Pub Date : 2013-09-01DOI: 10.1177/1754045313495634
{"title":"Free communication and poster presentations from the British Menopause Society 23rd Annual Conference","authors":"","doi":"10.1177/1754045313495634","DOIUrl":"https://doi.org/10.1177/1754045313495634","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"19 1","pages":"107 - 114"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313495634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65472585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-09-01DOI: 10.1177/1754045313504700
P. Shervington
{"title":"Women’s Health Concern: First year as the patient arm of the British Menopause Society","authors":"P. Shervington","doi":"10.1177/1754045313504700","DOIUrl":"https://doi.org/10.1177/1754045313504700","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"19 1","pages":"103 - 103"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313504700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65472723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-09-01DOI: 10.1177/1754045313504342
S. Moger
{"title":"Dr Jean Coope (1928–2013)","authors":"S. Moger","doi":"10.1177/1754045313504342","DOIUrl":"https://doi.org/10.1177/1754045313504342","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"19 1","pages":"137 - 137"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313504342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65472633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-03-01DOI: 10.1177/1754045312473873
E. Hogervorst
In this paper we describe potential reasons for the discrepancies between data from basic sciences and observational studies and those of large treatment studies investigating the association between brain function and sex steroids. Observational studies which often showed positive associations between hormone use and cognition can be affected by ‘recall bias’ and ‘healthy user bias’, while outcomes of treatment studies were hypothesized to be modified by age at treatment, age at or type of menopause, health status, addition of a progestogen or type of estrogen treatment. However, meta-analyses of data from treatment studies negate many of these hypotheses showing at best mainly short-term (up to 6 months) positive effects of estrogen treatment on cognition regardless of age. This positive effect may reverse, particularly in older women with prolonged hormone treatment, which was predominantly seen after addition of progestogen. Medroxyprogesterone acetate seemed to have worse effects on cognition than other types of progestogen in these long-term studies. Estradiol with or without a progestogen was three times more likely to have positive effects on cognition than conjugated equine estrogens. However, two-thirds of studies showed no associations at all which may be an underestimate given the possibility of publication bias. We briefly review alternative treatments, such as testosterone and soy-derived supplements, but currently insufficient data are available for conclusive comments. Women who have undergone surgical menopause or who undergo natural menopause before age 47 may benefit most from hormone treatment and a special case may need to be made for this group. Long-term safety studies for this group are urgently needed.
{"title":"Estrogen and the brain: does estrogen treatment improve cognitive function?","authors":"E. Hogervorst","doi":"10.1177/1754045312473873","DOIUrl":"https://doi.org/10.1177/1754045312473873","url":null,"abstract":"In this paper we describe potential reasons for the discrepancies between data from basic sciences and observational studies and those of large treatment studies investigating the association between brain function and sex steroids. Observational studies which often showed positive associations between hormone use and cognition can be affected by ‘recall bias’ and ‘healthy user bias’, while outcomes of treatment studies were hypothesized to be modified by age at treatment, age at or type of menopause, health status, addition of a progestogen or type of estrogen treatment. However, meta-analyses of data from treatment studies negate many of these hypotheses showing at best mainly short-term (up to 6 months) positive effects of estrogen treatment on cognition regardless of age. This positive effect may reverse, particularly in older women with prolonged hormone treatment, which was predominantly seen after addition of progestogen. Medroxyprogesterone acetate seemed to have worse effects on cognition than other types of progestogen in these long-term studies. Estradiol with or without a progestogen was three times more likely to have positive effects on cognition than conjugated equine estrogens. However, two-thirds of studies showed no associations at all which may be an underestimate given the possibility of publication bias. We briefly review alternative treatments, such as testosterone and soy-derived supplements, but currently insufficient data are available for conclusive comments. Women who have undergone surgical menopause or who undergo natural menopause before age 47 may benefit most from hormone treatment and a special case may need to be made for this group. Long-term safety studies for this group are urgently needed.","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"19 1","pages":"19 - 6"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045312473873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65472351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BMS meeting dates 2010","authors":"","doi":"10.1258/mi.2010.010024","DOIUrl":"https://doi.org/10.1258/mi.2010.010024","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"16 1","pages":"64 - 64"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/mi.2010.010024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66443296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magnesium is a critical physiological ion, and magnesium deficiency might contribute to the development of pre-eclampsia, to impaired neonatal development and to metabolic problems extending into adult life. Pharmacologically, magnesium is a calcium antagonist with substantial vasodilator properties but without myocardial depression. Cardiac output usually increases following magnesium administration, compensating for the vasodilatation and minimising hypotension. Neurologically, the inhibition of calcium channels and antagonism of the N-methylDaspartic acid (NMDA) receptor raises the possibility of neuronal protection, and magnesium administration to women with premature labour may decrease the incidence of cerebral palsy. It is the first-line anticonvulsant for the management of preeclampsia and eclampsia, and it should be administered to all patients with severe pre-eclampsia or eclampsia. Magnesium is a moderate tocolytic but the evidence for its effectiveness remains disputed. The side effects of magnesium therapy are generally mild but the major hazard of magnesium therapy is neuromuscular weakness.
{"title":"Best Practice & Research, Clinical Obstetrics & Gynaecology","authors":"H. Currie","doi":"10.1258/MI.2010.010017","DOIUrl":"https://doi.org/10.1258/MI.2010.010017","url":null,"abstract":"Magnesium is a critical physiological ion, and magnesium deficiency might contribute to the development of pre-eclampsia, to impaired neonatal development and to metabolic problems extending into adult life. Pharmacologically, magnesium is a calcium antagonist with substantial vasodilator properties but without myocardial depression. Cardiac output usually increases following magnesium administration, compensating for the vasodilatation and minimising hypotension. Neurologically, the inhibition of calcium channels and antagonism of the N-methylDaspartic acid (NMDA) receptor raises the possibility of neuronal protection, and magnesium administration to women with premature labour may decrease the incidence of cerebral palsy. It is the first-line anticonvulsant for the management of preeclampsia and eclampsia, and it should be administered to all patients with severe pre-eclampsia or eclampsia. Magnesium is a moderate tocolytic but the evidence for its effectiveness remains disputed. The side effects of magnesium therapy are generally mild but the major hazard of magnesium therapy is neuromuscular weakness.","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"16 1","pages":"94 - 94"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/MI.2010.010017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66443573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of the Menopause, 5th Edition","authors":"J. Ayres","doi":"10.1258/mi.2010.010002","DOIUrl":"https://doi.org/10.1258/mi.2010.010002","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"16 1","pages":"42 - 42"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/mi.2010.010002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66443206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How women stay feminine may be in the hands of a single gene","authors":"S. Brown","doi":"10.1258/mi.2010.010011","DOIUrl":"https://doi.org/10.1258/mi.2010.010011","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"220 1","pages":"2 - 4"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/mi.2010.010011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66442878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Menopause likely to become a truly mid-life event","authors":"S. Brown","doi":"10.1258/mi.2009.009042","DOIUrl":"https://doi.org/10.1258/mi.2009.009042","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"15 1","pages":"142 - 143"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/mi.2009.009042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66443075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"More evidence suggests that the timing of menopause is partly under genetic control","authors":"S. Brown","doi":"10.1258/mi.2009.009032","DOIUrl":"https://doi.org/10.1258/mi.2009.009032","url":null,"abstract":"","PeriodicalId":85745,"journal":{"name":"The journal of the British Menopause Society","volume":"15 1","pages":"96 - 99"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/mi.2009.009032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66442973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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