Pub Date : 2022-06-29DOI: 10.6859/aja.202206/PP.0003
Amit Kumar Saha, Bani P M Hembrom, Baisakhi Laha, T. Mitra, A. Hazra
BACKGROUND Infraumbilical surgery today is done preferentially under subarachnoid block. The relatively short duration of analgesia is a limiting factor which is overcome by adding an adjuvant to intrathecal bupivacaine. We aimed to determine optimum dose of intrathecal dexmedetomidine as adjuvant to 0.5% hyperbaric bupivacaine in infraumbilical surgery. METHODS A parallel group, double blind, randomized controlled trial was done with 105 adult patients posted for infraumbilical surgery under subarachnoid block. All subjects received 3.0 mL (15.0 mg) of 0.5% hyperbaric bupivacaine. Groups D5.0, D7.5, and D10.0 (n = 35 each) received additionally 5.0, 7.5, and 10.0 mcg intrathecal dexmedetomidine as adjuvant. The onset time of sensory block, its peak level and time to this level, maximum motor block and time to it, total duration of analgesia (time to first rescue), and vital parameters were recorded at intervals. Postoperative analgesia was assessed by visual analog scale score at 15 and 30 minutes, then every 30 minutes until 2 hours and then every hour until 6 hours. Treatment emergent adverse events (bradycardia, hypotension, and sedation) were documented. RESULTS Maximum sensory level achieved was higher in Group D10.0 than in the other two groups. There was significant and dose-dependent shortening of the mean time to peak sensory block (3.9, 3.3, and 2.9 min; P ＜ 0.001) and peak motor block (5.6, 5.3, and 4.8 min; P ＜ 0.001), and prolongation of postoperative analgesia duration (206.9, 220.8, and 244.0 min; P ＜ 0.001) with escalating doses (5.0, 7.5, and 10.0 mcg, respectively) of dexmedetomidine. Hemodynamic effects and adverse events were comparable in the three groups. CONCLUSIONS Intrathecal dexmedetomidine (10.0 mcg), as adjuvant to 0.5% hyperbaric bupivacaine (15.0 mg), facilitates rapid onset sensory and motor block and prolongs duration of postoperative analgesia in spinal anesthesia without significant adverse effects. Although absolute differences are modest, the results are better compared to 5.0 and 7.5 mcg doses.
{"title":"Comparison of Different Doses of Dexmedetomidine as Adjuvant for Infraumbilical Surgery in Patients Receiving Bupivacaine Spinal Anesthesia: A Randomized Controlled Trial.","authors":"Amit Kumar Saha, Bani P M Hembrom, Baisakhi Laha, T. Mitra, A. Hazra","doi":"10.6859/aja.202206/PP.0003","DOIUrl":"https://doi.org/10.6859/aja.202206/PP.0003","url":null,"abstract":"BACKGROUND\u0000Infraumbilical surgery today is done preferentially under subarachnoid block. The relatively short duration of analgesia is a limiting factor which is overcome by adding an adjuvant to intrathecal bupivacaine. We aimed to determine optimum dose of intrathecal dexmedetomidine as adjuvant to 0.5% hyperbaric bupivacaine in infraumbilical surgery.\u0000\u0000\u0000METHODS\u0000A parallel group, double blind, randomized controlled trial was done with 105 adult patients posted for infraumbilical surgery under subarachnoid block. All subjects received 3.0 mL (15.0 mg) of 0.5% hyperbaric bupivacaine. Groups D5.0, D7.5, and D10.0 (n = 35 each) received additionally 5.0, 7.5, and 10.0 mcg intrathecal dexmedetomidine as adjuvant. The onset time of sensory block, its peak level and time to this level, maximum motor block and time to it, total duration of analgesia (time to first rescue), and vital parameters were recorded at intervals. Postoperative analgesia was assessed by visual analog scale score at 15 and 30 minutes, then every 30 minutes until 2 hours and then every hour until 6 hours. Treatment emergent adverse events (bradycardia, hypotension, and sedation) were documented.\u0000\u0000\u0000RESULTS\u0000Maximum sensory level achieved was higher in Group D10.0 than in the other two groups. There was significant and dose-dependent shortening of the mean time to peak sensory block (3.9, 3.3, and 2.9 min; P ＜ 0.001) and peak motor block (5.6, 5.3, and 4.8 min; P ＜ 0.001), and prolongation of postoperative analgesia duration (206.9, 220.8, and 244.0 min; P ＜ 0.001) with escalating doses (5.0, 7.5, and 10.0 mcg, respectively) of dexmedetomidine. Hemodynamic effects and adverse events were comparable in the three groups.\u0000\u0000\u0000CONCLUSIONS\u0000Intrathecal dexmedetomidine (10.0 mcg), as adjuvant to 0.5% hyperbaric bupivacaine (15.0 mg), facilitates rapid onset sensory and motor block and prolongs duration of postoperative analgesia in spinal anesthesia without significant adverse effects. Although absolute differences are modest, the results are better compared to 5.0 and 7.5 mcg doses.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42351743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-29DOI: 10.6859/aja.202206/PP.0004
M. Hung, Yi-ping Wang
Received: 28 September 2020; Received in revised form: 20 January 2022; Accepted: 1 March 2022. Corresponding Author: Ming-Hui Hung, MD, Department of Anesthesiology, National Taiwan University Hospital Hsin-Chu Branch, No. 25, Ln. 442, Sec. 1, Jingguo Rd., North Dist., Hsinchu City 300195, Taiwan (hung.minghui@gmail.com). To the Editor, We read the article by Dr. Moriwaki et al. with great interest in a recent issue of the journal. To facilitate early recovery of neuromuscular function for stimulator-guided nerve blocks, the authors administered sugammadex 2 mg/kg 10 minutes after rocuronium 0.6 mg/kg to obtain adequate responses from nerve stimulation. While their protocol is feasible and their results are satisfactory, we have concerns about the strategy. Sugammadex might be a game-changer in the practice of general anesthesia. It can reverse any depths of rocuronium-induced neuromuscular blockade within minutes and notably without cholinergic adverse effects. Nonetheless, anesthesiologists should be reminded that any drug is poison without considering why (indication), when (timing), and how (dose). First, for patients who desired general anesthesia and peripheral nerve block for pain control, we argue that using a supraglottic airway device without muscle relaxant during moderate-to-deep sedation or general anesthesia is sufficient to perform stimulator-guided nerve block. Even for long-hour procedures requiring a definite airway, general anesthesia with tracheal intubation can be performed after peripheral nerve blocks (block-before-intubation strategy). Second, the optimal depth of neuromuscular block without interfering with the use of a stimulator to guide nerve blocks is controversial. We did not know the specific depth of neuromuscular blockade 10 minutes after they gave rocuronium 0.6 mg/kg from their article. However, we found that all patients made a full recovery of neuromuscular function 7 minutes after sugammadex 2 mg/kg with a train-offour (TOF) ratio above 0.9 as shown in Figure 2 of the article done by Moriwaki et al. Unsurprisingly, many patients (72%) presented coughing and movement during surgery, most likely resulting from inadequate neuromuscular blockade hereafter. Anesthesiologists should be reminded that recommended doses of sugammadex from the package insert are relatively high for rapid and full reversal within 2–3 minutes in life-threatening scenarios. An excessive dose of sugammadex is not binding any rocuronium in the body. An unnecessary dose of sugammadex is associated with increasing drug cost and the occurrence of bradycardia and hypersensitivity reactions. Re-obtaining neuromuscular blockade after a high dose of sugammadex is another concern because rocuronium is not an option for muscle relaxation in the following hours. Therefore, it may be considered that anesthesiologists gave a low dose of sugammadex with TOF monitor to a targeted depth of neuromuscular blockade in such cases, instead of full recovery of
{"title":"Reversal of Neuromuscular Blockade by Sugammadex for Stimulator-Guided Nerve Blocks After Tracheal Intubation: Is It Necessary?","authors":"M. Hung, Yi-ping Wang","doi":"10.6859/aja.202206/PP.0004","DOIUrl":"https://doi.org/10.6859/aja.202206/PP.0004","url":null,"abstract":"Received: 28 September 2020; Received in revised form: 20 January 2022; Accepted: 1 March 2022. Corresponding Author: Ming-Hui Hung, MD, Department of Anesthesiology, National Taiwan University Hospital Hsin-Chu Branch, No. 25, Ln. 442, Sec. 1, Jingguo Rd., North Dist., Hsinchu City 300195, Taiwan (hung.minghui@gmail.com). To the Editor, We read the article by Dr. Moriwaki et al. with great interest in a recent issue of the journal. To facilitate early recovery of neuromuscular function for stimulator-guided nerve blocks, the authors administered sugammadex 2 mg/kg 10 minutes after rocuronium 0.6 mg/kg to obtain adequate responses from nerve stimulation. While their protocol is feasible and their results are satisfactory, we have concerns about the strategy. Sugammadex might be a game-changer in the practice of general anesthesia. It can reverse any depths of rocuronium-induced neuromuscular blockade within minutes and notably without cholinergic adverse effects. Nonetheless, anesthesiologists should be reminded that any drug is poison without considering why (indication), when (timing), and how (dose). First, for patients who desired general anesthesia and peripheral nerve block for pain control, we argue that using a supraglottic airway device without muscle relaxant during moderate-to-deep sedation or general anesthesia is sufficient to perform stimulator-guided nerve block. Even for long-hour procedures requiring a definite airway, general anesthesia with tracheal intubation can be performed after peripheral nerve blocks (block-before-intubation strategy). Second, the optimal depth of neuromuscular block without interfering with the use of a stimulator to guide nerve blocks is controversial. We did not know the specific depth of neuromuscular blockade 10 minutes after they gave rocuronium 0.6 mg/kg from their article. However, we found that all patients made a full recovery of neuromuscular function 7 minutes after sugammadex 2 mg/kg with a train-offour (TOF) ratio above 0.9 as shown in Figure 2 of the article done by Moriwaki et al. Unsurprisingly, many patients (72%) presented coughing and movement during surgery, most likely resulting from inadequate neuromuscular blockade hereafter. Anesthesiologists should be reminded that recommended doses of sugammadex from the package insert are relatively high for rapid and full reversal within 2–3 minutes in life-threatening scenarios. An excessive dose of sugammadex is not binding any rocuronium in the body. An unnecessary dose of sugammadex is associated with increasing drug cost and the occurrence of bradycardia and hypersensitivity reactions. Re-obtaining neuromuscular blockade after a high dose of sugammadex is another concern because rocuronium is not an option for muscle relaxation in the following hours. Therefore, it may be considered that anesthesiologists gave a low dose of sugammadex with TOF monitor to a targeted depth of neuromuscular blockade in such cases, instead of full recovery of","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44081112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-29DOI: 10.6859/aja.202206/PP.0001
Yoriko Murase, Y. Koyama, Kunishige Ogasawara, Kei Morita, K. Tsuzaki
{"title":"The Importance of Skin Testing in Patients With History of Anesthesia-Related Anaphylaxis.","authors":"Yoriko Murase, Y. Koyama, Kunishige Ogasawara, Kei Morita, K. Tsuzaki","doi":"10.6859/aja.202206/PP.0001","DOIUrl":"https://doi.org/10.6859/aja.202206/PP.0001","url":null,"abstract":"","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45605823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-29DOI: 10.6859/aja.202206/PP.0002
S. Bharadwaj, Sangeetha R. Palaniswamy
Synchrony between basic neuroscience investigations and clinical research has been deficient for quite some time. Translational research includes several dimensions such as laboratory research, clinical demands, government policies, and availability of funds. Through translational research, techniques of neuroanesthesia have become precise and secure over time. Perioperative translational science and contemporary translational research are the two major dimensions of translational research in perioperative neurosciences. The knowledge gap in perioperative neuroscience can be filled with scientific and technological advances with a multidisciplinary approach. In this review, we will discuss various domains of translational research in perioperative neurosciences and have a glance into the translated clinical applications.
{"title":"Translational Research in Perioperative Neurosciences.","authors":"S. Bharadwaj, Sangeetha R. Palaniswamy","doi":"10.6859/aja.202206/PP.0002","DOIUrl":"https://doi.org/10.6859/aja.202206/PP.0002","url":null,"abstract":"Synchrony between basic neuroscience investigations and clinical research has been deficient for quite some time. Translational research includes several dimensions such as laboratory research, clinical demands, government policies, and availability of funds. Through translational research, techniques of neuroanesthesia have become precise and secure over time. Perioperative translational science and contemporary translational research are the two major dimensions of translational research in perioperative neurosciences. The knowledge gap in perioperative neuroscience can be filled with scientific and technological advances with a multidisciplinary approach. In this review, we will discuss various domains of translational research in perioperative neurosciences and have a glance into the translated clinical applications.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42958157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.6859/aja.202206_60(2).0006
Mohamad Ali Barada, Omar Rajab, Ahmad Salah Naja, Pier Semaan, Loubna Sinno, Zoher Naja
Background: Several anesthetic techniques have been used for pilonidal sinus surgery such as general, spinal, and local anesthesia infiltration. However, the most effective technique remains controversial. The aim of this study was to assess the effectiveness of sacrococcygeal local anesthesia for complicated pilonidal cysts in terms of postoperative analgesic consumption.
Methods: This was a retrospective cohort study conducted by collecting data from medical records for male patients who underwent pilonidal surgery using sacrococcygeal local anesthesia from 2008 to 2018. Patients' demographics, operative data, and postoperative outcomes such as pain, nausea, as well as analgesic consumption at 0 and 3 hours were analyzed. Pain scores at rest and upon pressure were recorded using the Visual Analogue Scale. The length of complicated pilonidal sinus was considered to be greater than or equal to 7 cm with multiple openings.
Results: A total of 394 patients were included in the study, 173 patients (43.9%) had complicated cysts while 221 patients (56.1%) had uncomplicated cysts. The majority of patients were males (85.5% vs. 76.9% in the complicated and uncomplicated groups respectively). Patients' weight was significantly higher in the complicated cyst group (87.12 ± 17.07 vs. 82.43 ± 20.30 kg, P value = 0.02). Around 41% of the patients in the complicated group were obese (body mass index ≥ 30 kg/m^2) compared to 32.0% of the patients in the uncomplicated group. Mean arterial pressure and heart rate at baseline, intraoperatively and at the end of the operation were similar between the two groups. Pain scores at rest and upon pressure were low in both groups. Analgesic consumption was similar between the two groups. Eight patients (4.6%) in the complicated group required acetaminophen at 0 hour compared to 6 patients (2.7%) in the uncomplicated group. Three patients (1.7%) received ketoprofen at 0 hour in the complicated group and 3 patients (1.4%) in the other group. Three patients, 2 (1.2%) in the complicated group and 1 (0.5%) in the second group required tramadol hydrochloride.
Conclusions: Sacrococcygeal local anesthetic technique for complex pilonidal sinus surgery provided intra-operative hemodynamic stability as well as low post-operative pain and analgesic consumption.
背景:多种麻醉技术已被应用于毛窦手术，如全身、脊柱和局部麻醉浸润。然而，最有效的技术仍然存在争议。本研究的目的是评估骶尾椎局部麻醉对复杂毛鞘囊肿术后镇痛消耗的有效性。方法:回顾性队列研究，收集2008 - 2018年骶尾椎局部麻醉行脊髓膜手术的男性患者的病历资料。分析患者的人口统计学、手术数据和术后0和3小时的疼痛、恶心、镇痛药消耗等结果。使用视觉模拟量表记录休息和按压时的疼痛评分。复杂的毛窦长度大于等于7cm，有多个开口。结果:共纳入394例患者，其中合并囊肿173例(43.9%)，无合并囊肿221例(56.1%)。男性患者居多(并发症组为85.5%，无并发症组为76.9%)。合并囊肿组患者体重明显增高(87.12±17.07 vs. 82.43±20.30 kg, P值= 0.02)。并发症组约41%的患者为肥胖(体重指数≥30 kg/m^2)，而非并发症组为32.0%。两组患者基线、术中及术后平均动脉压和心率相似。两组休息时和受压时的疼痛评分均较低。两组镇痛药用量相似。并发症组8例患者(4.6%)在0小时需要对乙酰氨基酚，而非并发症组6例患者(2.7%)。并发症组3例(1.7%)患者在0小时接受酮洛芬治疗，其他组3例(1.4%)患者接受酮洛芬治疗。合并组2例(1.2%)，合并组1例(0.5%)需要盐酸曲马多。结论:骶尾骨局麻技术用于复杂毛窦手术，术中血流动力学稳定，术后疼痛和镇痛消耗低。
{"title":"Sacrococcygeal Local Anesthesia for Complicated Versus Uncomplicated Pilonidal Sinus Surgery: A Single Center Study.","authors":"Mohamad Ali Barada, Omar Rajab, Ahmad Salah Naja, Pier Semaan, Loubna Sinno, Zoher Naja","doi":"10.6859/aja.202206_60(2).0006","DOIUrl":"https://doi.org/10.6859/aja.202206_60(2).0006","url":null,"abstract":"<p><strong>Background: </strong>Several anesthetic techniques have been used for pilonidal sinus surgery such as general, spinal, and local anesthesia infiltration. However, the most effective technique remains controversial. The aim of this study was to assess the effectiveness of sacrococcygeal local anesthesia for complicated pilonidal cysts in terms of postoperative analgesic consumption.</p><p><strong>Methods: </strong>This was a retrospective cohort study conducted by collecting data from medical records for male patients who underwent pilonidal surgery using sacrococcygeal local anesthesia from 2008 to 2018. Patients' demographics, operative data, and postoperative outcomes such as pain, nausea, as well as analgesic consumption at 0 and 3 hours were analyzed. Pain scores at rest and upon pressure were recorded using the Visual Analogue Scale. The length of complicated pilonidal sinus was considered to be greater than or equal to 7 cm with multiple openings.</p><p><strong>Results: </strong>A total of 394 patients were included in the study, 173 patients (43.9%) had complicated cysts while 221 patients (56.1%) had uncomplicated cysts. The majority of patients were males (85.5% vs. 76.9% in the complicated and uncomplicated groups respectively). Patients' weight was significantly higher in the complicated cyst group (87.12 ± 17.07 vs. 82.43 ± 20.30 kg, P value = 0.02). Around 41% of the patients in the complicated group were obese (body mass index ≥ 30 kg/m^2) compared to 32.0% of the patients in the uncomplicated group. Mean arterial pressure and heart rate at baseline, intraoperatively and at the end of the operation were similar between the two groups. Pain scores at rest and upon pressure were low in both groups. Analgesic consumption was similar between the two groups. Eight patients (4.6%) in the complicated group required acetaminophen at 0 hour compared to 6 patients (2.7%) in the uncomplicated group. Three patients (1.7%) received ketoprofen at 0 hour in the complicated group and 3 patients (1.4%) in the other group. Three patients, 2 (1.2%) in the complicated group and 1 (0.5%) in the second group required tramadol hydrochloride.</p><p><strong>Conclusions: </strong>Sacrococcygeal local anesthetic technique for complex pilonidal sinus surgery provided intra-operative hemodynamic stability as well as low post-operative pain and analgesic consumption.</p>","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.6859/aja.202206_60(2).0001
Wei-Zen Sun, James L Reynolds
{"title":"Resilience in a Storm: Typhoon Omicron Hits Taiwan.","authors":"Wei-Zen Sun, James L Reynolds","doi":"10.6859/aja.202206_60(2).0001","DOIUrl":"https://doi.org/10.6859/aja.202206_60(2).0001","url":null,"abstract":"","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"43-45"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.6859/aja.202206_60(2).0008
R Sripriya, G Prabavathy
{"title":"Horner's Syndrome Following Thoracic Paravertebral Block-Radiological Evidence of Spread to Stellate Ganglion and Fascial Anatomy Facilitating the Spread.","authors":"R Sripriya, G Prabavathy","doi":"10.6859/aja.202206_60(2).0008","DOIUrl":"https://doi.org/10.6859/aja.202206_60(2).0008","url":null,"abstract":"","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":"87-88"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-04DOI: 10.6859/aja.202204/PP.0003
Po-Jen Yun, Zhi-Fu Wu, Tsai-Wang Huang, W. Tseng
Po-Jen Yun, Zhi-Fu Wu, Tsai-Wang Huang, Wei-Cheng Tseng Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
{"title":"Unilateral Negative-Pressure Pulmonary Edema Following One-Lung Ventilation for Thoracic Surgery.","authors":"Po-Jen Yun, Zhi-Fu Wu, Tsai-Wang Huang, W. Tseng","doi":"10.6859/aja.202204/PP.0003","DOIUrl":"https://doi.org/10.6859/aja.202204/PP.0003","url":null,"abstract":"Po-Jen Yun, Zhi-Fu Wu, Tsai-Wang Huang, Wei-Cheng Tseng Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47868341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-04DOI: 10.6859/aja.202204/PP.0002
Y. Yamamoto, Yusuke Naito, H. Nakatani, M. Ida, M. Kawaguchi
BACKGROUND Patients with alcohol drinking habits have less nausea and vomiting during chemotherapy because of cytochrome P450 enzyme induction. However, few studies have examined the effect of alcohol consumption on postoperative nausea and vomiting (PONV). We conducted a study to clarify the relationship between alcohol drinking habits and PONV. METHODS Data of patients undergoing hepatectomy under general anesthesia between 2016 and 2020 were retrospectively collected. Since alcohol drinking habits vary by gender, age, and comorbidities, propensity score matching was performed to adjust patient background before multivariate logistic regression analysis. RESULTS Seventy-eight patients in the alcohol consumption and non-consumption groups were matched by propensity matching. Univariate analysis showed that alcohol consumption (P = 0.04) and male (P ＜ 0.001) were the factors that significantly reduced PONV. Multiple logistic regression analysis including intraoperative factors showed that alcohol consumption (odds ratio, 0.36; 95% confidence interval [CI], 0.15-0.90) and female (odds ratio, 5.34; 95% CI, 2.0-14.2) were associated with PONV as factors affecting PONV. CONCLUSION Patients with no alcohol drinking habits may be at higher risk of PONV.
{"title":"Relationship Between Preoperative Alcohol Consumption and Postoperative Nausea and Vomiting in Liver Resection: A Propensity Score Matched Analysis in a Single Institute.","authors":"Y. Yamamoto, Yusuke Naito, H. Nakatani, M. Ida, M. Kawaguchi","doi":"10.6859/aja.202204/PP.0002","DOIUrl":"https://doi.org/10.6859/aja.202204/PP.0002","url":null,"abstract":"BACKGROUND\u0000Patients with alcohol drinking habits have less nausea and vomiting during chemotherapy because of cytochrome P450 enzyme induction. However, few studies have examined the effect of alcohol consumption on postoperative nausea and vomiting (PONV). We conducted a study to clarify the relationship between alcohol drinking habits and PONV.\u0000\u0000\u0000METHODS\u0000Data of patients undergoing hepatectomy under general anesthesia between 2016 and 2020 were retrospectively collected. Since alcohol drinking habits vary by gender, age, and comorbidities, propensity score matching was performed to adjust patient background before multivariate logistic regression analysis.\u0000\u0000\u0000RESULTS\u0000Seventy-eight patients in the alcohol consumption and non-consumption groups were matched by propensity matching. Univariate analysis showed that alcohol consumption (P = 0.04) and male (P ＜ 0.001) were the factors that significantly reduced PONV. Multiple logistic regression analysis including intraoperative factors showed that alcohol consumption (odds ratio, 0.36; 95% confidence interval [CI], 0.15-0.90) and female (odds ratio, 5.34; 95% CI, 2.0-14.2) were associated with PONV as factors affecting PONV.\u0000\u0000\u0000CONCLUSION\u0000Patients with no alcohol drinking habits may be at higher risk of PONV.","PeriodicalId":8482,"journal":{"name":"Asian journal of anesthesiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49292883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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