Pub Date : 2019-07-01DOI: 10.22631/RR.2019.69997.1071
Z. Rezaieyazdi, Marzieh Maghrebi, K. Hashemzadeh, M. Hatef, H. Esmaily, Mandana Khodashahi
Background and Objectives: To assess the correlation between lipoproteins, in particular lipoprotein a [Lp (a)], and inflammatory activity in rheumatoid arthritis (RA).Materials and Methods: In this retrospective case control study which lasted for 6 months, two groups were studied including RA patients (N= 70) and control healthy subjects (N= 52) who were matched by age and gender (P
{"title":"Correlation between lipid profile and lipoprotein (a) with inflammatory activity of rheumatoid arthritis","authors":"Z. Rezaieyazdi, Marzieh Maghrebi, K. Hashemzadeh, M. Hatef, H. Esmaily, Mandana Khodashahi","doi":"10.22631/RR.2019.69997.1071","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1071","url":null,"abstract":"Background and Objectives: To assess the correlation between lipoproteins, in particular lipoprotein a [Lp (a)], and inflammatory activity in rheumatoid arthritis (RA).Materials and Methods: In this retrospective case control study which lasted for 6 months, two groups were studied including RA patients (N= 70) and control healthy subjects (N= 52) who were matched by age and gender (P","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84332920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.22631/RR.2019.69997.1076
Z. Rezaieyazdi, Fatemeh Hajizadeh-Saffar, S. Sedighi, H. Mansouritorghabeh
Background and Objective: It has been proposed that anti-annexin V as a novel proposed mechanism for the increased prevalence of atherosclerosis among patients with Systemic Lupus Erythematosus (SLE). Here we aimed to compare anti-annexin V levels between SLE patients and healthy controls and to determine the correlation of anti-annexin with various cardiovascular risk factors. Materials and Method: Sixty patients with SLE and 30 healthy sex and age matched persons included in the current cross sectional study that was selected from outpatient Rheumatology clinics in the city of Mashhad-Iran. Anti-annexin V and the other parameters including cardiovascular risk factors(age, smoking, blood pressure, diabetes mellitus, lipoproteins levels, previous history of documented or clinically suspected atherosclerosis, obesity, premature ovarian failure, high sensitive C-reactive protein, vascular cell adhesion protein 1 and homocystein) measured using enzyme linked immuno-assay. Results: Anti-annexin V had a significant positive correlation with LDL levels in the SLE group (p=0.03). Anti-annexin V levels were not significantly different between the two groups (p=0.40). Conclusion: We could not show the role of anti-annexin V as a predictor of atherosclerosis risk in patients with lupus under study.
{"title":"Anti-Annexin V and Cardiovascular Risk Factors in Systemic Lupus Erythematosus","authors":"Z. Rezaieyazdi, Fatemeh Hajizadeh-Saffar, S. Sedighi, H. Mansouritorghabeh","doi":"10.22631/RR.2019.69997.1076","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1076","url":null,"abstract":"Background and Objective: It has been proposed that anti-annexin V as a novel proposed mechanism for the increased prevalence of atherosclerosis among patients with Systemic Lupus Erythematosus (SLE). Here we aimed to compare anti-annexin V levels between SLE patients and healthy controls and to determine the correlation of anti-annexin with various cardiovascular risk factors. Materials and Method: Sixty patients with SLE and 30 healthy sex and age matched persons included in the current cross sectional study that was selected from outpatient Rheumatology clinics in the city of Mashhad-Iran. Anti-annexin V and the other parameters including cardiovascular risk factors(age, smoking, blood pressure, diabetes mellitus, lipoproteins levels, previous history of documented or clinically suspected atherosclerosis, obesity, premature ovarian failure, high sensitive C-reactive protein, vascular cell adhesion protein 1 and homocystein) measured using enzyme linked immuno-assay. Results: Anti-annexin V had a significant positive correlation with LDL levels in the SLE group (p=0.03). Anti-annexin V levels were not significantly different between the two groups (p=0.40). Conclusion: We could not show the role of anti-annexin V as a predictor of atherosclerosis risk in patients with lupus under study.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87898858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.22631/RR.2019.69997.1072
M. Nazarinia, E. Esmaeilzadeh, Zohre Khodamoradi
Objectives: Investigating the sexual dysfunction in scleroderma patients and its relation to their vascular involvements. Method: A case control study was done on 80 married female scleroderma patients with age between 20-60 years old. Eighty normal individuals adjusted for age, place of living and socioeconomic status were also recruited. Sexual performance in both groups was assessed using FSFI standardized questionnaire, which evaluated it in 6 domains of desire, arousal, lubrication, orgasm, satisfaction, and pain. Micro and macro-vascular involvements of the patients were also determined using Raynaud Condition Score, Echocardiography, physical exam for assessing their digital ulcers and reviewing their medical records for past or present history of renal crisis and thromboembolic events. Results: The total score of FSFI in the case group was significantly lower compared to control one (16.68 ± 6.35, 19.69 ± 6.01, P-value
{"title":"Sexual Dysfunction in Female Scleroderma Patients and Its Correlation with Vascular Involvement","authors":"M. Nazarinia, E. Esmaeilzadeh, Zohre Khodamoradi","doi":"10.22631/RR.2019.69997.1072","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1072","url":null,"abstract":"Objectives: Investigating the sexual dysfunction in scleroderma patients and its relation to their vascular involvements. Method: A case control study was done on 80 married female scleroderma patients with age between 20-60 years old. Eighty normal individuals adjusted for age, place of living and socioeconomic status were also recruited. Sexual performance in both groups was assessed using FSFI standardized questionnaire, which evaluated it in 6 domains of desire, arousal, lubrication, orgasm, satisfaction, and pain. Micro and macro-vascular involvements of the patients were also determined using Raynaud Condition Score, Echocardiography, physical exam for assessing their digital ulcers and reviewing their medical records for past or present history of renal crisis and thromboembolic events. Results: The total score of FSFI in the case group was significantly lower compared to control one (16.68 ± 6.35, 19.69 ± 6.01, P-value","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82689719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.22631/RR.2019.69997.1075
Mandana Khodashahi, N. Saadati, Z. Rezaieyazdi, M. Sahebari, Z. Saremi
Background and Aims: Rheumatoid arthritis (RA) is the most common chronic inflammatory disease of the joints. To the best of our knowledge, inflammation is considered as the main stimulant of platelets, and there is an association between the mean platelet volume (MPV) and platelet reactivity. Increased platelet counts may be observed during the clinical active stages of RA patients and reduce in the remission period. The present study investigated the role of platelet indices in RA and its relationship with disease activity. Materials and Methods: This was an observational cross-sectional study, which was performed on 105 patients with RA and 35 participants as control group referred to Ghaem hospital of Mashhad in 2017. The participants were divided into 4 groups, including 1) the patients with newly diagnosed RA, 2) the patients with active RA, 3) the patients in remission, and 4) the controls. After completing the interview and questionnaire, 10 cc blood samples were obtained from all the subjects. The platelet number (PLT) and mean platelet volume (MPV) was measured. Results:The mean age of the participants was 49.06±11.08 years. MPV was higher in patients with RA than healthy control group (p
{"title":"Evaluation of Mean Platelet Volume in Patients With Rheumatoid Arthritis and its Relation With Severity of Disease","authors":"Mandana Khodashahi, N. Saadati, Z. Rezaieyazdi, M. Sahebari, Z. Saremi","doi":"10.22631/RR.2019.69997.1075","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1075","url":null,"abstract":"Background and Aims: Rheumatoid arthritis (RA) is the most common chronic inflammatory disease of the joints. To the best of our knowledge, inflammation is considered as the main stimulant of platelets, and there is an association between the mean platelet volume (MPV) and platelet reactivity. Increased platelet counts may be observed during the clinical active stages of RA patients and reduce in the remission period. The present study investigated the role of platelet indices in RA and its relationship with disease activity. Materials and Methods: This was an observational cross-sectional study, which was performed on 105 patients with RA and 35 participants as control group referred to Ghaem hospital of Mashhad in 2017. The participants were divided into 4 groups, including 1) the patients with newly diagnosed RA, 2) the patients with active RA, 3) the patients in remission, and 4) the controls. After completing the interview and questionnaire, 10 cc blood samples were obtained from all the subjects. The platelet number (PLT) and mean platelet volume (MPV) was measured. Results:The mean age of the participants was 49.06±11.08 years. MPV was higher in patients with RA than healthy control group (p","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81226959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.22631/RR.2019.69997.1074
S. Soltani, S. Aslani, S. Faezi, A. Jamshidi, E. Farhadi, M. Mahmoudi
Background: Systemic lupus erythematosus (SLE) is an autoimmune, autoinflammatory disorder in which genetic factors have been implicated in the etiopathogenesis of the disease. Elevated levels of vascular endothelial growth factor (VEGF) have been reported in patients with SLE. This study intended to evaluate the association of VEGFA gene rs833061 and rs2010963 single nucleotide polymorphisms (SNPs) with the risk of SLE susceptibility in the Iranian population.Methods: In this case-control study, 400 SLE patients and 400 age-, sex-, and ethnically-matched healthy controls were recruited. Genotyping of VEGFA gene rs833061 and rs2010963 polymorphisms in both SLE and control groups was done through the real-time PCR allelic discrimination technique.Results: It was detected that none of the alleles nor genotypes of both rs833061 and rs2010963 SNPs had a statistically significant difference between patient and control groups. Moreover, the haplotypes were not associated with the SLE susceptibility. However, rs833061 and rs2010963 polymorphisms were in linkage disequilibrium according to Dꞌ= 95 %, but not according to the r2= 42%. The associations between rs833061 (C vs. T: OR= 0.98, 95% CI= 0.80-1.20, P= 0.87) and rs2010963 (C vs. G: OR= 0.89, 95% CI= 0.73 - 1.09, P= 0.28) with risk of SLE were not significant. The clinical data of the patients, including anti-dsDNA (P= 0.036), anti-SSA (P= 0.039), and anti-SSAB (P= 0.036), were associated with the genotypes of VEGFA gene rs2010963 SNP.Conclusions: We recognize that VEGFA gene rs833061 and rs2010963 polymorphisms did not affect SLE susceptibility in the Iranian population.
{"title":"Association of Vascular Endothelial Growth Factor A gene polymorphisms with susceptibility to Systemic lupus erythematosus in Iranian population","authors":"S. Soltani, S. Aslani, S. Faezi, A. Jamshidi, E. Farhadi, M. Mahmoudi","doi":"10.22631/RR.2019.69997.1074","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1074","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is an autoimmune, autoinflammatory disorder in which genetic factors have been implicated in the etiopathogenesis of the disease. Elevated levels of vascular endothelial growth factor (VEGF) have been reported in patients with SLE. This study intended to evaluate the association of VEGFA gene rs833061 and rs2010963 single nucleotide polymorphisms (SNPs) with the risk of SLE susceptibility in the Iranian population.Methods: In this case-control study, 400 SLE patients and 400 age-, sex-, and ethnically-matched healthy controls were recruited. Genotyping of VEGFA gene rs833061 and rs2010963 polymorphisms in both SLE and control groups was done through the real-time PCR allelic discrimination technique.Results: It was detected that none of the alleles nor genotypes of both rs833061 and rs2010963 SNPs had a statistically significant difference between patient and control groups. Moreover, the haplotypes were not associated with the SLE susceptibility. However, rs833061 and rs2010963 polymorphisms were in linkage disequilibrium according to Dꞌ= 95 %, but not according to the r2= 42%. The associations between rs833061 (C vs. T: OR= 0.98, 95% CI= 0.80-1.20, P= 0.87) and rs2010963 (C vs. G: OR= 0.89, 95% CI= 0.73 - 1.09, P= 0.28) with risk of SLE were not significant. The clinical data of the patients, including anti-dsDNA (P= 0.036), anti-SSA (P= 0.039), and anti-SSAB (P= 0.036), were associated with the genotypes of VEGFA gene rs2010963 SNP.Conclusions: We recognize that VEGFA gene rs833061 and rs2010963 polymorphisms did not affect SLE susceptibility in the Iranian population.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82083042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.22631/RR.2019.69997.1073
Maryam Haghparast, E. Atabati, Vajihollah Raiisi, Ahmadreza Senzari, Gholamreza Sharifzadeh
Background: Fibromyalgia is a painful syndrome with a non-joint origin. The disease is of relatively high prevalence and is more common in women and people over 40 years of age. Method: In this case-control study, 35 healthy individuals were enrolled as the control group and 35 patients with fibromyalgia as the case group. The cervical MRI was performed for all the participants, and the graphs were interpreted by a specialist who was blind to the patient group.Results: Lesions were severe in 94.3% of the case group, 80% of the controls (P>0.05). Between the groups in the number of involved surfaces and mean lesion levels was no significant difference. In the case and control groups, 48.5% and 92.9% of the members had only one lesion. The rates of concurrent lesions in the case and control groups were 51.5% and 7.1%, (p < 0.001). In 60.6% of the case group and 17.9% of the control group, the lesion was severe (p = 0.001). The prevalence of annular tearing and stenosis of the canal was significantly higher in the case group than in the control group (p = 0.05 and p = 0.044, respectively). However, there was no significant difference between the groups in other lesions.Conclusion: Given the similarity of some of the symptoms in fibromyalgia and mechanical neck lesions, it is crucial to have timely and correct differentiation of these two diseases. Also, these results may suggest that long-term fibromyalgia can potentially exacerbate the symptoms of mechanical neck lesions.
{"title":"The Association Between Fibromyalgia and Mechanical Neck Lesions","authors":"Maryam Haghparast, E. Atabati, Vajihollah Raiisi, Ahmadreza Senzari, Gholamreza Sharifzadeh","doi":"10.22631/RR.2019.69997.1073","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1073","url":null,"abstract":"Background: Fibromyalgia is a painful syndrome with a non-joint origin. The disease is of relatively high prevalence and is more common in women and people over 40 years of age. Method: In this case-control study, 35 healthy individuals were enrolled as the control group and 35 patients with fibromyalgia as the case group. The cervical MRI was performed for all the participants, and the graphs were interpreted by a specialist who was blind to the patient group.Results: Lesions were severe in 94.3% of the case group, 80% of the controls (P>0.05). Between the groups in the number of involved surfaces and mean lesion levels was no significant difference. In the case and control groups, 48.5% and 92.9% of the members had only one lesion. The rates of concurrent lesions in the case and control groups were 51.5% and 7.1%, (p < 0.001). In 60.6% of the case group and 17.9% of the control group, the lesion was severe (p = 0.001). The prevalence of annular tearing and stenosis of the canal was significantly higher in the case group than in the control group (p = 0.05 and p = 0.044, respectively). However, there was no significant difference between the groups in other lesions.Conclusion: Given the similarity of some of the symptoms in fibromyalgia and mechanical neck lesions, it is crucial to have timely and correct differentiation of these two diseases. Also, these results may suggest that long-term fibromyalgia can potentially exacerbate the symptoms of mechanical neck lesions.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83612272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.22631/RR.2019.69997.1060
Nasibeh Alebooyeh, J. Moghimi, A. Hasani, R. Ghorbani, Golmehr Taheri
1 Faculty of Dentistry, Semnan University of Medical Sciences, Semnan, Iran. 2 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. 3 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran. 4 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. 5 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
{"title":"Periodontitis and rheumatoid arthritis: A neglected association in developing countries","authors":"Nasibeh Alebooyeh, J. Moghimi, A. Hasani, R. Ghorbani, Golmehr Taheri","doi":"10.22631/RR.2019.69997.1060","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1060","url":null,"abstract":"1 Faculty of Dentistry, Semnan University of Medical Sciences, Semnan, Iran. 2 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. 3 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran. 4 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. 5 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"381 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74412867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：