Pub Date : 2018-07-01DOI: 10.22631/RR.2018.69997.1047
Leila Mahmoudieh, Z. Zakeri, Y. Shahbakhsh
Hypertrophic osteoarthropathy manifests as digital clubbing, subperiosteal new bone formation in tubular bone and diffuse skin hypertrophy. It could be either primary or secondary. We report a 31-year-old man presenting with digital clubbing and diffuse skin thickening which started at puberty. X-rays showed subperiosteal new bone formation. All examinations for secondary causes were negative.
{"title":"Hypertrophic osteoarthropathy: Case report and literature review","authors":"Leila Mahmoudieh, Z. Zakeri, Y. Shahbakhsh","doi":"10.22631/RR.2018.69997.1047","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1047","url":null,"abstract":"Hypertrophic osteoarthropathy manifests as digital clubbing, subperiosteal new bone formation in tubular bone and diffuse skin hypertrophy. It could be either primary or secondary. We report a 31-year-old man presenting with digital clubbing and diffuse skin thickening which started at puberty. X-rays showed subperiosteal new bone formation. All examinations for secondary causes were negative.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86962443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.22631/RR.2018.69997.1051
Poopak Mohaghegh, B. Hamedi, S. Shenavandeh, A. Safaei, M. Nazarinia, E. Aflaki, Z. Habibagahi, Behnaz Valibeigi
Systemic lupus erythematosus (SLE) is considered one of the risk factors for cervical cytological abnormalities and high-risk HPV infection. However, there is a scarcity of data about the prevalence of high-risk HPV infection in patients with lupus. In order to define strategies for cancer prevention, we aimed to determine the prevalence of HPV infections in women with SLE compared to a control group. Fifty patients with SLE from the SLE clinic in Hafez Hospital, Shiraz University of Medical Sciences, were compared to 50 healthy married control women. In both groups, routine Pap smears were obtained, and the endocervical side of the spatula was sent for HPV DNA analysis. The case and control groups were compared for the presence and type of HPV infection as well as the relation between its presence with immunosuppressant use and disease activity. HPV infection was detected in 4% (2.50) of lupus patients, but it was not seen in the control group. HPV typing identified types 16 and 18 in these two patients. No relationship between HPV infection and immunosuppressant use or activity of disease was seen in the current study. There was no statistically significant difference in HPV prevalence between patients and the control group (P=0.495). Results of this study showed that SLE and the use of immunosuppressants in patients with lupus were not risks for high-risk HPV infection or cervical dysplasia in our area compared to the normal population, but further studies on more patients receiving immunosuppressants and biologics are recommended.
{"title":"Prevalence of human papilloma virus infections among women with systemic lupus erythematosus","authors":"Poopak Mohaghegh, B. Hamedi, S. Shenavandeh, A. Safaei, M. Nazarinia, E. Aflaki, Z. Habibagahi, Behnaz Valibeigi","doi":"10.22631/RR.2018.69997.1051","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1051","url":null,"abstract":"Systemic lupus erythematosus (SLE) is considered one of the risk factors for cervical cytological abnormalities and high-risk HPV infection. However, there is a scarcity of data about the prevalence of high-risk HPV infection in patients with lupus. In order to define strategies for cancer prevention, we aimed to determine the prevalence of HPV infections in women with SLE compared to a control group. Fifty patients with SLE from the SLE clinic in Hafez Hospital, Shiraz University of Medical Sciences, were compared to 50 healthy married control women. In both groups, routine Pap smears were obtained, and the endocervical side of the spatula was sent for HPV DNA analysis. The case and control groups were compared for the presence and type of HPV infection as well as the relation between its presence with immunosuppressant use and disease activity. HPV infection was detected in 4% (2.50) of lupus patients, but it was not seen in the control group. HPV typing identified types 16 and 18 in these two patients. No relationship between HPV infection and immunosuppressant use or activity of disease was seen in the current study. There was no statistically significant difference in HPV prevalence between patients and the control group (P=0.495). Results of this study showed that SLE and the use of immunosuppressants in patients with lupus were not risks for high-risk HPV infection or cervical dysplasia in our area compared to the normal population, but further studies on more patients receiving immunosuppressants and biologics are recommended.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81613159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.22631/RR.2018.69997.1052
Z. Mirfeizi, M. Sahebari, S. Nabavi, Masoumeh Salari, Masoud Saghafi, Z. Rezaieyazdi, N. Valizadeh, Houshang Raaftpanah
Sarcoidosis a systemic granulomatous disorder of unknown etiology with varying clinical pictures. HLA genes, especially HLA-DRB1, have been shown to be candidates for the etiology of sarcoidosis. This study examined the association between the polymorphism of HLA-DRB1 alleles and sarcoidosis in Iranian subjects. The study population included 58 patients with sarcoidosis and 68 healthy controls. Genomic DNA was extracted, and the polymorphisms of the HLA-DRB1 alleles were determined using a polymerase chain reaction with sequence-specific primer (PCR-SSP). The frequency of HLA-DRB1*07 was higher in sarcoidosis patients (25.8%) than in controls (15.3%); however no significant difference was observed between the two groups (P>0.05). The frequency of HLA-DRB1*11 was higher in the control group (31.9%) than in cases (22.4%), but no significant difference was detected between the groups (P>0.05). The results of the present study showed that there is no association between HLA-DRB1 alleles and susceptibility to sarcoidosis in Mashhad, Northeast Iran. Further studies with large sample sizes are required in order to clarify this issue.
{"title":"Human leukocyte antigen-DRB1 alleles in patients with sarcoidosis from Northeast Iran","authors":"Z. Mirfeizi, M. Sahebari, S. Nabavi, Masoumeh Salari, Masoud Saghafi, Z. Rezaieyazdi, N. Valizadeh, Houshang Raaftpanah","doi":"10.22631/RR.2018.69997.1052","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1052","url":null,"abstract":"Sarcoidosis a systemic granulomatous disorder of unknown etiology with varying clinical pictures. HLA genes, especially HLA-DRB1, have been shown to be candidates for the etiology of sarcoidosis. This study examined the association between the polymorphism of HLA-DRB1 alleles and sarcoidosis in Iranian subjects. The study population included 58 patients with sarcoidosis and 68 healthy controls. Genomic DNA was extracted, and the polymorphisms of the HLA-DRB1 alleles were determined using a polymerase chain reaction with sequence-specific primer (PCR-SSP). The frequency of HLA-DRB1*07 was higher in sarcoidosis patients (25.8%) than in controls (15.3%); however no significant difference was observed between the two groups (P>0.05). The frequency of HLA-DRB1*11 was higher in the control group (31.9%) than in cases (22.4%), but no significant difference was detected between the groups (P>0.05). The results of the present study showed that there is no association between HLA-DRB1 alleles and susceptibility to sarcoidosis in Mashhad, Northeast Iran. Further studies with large sample sizes are required in order to clarify this issue.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77791308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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