Journal of systems and integrative neuroscience最新文献

{"title":"Post-surgical reeducation of the burned adult","authors":"S. Khalfaoui, Abdellah El Marbouh, El Mustapha El Abbassi","doi":"10.15761/jsin.1000235","DOIUrl":"https://doi.org/10.15761/jsin.1000235","url":null,"abstract":"","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-related-potential (ERP) markers of traumatic brain injury (TBI) severity and cognitive function – Understanding how the brain works and thinks post TBI","authors":"Priya Miranda, Christopher D Cox, Michael Alexander, S. Danev, J. Lakey","doi":"10.15761/JSIN.1000225","DOIUrl":"https://doi.org/10.15761/JSIN.1000225","url":null,"abstract":"One fact is that other injuries often co-occur with traumatic brain Injury (TBI), thus event related potentials (ERPs) elicited using electroencephalography (EEG) machines like NeuralScan by Medeia often reflect the sum of both injuries. The second fact is that cognitive function includes domains from knowledge, attention, memory and working memory, judgment and evaluation, reasoning and “computation” to problem solving and decision-making. The third is that cross-border mental or neurocognitive or non-traumatic brain disorders that exhibit similar symptoms post-TBI will exhibit impairments in similar domains. Therefore, what if observing similar a) altered EEG-functional connectivity in post-TBI as in Alzheimer’s, epileptic seizures, schizophrenia, stroke etc or b) altered network geometries in post- TBI as in CNS tumors, depression etc is the status quo? What if the reason we are not able to identify pathognomic ERP-markers of cognitive impairment post-TBI that are highly specific and sensitive is simply because we are not thinking as the brain does? What if trying to validate ERP markers of TBI-severity and cognitive function post-TBI in the same manner one validates a candidate diagnostic test is what’s wrong in the first place? Is it possible that domain- and symptom-based identification, management and treatment of cognitive-impairments or TBI-severity are the way to go?","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune profile of a patient with Parkinson’s disease and autoimmune disease. A case report","authors":"Martin Eduardo Torres-Velasco, Eduardo Ichikawa-Escamilla, Jaquelín Leyva-Hernández, Raquel Espinosa-Cárdenas, I. González-Saavedra, M. Rodríguez‐Violante, L. Adalid-Peralta","doi":"10.15761/jsin.1000241","DOIUrl":"https://doi.org/10.15761/jsin.1000241","url":null,"abstract":"","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Americas’ opioid/psychostimulant epidemic would benefit from general population early identification of genetic addiction risk especially in children of alcoholics (COAs)","authors":"Blum K, Baron D, Hauser M, Henriksen S, Thanos Pk, Black C, Siwicki D, Modestino Ej, Downs Bw, Badgaiyan S, Simpatico Ta, Boyett B, Badgaiyan Rd","doi":"10.15761/JSIN.1000212","DOIUrl":"https://doi.org/10.15761/JSIN.1000212","url":null,"abstract":"This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Correspondence to: Blum K, Western University Health Sciences Graduate School of Biomedical Sciences, Pomona, CA, USA, Drd2gene@gmail.com. Conflicts of interest Kenneth Blum, PhD is the holder of a number of US and Foreign patents issued and pending related to Nutrigenomics and Nutraceuticals. Together with Geneus Health, LLC a developmental commercialization of the Genetic Addiction Risk Score (GARS)® with a sales license to Dominion Diagnostics, LLC. Kenneth Blum is a paid consultant (Chief Scientific Advisor) of Dominion Diagnostics, LLC, and is Chairman of The Board and CSO of Geneus Health, LLC. Dr. Blum is a member of the scientific advisory board of Dominion Diagnostics, LLC and is their Chief Scientific Advisor. Drs. Blum (Chairman), Badgaiyan, Thanos, Siwicki, Baron and Badgaiyan are members of Geneus Health Scientific Advisory Board. B.W Downs is the founder and owns stock in Victory International Nutrition, Inc., and that company is a licensed distributor of GARS and Restoregen products. The authors state that there are no other conflicts of interest. U.S. Department of Veterans Affairs Public Access Author manuscript J Syst Integr Neurosci. Author manuscript; available in PMC 2020 February 20.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"5 1","pages":"1 - 3"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Americas' opioid/psychostimulant epidemic would benefit from general population early identification of genetic addiction risk especially in children of alcoholics (COAs).","authors":"K Blum, D Baron, M Hauser, S Henriksen, P K Thanos, C Black, D Siwicki, E J Modestino, B W Downs, S Badgaiyan, T A Simpatico, B Boyett, R D Badgaiyan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"5 2","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37664668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death by Opioids: Are there non-addictive scientific solutions?","authors":"B William Downs,&nbsp;Kenneth Blum,&nbsp;David Baron,&nbsp;Abdalla Bowirrat,&nbsp;Lisa Lott,&nbsp;Raymond Brewer,&nbsp;Brent Boyett,&nbsp;David Siwicki,&nbsp;A Kenison Roy,&nbsp;Arwen Podesta,&nbsp;Sampada Badgaiyan,&nbsp;Raju Hajela,&nbsp;Lyle Fried,&nbsp;Rajendra D Badgaiyan","doi":"10.15761/JSIN.1000211","DOIUrl":"https://doi.org/10.15761/JSIN.1000211","url":null,"abstract":"<p><p>In the face of the current Opioid crisis in America killing close to 800,000 people since 2004, we are proposing a novel approach to assist in at least attenuating these unwanted premature deaths. While we applaud the wonderful efforts of our governmental institutes and professional societies (NIDA, NIAAA, ASAM, ABAM ) in their extraordinary efforts in combating this continued dilemma, the current approach is failing, and other alternative approaches should at least be tested. These truths present a serious ethical dilemma to scientists, clinicians and counselors in the Reward Deficiency Syndrome (RDS) treatment community. It is important to realize that the current DSM-5 does not actually accurately display the natural brain reward process. The human brain has not been designed to carve out specific drugs like opioids, alcohol, nicotine, cocaine, benzodiazepines or cannabis and process addictions such as gambling as distinct endophenotypes. This is true in spite of natural ligands for cannabinoids, endorphins, or even benzodiazepines. The most accurate endophenotype is indeed reward dysfunction (e.g hypodopaminergic or hyperdopaminergic). With this mind, we are hereby proposing that the current Medication Assisted Treatment (i.e. 'MAT') expands to needed individuals as an initial \"Band-Aid\" to reduce harm avoidance, with the long-term goal of prophylaxis. So, to be clear, there may be other promising modalities other than MAT such as repetitive transcranial magnetic stimulation (rTMS), exercise and even new medications with positive allosteric modulators of GABA-A receptors, as well as the highly researched Genetic Addiction Risk Score (GARS) coupled with precision KB220Z. This will induce \"dopamine homeostasis\" to effectively rebalance and restore healthier brain function by promoting the cross talk between various brain regions (e.g. Nucleus accumbens, cingulate gyrus, hippocampus etc.) resulting in dopamine homeostasis. Our laudable goal is to not only save lives, but to redeem joy and improve the quality of life in the recovery community through scientifically sound natural non-addicting alternatives.</p>","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904107/pdf/nihms-1059030.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37446863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International symposium of junior neuroscience investigators (ISJNI19) UPM, 25-27 April, 2019 (Part-IV)","authors":"Yousra Benmakhlouf, Naima Ghailani Nourouti, A. Barakat, I. Harzallah, R. Touraine, Mohcine Bennani Mechita","doi":"10.15761/jsin.1000204","DOIUrl":"https://doi.org/10.15761/jsin.1000204","url":null,"abstract":"chain reaction) product of ARX exon 2, performed in the molecular genetics laboratory in Saint Etienne (France). The average age of patients was 17± 0, 98 years (6-31 years). Our results showed that the prevalence of ID was 71% in boys versus 29% in girls, and several symptoms of ID were observed in our patients. The 24 bp duplication of ARX was not identified in any of the male patients tested. The prevention of ID is obviously based on the genetic, the social, the toxic and the infectious causes. Purpose of the study.- The objectives of this study were to: 1) to assess self-esteem, anxiety and depression in dyslexic Arabic-speaking children and adolescents, 2) to describe psychiatric comorbidities in these subjects by comparing them to their non-dyslexic peers. Patients and method.- 204 students (56 dyslexics and 149 good readers), pursuing their education in ordinary schools in the Beni Mellal-Khenifra region of Morocco, responded to Taylor's self-assessment scale of anxiety, the Beck's depression questionnaire, and the coopersmith self-esteem inventory (SEI). Results.- Overall, dyslexics are more anxious, more depressed and have a disturbed self-esteem compared to their \"normal\" peers. The percentage of psychiatric comorbidity is higher in the dyslexic group. Conclusion.- The results of this work highlight the need for a multidisciplinary approach that integrates emotional needs assessment into reeducational care of dyslexic children and adolescents In this study, the association between the reading acquisition level, the anxiety and depressive symptoms and self-esteem status is examined in children and adolescents school-age. Then, the links between these problems and academic achievement were analyzed. A sample of 245 students (130 boys and 115 girls) aged 9 to 17 years (M= 11.5 years), pursuing their studies in ordinary institutions school in the Beni Mellal-Khenifra region of Morocco, voluntarily participated in this research. The subjects completed the measurements of three self-evaluative scales: the Beck Depression Inventory (BDI), the Coopeersmith Scale of Self Esteem (SEI) and the Taylor questionnaire of manifest Anxiety. The results confirm that emotional manifestations are more frequent in \"weak readers\" and those with intermediate reading skills by comparing them to good readers. Academic performance and reading level are negatively correlated with anxious-depressive symptoms and positively with self-esteem (the correlations are significant). In each reading level, the analysis of the results does not show any relevant difference, in terms of the psycho-pathological disorders intensity, between girls and boys. These data urge education and public health officials to adopt multidisciplinary strategies to confront learning difficulties and emotional problems in the school environment. Mycotoxins are a group of chemical compounds produced mainly by Aspergillus, Penicillium, Alternaria and Fusarium species that could grow on foods and","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carnosine restores aging-induced elevation of corticosterone status and brain regional amyloid-beta in relation to down regulation of locomotor activity","authors":"S. Banerjee, B. Mukherjee, Poddar Mk","doi":"10.15761/jsin.1000210","DOIUrl":"https://doi.org/10.15761/jsin.1000210","url":null,"abstract":"The aim of the present investigation was to evaluate the role of carnosine on aging-induced Aβ deposition in different brain regions (prefrontal cortex, hippocampal CA1 and CA3 zones, hypothalamus, pons-medulla and cerebellum) in connection with the locomotor activity (open field locomotion and rearing count) and corticosterone status in plasma and adrenal gland. During aging, both in 18 and 24 months aged rats (a) a graded deposition of Aβ in their brain regions was observed with a maximum deposition in prefrontal cortex of 24 months aged rats without any Aβ deposition in cerebellum, (b) the plasma and adrenal corticosterone level was increased, and (c) locomotor activity were reduced. Carnosine (2.0 μg/Kg/day, i.t.; for 21 consecutive days) reduced the aging-induced brain regional graded Aβ deposition and attenuated the aging-induced increase of both plasma and adrenal corticosterone level as well as the locomotor activity. Thus, it may be concluded from these observations that (a) aging reduces both rearing and locomotor activities which may be correlated with the increase of corticosterone in both plasma and adrenal gland with a graded Aβ accumulation in the brain regions, except cerebellum and (b) carnosine attenuates these aging-induced phenomena, observed in those brain regions, plasma and adrenal gland, and also in locomotor activities. *Correspondence to: Mrinal K. Poddar, Ph.D, D.Sc, ICMR Emeritus Medical Scientist, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India, E-mail: mrinalkp@yahoo.com","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internalized stigma is associated with psychological distress among patients with substance use disorders in Egypt","authors":"Amira S. Mohammed Ali","doi":"10.15761/jsin.1000209","DOIUrl":"https://doi.org/10.15761/jsin.1000209","url":null,"abstract":"","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young pregnant woman with mild dysphagia: Diagnostic and treatment workup predicting laryngeal schwannoma","authors":"M. F, S. M., S. R., Spinato G, M. G","doi":"10.15761/jsin.1000207","DOIUrl":"https://doi.org/10.15761/jsin.1000207","url":null,"abstract":"Schwannomas of the larynx are uncommon, they represent the 0.1-1.5% of all the benign laryngeal tumours. Patients usually report multiple symptoms related to mass-effects and their treatment of choice is surgical excision. We present the case of a young woman presenting a schwannoma within her left false vocal fold, not suitable for endoscopic surgical approach. The suspected diagnosis of schwannoma was confirmed by the final histopathological report, showing a protein S110 positivity at the immunohistochemistry staining. Complete surgical excision is the treatment of choice and can be performed by either transoral or external approach depending on lesion dimension, patient’s laryngeal exposure and surgeon’s skills. In both cases we do suggest a conservative approach.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}