"https://doi.org/10.24820/ark.5550190.p011.981","url":null,"abstract":"Our research revealed that the introduction of a methyl group had a profound effect on the molecular geometry, resulting in a more twisted structure. As a consequence of this non-planar structure, the material exhibited aggregation-induced emission properties, making it a promising candidate for various practical applications. To support our findings, we used a range of analytical techniques, including UV-vis absorption spectra, fluorescence spectra, and theoretical calculations. This work provides valuable insights into the relationship between molecular structure and optical properties, which could inform the development of novel materials for a range of applications.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04DOI: 10.24820/ark.5550190.p012.127
M. Ciufolini, Léanne Racicot
We provide a summary of the discovery of the aryl exchange between a diaryliodonium triflate and an aryl iodide (iodonium metathesis reaction) and relevant mechanistic aspects thereof. Some initial applications are illustrated, together with more recent developments in the field of diarylhalonium metathesis; in particular, the noteworthy extension of the process to diaryl chloranes by Uchiyama and collaborators.
{"title":"Halonium Metathesis Reactions","authors":"M. Ciufolini, Léanne Racicot","doi":"10.24820/ark.5550190.p012.127","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.127","url":null,"abstract":"We provide a summary of the discovery of the aryl exchange between a diaryliodonium triflate and an aryl iodide (iodonium metathesis reaction) and relevant mechanistic aspects thereof. Some initial applications are illustrated, together with more recent developments in the field of diarylhalonium metathesis; in particular, the noteworthy extension of the process to diaryl chloranes by Uchiyama and collaborators.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140080596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04DOI: 10.24820/ark.5550190.p012.148
F. Khan, Adrija Ghosh, T. Jena, Sarwat Asma Ziya Ahmad
We describe here the acid-catalysed reaction of anilines with activated indanol using the inexpensive catalyst p-toluenesulfonic acid ( p -TSA). Various electron-donating as well as electron-withdrawing anilines are reacted with activated indanol. The reaction mechanism suggests the in-situ formation of a p -quinomethoxy methide intermediate, followed by the nucleophilic attack of the substituted or unsubstituted anilines.
{"title":"Acid-Catalysed N-Alkylation of Anilines with Activated 1-H-Indanol","authors":"F. Khan, Adrija Ghosh, T. Jena, Sarwat Asma Ziya Ahmad","doi":"10.24820/ark.5550190.p012.148","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.148","url":null,"abstract":"We describe here the acid-catalysed reaction of anilines with activated indanol using the inexpensive catalyst p-toluenesulfonic acid ( p -TSA). Various electron-donating as well as electron-withdrawing anilines are reacted with activated indanol. The reaction mechanism suggests the in-situ formation of a p -quinomethoxy methide intermediate, followed by the nucleophilic attack of the substituted or unsubstituted anilines.","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04DOI: 10.24820/ark.5550190.p012.082
N. Al-Awadi, Amal J. K. Alrajhei, Asaad S. Mohamed, Muna A. Mohammad, O. M. Habib
The preparative utility of the pyrolysis of acetylenic compounds is demonstrated in the flash vacuum pyrolysis of some propargyl ethers, amines and an ester that has resulted in interesting furans, indanones, quinoline, and chromenones as major products. The products of the pyrolysis of each substrate were analyzed, identified, characterized
{"title":"Flash vacuum pyrolysis (FVP) of aryl propargyl ethers, amines and acetylenic ester","authors":"N. Al-Awadi, Amal J. K. Alrajhei, Asaad S. Mohamed, Muna A. Mohammad, O. M. Habib","doi":"10.24820/ark.5550190.p012.082","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.082","url":null,"abstract":"The preparative utility of the pyrolysis of acetylenic compounds is demonstrated in the flash vacuum pyrolysis of some propargyl ethers, amines and an ester that has resulted in interesting furans, indanones, quinoline, and chromenones as major products. The products of the pyrolysis of each substrate were analyzed, identified, characterized","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.24820/ark.5550190.p012.136
Oleg A. Rakitin, Thierry Besson, Lidia S. Konstntinova, P. Koutentis, Sivaprasad Sivadasan, Valérie Thiéry, Tomás Torroba
With
与
{"title":"Contribution of Professor Charles Rees to the development of the chemistry of disulfur dichloride","authors":"Oleg A. Rakitin, Thierry Besson, Lidia S. Konstntinova, P. Koutentis, Sivaprasad Sivadasan, Valérie Thiéry, Tomás Torroba","doi":"10.24820/ark.5550190.p012.136","DOIUrl":"https://doi.org/10.24820/ark.5550190.p012.136","url":null,"abstract":"With","PeriodicalId":8432,"journal":{"name":"Arkivoc","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139957843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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