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Association of intensive care unit occupancy during admission and inpatient mortality: a retrospective cohort study. 入院期间重症监护室占用率与住院病人死亡率的关系:一项回顾性队列研究。
Pub Date : 2020-02-01 Epub Date: 2019-09-16 DOI: 10.1007/s12630-019-01476-8
Nicholas A Fergusson, Steve Ahkioon, Mahesh Nagarajan, Eric Park, Yichuan Ding, Najib Ayas, Vinay K Dhingra, Dean R Chittock, Donald E G Griesdale

Purpose: There is conflicting evidence regarding the influence of intensive care unit (ICU) occupancy at the time of admission on important patient outcomes such as mortality. The objective of this analysis was to characterize the association between ICU occupancy at the time of ICU admission and subsequent mortality.

Methods: This single-centre, retrospective cohort study included all patients admitted to the ICU at the Vancouver General Hospital between 4 January 2010 and 8 October 2017. Intensive care unit occupancy was defined as the number of ICU bed hours utilized in a day divided by the total amount of ICU bed hours available for that day. We constructed mixed-effects logistic regression models controlling for relevant covariates to assess the impact of admission occupancy quintiles on total inpatient (ICU and ward) and early (72-hr) ICU mortality.

Results: This analysis included 10,365 ICU admissions by 8,562 unique patients. Compared with ICU admissions in the median occupancy quintile, admissions in the highest and second highest occupancy quintile were associated with a significant increase in the odds of inpatient mortality (highest: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.12 to 1.59; P value < 0.001; second highest: OR, 1.21; 95% CI, 1.02 to 1.44; P value < 0.03). No association between admission occupancy and 72-hr ICU mortality was observed.

Conclusions: Admission to the ICU on days of high occupancy was associated with increased inpatient mortality, but not with increased 72-hr ICU mortality. Capacity strain on the ICU may result in significant negative consequences for patients, but further research is needed to fully characterize the complex effects of capacity strain.

目的:关于入院时重症监护病房(ICU)入住率对死亡率等重要患者预后的影响,目前存在相互矛盾的证据。这项分析的目的是确定重症监护室入院时的入住率与随后死亡率之间的关系:这项单中心回顾性队列研究纳入了 2010 年 1 月 4 日至 2017 年 10 月 8 日期间入住温哥华综合医院重症监护室的所有患者。重症监护病房占用率定义为一天内使用的重症监护病房床位小时数除以当天可用的重症监护病房床位总小时数。我们构建了控制相关协变量的混合效应逻辑回归模型,以评估入院占用率五分位数对住院患者(ICU和病房)总死亡率和ICU早期(72小时)死亡率的影响:该分析包括 8,562 名患者入住的 10,365 次 ICU。与入住率五分位数中位数的 ICU 相比,入住率五分位数最高和第二高的 ICU 与住院病人死亡几率的显著增加有关(最高:几率比 [OR],1.33;95% 置信区间 [CI],1.12 至 1.59;P 值 <0.001;第二高:几率比 [OR],1.21;95% 置信区间 [CI],1.12 至 1.59;P 值 <0.001;P 值 <0.001):OR,1.21;95% 置信区间 [CI],1.02 至 1.44;P 值 < 0.03)。入院时间与重症监护室72小时死亡率之间没有关联:结论:入住率高的重症监护病房与住院患者死亡率增加有关,但与重症监护病房 72 小时死亡率增加无关。重症监护室的容量紧张可能会给患者带来严重的负面影响,但要全面了解容量紧张的复杂影响还需要进一步的研究。
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引用次数: 13
A new urticarial rash, diarrhoea and refractory hypotension in a man with a history of migraines. 一名有偏头痛病史的男子新发荨麻疹、腹泻和难治性低血压。
IF 4.4 Pub Date : 2016-10-01 DOI: 10.7861/clinmedicine.16-5-451
Lucy Lamb, David Lowe

We present the case of a man with a history of migraines treated with propanolol, referred with a rash, diarrhoea, vomiting and hypotension. Our case highlights how prior beta-blocker use may prolong anaphylaxis and cause refractory hypotension.

我们介绍了一例男性病例,他有偏头痛病史,曾接受过普萘洛尔治疗,转诊时出现皮疹、腹泻、呕吐和低血压。我们的病例强调了之前使用过β-受体阻滞剂可能会延长过敏性休克的时间并导致难治性低血压。
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引用次数: 0
Industry structure, competitive rivalry, and firm profitability 产业结构、竞争对手与企业盈利能力
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90027-5
Masoud Hemmasi, Lee A. Graf, Calvin E. Kellogg
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引用次数: 10
Corporate governance: A stakeholder interpretation 公司治理:利益相关者的解释
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90022-Y
R. Edward Freeman, William M. Evan
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引用次数: 927
Stakeholder management and corporate performance 利益相关者管理与公司绩效
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90023-Z
Lee E. Preston, Harry J. Sapienza
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引用次数: 387
Investors' risk tolerance and return aspirations, and financial advisors' interpretations: A conceptual model and exploratory data 投资者的风险承受能力、回报期望与财务顾问的解释:一个概念模型和探索性数据
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90024-2
Glenn E. Snelbecker, Michael J. Roszkowski, Neal E. Cutler
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引用次数: 56
Transaction costs, behavior modes, and Chinese reform 交易成本、行为模式与中国改革
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90026-4
T.Y. Shen
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引用次数: 3
Ethical investments: Preferences and morality 伦理投资:偏好与道德
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90025-3
Alan Lewis, John Cullis
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引用次数: 27
Indexes volume 19 (1990) 索引第19卷(1990年)
Pub Date : 1990-12-01 DOI: 10.1016/0090-5720(90)90028-6
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引用次数: 0
Organizational theory and the problem of the shift in the Phillips Curve 组织理论与菲利普斯曲线移位问题
Pub Date : 1990-09-01 DOI: 10.1016/0090-5720(90)90032-3
Jerald Hage
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引用次数: 0
期刊
The Journal of behavioral economics
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