Pub Date : 2019-04-01DOI: 10.26655/AJNANOMAT.2019.3.2
M. Haque
ABSTRACT: Nano technology refers to enhancing the function and delivering the upcoming smart solutions to products at the nanoscale level. It relates to organizing the molecules for altering in dimension and characteristic for improvement like smart fabric. These fabrics could assist producers with the added prominence on a standard of living, visual attraction, and system wanted technological produces. Nanosize particles can unveil unpredicted characteristics dissimilar from the bulk matter. The fundamental principle is that the features could radically be altered after the material is decreased to the nanometer scale. Nanotechnology has multipurpose functions in fabric manufacturing in producing the stain and wrinkles defiance, flame retardant, antimicrobial and antistatic properties, moisture control, ultraviolet protection, and release features. The nanomaterials inside the fabric could influence numerous qualities, comprising reduction, electrical conductivity, flammability, and strength. Nanotechnology has additionally created a significant impression on various application and implementation. Nano-doctored fabrics may advance numerous fabrications as the nano-science progresses further.
{"title":"Nano Fabrics in the 21st century: a review","authors":"M. Haque","doi":"10.26655/AJNANOMAT.2019.3.2","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.3.2","url":null,"abstract":"ABSTRACT: Nano technology refers to enhancing the function and delivering the upcoming smart solutions to products at the nanoscale level. It relates to organizing the molecules for altering in dimension and characteristic for improvement like smart fabric. These fabrics could assist producers with the added prominence on a standard of living, visual attraction, and system wanted technological produces. Nanosize particles can unveil unpredicted characteristics dissimilar from the bulk matter. The fundamental principle is that the features could radically be altered after the material is decreased to the nanometer scale. Nanotechnology has multipurpose functions in fabric manufacturing in producing the stain and wrinkles defiance, flame retardant, antimicrobial and antistatic properties, moisture control, ultraviolet protection, and release features. The nanomaterials inside the fabric could influence numerous qualities, comprising reduction, electrical conductivity, flammability, and strength. Nanotechnology has additionally created a significant impression on various application and implementation. Nano-doctored fabrics may advance numerous fabrications as the nano-science progresses further.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77368987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.26655/AJNANOMAT.2019.3.9
A. Suganthi, S. Satheshkumar, Ravi T.K
A simple, specific, sensitive and rapid stability-indicating high performance thin layer chromatographic method has been developed for the simultaneous estimation of ledipasvir and sofosbuvir in combined dosage form. In this method, the separation was achieved on silica gel 60F254 thin layer chromatography plates using mobile phase comprising of hexane: ethyl acetate: methanol (5:3:2,v/v/v) with 3 drops of ammonia at 288 nm as selected wavelength on a densitometer. The Rf value of sofosbuvir and ledipasvir were observed to be 0.21±0.02 and 0.43±0.02, respectively. The linearity, precision, accuracy, robustness, specificity, limit of detection and limit of quantitation of the method were validated according to the ICH guidelines. The linear regression analysis for calibration plots produced r2=0.9948±0.0005 and r2 = 0.9927±0.0003 for ledipasvir and sofosbuvir, respectively. Percent recovery of the drugs from tablet formulation was carried out by standard addition method and was found to be close to 100 and relative standard deviation was less than 2%, which indicated good accuracy and precision of the method. The factors evaluated in the robustness test were determined to have an insignificant effect on the selected responses. To make the method more specific stress studies were conducted for both drugs individually as well as in the combined form by subjected to acid, alkali and neutral hydrolysis, oxidation, thermal and photolytic degradation. Degradation studies indicated ledipasvir to be susceptible to acid and alkaline hydrolysis, thermal, photolytic and oxidative degradation whereas sofosbuvir was susceptible only to alkaline hydrolysis. The degradation product peaks were well resolved from the pure drug with significant differences in their Rf values. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulation.
{"title":"“Development of validated specific stability-indicating HPTLC method for the simultaneous determination of Ledipasvir and Sofosbuvir in fixed dose tablet formulation”","authors":"A. Suganthi, S. Satheshkumar, Ravi T.K","doi":"10.26655/AJNANOMAT.2019.3.9","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.3.9","url":null,"abstract":"A simple, specific, sensitive and rapid stability-indicating high performance thin layer chromatographic method has been developed for the simultaneous estimation of ledipasvir and sofosbuvir in combined dosage form. In this method, the separation was achieved on silica gel 60F254 thin layer chromatography plates using mobile phase comprising of hexane: ethyl acetate: methanol (5:3:2,v/v/v) with 3 drops of ammonia at 288 nm as selected wavelength on a densitometer. The Rf value of sofosbuvir and ledipasvir were observed to be 0.21±0.02 and 0.43±0.02, respectively. The linearity, precision, accuracy, robustness, specificity, limit of detection and limit of quantitation of the method were validated according to the ICH guidelines. The linear regression analysis for calibration plots produced r2=0.9948±0.0005 and r2 = 0.9927±0.0003 for ledipasvir and sofosbuvir, respectively. Percent recovery of the drugs from tablet formulation was carried out by standard addition method and was found to be close to 100 and relative standard deviation was less than 2%, which indicated good accuracy and precision of the method. The factors evaluated in the robustness test were determined to have an insignificant effect on the selected responses. To make the method more specific stress studies were conducted for both drugs individually as well as in the combined form by subjected to acid, alkali and neutral hydrolysis, oxidation, thermal and photolytic degradation. Degradation studies indicated ledipasvir to be susceptible to acid and alkaline hydrolysis, thermal, photolytic and oxidative degradation whereas sofosbuvir was susceptible only to alkaline hydrolysis. The degradation product peaks were well resolved from the pure drug with significant differences in their Rf values. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulation.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76963735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.26655/AJNANOMAT.2019.3.8
Y. Tyagi, N. Madhav
Delivery of API molecules to the brain is a challenging task. The main aim of this review is to present ocular route as a powerful region and focus on the various Nano-formulations. Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. Though the topical and localized application are still an acceptable and preferred way to achieve therapeutic level of drugs used to treat ocular disorders but the primitive ophthalmic solution, suspension, and ointment dosage form are no longer sufficient to combat various ocular diseases. This article reviews the constraints with conventional ocular therapy and explores various novel approaches, in general, to improve ocular bioavailability of the drugs, advantages of vesicular approach over these and the future challenges to render the vesicular system more effective.
{"title":"RECENT RESEARCH INNOVATIONS IN DRUG DELIVERY ‘THROUGH AND TO’ OCULAR ROUTE","authors":"Y. Tyagi, N. Madhav","doi":"10.26655/AJNANOMAT.2019.3.8","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.3.8","url":null,"abstract":"Delivery of API molecules to the brain is a challenging task. The main aim of this review is to present ocular route as a powerful region and focus on the various Nano-formulations. Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. Though the topical and localized application are still an acceptable and preferred way to achieve therapeutic level of drugs used to treat ocular disorders but the primitive ophthalmic solution, suspension, and ointment dosage form are no longer sufficient to combat various ocular diseases. This article reviews the constraints with conventional ocular therapy and explores various novel approaches, in general, to improve ocular bioavailability of the drugs, advantages of vesicular approach over these and the future challenges to render the vesicular system more effective.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83741166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.26655/AJNANOMAT.2019.3.10
B. P. Kumar, Avvaru Praveen Kumar, P. Binduc, A. K. Mukherjee, A. Patra
The europium silsesquioxane complexes are synthesized with Eu(NO3)3∙6H2O to corner cap with incomplete condensation of hepta(3,3,3-trifluoropropyl)-tricycloheptasiloxane trisodium silanolate (7F-T7-(ONa)3 along with the 1,3,5,7,9,11,14-hepta isobutyltricyclo [7,3,3,15,14] heptasiloxane-3,7,11-trisilanol (trisilanolisobutyl-POSS). These europium silsesquioxane complexes are highly soluble in organic solvents and show a red emission. Photoluminescence of Eu3+-CF-POSS is higher compared with Eu3+-CH-POSS. This fluorescence enhancement is due to the significant effect of the large POSS units. The europium silsesquioxane complexes were characterized by Fourier transform infrared spectrophotometer (FT–IR), field emission scanning electron microscopy (FE–SEM), energy dispersive X-ray analysis (EDX) and thermogravimetric analysis (TGA). The excitation and emission pattern of polyhedral europium silsesquioxanes was studied using photoluminescence spectrophotometer. The results show an excellent emission property at the wavelength between 612 and 620 nm which correspond to the 5D0–7F2 transition of europium in polyhedral silsesquioxanes.
{"title":"Red Light Emission of POSS Triol Chelated with Europium","authors":"B. P. Kumar, Avvaru Praveen Kumar, P. Binduc, A. K. Mukherjee, A. Patra","doi":"10.26655/AJNANOMAT.2019.3.10","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.3.10","url":null,"abstract":"The europium silsesquioxane complexes are synthesized with Eu(NO3)3∙6H2O to corner cap with incomplete condensation of hepta(3,3,3-trifluoropropyl)-tricycloheptasiloxane trisodium silanolate (7F-T7-(ONa)3 along with the 1,3,5,7,9,11,14-hepta isobutyltricyclo [7,3,3,15,14] heptasiloxane-3,7,11-trisilanol (trisilanolisobutyl-POSS). These europium silsesquioxane complexes are highly soluble in organic solvents and show a red emission. Photoluminescence of Eu3+-CF-POSS is higher compared with Eu3+-CH-POSS. This fluorescence enhancement is due to the significant effect of the large POSS units. The europium silsesquioxane complexes were characterized by Fourier transform infrared spectrophotometer (FT–IR), field emission scanning electron microscopy (FE–SEM), energy dispersive X-ray analysis (EDX) and thermogravimetric analysis (TGA). The excitation and emission pattern of polyhedral europium silsesquioxanes was studied using photoluminescence spectrophotometer. The results show an excellent emission property at the wavelength between 612 and 620 nm which correspond to the 5D0–7F2 transition of europium in polyhedral silsesquioxanes.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79678078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.26655/AJNANOMAT.2019.3.7
A. D. Khalaji, S. J. Peyghoun, M. Dušek, V. Eigner
Nano-sized powder of a new 1D copper(I) coordination polymer, [Cu(nba2en)(NCS)]n (1), (nba2en = N,Nʹ-bis(4-ntrobenzylidene)ethane-1,2-diamine, was synthesized using ultrasonic bath assisted and characterized by scanning electron microscopy (SEM), IR and 1H-NMR spectroscopy, and elemental analyses. Thermal stability of 1 was studied using thermogravimetric (TG) and differential thermal analyses (DTA). The crystal structure was investigated by single-crystal X-ray diffraction. The structure of 1 consists of a 1D polymeric chain in which copper(I) ions are bridged by two thiocyanate group bonding in an end-to-end fashion, with CuCu separation 5.556(4) A.
采用超声浴辅助合成了新型一维铜(I)配位聚合物[Cu(nba2en)(NCS)]n (1)， (nba2en = n, n′-双(4-对苄基)乙烷-1,2-二胺的纳米粉体，并用扫描电镜(SEM)、红外光谱(IR)、核磁共振波谱(1H-NMR)和元素分析对粉体进行了表征。用热重法(TG)和差热分析法(DTA)研究了1的热稳定性。用单晶x射线衍射分析了其晶体结构。1的结构由一个一维聚合物链组成，其中铜(I)离子由两个硫氰酸盐基团以端到端的方式桥接，Cu的分离度为5.556(4)a。
{"title":"Nano-Sized and Single Crystal of a 1D Copper(I) Coordination Polymer: Preparation, Characterization, Thermal and Structural Studies","authors":"A. D. Khalaji, S. J. Peyghoun, M. Dušek, V. Eigner","doi":"10.26655/AJNANOMAT.2019.3.7","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.3.7","url":null,"abstract":"Nano-sized powder of a new 1D copper(I) coordination polymer, [Cu(nba2en)(NCS)]n (1), (nba2en = N,Nʹ-bis(4-ntrobenzylidene)ethane-1,2-diamine, was synthesized using ultrasonic bath assisted and characterized by scanning electron microscopy (SEM), IR and 1H-NMR spectroscopy, and elemental analyses. Thermal stability of 1 was studied using thermogravimetric (TG) and differential thermal analyses (DTA). The crystal structure was investigated by single-crystal X-ray diffraction. The structure of 1 consists of a 1D polymeric chain in which copper(I) ions are bridged by two thiocyanate group bonding in an end-to-end fashion, with CuCu separation 5.556(4) A.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87576362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.26655/AJNANOMAT.2019.1.1
Salami Mutiah, H. Louis, Amusan Oluwatobi Omotola, Saud Uz Zafar, T. Magu, Adejoke T. Hamzat, Amos I. Pigweh, O. Akakuru, A. T. Adeleye, B. Ita
Batteries are a major technological challenge in this new century as they are a key method to make use of energy efficiently. Nowadays Lithium-ion batteries (LIBs) appeared to be one of the most important energy storage technologies. Today’s Li-ion technology has conquered the portable electronic markets and still on the track of fast development. The success of lithium-ion technology will depend largely on the cost, safety, cycle life, energy, and power, which are in turn determined by the component materials used for its fabrication. Accordingly, this review focuses on the challenges of organic based materials and prospects associated with the electrode materials. Specifically, the issues associated with organic based batteries, advances and prospects are presented. This review aims to summarize the fundamentals of the polymer-based material for lithium-ion batteries (LIBs) and specifically highlight its recent major advancement in material design, challenges, performance and finally its prospects. We anticipate that this Review will inspire further improvement in organic electrolyte materials and the electrode for the battery as energy device storages. Some of these concepts, relying on new ways to prepare electrode materials by the use of eco-efficient processes, on the use of organic rather than inorganic materials in order to overcome environmental issues associated with their use. Organic electrodes are important for solid electrode batteries because they can make device cost-effective, allow flexibility, and can also enable the use of multivalent ions without the problems typically associated with inorganic compounds.
{"title":"Polymer-based Material for Lithium-Ion Batteries: Structure, Material Engineering, Device Performance and Challenges (Review)","authors":"Salami Mutiah, H. Louis, Amusan Oluwatobi Omotola, Saud Uz Zafar, T. Magu, Adejoke T. Hamzat, Amos I. Pigweh, O. Akakuru, A. T. Adeleye, B. Ita","doi":"10.26655/AJNANOMAT.2019.1.1","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.1.1","url":null,"abstract":"Batteries are a major technological challenge in this new century as they are a key method to make use of energy efficiently. Nowadays Lithium-ion batteries (LIBs) appeared to be one of the most important energy storage technologies. Today’s Li-ion technology has conquered the portable electronic markets and still on the track of fast development. The success of lithium-ion technology will depend largely on the cost, safety, cycle life, energy, and power, which are in turn determined by the component materials used for its fabrication. Accordingly, this review focuses on the challenges of organic based materials and prospects associated with the electrode materials. Specifically, the issues associated with organic based batteries, advances and prospects are presented. This review aims to summarize the fundamentals of the polymer-based material for lithium-ion batteries (LIBs) and specifically highlight its recent major advancement in material design, challenges, performance and finally its prospects. We anticipate that this Review will inspire further improvement in organic electrolyte materials and the electrode for the battery as energy device storages. Some of these concepts, relying on new ways to prepare electrode materials by the use of eco-efficient processes, on the use of organic rather than inorganic materials in order to overcome environmental issues associated with their use. Organic electrodes are important for solid electrode batteries because they can make device cost-effective, allow flexibility, and can also enable the use of multivalent ions without the problems typically associated with inorganic compounds.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80584839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.26655/AJNANOMAT.2019.1.8
S. Reddy, Swapna Peyyala
Pure, Al doped and (Co, Al) co-doped ZnO nanopowders have been synthesized through chemical co precipitation method at Room temperature, using poly ethylene glycol (PEG) as stabilizing agent. The synthesized samples are characterized by X-ray Diffraction (XRD), Scanning electron microscopy (SEM) & Energy-Dispersive X-ray spectroscopy (EDS), Transmission electron microscopy (TEM), High resolution TEM, SAED and Vibrating sample magnetometer (VSM). XRD results reveals that all the samples possess hexagonal wurtzite crystal structure with no secondary phases. SEM analysis demonstrated the morphology of the Pure, Al doped and (Co, Al) co-doped ZnO nanoparticles while EDS spectrum shows the incorporation of dopant elements. TEM illustrations reveal the exact size of the crystallites, which is approximately confirmed by the XRD data. HRTEM images of the Pure and Al doped ZnO nanoparticles shows clear lattice fringes about 5 nm and co-doped images reveal lattice fringes are about 2 nm. In determining the magnetic properties, VSM technique has been used and VSM analysis of (Co, Al) co-doped samples reveal Super paramagnetic or weak ferro magnetic nature at Room temperature.
{"title":"Synthesis And Characterization of Al Doped And (Co, Al) co-doped ZnO Nanoparticles via Chemical co-precipitation Method","authors":"S. Reddy, Swapna Peyyala","doi":"10.26655/AJNANOMAT.2019.1.8","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.1.8","url":null,"abstract":"Pure, Al doped and (Co, Al) co-doped ZnO nanopowders have been synthesized through chemical co precipitation method at Room temperature, using poly ethylene glycol (PEG) as stabilizing agent. The synthesized samples are characterized by X-ray Diffraction (XRD), Scanning electron microscopy (SEM) & Energy-Dispersive X-ray spectroscopy (EDS), Transmission electron microscopy (TEM), High resolution TEM, SAED and Vibrating sample magnetometer (VSM). XRD results reveals that all the samples possess hexagonal wurtzite crystal structure with no secondary phases. SEM analysis demonstrated the morphology of the Pure, Al doped and (Co, Al) co-doped ZnO nanoparticles while EDS spectrum shows the incorporation of dopant elements. TEM illustrations reveal the exact size of the crystallites, which is approximately confirmed by the XRD data. HRTEM images of the Pure and Al doped ZnO nanoparticles shows clear lattice fringes about 5 nm and co-doped images reveal lattice fringes are about 2 nm. In determining the magnetic properties, VSM technique has been used and VSM analysis of (Co, Al) co-doped samples reveal Super paramagnetic or weak ferro magnetic nature at Room temperature.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78656946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.26655/AJNANOMAT.2019.1.4
Fatemeh Houshmand, Hamide Neckoudaria, M. Baghdadi
The present study is an attempt to provide an insight into the stability, in terms of interaction energy and thermodynamic parameter, and reactivity, quantified by reactivity descriptors, of the chitosan-MX and its analogous (EMX and ZMX) system. In this system a component is, MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) a mutagenic halogenated disinfection by products which present in drinking water. And, chitosan is an eco-friendly nano-adsorbent to remove oils, grease, heavy metals and the fine particulate matter from water solution. Electronic and structural properties of chitosan during functionalization by metal were studied by density functional theory (DFT) calculations. Isolated and functionalized chitosan were optimized and their properties were evaluated. The results indicated that the properties of linking sites detect the most significant effects of functionalization process. Degradation efficiency of MX and its analogous in water solvent and also the possibility of absorption of MX by chitosan nanoparticles in aqueous solution were studied via different level of theory.
{"title":"Host-guest interaction in chitosan– MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) complexes in water solution: Density Functional Study","authors":"Fatemeh Houshmand, Hamide Neckoudaria, M. Baghdadi","doi":"10.26655/AJNANOMAT.2019.1.4","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.1.4","url":null,"abstract":"The present study is an attempt to provide an insight into the stability, in terms of interaction energy and thermodynamic parameter, and reactivity, quantified by reactivity descriptors, of the chitosan-MX and its analogous (EMX and ZMX) system. In this system a component is, MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) a mutagenic halogenated disinfection by products which present in drinking water. And, chitosan is an eco-friendly nano-adsorbent to remove oils, grease, heavy metals and the fine particulate matter from water solution. Electronic and structural properties of chitosan during functionalization by metal were studied by density functional theory (DFT) calculations. Isolated and functionalized chitosan were optimized and their properties were evaluated. The results indicated that the properties of linking sites detect the most significant effects of functionalization process. Degradation efficiency of MX and its analogous in water solvent and also the possibility of absorption of MX by chitosan nanoparticles in aqueous solution were studied via different level of theory.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85437150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.26655/AJNANOMAT.2019.1.5
Somayeh Deljoo, Navid Rabiee, M. Rabiee
Extensive studies on curcumin has improved that it has certain therapeutic role for different kinds of diseases such as cancer. Regardless of its positive features, its application is hampered by its low water solubility, bioavailability, and low cellular uptake. During last year’s several ways have been developed to protect curcumin from degradation and increase its capability to targeting unhealthy cells. The progress in nanotechnology encouraged nanotechnologists to formulate nanoparticles encapsulating curcumin, such as polymer nanoparticles, solid nanoparticles, liposome/lipid nanoparticles, micelles, dendrimers, polymer conjugates, etc. to enhance sustained release of curcumin at target cells and to improve curcumin bioavailability. Nowadays newer formulations of nanoparticles as called Hybrid nanoparticles are designed in order to efficient and specific targeting of curcumin that result in improved therapeutic efficacy of curcumin with high biocompatibility with the aid of aptamers, folic acid, chitosan coated halloysite loaded with curcumin-Au hybrid nanoparticle and so on. This review describes a number of hybrid nanoparticles formulated and their efficacy in specific targeting to cancerous cells.
{"title":"Curcumin-hybrid Nanoparticles in Drug Delivery System (Review)","authors":"Somayeh Deljoo, Navid Rabiee, M. Rabiee","doi":"10.26655/AJNANOMAT.2019.1.5","DOIUrl":"https://doi.org/10.26655/AJNANOMAT.2019.1.5","url":null,"abstract":"Extensive studies on curcumin has improved that it has certain therapeutic role for different kinds of diseases such as cancer. Regardless of its positive features, its application is hampered by its low water solubility, bioavailability, and low cellular uptake. During last year’s several ways have been developed to protect curcumin from degradation and increase its capability to targeting unhealthy cells. The progress in nanotechnology encouraged nanotechnologists to formulate nanoparticles encapsulating curcumin, such as polymer nanoparticles, solid nanoparticles, liposome/lipid nanoparticles, micelles, dendrimers, polymer conjugates, etc. to enhance sustained release of curcumin at target cells and to improve curcumin bioavailability. Nowadays newer formulations of nanoparticles as called Hybrid nanoparticles are designed in order to efficient and specific targeting of curcumin that result in improved therapeutic efficacy of curcumin with high biocompatibility with the aid of aptamers, folic acid, chitosan coated halloysite loaded with curcumin-Au hybrid nanoparticle and so on. This review describes a number of hybrid nanoparticles formulated and their efficacy in specific targeting to cancerous cells.","PeriodicalId":8523,"journal":{"name":"Asian Journal of Nanoscience and Materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76416214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.26655/AJNANOMAT.2019.1.3
Soghra Fathalipour, Mahdiye Ghanbarizadeh
In this research,Ag NPs were loaded on cysteine modified poly(acrylic acid) (PAA) hydrogel. Obtainedcysteine-hydrogel (Chydrogel) having different functional groups could stabilize Ag NPs better than un-modified hydrogel due to the presence of disulfid bondings. First, obtained PAA hydrogel from radical polymerization was conjugated with cysteine-hydrochloride (Cys) through amidation reaction and then was used as a substrate and stabilization reagent for Ag ions. Ag ions were reduced on Chydrogel in the presence ofNaBH4 as reducing reagent. The resultant nanocomposite was well characterized by using UV–vis, FT-IR, XRD and SEM techniques. Furthermore, the resultant Ag NPs on the surface of Chydrogel showedhigh antibacterial behavior against Gram-negative E. coliand Gram-positive S. aureusdue to the high reaction of thiol-functions with the outer cell surface.
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