Inclined columns are emerging as a fascinating innovation in the field of structural engineering and architecture. Their capacity to effectively transfer loads, particularly in applications like angled facades and bridges, has made them a desirable option in contemporary buildings. Inclined columns structural behaviour and moment resistance capabilities are crucial in modern engineering. Resolving this issue is essential in enhancing inclined column systems, functionality and safety. This study investigates three distinct inclined column configurations that involve a basic inclined column, an inclined column with triangular supports, and an inclined column with banding reinforcement. A comparison was made with the conventional vertical inclined column designs, with an emphasis on their efficiency, applicability for modern architectural and engineering applications, and performance. Utilizing the sophisticated finite element program Abaqus, an in-depth set of analyses was conducted to investigate the complex behaviours of load–displacement interactions, stress–strain correlations, and moment responses. The results indicate that inclined columns with banding reinforcement significantly outperform the others in terms of moment resistance, load-carrying capacity, and overall structural efficiency. In addition to FEM analysis, advanced predictive modelling techniques, including Artificial Neural Networks (ANN) and Response Surface Methodology (RSM), were employed to enhance further the understanding of the columns behaviour along with performance analysis. With an R2 value of 0.997, the Artificial Neural Network (ANN) model has remarkable performance and exemplifies an outstanding fit. In contrast, the Response Surface Methodology (RSM) model demonstrates a slightly lower R2 value of 0.985, which still indicates a solid fit. These models offer a more precise prediction of the structural performance by capturing the complex, non-linear interactions within the systems.