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In Silico Functional Analysis of Variants in Genes Associated with Sudden Cardiac Death in Cases of the National Institute of Legal Medicine of Colombia 哥伦比亚国家法律医学研究所病例中与心源性猝死相关基因变异的计算机功能分析
Pub Date : 2023-01-01 DOI: 10.20431/2456-0049.0701001
Joseph Alape Ariza, Andrea Pinzon Reyes, Arbey Hernan Medina Rocha, Rodrigo Cabrera Perez, Clara Isabel Bermudez Santana
: Diseases of cardiovascular origin such as cardiomiopathies and channelopathíes are the main causes of sudden cardiac death and in some cases are difficult to diagnose during autoposy. We present an in silico analysis using bioinformatic tools, for the analysis of possibly pathogenic variants in genes associated with sudden cardiac death. Algorithms were used to predict pathogenicity, predicting the impact of SNPs on proteins, genomic specificity andprotein-protein interaction. We found that variants in the KCNH2, ANK3, TTN, CAV3 and DSP genes cause structural alterations, molecular, cellular and interstitial changes in the heart that can trigger sudden death.
心血管疾病,如心脏病和channelopathíes是心源性猝死的主要原因,在某些情况下很难在尸检中诊断。我们提出了一项使用生物信息学工具的计算机分析,用于分析与心源性猝死相关的基因中可能的致病变异。算法用于预测致病性,预测snp对蛋白质、基因组特异性和蛋白质-蛋白质相互作用的影响。我们发现KCNH2、ANK3、TTN、CAV3和DSP基因的变异会导致心脏的结构改变、分子、细胞和间质改变,从而引发猝死。
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引用次数: 0
Forensic Science in Ayurveda 阿育吠陀的法医学
Pub Date : 2023-01-01 DOI: 10.20431/2456-0049.0701003
Dr. Maheshkumar N. Chaudhari, Dr. Janhavi Mahesh kumar Chaudhari
: Ayurveda is a complete science. It is a Upveda of Atharvaveda & not deprived from forensic science. Forensic Science is the integral part of Ayurveda, Maharishi Charak wrote Charak Samhita, which is world first novel of medicine. Acharya Charak distributed whole medical science in different 8 sthanas (sections). He completely dedicated one section on forensic science by the name of Indriya Sthan. This sthan (section) contains total twelve (12) chapters & all chapters are well elaborated by forensic science regarding the prognosis of the patients & the diseases, where Acharya Sushruta, in his scripture Sushruta Samhita, not separately dedicated whole section for forensic science, but he didn’t missed it. Acharya sushruta illucidated part of forensic Science in his Sutra Sthan chapter 29, 30, 31&32. As Sushruta samhita mainly deals with surgical techniques. So Acharya Sushruta not spended complete one section for Indriya sthan (Forensic Science in Ayurveda). But the treatment of various poisons, symptoms of poisoner & investigations techniques & its defection methodsare well elaborated in his Kalpasthan. In Ayurveda
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引用次数: 0
Is it Possible to Determine the Length of the Human Body by the Parameters of the Mandible? 能否通过下颌骨的参数来确定人体的长度?
Pub Date : 2023-01-01 DOI: 10.20431/2456-0049.0701002
Joseph Alape Ariza, Andrea Pinzon Reyes, Arbey Hernan Medina Rocha, Rodrigo Cabrera Perez, Clara Isabel Bermudez Santana
: This study was conducted to investigate the possibility of determining the length of the human body by the size of the mandible. The material of the study was craniological series of Azerbaijanis in number of 50 male mandibles from the museum collection. On each mandible 13 metric features were studied, and the body length of the individual (whose skull was studied) was known. The database of mandible metrics and body length was subjected to statistical analysis. The results of the correlation analysis showed that 6 mandible parameters had an acceptable relationship with body length in the context of regression analysis (r value>0.4). Using these dimensions and applying mathematical modeling it was possible to construct 1 equation of multiple linear regressions for reconstruction of human body length by mandible parameters. This equation can be used only as an additional research method.
本研究是为了探讨通过下颌骨的大小来确定人体长度的可能性。该研究的材料是博物馆收藏的50个阿塞拜疆男性下颌骨的颅骨系列。在每个下颌骨上研究了13个度量特征,并且知道了个体的体长(研究了其头骨)。对下颌骨指标和体长数据库进行统计分析。相关分析结果显示,6个下颌骨参数与体长的关系在回归分析中均可接受(r值>0.4)。利用这些维度并应用数学模型,可以构建1个多元线性回归方程,用于下颌骨参数重建人体长度。这个方程只能作为一种附加的研究方法。
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引用次数: 0
Industrial Pollution 工业污染
Pub Date : 2020-01-01 DOI: 10.20431/2456-0049.0501004
K. Pulipati
Nature is so kind and gracious to the inhabitants of this beautiful planet Earth and its intelligent monitoring renders this planet ecologically well balanced making the life on this planet happy and comfortable. The one who exploits the resources of this planet to its fullest extent is the human his incessant search and research for alternatives to derive more comforts, benefits and facilities lead to the ecological imbalance in the nature.
大自然对这个美丽星球上的居民是如此仁慈和亲切,它的智能监控使这个星球生态平衡良好,使这个星球上的生活快乐和舒适。最大限度地利用这个星球资源的人是人类,他不断地寻找和研究替代品,以获得更多的舒适,利益和设施,导致自然界的生态失衡。
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引用次数: 0
Age Estimation by Ossification at Elbow Joints – A Cross Sectional Study 肘关节骨化的年龄估计-一项横断面研究
Pub Date : 2019-01-01 DOI: 10.20431/2456-0049.0402002
Vijay Kumar
The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed as an ossification center, enlarge and arrange them in rows.1 The study was carried out involving 100 school students of age group 14 to 16 years at residential school nearest to the Dept of Forensic Medicine, Adichunchanagiri Institute of Medical Sciences. In 14 years boys, conjoint epiphysis was in Stage 4 union in 4 subjects and Stage 5 union in 20 subjects. In 15 years boys, conjoint epiphysis was in Stage 4 union in 3 subjects and Stage 5 union in 22 subjects. In 14 years boys, medial epicondyle was in Stage 3 union in 21 subjects and Stage 5 union in 4 subjects. In 15 years boys, medial epicondyle was in Stage 3 union in 14 subjects and Stage 5 union in 9 subjects. In 14 years boys, proximal end of radius was in Stage 3 union in 14 subjects and Stage 5 union in 10 subjects. In 15 years boys, proximal end of radius was in Stage 3 union in 13 subjects and Stage 5 union in 8 subjects. In 14 years boys, proximal end of ulna was in Stage 3 union in 12 subjects and Stage 5 union in 10 subjects. In 15 years boys, proximal end of ulna was in Stage 3 union in 6 subjects and Stage 5 union in 9 subjects.
软骨骨化的第一步是软骨细胞,在骨化开始的地方,也就是骨化中心,扩大并排列成行这项研究是在离Adichunchanagiri医学科学研究所法医学系最近的寄宿学校的100名14至16岁的学生中进行的。在14岁的男孩中,4名患者的关节骨骺处于4期愈合,20名患者处于5期愈合。在15岁的男孩中,3名患者的关节骨骺处于4期愈合,22名患者处于5期愈合。在14岁的男孩中,21例内上髁处于3期愈合,4例处于5期愈合。在15岁的男孩中,14例内上髁处于3期愈合,9例处于5期愈合。在14岁的男孩中,14例桡骨近端处于3期愈合,10例处于5期愈合。在15岁的男孩中,13例桡骨近端处于3期愈合,8例处于5期愈合。在14岁的男孩中,尺骨近端有12例处于3期愈合,10例处于5期愈合。15岁男孩中,尺骨近端3期愈合6例,5期愈合9例。
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引用次数: 0
Toxic Effects of Sexual Drug Overdose: Sildenafil (Viagra) 性药物过量的毒性作用:西地那非(伟哥)
Pub Date : 2019-01-01 DOI: 10.20431/2456-0049.0401003
Rohit Verma, M. S. Sankhla, R. Kumar
Sildenafil is the sexual drug. Sildenafil is a new oral drug specially aimed at the cure of erectile dysfunction [1]. Sildenafil citrate is a discerning inhibitor of phosphodiesterase 5 (PDE5) and stayed the initial agent through this way of act for the cure of man erectile dysfunction [2]. Male erectile dysfunction (ED) is the determined or recurring incapability to reach, or to uphold till end of the sexual action, a suitable erection [3]. Sildenafil (Viagra) conventional Food and Drug Administration approval in March 1998 such as the earliest oral agent for erectile dysfunction [4]. Sildenafil workings such as a modest inhibitor of an enzyme of the phosphodiesterase type five class (PDE-5). Here are eleven forms of phosphodiesterase found over the body [5, 6]. Sildenafil is a weak vasodilator, resultant in lesser, transitory decreases in systolic (10 mmHg) and diastolic (7 mmHg) blood pressure (BP) when directed orally; no clinically important special effects on heart rate (HR) have been stated [7]. Sildenafil is quickly engrossed, by maximum plasma concentrations happening in one hour after oral admin then a mean fatal half-life of three to five hours [5]. Since the approval of sildenafil, several information of unexpected death amid patients preserved by this drug have upraised about worries concerning its care in patients with coronary artery disease [8].
西地那非是一种性药。西地那非是一种专门用于治疗勃起功能障碍的新型口服药物[1]。柠檬酸西地那非是一种特异性磷酸二酯酶5 (PDE5)抑制剂,通过这种作用方式一直是治疗男性勃起功能障碍的初始药物[2]。男性勃起功能障碍(ED)是指确定的或反复出现的无法达到或维持到性行为结束的适当勃起[3]。西地那非(伟哥)常规于1998年3月获fda批准等最早用于治疗勃起功能障碍的口服药物[4]。西地那非的作用是一种磷酸二酯酶5类(PDE-5)的适度抑制剂。以下是在人体中发现的11种磷酸二酯酶[5,6]。西地那非是一种弱血管扩张剂,口服时可导致较小的短暂性收缩压(10mmhg)和舒张压(7mmhg)血压(BP)下降;对心率(HR)没有临床重要的特殊影响[7]。西地那非被迅速吸收,在口服给药后一小时内出现最大血浆浓度,然后平均致命半衰期为3至5小时[5]。自西地那非获批以来,一些使用该药保存的患者意外死亡的消息引起了人们对冠状动脉疾病患者使用该药的担忧[8]。
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引用次数: 3
Youth Becoming Addict of Cannabis and its Advancement at the Cost of Health 青少年吸食大麻成瘾及其发展以健康为代价
Pub Date : 2019-01-01 DOI: 10.20431/2456-0049.0401002
Himanshu Yadav, M. S. Sankhla, R. Kumar
The cannabis, also called hemp plant has been in existence on earth since eternity and grows well in almost everywhere in this world, but has been known chiefly as a reservoir of fibre for the fabrication of textiles and rope [1]. Cannabis derived term of the plant Cannabis sativa, Cannabis indica and, of venial implification Cannabis ruderalis [2]. Most of the people smoke marijuana in hand-rolled cigarettes called joints; in pipes, water pipes (sometimes called bongs), or in blunts (marijuana rolled in cigar wraps)[3]. The most regularly used illicit drug is Marijuana (22.2 million population has smoked this in past three years) in comformity with the 2015 National Survey on Drug Use and Health [4]. In 12 graders, the rate of use were maximum still: 35.6% had smoked marijuana during the year former to the assess and 2205% used in the past month; 6.0% said they used marijuana everyday or near-daily [5].
大麻,也被称为大麻植物,自古以来就存在于地球上,在世界上几乎任何地方都生长良好,但主要被认为是制造纺织品和绳子的纤维储存库[1]。大麻植物大麻(Cannabis sativa, Cannabis indica)的衍生名词,也可译为大麻(Cannabis ruderalis)[2]。大多数人用手卷的香烟抽大麻,这种香烟被称为“关节”;在烟斗里,在水管里(有时被称为烟斗),或者在blunts里(大麻卷在雪茄包里)[3]。2015年全国药物使用与健康调查显示,最常使用的非法药物是大麻(近三年内有2220万人吸食大麻)[4]。在12年级学生中,使用率最高:35.6%的学生在前一年吸食大麻,2205%的学生在过去一个月吸食大麻;6.0%的人表示每天或几乎每天使用大麻[5]。
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引用次数: 0
A Descriptive Study of Gender Difference in Digit Ratio among Bini Ethnic Group of southern Nigeria 尼日利亚南部比尼族手指比例性别差异的描述性研究
Pub Date : 2019-01-01 DOI: 10.20431/2456-0049.0402004
J. Paul, D. Akinola, C. Obiandu
There are divers works on digit ratio as a subject matter insinuating that it expresses dimorphism in sexes. If this is true, it means that it could serve as a means of identification in forensic and population studies. Digit ratio has also been used to investigate interpopulation affinity stating tribal or population similarity. [2] It has been speculated that sexual differences in 2D:4D are mainly caused by the shift along the common allometric line with non-zero intercept, which means 2D:4D necessarily decreases with increasing finger length, and the fact that men have longer fingers than women (which may be the basis for the sex difference in digit ratios and/or any putative hormonal influence on the ratios [3-5].
以手指比例为题材的作品多种多样,暗示着它表达了两性的二态性。如果这是真的,这意味着它可以作为法医和人口研究中的一种识别手段。数字比率也被用来调查群体间亲和力,说明部落或群体的相似性。[2]据推测,2D:4D的性别差异主要是由于沿非零截距的共同异速生长线的移动引起的,这意味着2D:4D必然随着手指长度的增加而减少,并且男性的手指比女性长(这可能是手指比例的性别差异和/或任何假定的激素对比例的影响的基础[3-5]。
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引用次数: 0
Forensic Identification of Suspected Document on the Basis of their Ink Profiling 基于墨迹分析的可疑文件的法医鉴定
Pub Date : 2019-01-01 DOI: 10.20431/2456-0049.0402001
Suneet Kumar, V. Saran, Rajeev Kumar, M. S. Sankhla, Ramesh Kumar, Pandey
The forensic suspected/questioned document is a very challenging ground. Hardly a day energy by deprived of some document playing a portion in the life of human lives. Questioned documents are verified consistently in forensic science laboratories for their genuineness. Human development has observed script organizations mean while early period also for footage determinations or as a means of communication. The script resources and tools used in the earlier comprised stone, wax, vellum, quills, leaf, wooden materials, etc. [1]. In questioned document cases, one of the current significant features contains the proof of identity and judgement of indicator (permanent and whiteboard) pen inks which are extensively used for numerous requests. These inks are finished up of colorants (i.e., dye or pigment), a solvent or thinners, resins, surfactants, lubricants, emulsifiers, and additives [2]. The most significant query for file specialists is to response whether the liquid ink used is similar or dissimilar in the manufacture of a document. Consequently, the present method delivers valued vision to the forensic expert production with questioned document inspections. It also helps in the connection of unidentified pointer inks to the enduring or whiteboard markers which can thin down the statistics of alleged samples [3].
法医怀疑/质疑文件是一个非常具有挑战性的领域。几乎没有一天的精力被剥夺了一些文件在人类生活中起着重要作用。被质疑的文件的真实性在法医学实验室得到一致的核实。人类发展已观察到剧本组织的同时,早期也用于素材确定或作为一种交流手段。早期使用的文字资源和工具包括石头、蜡、皮纸、羽毛笔、树叶、木质材料等[1]。在被质疑的文件案件中,目前的一个重要特征包括身份证明和判断指示器(永久和白板)钢笔墨水,这被广泛用于许多请求。这些油墨是由着色剂(即染料或颜料)、溶剂或稀释剂、树脂、表面活性剂、润滑剂、乳化剂和添加剂[2]组成的。对于文件专家来说,最重要的查询是响应在制作文件时使用的液体墨水是相似的还是不同的。因此,本方法提供有价值的视觉与质疑文件检查的法医专家生产。它还有助于将未识别的指针墨水连接到持久或白板标记,这可以减少所谓样本的统计[3]。
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引用次数: 0
A Microbial Approach to Forensic Science 法医科学的微生物方法
Pub Date : 2019-01-01 DOI: 10.20431/2456-0049.0402003
Ruddhida R Vidwans, D. Usha
Bacteria’s are the small single cellular primitive organisms on the earth (Rosenberg, E.2017). They are present ubiquitously, including exogenous and endogenous environment of almost all the living organisms existing on the earth. Many of these microbes are known to carry out various functions in the biosystems of the mammals for eg. Maintaining Skin pH (Linares, 2015), endogenous bacteria helps in digestion, metabolism processes, and in Melanogaster drosophila they help in choosing a partner for reproduction (Blum JE, 2013). Apart from the above mentioned functions they also help in degradation of complex organic substances. They are also very useful in the food industry to prepare cakes and breads to wine and alcohol (Breeze, 2018). Infact to be on more interesting part of these organisms that they are even present in extreme climatic conditions, these types of bacteria are known as extremophiles. The bacteria named Prologues fumarii grows in the temp. Of 80-113 deg C (Hafenbradl, 1997). Whereas, the bacteria named Psychrophiles can grow in very cold climatic conditions. Few of them are even noted to grow between the glacier layers (D'Amico et al, 2006).
细菌是地球上的小型单细胞原始生物(Rosenberg, E.2017)。它们无处不在,包括地球上几乎所有生物的外源性和内源性环境。众所周知,这些微生物中的许多在哺乳动物的生物系统中发挥着各种功能,例如:维持皮肤pH值(Linares, 2015),内源性细菌有助于消化、代谢过程,在黑腹果蝇中,它们有助于选择繁殖伴侣(Blum JE, 2013)。除了上述功能外,它们还有助于降解复杂的有机物质。它们在食品工业中也非常有用,可以为葡萄酒和酒精准备蛋糕和面包(Breeze, 2018)。事实上,这些生物中更有趣的部分是它们甚至存在于极端气候条件下,这些类型的细菌被称为极端微生物。被称为富马杆菌的细菌在80-113摄氏度的温度下生长(Hafenbradl, 1997)。然而,被称为嗜冷菌的细菌可以在非常寒冷的气候条件下生长。甚至很少有人注意到它们生长在冰川层之间(D’amico et al, 2006)。
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引用次数: 0
期刊
ARC Journal of Forensic Science
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