A. A. Wiraguna, L. M. Rusyati, Dewa Ayu Vanessa Vijayamurthy
Introduction: The pathogenesis of PPROM is complex and not fully understood. Recent studies showed that such role of genital tract infection as bacterial vaginosis in the pathogenesis of PPROM turned out to be present. They produce lipase enzymes in which they can form compounds with the fibrous tissue of amniotic membrane resulting in increased risk of rupture of the membrane.Objective This study aims to prove that bacterial vaginosis is a risk factor for preterm premature rupture of membrane.Material and methods: This research used case control method. Sampling was using the consecutive sampling method and had fulfilled inclusion and exclusion criteria with age-based matching, then vaginal swab sampling was conducted, painted with gram staining in the Dermalotogy and Venereology Laboratory of Sanglah Hospital, and Nugent score.Result: Total of 76 pregnant women with 24-36 weeks of gestation were investigated, 38 mothers with PPROM and 38 mothers with normal pregnancy. Average score of Nugent at preterm PROM was 7.18 and in normal pregnancy was 2.37. Bacterial vaginosis risking for PPROM 7 times (OR= 7.0, 95% CI= 1.21-17.68, p= 0.001).Conclusion: Bacterial vaginosis as a risk factor for the occurrence of PPROM.
{"title":"Bacterial vaginosis as a risk factor of preterm premature rupture of membrane (PPROM)","authors":"A. A. Wiraguna, L. M. Rusyati, Dewa Ayu Vanessa Vijayamurthy","doi":"10.15562/BDV.V1I2.13","DOIUrl":"https://doi.org/10.15562/BDV.V1I2.13","url":null,"abstract":"Introduction: The pathogenesis of PPROM is complex and not fully understood. Recent studies showed that such role of genital tract infection as bacterial vaginosis in the pathogenesis of PPROM turned out to be present. They produce lipase enzymes in which they can form compounds with the fibrous tissue of amniotic membrane resulting in increased risk of rupture of the membrane.Objective This study aims to prove that bacterial vaginosis is a risk factor for preterm premature rupture of membrane.Material and methods: This research used case control method. Sampling was using the consecutive sampling method and had fulfilled inclusion and exclusion criteria with age-based matching, then vaginal swab sampling was conducted, painted with gram staining in the Dermalotogy and Venereology Laboratory of Sanglah Hospital, and Nugent score.Result: Total of 76 pregnant women with 24-36 weeks of gestation were investigated, 38 mothers with PPROM and 38 mothers with normal pregnancy. Average score of Nugent at preterm PROM was 7.18 and in normal pregnancy was 2.37. Bacterial vaginosis risking for PPROM 7 times (OR= 7.0, 95% CI= 1.21-17.68, p= 0.001).Conclusion: Bacterial vaginosis as a risk factor for the occurrence of PPROM.","PeriodicalId":8684,"journal":{"name":"Bali Dermatology and Venereology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79186314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% IK 2,765-8,332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.
{"title":"The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris","authors":"G. A. Praharsini, A. A. Wiraguna, Stefani Nurhadi","doi":"10.15562/BDV.V1I2.8","DOIUrl":"https://doi.org/10.15562/BDV.V1I2.8","url":null,"abstract":"Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% IK 2,765-8,332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.","PeriodicalId":8684,"journal":{"name":"Bali Dermatology and Venereology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88152976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Bullous pemphigoid is an autoimmune disorder. The incidence of bullous pemphigoid has increased over time, current understanding regarding treatment and complication is an important issue considering the disease often occur in elderly resulting in high rates of morbidity to the patients. Aim of current case report is to describe the clinical relevance regarding symptom and treatment of bullous pemphigoid.Case presentation: A 65 years old female patient, came with chief complaints of bullae in abdominal region with itching and burning sensation in the ruptured bullae. Over time bullae spread in lower and upper extremity. Patient was admitted for four days with therapy intravenous steroids, oral antihistamine, and potent topical steroids. Patient was discharged from hospital in well condition.Conclusion: Bullous pemphigoid is an inflammatory autoimmune skin disease and usually result in good prognosis with adequate management.Keywords: autoimmune, bullous, pemphigoid, skin, disease.
{"title":"Bullous pemphigoid in 65 years old female: a case report","authors":"I. M. Sanjaya, Putu Artana, Embun Dini Hari","doi":"10.15562/BDV.V1I2.7","DOIUrl":"https://doi.org/10.15562/BDV.V1I2.7","url":null,"abstract":"Introduction: Bullous pemphigoid is an autoimmune disorder. The incidence of bullous pemphigoid has increased over time, current understanding regarding treatment and complication is an important issue considering the disease often occur in elderly resulting in high rates of morbidity to the patients. Aim of current case report is to describe the clinical relevance regarding symptom and treatment of bullous pemphigoid.Case presentation: A 65 years old female patient, came with chief complaints of bullae in abdominal region with itching and burning sensation in the ruptured bullae. Over time bullae spread in lower and upper extremity. Patient was admitted for four days with therapy intravenous steroids, oral antihistamine, and potent topical steroids. Patient was discharged from hospital in well condition.Conclusion: Bullous pemphigoid is an inflammatory autoimmune skin disease and usually result in good prognosis with adequate management.Keywords: autoimmune, bullous, pemphigoid, skin, disease. ","PeriodicalId":8684,"journal":{"name":"Bali Dermatology and Venereology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73559609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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