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Natural Dye of Beetroot 甜菜根天然染料
Pub Date : 2023-09-18 DOI: 10.14500/aro.11286
Tara F. Tahir, Kurdistan F. Aziz, Dashne M. Kokhasmail
In this study, a simple and indirect spectrophotometric method for the quantification of atenolol in pharmaceutical formulations, utilizing a natural food dye extracted from red beet root, is presented. The process involves the oxidation of atenolol in a 1 mol/LHCl acidic medium, using an excess of potassium persulfate. Subsequently, the resulting tablet solution is employed to fade the red beetroot dye, and the solution is measured spectrophotometrically. The optimized reaction conditions consist of a 16 µg/mL atenolol solution, 2.1 mL (100 µg/mL) of potassium persulfate, and 5 mL (100 µg/mL) of red beetroot dye. Spectrophotometric measurements were performed at 535 nm, and the linear range for quantification was found to be 4–22 µg/mL (R2 = 0.9987). The method exhibited a limit of detection of 0.01 µg/mL. Notably, the proposed method was successfully applied to analyze various commercial brands of pharmaceutical formulations; yielding results consistent with those obtained using the pharmacopeia method. This research offers a valuable and accessible technique for atenolol quantification, demonstrating potential significance in pharmaceutical analysis and quality control processes.
在本研究中,提出了一种简单的间接分光光度法,利用从红甜菜根中提取的天然食用染料,定量测定药物制剂中阿替洛尔的含量。该过程包括在1 mol/LHCl酸性介质中使用过量的过硫酸钾氧化阿替洛尔。随后,将得到的片剂溶液用于红甜菜根染料的褪色,并对溶液进行分光光度测定。优化后的反应条件为:阿替洛尔溶液16µg/mL,过硫酸钾2.1 mL(100µg/mL),红甜菜根染料5 mL(100µg/mL)。在535 nm处进行分光光度测定,定量线性范围为4 ~ 22µg/mL (R2 = 0.9987)。方法的检出限为0.01µg/mL。值得注意的是,所提出的方法成功地应用于分析各种商业品牌的药物配方;所得结果与药典方法一致。本研究为阿替洛尔的定量分析提供了一种有价值且易于获得的技术,在药物分析和质量控制过程中具有潜在的意义。
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ARO. The Scientific Journal of Koya University
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