首页 > 最新文献

Nanotechnology and Precision Engineering最新文献

英文 中文
Electromagnetic vibrational energy harvester with targeted frequency-tuning capability based on magnetic levitation 基于磁悬浮技术、具有定向频率调节能力的电磁振动能量收集器
Pub Date : 2024-05-14 DOI: 10.1063/10.0025788
Chengbo Hu, Xinyi Wang, Zhifei Wang, Shudong Wang, Yuanyuan Liu, Yunjia Li
This article presents a compact magnetic levitation energy harvester (MLEH) with tunable resonant frequency. Unlike many of the reported tunable harvesters with unknown tuning results, the proposed MLEH can be tuned toward designated resonant frequency values within its tuning range. The targeted tuning processes is realized by a nonlinear magnet repulsive force exerted on a Halbach magnet array, combined with a calibrated scaling system. At a sinusoidal acceleration of ±0.15 g, the maximum frequency tuning range of the proposed MLEH is 6.3 Hz (8.1–14.4 Hz), which is 77.8% of its resonant MLEH (8.1 Hz). At a frequency of 9.7 Hz, the output power is 462.1 μW and the calculated normalized power density is 496 μW cm−3 g−2.
本文介绍了一种谐振频率可调的紧凑型磁悬浮能量收集器(MLEH)。与许多调谐结果未知的可调式能量收集器不同,所提出的磁悬浮能量收集器可在其调谐范围内调谐到指定的谐振频率值。目标调谐过程是通过施加在哈尔巴赫磁体阵列上的非线性磁体斥力与校准缩放系统相结合来实现的。在 ±0.15 g 的正弦加速度下,拟议 MLEH 的最大频率调谐范围为 6.3 Hz(8.1-14.4 Hz),是其共振 MLEH(8.1 Hz)的 77.8%。频率为 9.7 Hz 时,输出功率为 462.1 μW,计算得出的归一化功率密度为 496 μW cm-3 g-2。
{"title":"Electromagnetic vibrational energy harvester with targeted frequency-tuning capability based on magnetic levitation","authors":"Chengbo Hu, Xinyi Wang, Zhifei Wang, Shudong Wang, Yuanyuan Liu, Yunjia Li","doi":"10.1063/10.0025788","DOIUrl":"https://doi.org/10.1063/10.0025788","url":null,"abstract":"This article presents a compact magnetic levitation energy harvester (MLEH) with tunable resonant frequency. Unlike many of the reported tunable harvesters with unknown tuning results, the proposed MLEH can be tuned toward designated resonant frequency values within its tuning range. The targeted tuning processes is realized by a nonlinear magnet repulsive force exerted on a Halbach magnet array, combined with a calibrated scaling system. At a sinusoidal acceleration of ±0.15 g, the maximum frequency tuning range of the proposed MLEH is 6.3 Hz (8.1–14.4 Hz), which is 77.8% of its resonant MLEH (8.1 Hz). At a frequency of 9.7 Hz, the output power is 462.1 μW and the calculated normalized power density is 496 μW cm−3 g−2.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular dynamics simulation study of nitrogen vacancy color centers prepared by carbon ion implantation into diamond 碳离子植入金刚石制备的氮空位彩色中心的分子动力学模拟研究
Pub Date : 2024-05-06 DOI: 10.1063/10.0025756
Wei Zhao, Zongwei Xu, Pengfei Wang, Hanyi Chen
Nitrogen vacancy (NV) color centers in diamond have useful applications in quantum sensing and fluorescent marking. They can be generated experimentally by ion implantation, femtosecond lasers, and chemical vapor deposition. However, there is a lack of studies of the yield of NV color centers at the atomic scale. In the molecular dynamics simulations described in this paper, NV color centers are prepared by ion implantation in diamond with pre-doped nitrogen and subsequent annealing. The differences between the yields of NV color centers produced by implantation of carbon (C) and nitrogen (N) ions, respectively, are investigated. It is found that C-ion implantation gives a greater yield of NV color centers and superior location accuracy. The effects of different pre-doping concentrations (400–1500 ppm) and implantation energies (1.0–3.0 keV) on the NV color center yield are analyzed, and it is shown that a pre-doping concentration of 1000 ppm with 2 keV C-ion implantation can produce a 13% yield of NV color centers after 1600 K annealing for 7.4 ns. Finally, a brief comparison of the NV color center identification methods is presented, and it is found that the error rate of an analysis utilizing the identify diamond structure + coordination analysis method is reduced by about 7% compared with conventional identification methods.
金刚石中的氮空位(NV)色彩中心可用于量子传感和荧光标记。它们可以通过离子注入、飞秒激光和化学气相沉积等实验方法生成。然而,目前还缺乏对原子尺度上 NV 色心产率的研究。在本文所述的分子动力学模拟中,NV 色心是通过在预掺氮的金刚石中进行离子注入并随后退火制备的。研究了分别通过植入碳(C)离子和氮(N)离子制备的 NV 颜色中心的产量差异。结果发现,C 离子植入能产生更多的 NV 颜色中心,而且定位精度更高。分析了不同的预掺杂浓度(400-1500 ppm)和植入能量(1.0-3.0 keV)对 NV 颜色中心产率的影响,结果表明,预掺杂浓度为 1000 ppm、2 keV 的 C 离子植入在 1600 K 退火 7.4 ns 后可产生 13% 的 NV 颜色中心产率。最后,还对 NV 颜色中心识别方法进行了简要比较,发现与传统识别方法相比,利用识别金刚石结构 + 配位分析方法进行分析的错误率降低了约 7%。
{"title":"Molecular dynamics simulation study of nitrogen vacancy color centers prepared by carbon ion implantation into diamond","authors":"Wei Zhao, Zongwei Xu, Pengfei Wang, Hanyi Chen","doi":"10.1063/10.0025756","DOIUrl":"https://doi.org/10.1063/10.0025756","url":null,"abstract":"Nitrogen vacancy (NV) color centers in diamond have useful applications in quantum sensing and fluorescent marking. They can be generated experimentally by ion implantation, femtosecond lasers, and chemical vapor deposition. However, there is a lack of studies of the yield of NV color centers at the atomic scale. In the molecular dynamics simulations described in this paper, NV color centers are prepared by ion implantation in diamond with pre-doped nitrogen and subsequent annealing. The differences between the yields of NV color centers produced by implantation of carbon (C) and nitrogen (N) ions, respectively, are investigated. It is found that C-ion implantation gives a greater yield of NV color centers and superior location accuracy. The effects of different pre-doping concentrations (400–1500 ppm) and implantation energies (1.0–3.0 keV) on the NV color center yield are analyzed, and it is shown that a pre-doping concentration of 1000 ppm with 2 keV C-ion implantation can produce a 13% yield of NV color centers after 1600 K annealing for 7.4 ns. Finally, a brief comparison of the NV color center identification methods is presented, and it is found that the error rate of an analysis utilizing the identify diamond structure + coordination analysis method is reduced by about 7% compared with conventional identification methods.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141006172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voltage-modulated polymer nanopore field-effect transistor for multi-sized nanoparticle detection 用于多尺寸纳米粒子检测的电压调制聚合物纳米孔场效应晶体管
Pub Date : 2024-05-06 DOI: 10.1063/10.0025754
Feng Zhou, Lin Li, Qiannan Xue
Solid-state nanopores offer a range of distinct advantages over biological nanopores, such as structural diversity and greater stability and durability; this makes them highly promising for high-resolution nanoparticle sensing. Biological nanopores can exhibit gating characteristics with stress-responsive switches and can demonstrate specificity toward particular molecules. Drawing inspiration from biological nanopores, this paper introduces a novel polymer nanopore with field-effect characteristics, leveraging a conductive polymer in its construction to showcase intriguing gating behavior. Notably, in this device, the polymer layer serves as the gate, enabling precise control over the source–drain current response inside and outside the pore by simply adjusting the gate voltage. This unique feature allows fine-tuning of the nanopore’s sensitivity to nanoparticles of varying sizes and facilitates its operation in multiple modes. Experimental results reveal that the developed polymer nanopore field-effect transistor demonstrates remarkable selectivity in detecting nanoparticles of various sizes under different applied voltages. The proposed single device demonstrates the exceptional ability to detect multiple types of nanoparticle, showcasing its immense potential for a wide range of applications in biological-particle analysis and medical diagnostics.
与生物纳米孔相比,固态纳米孔具有一系列明显的优势,如结构多样性、更高的稳定性和耐久性;这使得它们在高分辨率纳米粒子传感方面大有可为。生物纳米孔具有应力响应开关的门控特性,对特定分子具有特异性。本文从生物纳米孔中汲取灵感,介绍了一种具有场效应特性的新型聚合物纳米孔,在其构造中利用了导电聚合物,展示了引人入胜的门控行为。值得注意的是,在该器件中,聚合物层充当了栅极,只需调节栅极电压,就能精确控制孔内外的源漏电流响应。这一独特功能可以微调纳米孔对不同尺寸纳米粒子的敏感性,并促进其在多种模式下运行。实验结果表明,所开发的聚合物纳米孔场效应晶体管在不同的外加电压下检测不同大小的纳米粒子时,具有显著的选择性。所提出的单个器件展示了检测多种类型纳米粒子的卓越能力,显示了其在生物粒子分析和医疗诊断领域广泛应用的巨大潜力。
{"title":"Voltage-modulated polymer nanopore field-effect transistor for multi-sized nanoparticle detection","authors":"Feng Zhou, Lin Li, Qiannan Xue","doi":"10.1063/10.0025754","DOIUrl":"https://doi.org/10.1063/10.0025754","url":null,"abstract":"Solid-state nanopores offer a range of distinct advantages over biological nanopores, such as structural diversity and greater stability and durability; this makes them highly promising for high-resolution nanoparticle sensing. Biological nanopores can exhibit gating characteristics with stress-responsive switches and can demonstrate specificity toward particular molecules. Drawing inspiration from biological nanopores, this paper introduces a novel polymer nanopore with field-effect characteristics, leveraging a conductive polymer in its construction to showcase intriguing gating behavior. Notably, in this device, the polymer layer serves as the gate, enabling precise control over the source–drain current response inside and outside the pore by simply adjusting the gate voltage. This unique feature allows fine-tuning of the nanopore’s sensitivity to nanoparticles of varying sizes and facilitates its operation in multiple modes. Experimental results reveal that the developed polymer nanopore field-effect transistor demonstrates remarkable selectivity in detecting nanoparticles of various sizes under different applied voltages. The proposed single device demonstrates the exceptional ability to detect multiple types of nanoparticle, showcasing its immense potential for a wide range of applications in biological-particle analysis and medical diagnostics.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141010863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic 3D printing of composite structures with decreased cracking 仿生三维打印复合材料结构,减少开裂现象
Pub Date : 2024-04-23 DOI: 10.1063/10.0025654
Fan Du, Kai Li, Mingzhen Li, Junyang Fang, Long Sun, Chao Wang, Yexin Wang, Maiqi Liu, Jinbang Li, Xiaoying Wang
The development of tissue engineering and regeneration research has created new platforms for bone transplantation. However, the preparation of scaffolds with good fiber integrity is challenging, because scaffolds prepared by traditional printing methods are prone to fiber cracking during solvent evaporation. Human skin has an excellent natural heat-management system, which helps to maintain a constant body temperature through perspiration or blood-vessel constriction. In this work, an electrohydrodynamic-jet 3D-printing method inspired by the thermal-management system of skin was developed. In this system, the evaporation of solvent in the printed fibers can be adjusted using the temperature-change rate of the substrate to prepare 3D structures with good structural integrity. To investigate the solvent evaporation and the interlayer bonding of the fibers, finite-element analysis simulations of a three-layer microscale structure were carried out. The results show that the solvent-evaporation path is from bottom to top, and the strain in the printed structure becomes smaller with a smaller temperature-change rate. Experimental results verified the accuracy of these simulation results, and a variety of complex 3D structures with high aspect ratios were printed. Microscale cracks were reduced to the nanoscale by adjusting the temperature-change rate from 2.5 to 0.5 °C s−1. Optimized process parameters were selected to prepare a tissue engineering scaffold with high integrity. It was confirmed that this printed scaffold had good biocompatibility and could be used for bone-tissue regeneration. This simple and flexible 3D-printing method can also help with the preparation of a wide range of micro- and nanostructured sensors and actuators.
组织工程和再生研究的发展为骨移植创造了新的平台。然而,制备具有良好纤维完整性的支架具有挑战性,因为用传统印刷方法制备的支架容易在溶剂蒸发过程中发生纤维开裂。人体皮肤具有出色的天然热管理系统,可通过排汗或血管收缩保持体温恒定。在这项工作中,受皮肤热管理系统的启发,开发了一种电流体动力喷射三维打印方法。在该系统中,打印纤维中的溶剂蒸发可通过基底的温度变化率进行调节,从而制备出具有良好结构完整性的三维结构。为了研究溶剂蒸发和纤维的层间结合,对三层微尺度结构进行了有限元分析模拟。结果表明,溶剂蒸发的路径是自下而上的,打印结构的应变随着温度变化率的降低而变小。实验结果验证了这些模拟结果的准确性,并打印出了各种复杂的高纵横比三维结构。通过将温度变化率从 2.5°C s-1 调整到 0.5°C s-1,微尺度裂缝被减小到纳米尺度。通过优化工艺参数,制备出了具有高完整性的组织工程支架。实验证实,这种打印支架具有良好的生物相容性,可用于骨组织再生。这种简单灵活的三维打印方法还有助于制备各种微纳米结构的传感器和致动器。
{"title":"Biomimetic 3D printing of composite structures with decreased cracking","authors":"Fan Du, Kai Li, Mingzhen Li, Junyang Fang, Long Sun, Chao Wang, Yexin Wang, Maiqi Liu, Jinbang Li, Xiaoying Wang","doi":"10.1063/10.0025654","DOIUrl":"https://doi.org/10.1063/10.0025654","url":null,"abstract":"The development of tissue engineering and regeneration research has created new platforms for bone transplantation. However, the preparation of scaffolds with good fiber integrity is challenging, because scaffolds prepared by traditional printing methods are prone to fiber cracking during solvent evaporation. Human skin has an excellent natural heat-management system, which helps to maintain a constant body temperature through perspiration or blood-vessel constriction. In this work, an electrohydrodynamic-jet 3D-printing method inspired by the thermal-management system of skin was developed. In this system, the evaporation of solvent in the printed fibers can be adjusted using the temperature-change rate of the substrate to prepare 3D structures with good structural integrity. To investigate the solvent evaporation and the interlayer bonding of the fibers, finite-element analysis simulations of a three-layer microscale structure were carried out. The results show that the solvent-evaporation path is from bottom to top, and the strain in the printed structure becomes smaller with a smaller temperature-change rate. Experimental results verified the accuracy of these simulation results, and a variety of complex 3D structures with high aspect ratios were printed. Microscale cracks were reduced to the nanoscale by adjusting the temperature-change rate from 2.5 to 0.5 °C s−1. Optimized process parameters were selected to prepare a tissue engineering scaffold with high integrity. It was confirmed that this printed scaffold had good biocompatibility and could be used for bone-tissue regeneration. This simple and flexible 3D-printing method can also help with the preparation of a wide range of micro- and nanostructured sensors and actuators.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flexible polydimethylsiloxane pressure sensor with micro-pyramid structures and embedded silver nanowires: A novel application in urinary flow measurement 具有微金字塔结构和嵌入式银纳米线的柔性聚二甲基硅氧烷压力传感器:尿流测量中的新型应用
Pub Date : 2024-04-23 DOI: 10.1063/10.0025653
Ben-Song Wang, Ang Gao, Song-Wei Huang, Qi-Hong Ning, Cheng Zhou, Qi-Xiang Song, Da-Xiang Cui
Flexible pressure sensors are lightweight and highly sensitive, making them suitable for use in small portable devices to achieve precise measurements of tiny forces. This article introduces a low-cost and easy-fabrication strategy for piezoresistive flexible pressure sensors. By embedding silver nanowires into a polydimethylsiloxane layer with micro-pyramids on its surface, a flexible pressure sensor is created that can detect low pressure (17.3 Pa) with fast response (<20 ms) and high sensitivity (69.6 mA kPa−1). Furthermore, the pressure sensor exhibits a sensitive and stable response to a small amount of water flowing on its surface. On this basis, the flexible pressure sensor is innovatively combined with a micro-rotor to fabricate a novel urinary flow-rate meter (uroflowmeter), and results from a simulated human urination experiment show that the uroflowmeter accurately captured all the essential shape characteristics that were present in the pump-simulated urination curves. Looking ahead, this research provides a new reference for using flexible pressure sensors in urinary flow-rate monitoring.
柔性压力传感器重量轻、灵敏度高,适合用于小型便携式设备,以实现对微小力的精确测量。本文介绍了压阻柔性压力传感器的低成本、易制造策略。通过将银纳米线嵌入表面有微金字塔的聚二甲基硅氧烷层,制造出了一种柔性压力传感器,它能检测低压(17.3 Pa),响应速度快(<20 ms),灵敏度高(69.6 mA kPa-1)。此外,该压力传感器还能对其表面的少量水流做出灵敏而稳定的响应。在此基础上,创新性地将柔性压力传感器与微型转子相结合,制造出一种新型尿流量计(尿流量计),模拟人体排尿实验的结果表明,尿流量计准确捕捉到了泵模拟排尿曲线的所有基本形状特征。展望未来,这项研究为在尿流速率监测中使用柔性压力传感器提供了新的参考。
{"title":"Flexible polydimethylsiloxane pressure sensor with micro-pyramid structures and embedded silver nanowires: A novel application in urinary flow measurement","authors":"Ben-Song Wang, Ang Gao, Song-Wei Huang, Qi-Hong Ning, Cheng Zhou, Qi-Xiang Song, Da-Xiang Cui","doi":"10.1063/10.0025653","DOIUrl":"https://doi.org/10.1063/10.0025653","url":null,"abstract":"Flexible pressure sensors are lightweight and highly sensitive, making them suitable for use in small portable devices to achieve precise measurements of tiny forces. This article introduces a low-cost and easy-fabrication strategy for piezoresistive flexible pressure sensors. By embedding silver nanowires into a polydimethylsiloxane layer with micro-pyramids on its surface, a flexible pressure sensor is created that can detect low pressure (17.3 Pa) with fast response (<20 ms) and high sensitivity (69.6 mA kPa−1). Furthermore, the pressure sensor exhibits a sensitive and stable response to a small amount of water flowing on its surface. On this basis, the flexible pressure sensor is innovatively combined with a micro-rotor to fabricate a novel urinary flow-rate meter (uroflowmeter), and results from a simulated human urination experiment show that the uroflowmeter accurately captured all the essential shape characteristics that were present in the pump-simulated urination curves. Looking ahead, this research provides a new reference for using flexible pressure sensors in urinary flow-rate monitoring.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140668411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An electrochemiluminescent magneto-immunosensor for ultrasensitive detection of hs-cTnI on a microfluidic chip 微流控芯片上超灵敏检测 hs-cTnI 的电化学发光磁性免疫传感器
Pub Date : 2024-04-23 DOI: 10.1063/10.0025652
Yun Hui, Zhen Zhao, Weiliang Shu, Fengshan Shen, Weijun Kong, Shengyong Geng, Zhen Xu, Tianzhun Wu, Wenhua Zhou, Xuefeng Yu
Sensitive detection and precise quantitation of trace-level crucial biomarkers in a complex sample matrix has become an important area of research. For example, the detection of high-sensitivity cardiac troponin I (hs-cTnI) is strongly recommended in clinical guidelines for early diagnosis of acute myocardial infarction. Based on the use of an electrode modified by single-walled carbon nanotubes (SWCNTs) and a Ru(bpy)32+-doped silica nanoparticle (Ru@SiO2)/tripropylamine (TPA) system, a novel type of electrochemiluminescent (ECL) magneto-immunosensor is developed for ultrasensitive detection of hs-cTnI. In this approach, a large amount of [Ru(bpy)3]2+ is loaded in SiO2 (silica nanoparticles) as luminophores with high luminescent efficiency and SWCNTs as electrode surface modification material with excellent electrooxidation ability for TPA. Subsequently, a hierarchical micropillar array of microstructures is fabricated with a magnet placed at each end to efficiently confine a single layer of immunomagnetic microbeads on the surface of the electrode and enable 7.5-fold signal enhancement. In particular, the use of transparent SWCNTs to modify a transparent ITO electrode provides a two-order-of-magnitude ECL signal amplification. A good linear calibration curve is developed for hs-cTnI concentrations over a wide range from 10 fg/ml to 10 ng/ml, with the limit of detection calculated as 8.720 fg/ml (S/N = 3). This ultrasensitive immunosensor exhibits superior detection performance with remarkable stability, reproducibility, and selectivity. Satisfactory recoveries are obtained in the detection of hs-cTnI in human serum, providing a potential analysis protocol for clinical applications.
在复杂的样品基质中对痕量水平的关键生物标记物进行灵敏检测和精确定量已成为一个重要的研究领域。例如,临床指南强烈建议检测高灵敏度心肌肌钙蛋白 I(hs-cTnI),以便早期诊断急性心肌梗死。基于使用单壁碳纳米管(SWCNTs)修饰的电极和掺杂 Ru(bpy)32+ 的二氧化硅纳米粒子(Ru@SiO2)/三丙胺(TPA)系统,开发了一种新型电化学发光(ECL)磁性免疫传感器,用于超灵敏检测 hs-cTnI。在该方法中,大量[Ru(bpy)3]2+被负载在具有高发光效率的二氧化硅纳米颗粒(SiO2)中作为发光体,而 SWCNTs 作为电极表面改性材料对 TPA 具有优异的电氧化能力。随后,通过在电极两端各放置一块磁铁,制作出分层微柱阵列微结构,从而将单层免疫磁性微珠有效地限制在电极表面,使信号增强 7.5 倍。特别是,使用透明的 SWCNT 来修饰透明的 ITO 电极,可实现两个数量级的 ECL 信号放大。在 10 fg/ml 至 10 ng/ml 的宽范围内,hs-cTnI 浓度的线性校准曲线良好,检测限为 8.720 fg/ml(S/N = 3)。这种超灵敏免疫传感器具有卓越的检测性能、稳定性、再现性和选择性。在检测人血清中的 hs-cTnI 时获得了令人满意的回收率,为临床应用提供了一种潜在的分析方案。
{"title":"An electrochemiluminescent magneto-immunosensor for ultrasensitive detection of hs-cTnI on a microfluidic chip","authors":"Yun Hui, Zhen Zhao, Weiliang Shu, Fengshan Shen, Weijun Kong, Shengyong Geng, Zhen Xu, Tianzhun Wu, Wenhua Zhou, Xuefeng Yu","doi":"10.1063/10.0025652","DOIUrl":"https://doi.org/10.1063/10.0025652","url":null,"abstract":"Sensitive detection and precise quantitation of trace-level crucial biomarkers in a complex sample matrix has become an important area of research. For example, the detection of high-sensitivity cardiac troponin I (hs-cTnI) is strongly recommended in clinical guidelines for early diagnosis of acute myocardial infarction. Based on the use of an electrode modified by single-walled carbon nanotubes (SWCNTs) and a Ru(bpy)32+-doped silica nanoparticle (Ru@SiO2)/tripropylamine (TPA) system, a novel type of electrochemiluminescent (ECL) magneto-immunosensor is developed for ultrasensitive detection of hs-cTnI. In this approach, a large amount of [Ru(bpy)3]2+ is loaded in SiO2 (silica nanoparticles) as luminophores with high luminescent efficiency and SWCNTs as electrode surface modification material with excellent electrooxidation ability for TPA. Subsequently, a hierarchical micropillar array of microstructures is fabricated with a magnet placed at each end to efficiently confine a single layer of immunomagnetic microbeads on the surface of the electrode and enable 7.5-fold signal enhancement. In particular, the use of transparent SWCNTs to modify a transparent ITO electrode provides a two-order-of-magnitude ECL signal amplification. A good linear calibration curve is developed for hs-cTnI concentrations over a wide range from 10 fg/ml to 10 ng/ml, with the limit of detection calculated as 8.720 fg/ml (S/N = 3). This ultrasensitive immunosensor exhibits superior detection performance with remarkable stability, reproducibility, and selectivity. Satisfactory recoveries are obtained in the detection of hs-cTnI in human serum, providing a potential analysis protocol for clinical applications.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facile in situ synthesis and characterization of Fe@Si/zeolite Na composites with magnetic core–shell structures from natural materials for enhanced curcumin loading capacity 利用天然材料原位合成并表征具有磁核壳结构的 Fe@Si/zeolite Na 复合材料,提高姜黄素负载能力
Pub Date : 2024-04-17 DOI: 10.1063/10.0025584
Munasir Nasir, Nuhaa Faaizatunnisa, M. N. Ariesta, Lydia Rohmawati, Rifqi Aulia Nurazizah
Curcumin is a natural polyphenol that is used in various traditional medicines. However, its inherent properties, such as its rapid degradation and metabolism, low bioavailability, and short half-life, are serious problems that must be resolved. To this end, a drug carrier incorporating natural magnetic cores in a zeolite framework was developed and applied to the loading of curcumin in ethanol solutions. In this system, curcumin is encapsulated in a zeolite Na (ZNA) magnetic core–shell structure (Fe@Si/ZNA), which can be easily synthesized using an in situ method. Synthesis of Fe3O4 nanoparticles was carried out from natural materials using a co-precipitation method. Analysis of the prepared magnetic core–shell structures and composites was carried out using vibrating-sample magnetometery, Fourier transform infrared spectroscopy, transmission electron microscopy, and x-ray diffraction. The cumulative loading of curcumin in the ZNA composite with 9% nanoparticles was found to reach 90.70% with a relatively long half-life of 32.49 min. Stability tests of curcumin loading in the composite showed that adding magnetic particles to the zeolite framework also increased the stability of the composite structure. Adsorption kinetics and isotherm studies also found that the system follows the pseudo-second-order and Langmuir isotherm models.
姜黄素是一种天然多酚,被用于多种传统药物中。然而,姜黄素的固有特性,如降解和代谢快、生物利用率低、半衰期短等,都是亟待解决的严重问题。为此,我们开发了一种在沸石框架中加入天然磁芯的药物载体,并将其应用于姜黄素在乙醇溶液中的负载。在这一系统中,姜黄素被包裹在沸石 Na(ZNA)磁芯壳结构(Fe@Si/ZNA)中,而这种磁芯壳结构可以通过原位法轻松合成。利用共沉淀法从天然材料中合成了 Fe3O4 纳米粒子。利用振动样品磁强计、傅立叶变换红外光谱、透射电子显微镜和 X 射线衍射对制备的磁性核壳结构和复合材料进行了分析。结果发现,在含有 9% 纳米颗粒的 ZNA 复合材料中,姜黄素的累积负载量达到了 90.70%,半衰期相对较长,为 32.49 分钟。对复合材料中姜黄素负载量的稳定性测试表明,在沸石框架中添加磁性颗粒也提高了复合材料结构的稳定性。吸附动力学和等温线研究还发现,该系统遵循伪二阶和朗缪尔等温线模型。
{"title":"Facile in situ synthesis and characterization of Fe@Si/zeolite Na composites with magnetic core–shell structures from natural materials for enhanced curcumin loading capacity","authors":"Munasir Nasir, Nuhaa Faaizatunnisa, M. N. Ariesta, Lydia Rohmawati, Rifqi Aulia Nurazizah","doi":"10.1063/10.0025584","DOIUrl":"https://doi.org/10.1063/10.0025584","url":null,"abstract":"Curcumin is a natural polyphenol that is used in various traditional medicines. However, its inherent properties, such as its rapid degradation and metabolism, low bioavailability, and short half-life, are serious problems that must be resolved. To this end, a drug carrier incorporating natural magnetic cores in a zeolite framework was developed and applied to the loading of curcumin in ethanol solutions. In this system, curcumin is encapsulated in a zeolite Na (ZNA) magnetic core–shell structure (Fe@Si/ZNA), which can be easily synthesized using an in situ method. Synthesis of Fe3O4 nanoparticles was carried out from natural materials using a co-precipitation method. Analysis of the prepared magnetic core–shell structures and composites was carried out using vibrating-sample magnetometery, Fourier transform infrared spectroscopy, transmission electron microscopy, and x-ray diffraction. The cumulative loading of curcumin in the ZNA composite with 9% nanoparticles was found to reach 90.70% with a relatively long half-life of 32.49 min. Stability tests of curcumin loading in the composite showed that adding magnetic particles to the zeolite framework also increased the stability of the composite structure. Adsorption kinetics and isotherm studies also found that the system follows the pseudo-second-order and Langmuir isotherm models.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Particle distributions in Lamb wave based acoustofluidics 基于 Lamb 波的声流体中的粒子分布
Pub Date : 2024-03-15 DOI: 10.1063/10.0024320
Chuanchao Zhang, Xian Chen, Wei Wei, Xuejiao Chen, Quanning Li, Xuexin Duan
Acoustic streaming enabled by a Lamb wave resonator (LWR) is efficient for particle trapping and enrichment in microfluidic channels. However, because Lamb waves combine the features of bulk acoustic waves and surface acoustic waves, the resulting acoustic streaming in the LWR occurs in multiple planes, and the particle flow behavior in this acoustofluidic system is largely unknown. Reported here are numerical simulations and laboratory experiments conducted to investigate the boundary conditions for particle motion inside a microvortex induced by an LWR. Upon dynamic capture, the particles’ trajectories become orbital paths within an acoustic vortex. The suspended particles encounter two distinct acoustic phenomena, i.e., the drag force resulting from acoustic streaming and the acoustic radiation force, which exert forces in various directions on the particles. When the acoustic radiation force and the fluid drag force are dominant for large and small particles in a mixed solution, respectively, the large particles reside within the vortex while the small particles remain at its periphery. Conversely, when the acoustic radiation force is dominant for both types of particles, the distribution pattern is reversed.
利用兰姆波谐振器(LWR)产生的声流可在微流体通道中有效地捕获和富集粒子。然而,由于兰姆波结合了体声波和表面声波的特点,在 LWR 中产生的声流发生在多个平面上,而粒子在这种声流体系统中的流动行为在很大程度上是未知的。本文通过数值模拟和实验室实验,研究了粒子在 LWR 诱导的微涡流内运动的边界条件。在动态捕获后,粒子的运动轨迹成为声漩涡内的轨道路径。悬浮粒子会遇到两种不同的声学现象,即声流产生的阻力和声辐射力,它们会对粒子施加不同方向的力。当声波辐射力和流体阻力分别对混合溶液中的大颗粒和小颗粒起主导作用时,大颗粒会停留在漩涡内,而小颗粒则停留在漩涡外围。相反,当声波辐射力对两种粒子都起主导作用时,分布模式则相反。
{"title":"Particle distributions in Lamb wave based acoustofluidics","authors":"Chuanchao Zhang, Xian Chen, Wei Wei, Xuejiao Chen, Quanning Li, Xuexin Duan","doi":"10.1063/10.0024320","DOIUrl":"https://doi.org/10.1063/10.0024320","url":null,"abstract":"Acoustic streaming enabled by a Lamb wave resonator (LWR) is efficient for particle trapping and enrichment in microfluidic channels. However, because Lamb waves combine the features of bulk acoustic waves and surface acoustic waves, the resulting acoustic streaming in the LWR occurs in multiple planes, and the particle flow behavior in this acoustofluidic system is largely unknown. Reported here are numerical simulations and laboratory experiments conducted to investigate the boundary conditions for particle motion inside a microvortex induced by an LWR. Upon dynamic capture, the particles’ trajectories become orbital paths within an acoustic vortex. The suspended particles encounter two distinct acoustic phenomena, i.e., the drag force resulting from acoustic streaming and the acoustic radiation force, which exert forces in various directions on the particles. When the acoustic radiation force and the fluid drag force are dominant for large and small particles in a mixed solution, respectively, the large particles reside within the vortex while the small particles remain at its periphery. Conversely, when the acoustic radiation force is dominant for both types of particles, the distribution pattern is reversed.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single micro-LED manipulation system based on micro-gripper 基于微型夹具的单个微型 LED 操作系统
Pub Date : 2024-02-02 DOI: 10.1063/10.0024319
Jie Bai, Pingjuan Niu, Erdan Gu, Jianming Li, Clarence Augustine TH Tee
Micro-LEDs (μLEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μLED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μLED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μLED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. Traditional grippers are too large to manipulate μLEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μLED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μLED arrays.
微型 LED(μLED)在亮度、功耗和响应速度方面都具有优势。此外,它们还可用作通过柔性电子皮肤植入人体的微型传感器。转印技术是制造基于μLED器件的关键技术之一。虽然转移印花的方法层出不穷,但提高μLED阵列的成品率仍是一项艰巨的任务。在本文中,我们提出了一种新方法,利用创新设计的压电驱动非对称微型夹具,提高通过冲压方法转移的 μLED 阵列的成品率。传统的抓手太大,无法操纵微型 LED,因此在抓手顶端增加了两个微型悬臂。基于微型机械手和三维定位系统,我们构建了一个 μLED 操作系统。使用该系统的实验结果表明,它可以成功地操纵微型 LED 阵列。
{"title":"A single micro-LED manipulation system based on micro-gripper","authors":"Jie Bai, Pingjuan Niu, Erdan Gu, Jianming Li, Clarence Augustine TH Tee","doi":"10.1063/10.0024319","DOIUrl":"https://doi.org/10.1063/10.0024319","url":null,"abstract":"Micro-LEDs (μLEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μLED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μLED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μLED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. Traditional grippers are too large to manipulate μLEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μLED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μLED arrays.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139808876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single micro-LED manipulation system based on micro-gripper 基于微型夹具的单个微型 LED 操作系统
Pub Date : 2024-02-02 DOI: 10.1063/10.0024319
Jie Bai, Pingjuan Niu, Erdan Gu, Jianming Li, Clarence Augustine TH Tee
Micro-LEDs (μLEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μLED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μLED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μLED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. Traditional grippers are too large to manipulate μLEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μLED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μLED arrays.
微型 LED(μLED)在亮度、功耗和响应速度方面都具有优势。此外,它们还可用作通过柔性电子皮肤植入人体的微型传感器。转印技术是制造基于μLED器件的关键技术之一。虽然转移印花的方法层出不穷,但提高μLED阵列的成品率仍是一项艰巨的任务。在本文中,我们提出了一种新方法,利用创新设计的压电驱动非对称微型夹具,提高通过冲压方法转移的 μLED 阵列的成品率。传统的抓手太大,无法操纵微型 LED,因此在抓手顶端增加了两个微型悬臂。基于微型机械手和三维定位系统,我们构建了一个 μLED 操作系统。使用该系统的实验结果表明,它可以成功地操纵微型 LED 阵列。
{"title":"A single micro-LED manipulation system based on micro-gripper","authors":"Jie Bai, Pingjuan Niu, Erdan Gu, Jianming Li, Clarence Augustine TH Tee","doi":"10.1063/10.0024319","DOIUrl":"https://doi.org/10.1063/10.0024319","url":null,"abstract":"Micro-LEDs (μLEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μLED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μLED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μLED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. Traditional grippers are too large to manipulate μLEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μLED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μLED arrays.","PeriodicalId":87330,"journal":{"name":"Nanotechnology and Precision Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Nanotechnology and Precision Engineering
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1