Pub Date : 2021-01-01DOI: 10.29011/2575-8241.001193
H. H. A. Allah
Despite the good results, however, spinal surgeries for Idiopathic Scoliosis is associated with compromises. Neurologic injury is the most severe complication and is, all things considered, the most dreaded since it can occur at either the intra-or post-operative stage. Additional complications include dural tears and ophthalmologic or fringe neuropathy, which can be caused by persistent positioning. All spine surgeons must be entirely familiar with all likely developments of complications, as well as proper control.
{"title":"Surgical Complications of Idiopathic Scoliosis: Current Perspectives","authors":"H. H. A. Allah","doi":"10.29011/2575-8241.001193","DOIUrl":"https://doi.org/10.29011/2575-8241.001193","url":null,"abstract":"Despite the good results, however, spinal surgeries for Idiopathic Scoliosis is associated with compromises. Neurologic injury is the most severe complication and is, all things considered, the most dreaded since it can occur at either the intra-or post-operative stage. Additional complications include dural tears and ophthalmologic or fringe neuropathy, which can be caused by persistent positioning. All spine surgeons must be entirely familiar with all likely developments of complications, as well as proper control.","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29011/2575-8241.001188
H. Bliddal, A. Overgaard, A. Hartkopp, J. Beier, P. Conaghan, M. Henriksen
Objective: Intra-Articular (IA) injection of polyacrylamide hydrogel (PAAG) is a possible treatment for symptomatic Osteoarthritis (OA) of the knee. This study evaluated the efficacy and safety of a single injection of 6 ml intra-articular PAAG over 26 weeks. Methods: Open-label study in patients with symptomatic and radiographically confirmed knee OA . Primary outcome was change in WOMAC pain after 13 weeks. Secondary outcomes were WOMAC stiffness and function subscales, Patient Global Assessment of disease impact (PGA) and proportion of OMERACT-OARSI responders. Follow-up time points were 4, 13 and 26 weeks. Results: 49 patients (31 females) received PAAG, with 48 patients completing the 13 and 46 the 26 weeks assessments. Mean change in WOMAC pain after 13 weeks was -18.3 points [95% CI-23.4 to -13.3]; P<.0001 and at 26 weeks -20.8 points [95% CI -26.3 to -15.3]; P<0.0001 with similar benefits for WOMAC stiffness, physical function, and PGA. After 13 weeks 64.6% were OMERACT-OARSI responders and this was maintained at 26 weeks.. During the 13 weeks, 18 patients reported 23 adverse events, 13 of which were related to PAAG, none severe. Two serious adverse events, atrial fibrillation and gastrointestinal pain, were assessed as ‘not related’ to PAAG. Conclusions: PAAG can be delivered in a single 6 ml injection and this non-randomized trial in patients with knee OA demon-strated beneficial clinical effects at 13 and 26 weeks. No serious adverse events were seen with PAAG. These encouraging results need to be confirmed in controlled studies.
目的:聚丙烯酰胺水凝胶(PAAG)关节内注射是治疗膝关节症状性骨关节炎(OA)的一种可能方法。本研究评估了单次注射6ml关节内PAAG 26周的疗效和安全性。方法:对有症状和影像学证实的膝关节OA患者进行开放标签研究。主要结局是13周后WOMAC疼痛的改变。次要结局是WOMAC僵硬和功能亚量表、患者疾病影响总体评估(PGA)和OMERACT-OARSI应答者的比例。随访时间分别为4周、13周和26周。结果:49例患者(31名女性)接受了PAAG治疗，其中48例完成了13周评估，46例完成了26周评估。13周后WOMAC疼痛的平均变化为-18.3点[95% CI-23.4至-13.3];P <。0001和26周时-20.8点[95% CI -26.3至-15.3];P<0.0001，在WOMAC刚度、物理功能和PGA方面具有相似的益处。13周后，64.6%的患者对OMERACT-OARSI有反应，这一数据在26周时保持不变。在13周内，18例患者报告了23例不良事件，其中13例与PAAG相关，无严重事件。心房颤动和胃肠道疼痛这两个严重不良事件被评估为与PAAG“无关”。结论:PAAG可以通过单次6ml注射给药，这项针对膝关节OA患者的非随机试验在13周和26周时显示出有益的临床效果。PAAG未见严重不良事件。这些令人鼓舞的结果需要在对照研究中得到证实。
{"title":"Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: A 6 Months Prospective Study","authors":"H. Bliddal, A. Overgaard, A. Hartkopp, J. Beier, P. Conaghan, M. Henriksen","doi":"10.29011/2575-8241.001188","DOIUrl":"https://doi.org/10.29011/2575-8241.001188","url":null,"abstract":"Objective: Intra-Articular (IA) injection of polyacrylamide hydrogel (PAAG) is a possible treatment for symptomatic Osteoarthritis (OA) of the knee. This study evaluated the efficacy and safety of a single injection of 6 ml intra-articular PAAG over 26 weeks. Methods: Open-label study in patients with symptomatic and radiographically confirmed knee OA . Primary outcome was change in WOMAC pain after 13 weeks. Secondary outcomes were WOMAC stiffness and function subscales, Patient Global Assessment of disease impact (PGA) and proportion of OMERACT-OARSI responders. Follow-up time points were 4, 13 and 26 weeks. Results: 49 patients (31 females) received PAAG, with 48 patients completing the 13 and 46 the 26 weeks assessments. Mean change in WOMAC pain after 13 weeks was -18.3 points [95% CI-23.4 to -13.3]; P<.0001 and at 26 weeks -20.8 points [95% CI -26.3 to -15.3]; P<0.0001 with similar benefits for WOMAC stiffness, physical function, and PGA. After 13 weeks 64.6% were OMERACT-OARSI responders and this was maintained at 26 weeks.. During the 13 weeks, 18 patients reported 23 adverse events, 13 of which were related to PAAG, none severe. Two serious adverse events, atrial fibrillation and gastrointestinal pain, were assessed as ‘not related’ to PAAG. Conclusions: PAAG can be delivered in a single 6 ml injection and this non-randomized trial in patients with knee OA demon-strated beneficial clinical effects at 13 and 26 weeks. No serious adverse events were seen with PAAG. These encouraging results need to be confirmed in controlled studies.","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.29011/2575-8241.001180
{"title":"Hook Plate Fixation of Lateral one Third Clavicle Fracture with Coracoclavicular Ligaments Repair","authors":"","doi":"10.29011/2575-8241.001180","DOIUrl":"https://doi.org/10.29011/2575-8241.001180","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.29011/2575-8241.001178
{"title":"Use of Headless Screws for the Treatment of Type IV Capitellum Fractures in Adults","authors":"","doi":"10.29011/2575-8241.001178","DOIUrl":"https://doi.org/10.29011/2575-8241.001178","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.29011/2575-8241.001136
{"title":"Abraham Colles (1773-1843), Physician, Surgeon and Anatomist","authors":"","doi":"10.29011/2575-8241.001136","DOIUrl":"https://doi.org/10.29011/2575-8241.001136","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69467492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.29011/2575-8241.001179
Mohammed El-Sadek, Emad Abd-Elhady
Background: soft tissues balancing and flexion knees deformity were difficulties’ in patients with advanced knee arthritis man aged by Total Knee Arthroplasty (TKA). Objectives: the purpose of our study was the evaluation of clinical and radiological results of patients with advanced primary Osteoarthritis knee with fixed flexion deformity. Patient & Method: prospective study of twenty five knees (twenty one patients unilateral and two patients bilateral) with primary Advanced OA with moderate to severe fixed flexion deformity with varus knee deformity in ten knees (varus range 15-25o). All patients were managed by primary TKA with appropriate soft tissues balancing from June, 2010 to July, 2018 in our university hospital. There were 9 male and 12 female with bilateral knee deformity in two female patients. They were classified into two groups, group I: patients with moderate flexion deformity (MF) with flexion deformity less than 30°, in 14 knees (56%) and group II: patients with severe flexion deformity (SF) with flexion more than 30° in 11 knees ( 44%). Metal augment in 7 knees long stem tibia in 4 cases 100 mm all was sacrificed PCL with posterior stabilized prosthesis. The patient’s clinical and radiological information were evaluated preoperative, Intraoperative and postoperative at a standard period and yearly follow up for two years. Results: We had no intraoperative complications in this study. Soft tissue release surgery and additional bone cuts were performed in group II. The mean age was 59±5.97 (range 48-71), mean flexion contracture deformity was 34±11.63 (range 20-60), mean preoperative ROM was 65±9.34 (range 45-80) and mean postoperative ROM was 99±932 (range 65-110). There was no difference between group I and group II postoperative ROM (112±10.23 and 115±9.2). In group I mean Knee Society Score (KSS) improved from 34 (0 to 71) to 88 (38 to 100) (p < 0.001) and the KSS Functional Score from 43 (0 to 70) to 86 (0 to 100). No knees required manipulations under anaethesia (MUA) and none of the knees had flexion instability. Group II mean Knee Society Score (KSS) improved from 28(0 to 56) to 85 (40 to 100) and the KSS Functional Score from 43 (0 to 70) to 84 (0 to 100). Two knees (8%) required manipulations under anaethesia (MUA) and none of the knees had flexion instability. We had no infection complication and no cases with patellar dislocation or subluxation seen in this study. Conclusion: Preoperative planning of the knees with severe flexion contracture managed by primary TKA with good soft tissues balancing can be performed successfully.
{"title":"Total Knee Arthroplasty in Patients with Fixed Flexion Contracture","authors":"Mohammed El-Sadek, Emad Abd-Elhady","doi":"10.29011/2575-8241.001179","DOIUrl":"https://doi.org/10.29011/2575-8241.001179","url":null,"abstract":"Background: soft tissues balancing and flexion knees deformity were difficulties’ in patients with advanced knee arthritis man aged by Total Knee Arthroplasty (TKA). Objectives: the purpose of our study was the evaluation of clinical and radiological results of patients with advanced primary Osteoarthritis knee with fixed flexion deformity. Patient & Method: prospective study of twenty five knees (twenty one patients unilateral and two patients bilateral) with primary Advanced OA with moderate to severe fixed flexion deformity with varus knee deformity in ten knees (varus range 15-25o). All patients were managed by primary TKA with appropriate soft tissues balancing from June, 2010 to July, 2018 in our university hospital. There were 9 male and 12 female with bilateral knee deformity in two female patients. They were classified into two groups, group I: patients with moderate flexion deformity (MF) with flexion deformity less than 30°, in 14 knees (56%) and group II: patients with severe flexion deformity (SF) with flexion more than 30° in 11 knees ( 44%). Metal augment in 7 knees long stem tibia in 4 cases 100 mm all was sacrificed PCL with posterior stabilized prosthesis. The patient’s clinical and radiological information were evaluated preoperative, Intraoperative and postoperative at a standard period and yearly follow up for two years. Results: We had no intraoperative complications in this study. Soft tissue release surgery and additional bone cuts were performed in group II. The mean age was 59±5.97 (range 48-71), mean flexion contracture deformity was 34±11.63 (range 20-60), mean preoperative ROM was 65±9.34 (range 45-80) and mean postoperative ROM was 99±932 (range 65-110). There was no difference between group I and group II postoperative ROM (112±10.23 and 115±9.2). In group I mean Knee Society Score (KSS) improved from 34 (0 to 71) to 88 (38 to 100) (p < 0.001) and the KSS Functional Score from 43 (0 to 70) to 86 (0 to 100). No knees required manipulations under anaethesia (MUA) and none of the knees had flexion instability. Group II mean Knee Society Score (KSS) improved from 28(0 to 56) to 85 (40 to 100) and the KSS Functional Score from 43 (0 to 70) to 84 (0 to 100). Two knees (8%) required manipulations under anaethesia (MUA) and none of the knees had flexion instability. We had no infection complication and no cases with patellar dislocation or subluxation seen in this study. Conclusion: Preoperative planning of the knees with severe flexion contracture managed by primary TKA with good soft tissues balancing can be performed successfully.","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.29011/2575-8241.001183
{"title":"Is Artificial Intelligence Improving the Quality Of Detection in Orthopaedic Imaging? A Systematic Review","authors":"","doi":"10.29011/2575-8241.001183","DOIUrl":"https://doi.org/10.29011/2575-8241.001183","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Degenerative Disc Disease (DDD) causes a nagging to severe back pain as well as numbing sensation to the extremities leading to loss of overall patients' height and weakness to leg muscles. Degenerative disc disease is often observed in aging patients as well as patients who have suffered from a back injury. Cervical Degenerative Disc Disease (CDDD) is a progressive condition that leads to the degeneration of the intervertebral discs supporting the cervical vertebral column. Anterior Cervical Interbody Fusion (ACIF) has been the longstanding treatment option for severe degenerative disc disease; however, ACIF presents various novel complications, necessitating numerous comparative device studies to reduce the negative effects of spinal fusion. Cervical disc arthroplasty, the recent focus of clinical attention, was one of the alternatives studied to mitigate the complications associated with vertebral fusion but presents its own disadvantages. These complications prompted further investigation and modifications that can be introduced into these devices. We will be discussing the nano-scale interactions between the implant and extracellular matrix play a crucial role in device integration and efficacy, providing an additional approach towards a device's overall success.
{"title":"Nano-Scale Surface Modifications to Advance Current Treatment Options for Cervical Degenerative Disc Disease (CDDD).","authors":"Anne Yau, Ian Sands, Yupeng Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Degenerative Disc Disease (DDD) causes a nagging to severe back pain as well as numbing sensation to the extremities leading to loss of overall patients' height and weakness to leg muscles. Degenerative disc disease is often observed in aging patients as well as patients who have suffered from a back injury. Cervical Degenerative Disc Disease (CDDD) is a progressive condition that leads to the degeneration of the intervertebral discs supporting the cervical vertebral column. Anterior Cervical Interbody Fusion (ACIF) has been the longstanding treatment option for severe degenerative disc disease; however, ACIF presents various novel complications, necessitating numerous comparative device studies to reduce the negative effects of spinal fusion. Cervical disc arthroplasty, the recent focus of clinical attention, was one of the alternatives studied to mitigate the complications associated with vertebral fusion but presents its own disadvantages. These complications prompted further investigation and modifications that can be introduced into these devices. We will be discussing the nano-scale interactions between the implant and extracellular matrix play a crucial role in device integration and efficacy, providing an additional approach towards a device's overall success.</p>","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946151/pdf/nihms-1576403.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25467982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01Epub Date: 2019-01-31DOI: 10.29011/2575-8241.001127
Dan Xi
There have been significant increased publications of preclinical studies and clinical trials of vitamin C (ascorbate) on cancer therapeutics in the past a few years. In this communication reflecting my personal opinions, I will highlight the main points of current research status; discuss impacts of vitamin C on immune cell function and inflammation at tumor microenvironment, and tumor metastasis; and propose stimulating questions and direction for future research in this area.
{"title":"Vitamin C in Cancer Therapeutics and Metastasis.","authors":"Dan Xi","doi":"10.29011/2575-8241.001127","DOIUrl":"10.29011/2575-8241.001127","url":null,"abstract":"<p><p>There have been significant increased publications of preclinical studies and clinical trials of vitamin C (ascorbate) on cancer therapeutics in the past a few years. In this communication reflecting my personal opinions, I will highlight the main points of current research status; discuss impacts of vitamin C on immune cell function and inflammation at tumor microenvironment, and tumor metastasis; and propose stimulating questions and direction for future research in this area.</p>","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553485/pdf/nihms-1009972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40551303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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