Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00028-7
Benn E Smith
{"title":"Cloud interference pattern analysis (IPA) in thoracic paraspinal muscles in motor neuron disease.","authors":"Benn E Smith","doi":"10.1016/s1567-424x(08)00028-7","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00028-7","url":null,"abstract":"","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"281-5"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00028-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29193171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00005-6
R D Henderson, P G Ridall, A N Pettitt, P A McCombe
{"title":"Results of Bayesian statistical analysis in normal and ALS subjects.","authors":"R D Henderson, P G Ridall, A N Pettitt, P A McCombe","doi":"10.1016/s1567-424x(08)00005-6","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00005-6","url":null,"abstract":"","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"57-63"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00005-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00029-9
Jasper R Daube, Julia Traue, William Litchy, Nima Mowzoon, Adil E Bharucha
Trauma to the external anal sphincter resulting in incontinence is a relatively common disorder. Methods to detect damage include pudendal nerve conduction studies and needle EMG. We have applied a quantitative EMG technique using decomposition-enhanced software to isolate motor unit potentials (MUPs) and their surface representation from an anal probe electrode in healthy nulliparous women. MUPs were readily isolated and metric values compared favorably with those recorded with different software.
{"title":"Anal sphincter motor unit potential (MUP) differences between sides, between rest and voluntary contraction, and between MUP analysis programs in normal subjects.","authors":"Jasper R Daube, Julia Traue, William Litchy, Nima Mowzoon, Adil E Bharucha","doi":"10.1016/s1567-424x(08)00029-9","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00029-9","url":null,"abstract":"<p><p>Trauma to the external anal sphincter resulting in incontinence is a relatively common disorder. Methods to detect damage include pudendal nerve conduction studies and needle EMG. We have applied a quantitative EMG technique using decomposition-enhanced software to isolate motor unit potentials (MUPs) and their surface representation from an anal probe electrode in healthy nulliparous women. MUPs were readily isolated and metric values compared favorably with those recorded with different software.</p>","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"287-92"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00029-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29193172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00009-3
Xuan Kong, Zhixiu Han, Shai N Gozani
{"title":"Incremental stimulation MUNE: automation with global path search and alternation pattern recognition.","authors":"Xuan Kong, Zhixiu Han, Shai N Gozani","doi":"10.1016/s1567-424x(08)00009-3","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00009-3","url":null,"abstract":"","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00009-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00015-9
Clifton L Gooch, Seth L Pullman, Dikoma C Shungu, Aziz M Uluğ, Stephen Chane, Paul H Gordon, Ming X Tang, Xiangling Mao, Lewis P Rowland, Hiroshi Mitsumoto
We prospectively studied 64 patients with motor neuron disease (amyotrophic lateral sclerosis (ALS), familial ALS (fALS), progressive muscular atrophy (PMA) and primary lateral sclerosis (PLS)) using multiple point stimulation motor unit number estimation (MUNE), transcranial magnetic stimulation (TMS), proton magnetic resonance spectroscopic imaging (1H MRSI), diffusion tensor imaging (MRDTI), and clinical measures at baseline and every 3 months thereafter for 15 months. Substantial differences in MUNE were noted among the motor neuron disease subgroups (P = 0.0005) and mean values for each motor neuron disease subgroup were significantly lower vs. controls (ALS = 76, fALS = 80, PMA = 29, and PLS = 174) vs. the normal control average (267). MUNE correlated well with % FVC (r = 0.32; P = 0.01), manual muscle testing (r = 0.52; P < 0.0005), grip strength (r = 0.34; P = 0.007), and pinch strength (r = 0.49; P < 0.0005). Overall, MUNE showed the greatest significant change over time of any measure, clinical or otherwise, tested in this study (-2.35 linear trend % change per month, mean). MUNE clearly delineates lower motor neuron dysfunction, strongly correlates with important clinical functions (such as strength and respiration) and is a highly sensitive marker of disease progression over time. These features make MUNE an important tool for both the study of the pathophysiology of the motor neuron diseases, as well as an important measure for incorporation into future clinical trials.
{"title":"Motor unit number estimation (MUNE) in diseases of the motor neuron: utility and comparative analysis in a multimodal biomarker study.","authors":"Clifton L Gooch, Seth L Pullman, Dikoma C Shungu, Aziz M Uluğ, Stephen Chane, Paul H Gordon, Ming X Tang, Xiangling Mao, Lewis P Rowland, Hiroshi Mitsumoto","doi":"10.1016/s1567-424x(08)00015-9","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00015-9","url":null,"abstract":"<p><p>We prospectively studied 64 patients with motor neuron disease (amyotrophic lateral sclerosis (ALS), familial ALS (fALS), progressive muscular atrophy (PMA) and primary lateral sclerosis (PLS)) using multiple point stimulation motor unit number estimation (MUNE), transcranial magnetic stimulation (TMS), proton magnetic resonance spectroscopic imaging (1H MRSI), diffusion tensor imaging (MRDTI), and clinical measures at baseline and every 3 months thereafter for 15 months. Substantial differences in MUNE were noted among the motor neuron disease subgroups (P = 0.0005) and mean values for each motor neuron disease subgroup were significantly lower vs. controls (ALS = 76, fALS = 80, PMA = 29, and PLS = 174) vs. the normal control average (267). MUNE correlated well with % FVC (r = 0.32; P = 0.01), manual muscle testing (r = 0.52; P < 0.0005), grip strength (r = 0.34; P = 0.007), and pinch strength (r = 0.49; P < 0.0005). Overall, MUNE showed the greatest significant change over time of any measure, clinical or otherwise, tested in this study (-2.35 linear trend % change per month, mean). MUNE clearly delineates lower motor neuron dysfunction, strongly correlates with important clinical functions (such as strength and respiration) and is a highly sensitive marker of disease progression over time. These features make MUNE an important tool for both the study of the pathophysiology of the motor neuron diseases, as well as an important measure for incorporation into future clinical trials.</p>","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"153-62"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00015-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00001-9
W F Brown
{"title":"Motor unit number estimations (MUNEs): past, present and future.","authors":"W F Brown","doi":"10.1016/s1567-424x(08)00001-9","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00001-9","url":null,"abstract":"","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"3-23"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00001-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P G Ridall, A N Pettitt, P A McCombe, R D Henderson
{"title":"Bayesian analysis of the stimulus-response curve.","authors":"P G Ridall, A N Pettitt, P A McCombe, R D Henderson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"47-56"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00017-2
Arun Aggarwal
{"title":"Detection of pre-clinical motor unit loss in familial amyotrophic lateral sclerosis.","authors":"Arun Aggarwal","doi":"10.1016/s1567-424x(08)00017-2","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00017-2","url":null,"abstract":"","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"171-9"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00017-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/s1567-424x(08)00021-4
Jeremy M Shefner
MUNE provides valuable information when applied to animal models of motor neuron disease. It is potentially useful as a supplement to therapeutic trials on the SOD-1 transgenic mouse model and has been able to show increases in the functioning motor units in response to some stem cell transplantation. Even in models that have subtle or imperceptible phenotypes, MUNE can show reductions in motor unit compliment. Thus, it is a valuable addition to the armamentarium of investigative tools when studying models of motor unit loss.
{"title":"Recent MUNE studies in animal models of motor neuron disease.","authors":"Jeremy M Shefner","doi":"10.1016/s1567-424x(08)00021-4","DOIUrl":"https://doi.org/10.1016/s1567-424x(08)00021-4","url":null,"abstract":"<p><p>MUNE provides valuable information when applied to animal models of motor neuron disease. It is potentially useful as a supplement to therapeutic trials on the SOD-1 transgenic mouse model and has been able to show increases in the functioning motor units in response to some stem cell transplantation. Even in models that have subtle or imperceptible phenotypes, MUNE can show reductions in motor unit compliment. Thus, it is a valuable addition to the armamentarium of investigative tools when studying models of motor unit loss.</p>","PeriodicalId":85606,"journal":{"name":"Supplements to Clinical neurophysiology","volume":"60 ","pages":"203-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1567-424x(08)00021-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29191148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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