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Evaluation and Diagnosis of Acute Chest Pain 急性胸痛的评估与诊断
Pub Date : 2023-06-01 DOI: 10.3904/kjm.2023.98.3.125
Seung Hun Lee, Min Chul Kim, D. Sim, Y. Hong, Ju Han Kim, Youngkeun Ahn, M. Jeong
Acute chest pain is a frequent cause of visits to emergency departments. As the major etiologies of such pain include life-threatening acute myocardial infarction, aortic dissection, and pulmonary embolism, prompt diagnosis and management are essential. After exclusion of coronary artery disease, other cardiac causes must be considered. In this review, we discuss the diagnosis of acute chest pain with a focus on clinical symptoms and the initial examination.
急性胸痛是急诊科就诊的常见原因。由于这种疼痛的主要病因包括危及生命的急性心肌梗死、主动脉夹层和肺栓塞,及时诊断和治疗是必不可少的。排除冠状动脉疾病后,必须考虑其他心脏原因。在这篇综述中,我们讨论急性胸痛的诊断,重点是临床症状和初步检查。
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引用次数: 0
Improvement in Dasatinib-Induced Proteinuria after Switching to Nilotinib: A Case Report 改用尼洛替尼后达沙替尼所致蛋白尿的改善:1例报告
Pub Date : 2023-06-01 DOI: 10.3904/kjm.2023.98.3.144
Joohee Jeon, Dongyeong Lee, Jae-Sung Ahn, C. H. Baek, Hyosang Kim
Tyrosine kinase inhibitors (TKIs), such as imatinib, dasatinib, and nilotinib, have been used to treat chronic myelogenous leukemia (CML). The adverse effects of these TKIs vary according to the site of signaling pathway inhibition. Here, we report a case of dasatinib- induced proteinuria. A 56-year-old Korean woman was diagnosed with CML and treated with dasatinib. However, 3 years later, the patient developed hypertension and microalbuminuria. Losartan was ineffective, so a kidney biopsy was performed, which revealed dasatinib-associated glomerular changes. Subsequently, dasatinib was switched to nilotinib. After 1 month, the spot urine protein/creatinine ratio decreased from 2,985.0 mg/g to 237.8 mg/g. This case of heavy proteinuria developed after long-term TKI treatment and improved rapidly after switching to another TKI. The proposed strategy is important because it eliminates the need to discontinue the medication or use immunosuppressive drugs to treat proteinuria.
酪氨酸激酶抑制剂(TKIs),如伊马替尼、达沙替尼和尼罗替尼,已被用于治疗慢性髓性白血病(CML)。这些TKIs的不良反应根据信号通路抑制的部位而有所不同。在此,我们报告一例达沙替尼引起的蛋白尿。一名56岁的韩国妇女被诊断为慢性粒细胞白血病并接受达沙替尼治疗。然而,3年后,患者出现高血压和微量白蛋白尿。氯沙坦无效,因此进行了肾活检,发现达沙替尼相关的肾小球改变。随后,达沙替尼转为尼罗替尼。1个月后,斑点尿蛋白/肌酐比值由2985.0 mg/g降至237.8 mg/g。该病例在长期TKI治疗后出现重度蛋白尿,并在切换到另一种TKI后迅速改善。建议的策略很重要,因为它消除了停药或使用免疫抑制药物治疗蛋白尿的需要。
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引用次数: 0
Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 Revision 韩国息肉切除术后结肠镜监测指南:2022年修订
Pub Date : 2023-06-01 DOI: 10.3904/kjm.2023.98.3.102
S. Y. Kim
The risk of developing metachronous advanced neoplasia is associated with the presence of polyps in index colonoscopy. Therefore, it is essential to establish the optimal colonoscopy surveillance period following polypectomy. In the 2020s, international guidelines published by the US Multi-Society Task Force, European Society of Gastrointestinal Endoscopy, and British Society of Gastroenterology were revised. In 2022, the Korean postpolypectomy colonoscopic surveillance guidelines were revised to recommend surveillance for adenoma size ≥ 10 mm, ≥ 3 adenomas, tubulovillous or villous adenoma, adenoma with high-grade dysplasia, traditional serrated adenoma, sessile serrated lesion (SSL) with dysplasia, serrated polyp with size ≥ 10 mm, and ≥ 3 SSLs.
发生异时性晚期肿瘤的风险与结肠镜检查中息肉的存在有关。因此,确定息肉切除术后的最佳结肠镜监测期是必要的。在21世纪20年代,美国多学会工作组、欧洲胃肠内镜学会和英国胃肠病学学会发布的国际指南进行了修订。2022年,韩国息肉切除后结肠镜监测指南进行了修订,推荐监测大小≥10mm的腺瘤、≥3个腺瘤、管状绒毛状或绒毛状腺瘤、高度发育不良的腺瘤、传统锯齿状腺瘤、伴发育不良的无柄锯齿状病变(SSL)、大小≥10mm的锯齿状息肉和≥3个SSLs。
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引用次数: 0
Interpretation of Thyroid Autoantibodies in Hyperthyroidism 甲状腺机能亢进患者甲状腺自身抗体的解释
Pub Date : 2023-06-01 DOI: 10.3904/kjm.2023.98.3.132
Han-sang Baek, D. Lim
Thyrotoxicosis is a clinical state with a variety of various etiologies that results from excess thyroid hormones, including hyperthyroidism and thyroiditis. Graves' disease (GD) is a well-known autoimmune thyroid disease that causes hyperthyroidism, and its pathogenesis is mainly driven by the thyroid-stimulating hormone receptor antibody (TSHRAb), which is highly specific for GD. Measuring the TSHRAb is a fast and accurate diagnostic tool for GD and has been used to monitor disease activity and the treatment response. However, conventional TSH-binding inhibitory immunoglobulin (TBII) does not differentiate between stimulating, blocking, or neutral antibodies. In contrast, thyroid stimulatory immunoglobulin bioassays differentiate between stimulating and blocking antibodies and have comparably high sensitivity and specificity to TBII for GD. We also discuss the role of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) in thyrotoxicosis, although they are less specific than TSHRAb for GD. TPOAb is associated with autoimmune thyroiditis, while TgAb appears with TPOAb in patients with autoimmune thyroid disease. In addition, TPOAb or TgAb may be associated with a low recurrence of GD after discontinuing anti-thyroid drugs. Clinicians should interpret thyroid autoantibodies in the context of the patient's clinical presentation and consider their implications to manage and monitor thyrotoxicosis.
甲状腺毒症是一种由甲状腺激素过多引起的多种病因的临床状态,包括甲状腺功能亢进和甲状腺炎。Graves' s disease (GD)是一种众所周知的甲状腺功能亢进的自身免疫性疾病,其发病机制主要由促甲状腺激素受体抗体(TSHRAb)驱动,该抗体对GD具有高度特异性。测量TSHRAb是一种快速准确的GD诊断工具,已被用于监测疾病活动性和治疗反应。然而,传统的tsh结合抑制性免疫球蛋白(TBII)不能区分刺激、阻断或中性抗体。相比之下,甲状腺刺激免疫球蛋白生物测定法区分刺激抗体和阻断抗体,对GD的TBII具有相当高的敏感性和特异性。我们还讨论了甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TgAb)在甲状腺毒症中的作用,尽管它们对GD的特异性不如TSHRAb。TPOAb与自身免疫性甲状腺炎相关,而TgAb在自身免疫性甲状腺疾病患者中与TPOAb一起出现。此外,TPOAb或TgAb可能与停用抗甲状腺药物后GD复发率低有关。临床医生应该在患者临床表现的背景下解释甲状腺自身抗体,并考虑其对管理和监测甲状腺毒症的影响。
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引用次数: 0
Myasthenia Gravis Presenting as Sudden–onset Isolated Hypercapnic Respiratory Failure 重症肌无力表现为突发性孤立性高碳酸血症性呼吸衰竭
Pub Date : 2023-04-01 DOI: 10.3904/kjm.2023.98.2.88
Won-Young Kim, Sung Jin Park, Moon Seong Baek, K. Kim, Dae-yong Lee, Byoung-Whui Choi
Myasthenic crisis, which can be life-threatening due to severe respiratory failure, occurs in 15-20% of patients with myasthenia gravis. However, the crisis often develops within 1-2 years after diagnosis and is very rare as a first symptom of myasthenia gravis; isolated sudden-onset hypercapnic respiratory failure without other symptoms of myasthenia gravis is even rarer. A 63-year-old woman presented to the emergency department with fever and dizziness. Chest computed tomography showed multifocal peribronchial ground-glass opacities, and a diagnosis of pneumonia was made. Initially, the patient did not have dyspnea. However, she developed acute hypercapnic respiratory failure and was intubated. After mechanical ventilation, her hypercapnia improved initially, but worsened on initiation of weaning from the ventilator. As she had a high acetylcholine receptor antibody titer, myasthenia gravis was diagnosed. Her hypercapnia improved after treatment with pyridostigmine and methylprednisolone.
重症肌无力危象发生在15-20%的重症肌无力患者中,由于严重的呼吸衰竭可危及生命。然而,危机通常在诊断后1-2年内发生,并且作为重症肌无力的第一症状非常罕见;孤立的突发性高碳酸血症性呼吸衰竭,无其他重症肌无力症状更是罕见。一名63岁女性以发烧和头晕就诊于急诊科。胸部电脑断层显示支气管周围多灶性磨玻璃影,诊断为肺炎。最初,患者没有呼吸困难。然而,她出现急性高碳酸血症性呼吸衰竭并插管。机械通气后,她的高碳酸血症最初有所改善,但在开始脱离呼吸机后恶化。由于患者乙酰胆碱受体抗体滴度高,诊断为重症肌无力。经吡哆斯的明和甲基强的松龙治疗后,高碳酸血症有所改善。
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引用次数: 0
Immune-related Adverse Effect after BNT162b2 Vaccination with Parallel Immune Checkpoint Inhibitor Therapy: A Case Report 平行免疫检查点抑制剂治疗BNT162b2疫苗接种后的免疫相关不良反应:一例报告
Pub Date : 2023-04-01 DOI: 10.3904/kjm.2023.98.2.93
Won Myung Kim, Mun Su Park, Dong Hyun Seo, Jung Yun Lee, J. Pyo
COVID-19 vaccination is essential in cancer patients. However, there is limited evidence of the prognosis of these patients, especially for those taking immune checkpoint inhibitors (ICIs). We present a patient on pembrolizumab for advanced endometrioid adenocarcinoma experiencing continuous diarrhea and subsequent episodes of fever with pain in multiple joints following a second dose of the BNT162b2 mRNA COVID-19 vaccine. An ICI-induced immune-related adverse effect (irAE) was the main diagnosis; cytokine release syndrome and rheumatoid arthritis were also considered. Notably, the novel irAE occurred after the 19th pembrolizumab trial, highlighting the potential effect of changes in systemic immunogenicity after BNT162b2 vaccination. Ultimately, the patient was treated with steroid, which alleviated her symptoms. Here, we report a rare adverse effect after COVID-19 vaccination in an endometrioid carcinoma patient on ICI therapy. This report shows that there is a need to consider and investigate vaccine-related adverse events.
COVID-19疫苗接种对癌症患者至关重要。然而,这些患者的预后证据有限,特别是那些服用免疫检查点抑制剂(ICIs)的患者。我们报告了一名接受派姆单抗治疗晚期子宫内膜样腺癌的患者,在接受第二剂BNT162b2 mRNA COVID-19疫苗后,出现持续腹泻和随后的多关节疼痛的发热发作。ici诱导的免疫相关不良反应(irAE)是主要诊断;细胞因子释放综合征和类风湿关节炎也被考虑在内。值得注意的是,新的irAE发生在第19次派姆单抗试验之后,突出了接种BNT162b2后全身免疫原性变化的潜在影响。最终,患者接受了类固醇治疗,减轻了症状。在这里,我们报告了一例子宫内膜样癌患者在ICI治疗后接种COVID-19疫苗后罕见的不良反应。该报告表明,有必要考虑和调查与疫苗有关的不良事件。
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引用次数: 0
New Guidelines for Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis 特发性肺纤维化和进行性肺纤维化新指南
Pub Date : 2023-04-01 DOI: 10.3904/kjm.2023.98.2.64
H. Yoo
Idiopathic pulmonary fibrosis (IPF) is the most common and fatal idiopathic interstitial pneumonia and is characterized by chronic progressive pulmonary fibrosis of indeterminate etiology. In 2018, the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society published joint clinical practice guidelines for IPF. The guidelines require exclusion of known causes of interstitial lung disease and identification of a radiological and/or pathologic pattern of usual interstitial pneumonia (UIP). The diagnosis of IPF is a multidisciplinary process, involving pulmonologists, radiologists, pathologists and, if necessary, experts in other medical fields. The 2022 guidelines for IPF revisit and clarify the radiological and pathological features of UIP. In addition, recommendations regarding transbronchial lung cryobiopsy, antacid medication, and antireflux surgery are revised or established based on up-to-date evidence in the 2022 guidelines. The new guidelines also encompass the definition and treatment of progressive pulmonary fibrosis (PPF). PPF comprises diverse fibrotic interstitial lung diseases other than IPF, which progress despite standard treatment. The diagnosis of PPF is based on symptoms, physiologic evidence, and radiologic evidence of progression. The use of nintedanib was suggested for patients with PPF other than IPF who are unresponsive to standard treatment. This review introduces and discusses the recommendations for the diagnosis and treatment of IPF and PPF in the new international guidelines.
特发性肺纤维化(IPF)是最常见和最致命的特发性间质性肺炎,其特征是病因不明的慢性进行性肺纤维化。2018年,美国胸科学会、欧洲呼吸学会、日本呼吸学会和拉丁美洲胸科学会联合发布了IPF临床实践指南。该指南要求排除间质性肺病的已知病因,并确定通常间质性肺炎(UIP)的放射学和/或病理学模式。IPF的诊断是一个多学科过程,涉及肺科医生、放射科医生、病理学家,必要时还包括其他医学领域的专家。2022年IPF指南重新审视并阐明了UIP的放射学和病理特征。此外,关于经支气管肺低温活检、抗酸药物和抗反流手术的建议在2022年指南中根据最新证据进行了修订或建立。新指南还包括进行性肺纤维化(PPF)的定义和治疗。PPF包括多种纤维化间质性肺疾病,而不是IPF,尽管进行了标准治疗,但仍会进展。PPF的诊断是基于症状、生理证据和进展的放射学证据。建议对标准治疗无反应的PPF(非IPF)患者使用尼达尼布。本综述介绍并讨论了新的国际指南中关于IPF和PPF诊断和治疗的建议。
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引用次数: 0
SGLT2 Inhibitors: Emerging Drugs in Heart Failure SGLT2抑制剂:治疗心力衰竭的新药物
Pub Date : 2023-04-01 DOI: 10.3904/kjm.2023.98.2.59
D. Cho
Sodium-glucose cotransporter 2 (SGLT2) inhibitors constitute a class of diabetes medications that have demonstrated the potential to improve outcomes for heart failure (HF) patients. Although they were originally developed to treat diabetes, clinical trials have demonstrated their ability to both reduce the risk and improve the prognosis of HF. SGLT2 inhibitors have unique mechanisms of action, including improvement of water retention and promotion of lipolysis, which contribute to their effectiveness in treating HF. They are considered essential primary treatment options for patients with HF, regardless of diabetes status and ejection fraction. Overall, the use of SGLT2 inhibitors in patients with HF is expected to increase in the future and may further improve treatment outcomes for HF patients.
钠-葡萄糖共转运蛋白2 (SGLT2)抑制剂是一类糖尿病药物,已被证明有改善心力衰竭(HF)患者预后的潜力。虽然它们最初是为了治疗糖尿病而开发的,但临床试验已经证明它们能够降低心衰的风险并改善预后。SGLT2抑制剂具有独特的作用机制,包括改善水潴留和促进脂肪分解,这有助于其治疗心衰的有效性。无论糖尿病状态和射血分数如何,它们都被认为是HF患者必不可少的主要治疗选择。总体而言,SGLT2抑制剂在HF患者中的应用预计将在未来增加,并可能进一步改善HF患者的治疗结果。
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引用次数: 0
Strategies to Reduce the Risk of Medical Malpractice Claims against Hospitalists 降低医疗事故对医院医生索赔风险的策略
Pub Date : 2023-04-01 DOI: 10.3904/kjm.2023.98.2.73
S. Han
The hospitalist system has recently been implemented in Korea. Claims against hospitalists may become a new medicolegal issue, as the number of medical malpractice claims is increasing. Hospitalist medical malpractice cases frequently involve more severe patient injuries than those involving claims against other physicians, and these cases frequently involve errors in clinical judgment and communication. Doctor-patient relationship issues, poor communication skills, and physicians at high risk of malpractice claims are risk factors for medical malpractice claims against hospitalists. Strategies to lower the risk of medical malpractice claims against hospitalists include empathetic communication with patients, standardized handoffs or discharge summaries, direct and close communication with outpatient physicians, and timely referral and consultation. Hospitalists will soon have a significant impact on inpatient care in Korea.
最近,韩国开始实行住院医师制。随着医疗事故索赔数量的增加,对医院医生的索赔可能成为一个新的医学法律问题。医院医生的医疗事故案件往往涉及更严重的病人伤害比那些涉及索赔其他医生,这些案件往往涉及错误的临床判断和沟通。医患关系问题、沟通技巧差、医生的医疗事故索赔风险高是医院医疗事故索赔的风险因素。降低对医院医生的医疗事故索赔风险的策略包括与患者进行移情沟通,标准化移交或出院总结,与门诊医生进行直接和密切的沟通,及时转诊和咨询。医院医生将对韩国的住院治疗产生重大影响。
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引用次数: 0
A 22-year-old Woman with Chronic Back Pain 22岁女性慢性背痛
Pub Date : 2023-04-01 DOI: 10.3904/kjm.2023.98.2.78
S. H. Kim, Hong Ki Min, Sang-Heon Lee, Hae-Rim Kim
Low back pain, categorized as nociceptive, neuropathic, or nociplastic, is the leading cause of disability in terms of years lived among young people. The lumbar spine may produce specific or non-specific pain. Treatment depends on the underlying cause of low back pain. This review discusses the classification, prevalence, diagnosis, and treatment of low back pain in young adults.
腰痛可分为伤害性、神经性或伤害性,是导致年轻人致残的主要原因。腰椎可产生特异性或非特异性疼痛。治疗取决于腰痛的根本原因。这篇综述讨论了年轻人腰痛的分类、流行、诊断和治疗。
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引用次数: 0
期刊
Chungang uihak = The Korean central journal of medicine
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