Pub Date : 2025-01-01Epub Date: 2025-01-15DOI: 10.1055/s-0044-1791661
Hélio A Ghizoni Teive, Léo Coutinho, Francisco E C Cardoso, Shoji Tsuji
The pioneers of neurology in Japan were professors Hiroshi Kawahara and Kinnosuke Miura. Kawahara published the first description of progressive bulbar palsy and wrote the first neurology textbook in Japan. Miura, on the other hand, published studies about amyotrophic lateral sclerosis, in addition to participating in the founding of the Japanese Society of Neurology. The influence of European neurology, particularly French and German, in the figures of Professor Jean-Martin Charcot and Professor Erwin Bälz, was fundamental in the consolidation of neurology in Japan.
{"title":"Neurology pioneers in Japan.","authors":"Hélio A Ghizoni Teive, Léo Coutinho, Francisco E C Cardoso, Shoji Tsuji","doi":"10.1055/s-0044-1791661","DOIUrl":"10.1055/s-0044-1791661","url":null,"abstract":"<p><p>The pioneers of neurology in Japan were professors Hiroshi Kawahara and Kinnosuke Miura. Kawahara published the first description of progressive bulbar palsy and wrote the first neurology textbook in Japan. Miura, on the other hand, published studies about amyotrophic lateral sclerosis, in addition to participating in the founding of the Japanese Society of Neurology. The influence of European neurology, particularly French and German, in the figures of Professor Jean-Martin Charcot and Professor Erwin Bälz, was fundamental in the consolidation of neurology in Japan.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 1","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-02-06DOI: 10.1055/s-0045-1802309
Tathiana Ghisi de Souza
{"title":"Letter to \"Cultural adaptation and reliability assessment of the Hammersmith neonatal neurological examination for Brazilian newborns at risk of cerebral palsy\".","authors":"Tathiana Ghisi de Souza","doi":"10.1055/s-0045-1802309","DOIUrl":"https://doi.org/10.1055/s-0045-1802309","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 1","pages":"1-2"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-09-10DOI: 10.1055/s-0044-1789226
Hélio Afonso Ghizoni Teive, Léo Coutinho, Carlos Henrique Ferreira Camargo
The establishment of Russian neurology in the late 19th century was significantly shaped by the neurology department at La Salpêtrière Hospital under Professor Jean-Martin Charcot's leadership. A group of Russian neurologists, guided by Professor Kozhevnikov and featuring his disciples such as Korsakov, Minor, Darkshevich, and Bekhterev, had the privilege of being mentored by Professor Charcot. Subsequently, they played pivotal roles in founding various neurology services in Russia, greatly influenced by the teachings and insights they acquired under Charcot's tutelage.
{"title":"Charcot's Russian pupils.","authors":"Hélio Afonso Ghizoni Teive, Léo Coutinho, Carlos Henrique Ferreira Camargo","doi":"10.1055/s-0044-1789226","DOIUrl":"10.1055/s-0044-1789226","url":null,"abstract":"<p><p>The establishment of Russian neurology in the late 19th century was significantly shaped by the neurology department at La Salpêtrière Hospital under Professor Jean-Martin Charcot's leadership. A group of Russian neurologists, guided by Professor Kozhevnikov and featuring his disciples such as Korsakov, Minor, Darkshevich, and Bekhterev, had the privilege of being mentored by Professor Charcot. Subsequently, they played pivotal roles in founding various neurology services in Russia, greatly influenced by the teachings and insights they acquired under Charcot's tutelage.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-4"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-03DOI: 10.1055/s-0044-1792091
Emanuelle de Oliveira Francelino, Marzia Puccioni-Sohler
Dengue is the main urban arbovirus in the Americas. The disease manifests in a varied spectrum: from asymptomatic cases to those with neurological involvement, which is considered a severe form of the disease. Its annual reemergence represents a serious public health problem. The rise in the number of cases causes an increase in the number of patients with neurological manifestations of the disease, which can range from headaches to more serious conditions such as encephalitis and Guillain-Barré syndrome, with high potential of death or sequelae. Dengue prevention and control strategies should also be a concern for neurologists. The aim of the present study is to carry out a narrative review of the current methods to prevent dengue fever and its severe forms, such as cases with neurological complications. The main control measures include vaccination, which is still carried out on a small scale, vector control, and individual protection. The CYD-TDV/Dengvaxia and TAK-003/DENVax vaccines, licensed for use by the Brazilian National Health Regulatory Agency (Agência Nacional de Vigilância Sanitária, ANVISA, in Portuguese), show efficacy against hospitalizations of 72.7% (95% confidence interval [95%CI]: 62.3-80.3%) and of 90.4% (95%CI: 82.6-94.7%) respectively. The TV003/TV005 vaccine, which is being studied by Intituto Butantan in Brazil, shows promising results, with an efficacy of 79.6% for symptomatic dengue. Vector control is based on biotechnological and behavioral measures, as well as on the improvement of basic sanitation conditions. The main individual protection measure is the use of topical repellents (icaridin). All of these actions represent important tools for the prevention of dengue fever and its neurological complications.
登革热是美洲主要的城市虫媒病毒。该病表现多样:从无症状病例到神经系统受累,这被认为是该病的严重形式。它每年重新出现是一个严重的公共卫生问题。病例数量的增加导致患有该疾病神经系统症状的患者人数增加,这些症状可能从头痛到脑炎和格林-巴罗综合征等更严重的疾病,死亡或后遗症的可能性很大。登革热的预防和控制策略也应该是神经科医生关注的问题。本研究的目的是对目前预防登革热及其严重形式(如伴有神经系统并发症的病例)的方法进行叙述性审查。主要控制措施包括仍在小规模开展的疫苗接种、病媒控制和个人保护。CYD-TDV/ denvaxia和TAK-003/DENVax疫苗获得巴西国家卫生监管机构(Agência Nacional de vigilica Sanitária,葡萄牙语ANVISA)的使用许可,显示住院率分别为72.7%(95%置信区间[95% ci]: 62.3-80.3%)和90.4% (95% ci: 82.6-94.7%)。巴西Butantan研究所正在研究的TV003/TV005疫苗显示出令人鼓舞的结果,对有症状的登革热的有效率为79.6%。病媒控制以生物技术和行为措施以及改善基本卫生条件为基础。主要的个人防护措施是使用局部驱蚊剂(伊卡苷)。所有这些行动都是预防登革热及其神经系统并发症的重要工具。
{"title":"Dengue and severe dengue with neurological complications: a challenge for prevention and control.","authors":"Emanuelle de Oliveira Francelino, Marzia Puccioni-Sohler","doi":"10.1055/s-0044-1792091","DOIUrl":"10.1055/s-0044-1792091","url":null,"abstract":"<p><p>Dengue is the main urban arbovirus in the Americas. The disease manifests in a varied spectrum: from asymptomatic cases to those with neurological involvement, which is considered a severe form of the disease. Its annual reemergence represents a serious public health problem. The rise in the number of cases causes an increase in the number of patients with neurological manifestations of the disease, which can range from headaches to more serious conditions such as encephalitis and Guillain-Barré syndrome, with high potential of death or sequelae. Dengue prevention and control strategies should also be a concern for neurologists. The aim of the present study is to carry out a narrative review of the current methods to prevent dengue fever and its severe forms, such as cases with neurological complications. The main control measures include vaccination, which is still carried out on a small scale, vector control, and individual protection. The CYD-TDV/Dengvaxia and TAK-003/DENVax vaccines, licensed for use by the Brazilian National Health Regulatory Agency (Agência Nacional de Vigilância Sanitária, ANVISA, in Portuguese), show efficacy against hospitalizations of 72.7% (95% confidence interval [95%CI]: 62.3-80.3%) and of 90.4% (95%CI: 82.6-94.7%) respectively. The TV003/TV005 vaccine, which is being studied by Intituto Butantan in Brazil, shows promising results, with an efficacy of 79.6% for symptomatic dengue. Vector control is based on biotechnological and behavioral measures, as well as on the improvement of basic sanitation conditions. The main individual protection measure is the use of topical repellents (icaridin). All of these actions represent important tools for the prevention of dengue fever and its neurological complications.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-10DOI: 10.1055/s-0044-1792092
Pedro Henrique Sirotheau Corrêa Alves, Fernanda de Oliveira Cirino, Leonardo Peixoto Garcia, João Paulo Moreira Fernandes, Andrea De Martino Luppi, Douglas Eulálio Antunes, Raquel Campos Pereira, Wilson Marques Junior, Isabela Maria Bernardes Goulart, Diogo Fernandes Dos Santos
Background: Carpal tunnel syndrome (CTS) has already been described as a possible form of neural leprosy presentation. However, the median nerve can be involved in this neuropathy in proximal segments and, sometimes, with an asymmetric impairment of the digital branches.
Objective: To detail the pattern of median nerve impairment through nerve conduction study (NCS) and ultrasound evaluation.
Methods: This cross-sectional study comprises 15 primary neural leprosy (PNL) patients and 14 patients with CTS who underwent peripheral nerve ultrasonography and NCS evaluation.
Results: From the total, 92.8% of patients with CTS and 80% with PNL had bilateral impairment of the median nerve, with 27 nerves in each group. Considering the cross-sectional area (CSA) of the tunnel (Mt) segment, 63% of the nerves in the CTS and 74.1% in the PNL groups were found to be thickened, with an average CSA of 13.4 ± 4.4 and 12.4 ± 4.6, respectively (p = 0.18). The CSA of the proximal tunnel (Mpt) segment showed thickening in only 3.7% in the CTS group and 96.3% in the PNL (p < 0.0001), with an average of 6.6 ± 1.3 and 17.0 ± 6.7, respectively (p < 0.001). Finally, 88.9% of the nerves in the PNL group and only 7.4% in the CSA (p < 0.0001) showed a reduction in conduction velocity in the distal forearm, with an average of 41.0 ± 6.3 and 53.2 ± 5.2, respectively (p < 0.0001).
Conclusion: The presence of neural thickening and demyelinating impairment in the segments proximal to the carpal tunnel favors the diagnosis of leprosy.
背景:腕管综合征(CTS)已被描述为神经性麻风病的一种可能表现形式。然而,正中神经可累及近端神经节段,有时指支不对称损伤。目的:通过神经传导研究(NCS)和超声检查,探讨正中神经损伤的表现。方法:对15例原发性神经性麻风(PNL)患者和14例CTS患者进行周围神经超声检查和NCS评价。结果:92.8%的CTS患者双侧正中神经受损,80%的PNL患者双侧正中神经受损,每组27条神经受损。从隧道(Mt)段的横断面积(CSA)来看,CTS组63%的神经增厚,PNL组74.1%的神经增厚,平均CSA分别为13.4±4.4和12.4±4.6 (p = 0.18)。CTS组Mpt节段CSA增厚率仅为3.7%,PNL组为96.3% (p p p p)结论:腕管近段神经增厚及脱髓鞘损伤有利于麻风的诊断。
{"title":"Median nerve impairment in leprosy: how does it differ from the classic carpal tunnel syndrome?","authors":"Pedro Henrique Sirotheau Corrêa Alves, Fernanda de Oliveira Cirino, Leonardo Peixoto Garcia, João Paulo Moreira Fernandes, Andrea De Martino Luppi, Douglas Eulálio Antunes, Raquel Campos Pereira, Wilson Marques Junior, Isabela Maria Bernardes Goulart, Diogo Fernandes Dos Santos","doi":"10.1055/s-0044-1792092","DOIUrl":"10.1055/s-0044-1792092","url":null,"abstract":"<p><strong>Background: </strong> Carpal tunnel syndrome (CTS) has already been described as a possible form of neural leprosy presentation. However, the median nerve can be involved in this neuropathy in proximal segments and, sometimes, with an asymmetric impairment of the digital branches.</p><p><strong>Objective: </strong> To detail the pattern of median nerve impairment through nerve conduction study (NCS) and ultrasound evaluation.</p><p><strong>Methods: </strong> This cross-sectional study comprises 15 primary neural leprosy (PNL) patients and 14 patients with CTS who underwent peripheral nerve ultrasonography and NCS evaluation.</p><p><strong>Results: </strong> From the total, 92.8% of patients with CTS and 80% with PNL had bilateral impairment of the median nerve, with 27 nerves in each group. Considering the cross-sectional area (CSA) of the tunnel (Mt) segment, 63% of the nerves in the CTS and 74.1% in the PNL groups were found to be thickened, with an average CSA of 13.4 ± 4.4 and 12.4 ± 4.6, respectively (<i>p</i> = 0.18). The CSA of the proximal tunnel (Mpt) segment showed thickening in only 3.7% in the CTS group and 96.3% in the PNL (<i>p</i> < 0.0001), with an average of 6.6 ± 1.3 and 17.0 ± 6.7, respectively (<i>p</i> < 0.001). Finally, 88.9% of the nerves in the PNL group and only 7.4% in the CSA (<i>p</i> < 0.0001) showed a reduction in conduction velocity in the distal forearm, with an average of 41.0 ± 6.3 and 53.2 ± 5.2, respectively (<i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong> The presence of neural thickening and demyelinating impairment in the segments proximal to the carpal tunnel favors the diagnosis of leprosy.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-10DOI: 10.1055/s-0044-1793932
George Nilton Nunes Mendes, Alessandra Braga Cruz Guedes de Morais, Laura Catherine Gioia, Grégory Jacquin, Alexandre Y Poppe, Felipe Hideki Soga, João Brainer Clares de Andrade
Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, pregnancy complications, and other nonthrombotic manifestations in the presence of antiphospholipid antibodies. Neurovascular complications, including ischemic stroke, cerebral venous thrombosis and cognitive impairment, pose significant challenges in management.
Objective: To comprehensively review relevant and updated clinical aspects of neurovascular manifestations of APS.
Methods: We conducted a narrative review using the PubMed, EMBASE, and Cochrane Library databases with medical terms related to APS and its neurovascular manifestations. English-language studies, published between January 1, 2015, and March 2024, were included. Key publications outside this timeframe were also considered. Studies with higher levels of evidence, such as randomized controlled trials and meta-analyses, were prioritized for inclusion.
Results: Stroke is a prevalent complication in APS, with arterial thrombosis being a predominant mechanism. Despite recent trials, direct oral anticoagulants (DOACs) have not shown superiority over vitamin K antagonists (VKAs) for secondary prevention in this population. Cerebral venous thrombosis (CVT), although rare, can also occur in APS, and while DOACs have shown promise as a treatment in a general population, caution is warranted due to potential harm. Cognitive impairment affects a considerable proportion of APS patients, with thrombotic and nonthrombotic mechanisms contributing to its pathophysiology. Future research should focus on optimal management strategies for cognitive impairment and the efficacy of anticoagulation and immunosuppression.
Conclusion: Understanding the complex interplay of neurovascular manifestations in APS is essential for guiding clinical decisions and improving patient outcomes. Despite advancements, some challenges remain in establishing effective preventive and treatment measures, highlighting the need for further research in this field.
{"title":"Neurovascular complications of antiphospholipid syndrome: a narrative review.","authors":"George Nilton Nunes Mendes, Alessandra Braga Cruz Guedes de Morais, Laura Catherine Gioia, Grégory Jacquin, Alexandre Y Poppe, Felipe Hideki Soga, João Brainer Clares de Andrade","doi":"10.1055/s-0044-1793932","DOIUrl":"10.1055/s-0044-1793932","url":null,"abstract":"<p><strong>Background: </strong> Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, pregnancy complications, and other nonthrombotic manifestations in the presence of antiphospholipid antibodies. Neurovascular complications, including ischemic stroke, cerebral venous thrombosis and cognitive impairment, pose significant challenges in management.</p><p><strong>Objective: </strong> To comprehensively review relevant and updated clinical aspects of neurovascular manifestations of APS.</p><p><strong>Methods: </strong> We conducted a narrative review using the PubMed, EMBASE, and Cochrane Library databases with medical terms related to APS and its neurovascular manifestations. English-language studies, published between January 1, 2015, and March 2024, were included. Key publications outside this timeframe were also considered. Studies with higher levels of evidence, such as randomized controlled trials and meta-analyses, were prioritized for inclusion.</p><p><strong>Results: </strong> Stroke is a prevalent complication in APS, with arterial thrombosis being a predominant mechanism. Despite recent trials, direct oral anticoagulants (DOACs) have not shown superiority over vitamin K antagonists (VKAs) for secondary prevention in this population. Cerebral venous thrombosis (CVT), although rare, can also occur in APS, and while DOACs have shown promise as a treatment in a general population, caution is warranted due to potential harm. Cognitive impairment affects a considerable proportion of APS patients, with thrombotic and nonthrombotic mechanisms contributing to its pathophysiology. Future research should focus on optimal management strategies for cognitive impairment and the efficacy of anticoagulation and immunosuppression.</p><p><strong>Conclusion: </strong> Understanding the complex interplay of neurovascular manifestations in APS is essential for guiding clinical decisions and improving patient outcomes. Despite advancements, some challenges remain in establishing effective preventive and treatment measures, highlighting the need for further research in this field.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-15DOI: 10.1055/s-0044-1793931
Raquel Garcia Rocco da Silva, Marcelo A Costa Lima, Claudia de Melo Moura, Jorge Luiz Luescher, Ludmila Nascimento Rodrigues Campos, Daniel de Souza E Silva, Márcia Gonçalves Ribeiro
Background: It is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy (DSP), because some genes are involved in specific biological pathways, acting in different ways in the pathogenic process.
Objective: To identify potential associations involving the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and interleukin 4 (IL-4 intron 3 variable number of tandem repeats [I3VNTR]) gene polymorphisms and DSP in the studied sample.
Methods: In total, 70 children and adolescents with type-1 diabetes underwent a nerve conduction studie (NCS) of the sural nerve. Saliva samples were collected for DNA extraction and genotyping of the MTHFR C677T and IL-4 I3VNTR polymorphisms.
Results: The prevalence of DSP was 15.71%. The participants with DSP presented higher mean levels of glycated hemoglobin, triglycerides, total cholesterol, and low-density lipoprotein (LDL) (p > 0.05). The NCS amplitudes were lower in individuals with DSP (p = 0.00). The mean conduction velocity was lower in people with the A1A1 genotype (p = 0.02). Maternal and paternal history of diabetes in great-grandparents were associated with DSP (p = 0.04 and 0.02, respectively). Glycated hemoglobin and impaired Achilles reflex were associated with the MTHFRCC genotype (p = 0.04 and 0.05 respectively) and high-density lipoprotein (HDL) cholesterol was associated with the MTHFRCT genotype (p = 0.05). We found no association between the polymorphisms investigated and DSP.
Conclusion: In the present study, we found no association involving the MTHFR C677T and IL-4 I3VNTR polymorphisms and DSP. However, the study provides other associations and suggests possible implications for these findings.
{"title":"Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics.","authors":"Raquel Garcia Rocco da Silva, Marcelo A Costa Lima, Claudia de Melo Moura, Jorge Luiz Luescher, Ludmila Nascimento Rodrigues Campos, Daniel de Souza E Silva, Márcia Gonçalves Ribeiro","doi":"10.1055/s-0044-1793931","DOIUrl":"10.1055/s-0044-1793931","url":null,"abstract":"<p><strong>Background: </strong> It is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy (DSP), because some genes are involved in specific biological pathways, acting in different ways in the pathogenic process.</p><p><strong>Objective: </strong> To identify potential associations involving the <i>5,10-methylenetetrahydrofolate reductase</i> (<i>MTHFR</i> C677T) and <i>interleukin 4</i> (<i>IL-4</i> intron 3 variable number of tandem repeats [I3VNTR]) gene polymorphisms and DSP in the studied sample.</p><p><strong>Methods: </strong> In total, 70 children and adolescents with type-1 diabetes underwent a nerve conduction studie (NCS) of the sural nerve. Saliva samples were collected for DNA extraction and genotyping of the <i>MTHFR</i> C677T and <i>IL-4</i> I3VNTR polymorphisms.</p><p><strong>Results: </strong> The prevalence of DSP was 15.71%. The participants with DSP presented higher mean levels of glycated hemoglobin, triglycerides, total cholesterol, and low-density lipoprotein (LDL) (<i>p</i> > 0.05). The NCS amplitudes were lower in individuals with DSP (<i>p</i> = 0.00). The mean conduction velocity was lower in people with the <i>A1A1</i> genotype (<i>p</i> = 0.02). Maternal and paternal history of diabetes in great-grandparents were associated with DSP (<i>p</i> = 0.04 and 0.02, respectively). Glycated hemoglobin and impaired Achilles reflex were associated with the <i>MTHFR</i> <i>CC</i> genotype (<i>p</i> = 0.04 and 0.05 respectively) and high-density lipoprotein (HDL) cholesterol was associated with the <i>MTHFR</i> <i>CT</i> genotype (<i>p</i> = 0.05). We found no association between the polymorphisms investigated and DSP.</p><p><strong>Conclusion: </strong> In the present study, we found no association involving the <i>MTHFR</i> C677T and <i>IL-4</i> I3VNTR polymorphisms and DSP. However, the study provides other associations and suggests possible implications for these findings.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2025-01-08DOI: 10.1055/s-0044-1801743
Osvaldo J M Nascimento
{"title":"Neurophysiology combined with sonography as a useful tool in median nerve leprosy diagnosis.","authors":"Osvaldo J M Nascimento","doi":"10.1055/s-0044-1801743","DOIUrl":"10.1055/s-0044-1801743","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-2"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-09-24DOI: 10.1055/s-0044-1790574
Gabriela Rodrigues Tomaz, Maria Eduarda Slhessarenko Fraife Barreto, Rafael Tuzino Leite Neves Maffei, Renato Barradas Rodrigues, Sebastião Boanerges de Araujo Neto, Marianna Pinheiro Moraes de Moraes, José Luiz Pedroso, Orlando Graziani Povoas Barsottini
{"title":"Multiple cerebral cavernomas in linear scleroderma: an unusual association.","authors":"Gabriela Rodrigues Tomaz, Maria Eduarda Slhessarenko Fraife Barreto, Rafael Tuzino Leite Neves Maffei, Renato Barradas Rodrigues, Sebastião Boanerges de Araujo Neto, Marianna Pinheiro Moraes de Moraes, José Luiz Pedroso, Orlando Graziani Povoas Barsottini","doi":"10.1055/s-0044-1790574","DOIUrl":"10.1055/s-0044-1790574","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-2"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-20DOI: 10.1055/s-0044-1792094
Luana Karoline Castro Silva, Cristian Douglas Dantas de Sousa, Ramon Távora Viana, Renata Viana Brígido de Moura Jucá, Johnnatas Mikael Lopes, Christina Danielli Coelho de Morais Faria, Shamyr Sulyvan de Castro, Lidiane Andrea Oliveira Lima
Background: Stroke remains a public health problem, reported as the third cause of disability. Among survivors, the ability to perform usual daily activities may be reduced, requiring rehabilitation.
Objective: To investigate the prevalence of self-reported stroke, the accessibility of healthcare, and the degree and percentage of patients with limitations in usual activities who are unassisted by physiotherapeutic treatment in different regions of the country.
Methods: This cross-sectional study was conducted using data from the 2019 National Health Survey. Participants aged 15 years or older from all five geographic regions of Brazil who reported a diagnosis of stroke were included. The data were analyzed using sample weighting and expressed as estimates along with a 95% confidence interval (CI).
Results: The national prevalence of self-reported stroke in Brazil was 1.9% (95%CI 1.7-2.0), equivalent to 1,975 individuals with diagnosis. Of these, 50.2% reported limitations in their daily activities, and more than half (54.6%) had regular follow-ups with healthcare professionals. However, only 24.6% reported having access to rehabilitation, while 73.4% of individuals with activity limitations received no physiotherapeutic treatment.
Conclusion: The prevalence of' self-reported stroke in the Brazilian population was 1.9%, with more than half experiencing limitations in their activities. While more than half of the stroke patients underwent follow-ups from a health professional, only ¼ of them reported having access to rehabilitation. Government interventions are necessary to ensure effective access to healthcare, including rehabilitation for the Brazilian population.
{"title":"Stroke in Brazil: prevalence, activity limitations, access to healthcare, and physiotherapeutic treatment.","authors":"Luana Karoline Castro Silva, Cristian Douglas Dantas de Sousa, Ramon Távora Viana, Renata Viana Brígido de Moura Jucá, Johnnatas Mikael Lopes, Christina Danielli Coelho de Morais Faria, Shamyr Sulyvan de Castro, Lidiane Andrea Oliveira Lima","doi":"10.1055/s-0044-1792094","DOIUrl":"10.1055/s-0044-1792094","url":null,"abstract":"<p><strong>Background: </strong> Stroke remains a public health problem, reported as the third cause of disability. Among survivors, the ability to perform usual daily activities may be reduced, requiring rehabilitation.</p><p><strong>Objective: </strong> To investigate the prevalence of self-reported stroke, the accessibility of healthcare, and the degree and percentage of patients with limitations in usual activities who are unassisted by physiotherapeutic treatment in different regions of the country.</p><p><strong>Methods: </strong> This cross-sectional study was conducted using data from the 2019 National Health Survey. Participants aged 15 years or older from all five geographic regions of Brazil who reported a diagnosis of stroke were included. The data were analyzed using sample weighting and expressed as estimates along with a 95% confidence interval (CI).</p><p><strong>Results: </strong> The national prevalence of self-reported stroke in Brazil was 1.9% (95%CI 1.7-2.0), equivalent to 1,975 individuals with diagnosis. Of these, 50.2% reported limitations in their daily activities, and more than half (54.6%) had regular follow-ups with healthcare professionals. However, only 24.6% reported having access to rehabilitation, while 73.4% of individuals with activity limitations received no physiotherapeutic treatment.</p><p><strong>Conclusion: </strong> The prevalence of' self-reported stroke in the Brazilian population was 1.9%, with more than half experiencing limitations in their activities. While more than half of the stroke patients underwent follow-ups from a health professional, only ¼ of them reported having access to rehabilitation. Government interventions are necessary to ensure effective access to healthcare, including rehabilitation for the Brazilian population.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}