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Supplements to Clinical neurophysiology最新文献

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1949–1953: President: H.H. Jasper 1949-1953:总统:H.H.贾斯帕
Pub Date : 2010-01-01 DOI: 10.1016/S1567-424X(10)61002-1
M. Nuwer, C. Lücking
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引用次数: 0
1985–1990: President: John E. Desmedt 1985-1990年:总统:约翰·e·德梅德特
Pub Date : 2010-01-01 DOI: 10.1016/S1567-424X(10)61011-2
M. Nuwer, C. Lücking
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引用次数: 0
Wave length and action potentials: history of the International Federation of Clinical Neurophysiology. 波长和动作电位:国际临床神经生理学联合会的历史。
Marc R Nuwer, Carl H Lücking
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引用次数: 0
1977–1981: President: R.G. Naquet 1977-1981:总裁:R.G.纳奎
Pub Date : 2010-01-01 DOI: 10.1016/S1567-424X(10)61009-4
M. Nuwer, C. Lücking
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引用次数: 0
1953–1957: President: W. Grey Walter 1953-1957:总统:w·格雷·沃尔特
Pub Date : 2010-01-01 DOI: 10.1016/S1567-424X(10)61003-3
M. Nuwer, C. Lücking
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引用次数: 0
Motor unit number estimates, quantitative motor unit analysis and clinical outcome measures in amyotrophic lateral sclerosis. 肌萎缩性侧索硬化症的运动单元数估计、定量运动单元分析和临床结果测量。
Pub Date : 2009-01-01 DOI: 10.1016/s1567-424x(08)00018-4
Shaun G Boe, Daniel W Stashuk, Timothy J Doherty
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引用次数: 6
Development and use of the incremental twitch subtraction MUNE method in mice. 小鼠增量抽搐减法MUNE方法的建立与应用。
Pub Date : 2009-01-01 DOI: 10.1016/s1567-424x(08)00022-6
Janka Hegedus, Kelvin E Jones, Tessa Gordon

We have used a technique to estimate the number of functioning motor units (MUNE) innervating a muscle in mice based on twitch tension. The MUNE technique was verified by modeling twitch tensions from isolated ventral root stimulation. Analysis by twitch tensions allowed us to identify motor unit fiber types. The MUNE technique was used to compare normal mice with transgenic superoxide dismutase-1 mutation (G94A) mice to assess the time course of motor unit loss with respect to fiber type. Motor unit loss was found to occur well in advance of behavioral changes and the degree of reinnervation is dependent upon motor unit fiber types.

我们使用了一种基于抽搐张力的技术来估计支配小鼠肌肉的功能运动单元(MUNE)的数量。通过模拟孤立的腹侧根刺激引起的抽搐张力,验证了MUNE技术。通过抽动张力分析,我们可以确定运动单元纤维的类型。采用MUNE技术比较正常小鼠和转基因超氧化物歧化酶-1突变(G94A)小鼠,以评估不同纤维类型运动单元损失的时间过程。我们发现运动单元的丧失在行为改变之前就会发生,神经再支配的程度取决于运动单元纤维的类型。
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引用次数: 10
Issues and expectations for EMG decomposition. 肌电图分解的问题和期望。
Pub Date : 2009-01-01 DOI: 10.1016/s1567-424x(08)00023-8
Kevin C McGill
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引用次数: 0
Decision support for QEMG. QEMG的决策支持。
Pub Date : 2009-01-01 DOI: 10.1016/s1567-424x(08)00025-1
L J Pino, D W Stashuk, S G Boe, T J Doherty

For clinicians to use quantitative electromyography (QEMG) to help determine the presence or absence of neuromuscular disease, they must manually interpret an exhaustive set of motor unit potential (MUP) or interference pattern statistics to formulate a clinically useful muscle characterization. A new method is presented for automatically categorizing a set of quantitative electromyographic (EMG) data as characteristic of data acquired from a muscle affected by a myopathic, normal or neuropathic disease process, based on discovering patterns of MUP feature values. From their numbers of occurrence in a set of training data, representative of each muscle category, discovered patterns of MUP feature values are expressed as conditional probabilities of detecting such MUPs in each category of muscle. The conditional probabilities of each MUP in a set of MUPs acquired from an examined muscle are combined using Bayes' rule to estimate conditional probabilities of the examined muscle being of each category type. Using simulated and clinical data, the ability of a "pattern discovery" based Bayesian (PD-based Bayesian) method to correctly categorize sets of test MUP data was compared to conventional methods which use data means and outliers. The simulated data were created by modeling the effects of myopathic and neuropathic diseases using a physiologically based EMG signal simulator. The clinical data was from controls and patients with known neuropathic disorders. PD-based Bayesian muscle characterization had an accuracy of 84.4% compared to 51.9% for the means and outlier based method when using all MUP features considered. PD-based Bayesian methods can accurately characterize a muscle. PD-based Bayesian muscle characterization automatically maximizes both sensitivity and specificity and provides transparent rationalizations for its characterizations. This leads to the expectation that clinicians using PD-based Bayesian muscle characterization will be provided with improved decision support compared to that provided by the status quo means and outlier based methods.

对于临床医生来说,使用定量肌电图(QEMG)来帮助确定神经肌肉疾病的存在与否,他们必须手动解释一套详尽的运动单位电位(MUP)或干扰模式统计数据,以制定临床有用的肌肉特征。提出了一种基于发现MUP特征值模式的新方法,用于自动分类一组定量肌电图(EMG)数据,作为从受肌病、正常或神经性疾病过程影响的肌肉获得的数据的特征。从它们在一组训练数据中的出现次数,代表每个肌肉类别,MUP特征值的发现模式被表示为在每个肌肉类别中检测到此类MUP的条件概率。使用贝叶斯规则组合从被检查肌肉中获得的一组MUP中的每个MUP的条件概率,以估计被检查肌肉的每个类别类型的条件概率。利用模拟和临床数据,将基于“模式发现”的贝叶斯(PD-based Bayesian)方法与使用数据均值和离群值的传统方法进行了比较,以正确分类测试MUP数据集。模拟数据是通过使用基于生理学的肌电图信号模拟器模拟肌病和神经性疾病的影响而产生的。临床数据来自对照组和已知神经性疾病的患者。当考虑所有MUP特征时,基于pd的贝叶斯肌肉表征的准确率为84.4%,而基于均值和离群值的方法的准确率为51.9%。基于pd的贝叶斯方法可以准确表征肌肉。基于pd的贝叶斯肌肉表征自动最大化灵敏度和特异性,并为其表征提供透明的合理化。这使得人们期望使用基于pd的贝叶斯肌肉表征的临床医生与使用现状手段和基于离群值的方法相比,能够提供更好的决策支持。
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引用次数: 1
The CMAP scan. CMAP扫描。
Pub Date : 2009-01-01 DOI: 10.1016/s1567-424x(08)00006-8
Gerhard H Visser, Joleen H Blok
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引用次数: 21
期刊
Supplements to Clinical neurophysiology
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